JP6191616B2 - 内服液剤 - Google Patents
内服液剤 Download PDFInfo
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- JP6191616B2 JP6191616B2 JP2014551015A JP2014551015A JP6191616B2 JP 6191616 B2 JP6191616 B2 JP 6191616B2 JP 2014551015 A JP2014551015 A JP 2014551015A JP 2014551015 A JP2014551015 A JP 2014551015A JP 6191616 B2 JP6191616 B2 JP 6191616B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Description
没食子酸類は、抗酸化作用を有することが知られており、今までに没食子酸類を配合してチオクト酸の光安定性を改善した内服液剤やトリプタン化合物の安定性低下を抑制した内服液剤が開示されている(特許文献1〜3)。一方で、没食子酸類は光照射により水に対する溶解度が低い副生成物を生じることが報告されており(非特許文献1)、沈殿の原因となってしまうことが考えられる。
(1)a)ビタミンB2又はその内服可能な塩、b)生薬由来成分、c)生薬由来成分1質量部(原生薬量)に対して1〜10質量部のポリビニルピロリドン、及びd)ビタミンB2の1質量部に対して0.02〜1.6質量部の没食子酸及びその誘導体から選ばれる少なくとも1種を配合したことを特徴とする内服液剤、
(2)ビタミンB2又はその内服可能な塩が、リボフラビン、リン酸リボフラビン、酪酸リボフラビン、フラビンアデニンヌクレオチド及びこれらの内服可能な塩から選ばれる(1)に記載の内服液剤、
(3)生薬由来成分が、ショウキョウ抽出物である(1)に記載の内服液剤、
(4)449nmの光透過率が0.1%以上である容器に充填した(1)〜(3)のいずれかに記載の内服液剤、
である。
リン酸リボフラビン16.93mg、ショウキョウ流エキス(原生薬量)100mg、没食子酸プロピル5mg、クエン酸475mg、ポリビニルピロリドン1000mgを精製水に溶解し、精製水を加えて全量を100mLとし、449nmの光透過率が0.3%の褐色ガラス瓶に充填しキャップを施し、80℃で25分間加熱殺菌して澄明な内服液剤を得た。
以下の比較例1、比較例2も実施例1と同様に調製した。それぞれの処方を表1に示す。
光安定性試験装置(LTL−400D5、株式会社ナガノサイエンス製)を用い、D65蛍光ランプを光源として、実施例1、比較例1及び比較例2で得た試験液を3000Lux×200時間曝光させた。これらの試験液中のリン酸リボフラビン残存率を液体クロマトグラフ法(カラム:ODS−80TS(東ソー)、移動相:水:アセトニトリル:リン酸=880:120:1、流速:1mL/min、検出波長:280nm)により定量した。調製直後に対する3000Lux×200時間曝光後のリン酸リボフラビン残存率(%)を表2に示す。
以下の実施例2、実施例3、比較例3も実施例1と同様に調製し、澄明な内服液剤を得た。それぞれの処方を表3に示す。
光安定性試験装置(LTL−400D5、株式会社ナガノサイエンス製)を用い、D65蛍光ランプを光源として、実施例2、実施例3及び比較例3で得た試験液を3000Lux×400時間曝光させた。これらの試験液中のリン酸リボフラビン残存率を液体クロマトグラフ法(カラム:ODS−80TS(東ソー)、移動相:水:アセトニトリル:リン酸=880:120:1、流速:1mL/min、検出波長:280nm)により定量した。調製直後に対する3000Lux×400時間曝光後のリン酸リボフラビン残存率(%)を表4に示す。
Claims (4)
- a)ビタミンB2又はその内服可能な塩、b)生薬由来成分、c)生薬由来成分1質量部(原生薬量)に対して1〜10質量部のポリビニルピロリドン、及びd)ビタミンB2の1質量部に対して0.02〜1.6質量部の没食子酸及びその誘導体から選ばれる少なくとも1種を配合したことを特徴とする内服液剤。
- ビタミンB2又はその内服可能な塩が、リボフラビン、リン酸リボフラビン、酪酸リボフラビン、フラビンアデニンヌクレオチド及びこれらの内服可能な塩から選ばれる請求項1に記載の内服液剤。
- 生薬由来成分が、ショウキョウ抽出物である請求項1に記載の内服液剤。
- 449nmの光透過率が0.1%以上である容器に充填した請求項1〜3のいずれかに記載の内服液剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012266256 | 2012-12-05 | ||
JP2012266256 | 2012-12-05 | ||
PCT/JP2013/080662 WO2014087818A1 (ja) | 2012-12-05 | 2013-11-13 | 内服液剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2014087818A1 JPWO2014087818A1 (ja) | 2017-01-05 |
