KR101625443B1 - 글루카르산의 세포적 제조 - Google Patents

글루카르산의 세포적 제조 Download PDF

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KR101625443B1
KR101625443B1 KR1020107024705A KR20107024705A KR101625443B1 KR 101625443 B1 KR101625443 B1 KR 101625443B1 KR 1020107024705 A KR1020107024705 A KR 1020107024705A KR 20107024705 A KR20107024705 A KR 20107024705A KR 101625443 B1 KR101625443 B1 KR 101625443B1
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inositol
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KR20110027652A (ko
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태 석 문
상-활 윤
크리스탈라 라넷 존스 프래더
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메사추세츠 인스티튜트 오브 테크놀로지
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01203—Uronate dehydrogenase (1.1.1.203)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/99—Miscellaneous (1.13.99)
    • C12Y113/99001—Inositol oxygenase (1.13.99.1), i.e. myo-inositol oxygenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y505/00—Intramolecular lyases (5.5)
    • C12Y505/01—Intramolecular lyases (5.5.1)
    • C12Y505/01004—Inositol-3-phosphate synthase (5.5.1.4)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020107024705A 2008-04-04 2009-04-03 글루카르산의 세포적 제조 Active KR101625443B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4250208P 2008-04-04 2008-04-04
US61/042,502 2008-04-04
PCT/US2009/002111 WO2009145838A2 (en) 2008-04-04 2009-04-03 Cellular production of glucaric acid

Publications (2)

Publication Number Publication Date
KR20110027652A KR20110027652A (ko) 2011-03-16
KR101625443B1 true KR101625443B1 (ko) 2016-05-30

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Country Link
US (2) US8835147B2 (enExample)
EP (1) EP2274417B1 (enExample)
JP (2) JP6196016B2 (enExample)
KR (1) KR101625443B1 (enExample)
CN (1) CN102066552B (enExample)
CA (1) CA2720526C (enExample)
DK (1) DK2274417T3 (enExample)
WO (1) WO2009145838A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20086236A0 (fi) * 2008-12-23 2008-12-23 Valtion Teknillinen Heksuronihapon konversio heksarihapoksi
KR101740848B1 (ko) 2011-11-14 2017-05-26 아사히 가세이 케미칼즈 가부시키가이샤 미오이노시톨 및 미오이노시톨 유도체의 제조 방법
EP2818552B1 (en) * 2012-02-24 2017-12-27 Asahi Kasei Kabushiki Kaisha Method for producing glucaric acid
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
CN105026548B (zh) * 2012-06-04 2019-06-18 盐水港精糖株式会社 D-葡萄糖二酸生产菌及d-葡萄糖二酸的制造方法
BR112015006255A2 (pt) * 2012-09-21 2017-08-22 Synthetic Genomics Inc Métodos para a produção de produtos químicos e derivados dos mesmos
US9528133B2 (en) 2012-09-21 2016-12-27 Synthetic Genomics, Inc. Compositions and methods for producing chemicals and derivatives thereof
CN106414753A (zh) * 2014-03-21 2017-02-15 合成基因组股份有限公司 用于生产化学品及其衍生物的组合物和方法
US20170130210A1 (en) * 2014-06-09 2017-05-11 Massachusetts Institute Of Technology Dynamic knockdown of central metabolism for redirecting glucose-6-phosphate fluxes
CN104312934A (zh) * 2014-10-22 2015-01-28 江南大学 一种构建重组酵母生物合成葡萄糖醛酸的方法
CN104312935B (zh) * 2014-10-22 2018-07-06 江南大学 一种构建重组酵母发酵生产葡萄糖二酸的方法
EP3480305A4 (en) 2016-06-30 2020-01-22 Cj Cheiljedang Corporation METHOD FOR THE ENZYMATIC PRODUCTION OF HIGHLY CONCENTRATED MYO-INOSITOL
CN106148292B (zh) * 2016-07-06 2019-05-17 江南大学 一种肌醇加氧酶突变体及其应用
EP3519567A4 (en) * 2016-10-03 2020-06-03 The Regents of The University of California MANIPULATED MICROORGANISMS FOR THE PRODUCTION OF CHEMICAL BASIC MATERIALS AND CELL BIOMASS
FR3067350B1 (fr) 2017-06-12 2020-12-11 Seprosys Procede d'obtention d'une solution d'acide glucarique libre et solution obtenue
HUE061086T2 (hu) 2017-06-22 2023-05-28 Archer Daniels Midland Co Eljárás furándikarbonsav-észterek elõállítására
CN107365806B (zh) * 2017-08-02 2020-04-03 南京师范大学 一种葡萄糖二酸的制备方法及其制备中的糖醛酸脱氢酶-nadh氧化酶和应用
CA3138481A1 (en) * 2019-05-17 2020-11-26 The Governing Council Of The University Of Toronto Enzymatic production of glucaric acid from glucuronic acid
CN110846436B (zh) * 2019-12-25 2021-09-28 江南大学 一种快速鉴别Ale和Lager型啤酒酵母的方法
CN111019852B (zh) * 2019-12-31 2021-11-23 江南大学 一种提高酿酒酵母工程菌株合成葡萄糖二酸效率的方法
CN110951794B (zh) * 2019-12-31 2022-03-25 江南大学 一种提高酿酒酵母工程菌生产葡萄糖二酸的发酵方法
KR102649855B1 (ko) * 2020-09-15 2024-03-22 경북대학교 산학협력단 갈락투론산을 발효하여 뮤식산을 생산하는 신규 효모 균주
WO2022204246A1 (en) * 2021-03-26 2022-09-29 Archer-Daniels-Midland Company Thermostable d-glucarate dehydratase that is resistant to inhibition by tartrate sequence submission
KR102626750B1 (ko) * 2021-12-27 2024-01-19 한국프라임제약주식회사 키로이노시톨 생성능이 우수한 락티카제이 바실러스 카제이 WiKim0135 균주 및 이의 혈당강하 용도
CN115820761A (zh) * 2022-11-28 2023-03-21 南京工业大学 一种生物法催化合成d-葡萄糖醛酸的方法
WO2024217529A1 (zh) * 2023-04-21 2024-10-24 西湖大学 一种新型的葡萄糖二酸生物合成路径及发酵生产葡萄糖二酸的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
DE19604798A1 (de) * 1996-02-09 1997-08-14 Herbstreith & Fox Kg Pektin Fa Herstellung von L-Ascorbinsäure
JP2004536577A (ja) 2001-03-19 2004-12-09 カーギル，インコーポレーテッド ミオイノシトールオキシゲナーゼ

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Publication number Publication date
EP2274417A2 (en) 2011-01-19
CN102066552A (zh) 2011-05-18
KR20110027652A (ko) 2011-03-16
CN102066552B (zh) 2014-03-12
CA2720526A1 (en) 2009-12-03
EP2274417A4 (en) 2012-05-02
EP2274417B1 (en) 2013-07-24
BRPI0911171A2 (pt) 2015-08-04
US20150093794A1 (en) 2015-04-02
US20110124065A1 (en) 2011-05-26
JP2011516063A (ja) 2011-05-26
JP6196016B2 (ja) 2017-09-13
CA2720526C (en) 2017-11-28
US8835147B2 (en) 2014-09-16
DK2274417T3 (da) 2013-10-28
WO2009145838A3 (en) 2010-02-18
JP2017018140A (ja) 2017-01-26
WO2009145838A2 (en) 2009-12-03

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