JP6191616B2 true JP6191616B2 (ja) | 2017-09-06 |
Family
ID=50883243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014551015A Active JP6191616B2 (ja) | 2012-12-05 | 2013-11-13 | 内服液剤 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20150343009A1 (ja) |
JP (1) | JP6191616B2 (ja) |
CN (1) | CN105007923A (ja) |
MX (1) | MX2015007091A (ja) |
PH (1) | PH12015501152A1 (ja) |
SG (1) | SG11201504068UA (ja) |
TW (1) | TW201438762A (ja) |
WO (1) | WO2014087818A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11083738B2 (en) * | 2017-09-28 | 2021-08-10 | Natals, Inc. | Dietary nutrient compositions |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3460089B2 (ja) * | 1991-12-10 | 2003-10-27 | 第一薬品工業株式会社 | 異臭生成を防止した内用液剤 |
JPH06145056A (ja) * | 1992-06-05 | 1994-05-24 | Zeria Pharmaceut Co Ltd | ビタミンb類配合液剤 |
JP3658878B2 (ja) * | 1996-08-05 | 2005-06-08 | 大正製薬株式会社 | 内服液剤 |
JP2001213764A (ja) * | 2000-01-31 | 2001-08-07 | Taisho Pharmaceut Co Ltd | 内服液剤 |
JP4168811B2 (ja) * | 2003-04-07 | 2008-10-22 | 大正製薬株式会社 | 飲料組成物 |
JP5040060B2 (ja) * | 2004-10-14 | 2012-10-03 | 大正製薬株式会社 | メチオニン配合内服液剤 |
JP5295571B2 (ja) * | 2005-12-28 | 2013-09-18 | ライオン株式会社 | 疲労回復用内服用液剤 |
JP5125146B2 (ja) * | 2006-03-02 | 2013-01-23 | 大正製薬株式会社 | 内服液剤 |
JP5089956B2 (ja) * | 2006-10-13 | 2012-12-05 | ライオン株式会社 | 内服用液剤製品 |
WO2013133408A1 (ja) * | 2012-03-09 | 2013-09-12 | 武田薬品工業株式会社 | 内服用液剤 |
-
2013
- 2013-11-13 WO PCT/JP2013/080662 patent/WO2014087818A1/ja active Application Filing
- 2013-11-13 TW TW102141286A patent/TW201438762A/zh unknown
- 2013-11-13 US US14/647,881 patent/US20150343009A1/en not_active Abandoned
- 2013-11-13 MX MX2015007091A patent/MX2015007091A/es unknown
- 2013-11-13 JP JP2014551015A patent/JP6191616B2/ja active Active
- 2013-11-13 SG SG11201504068UA patent/SG11201504068UA/en unknown
- 2013-11-13 CN CN201380063510.7A patent/CN105007923A/zh active Pending
-
2015
- 2015-05-22 PH PH12015501152A patent/PH12015501152A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20150343009A1 (en) | 2015-12-03 |
MX2015007091A (es) | 2015-09-25 |
SG11201504068UA (en) | 2015-07-30 |
JPWO2014087818A1 (ja) | 2017-01-05 |
PH12015501152A1 (en) | 2015-08-17 |
TW201438762A (zh) | 2014-10-16 |
WO2014087818A1 (ja) | 2014-06-12 |
CN105007923A (zh) | 2015-10-28 |
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