JP6154939B1 - ニンニク成分の吸収促進剤 - Google Patents
ニンニク成分の吸収促進剤 Download PDFInfo
- Publication number
- JP6154939B1 JP6154939B1 JP2016115985A JP2016115985A JP6154939B1 JP 6154939 B1 JP6154939 B1 JP 6154939B1 JP 2016115985 A JP2016115985 A JP 2016115985A JP 2016115985 A JP2016115985 A JP 2016115985A JP 6154939 B1 JP6154939 B1 JP 6154939B1
- Authority
- JP
- Japan
- Prior art keywords
- garlic
- egg yolk
- alliin
- sac
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000004611 garlic Nutrition 0.000 title claims abstract description 40
- 239000003655 absorption accelerator Substances 0.000 title 1
- 244000245420 ail Species 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- ZFAHNWWNDFHPOH-YFKPBYRVSA-N S-allylcysteine Chemical compound OC(=O)[C@@H](N)CSCC=C ZFAHNWWNDFHPOH-YFKPBYRVSA-N 0.000 claims abstract description 76
- 240000002234 Allium sativum Species 0.000 claims abstract description 39
- ZFAHNWWNDFHPOH-UHFFFAOYSA-N S-Allyl-L-cystein Natural products OC(=O)C(N)CSCC=C ZFAHNWWNDFHPOH-UHFFFAOYSA-N 0.000 claims abstract description 38
- 102000002322 Egg Proteins Human genes 0.000 claims abstract description 32
- 108010000912 Egg Proteins Proteins 0.000 claims abstract description 32
- 235000013345 egg yolk Nutrition 0.000 claims abstract description 32
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 32
- XUHLIQGRKRUKPH-GCXOYZPQSA-N Alliin Natural products N[C@H](C[S@@](=O)CC=C)C(O)=O XUHLIQGRKRUKPH-GCXOYZPQSA-N 0.000 claims abstract description 28
- XUHLIQGRKRUKPH-UHFFFAOYSA-N S-allyl-L-cysteine sulfoxide Natural products OC(=O)C(N)CS(=O)CC=C XUHLIQGRKRUKPH-UHFFFAOYSA-N 0.000 claims abstract description 28
- XUHLIQGRKRUKPH-DYEAUMGKSA-N alliin Chemical compound OC(=O)[C@@H](N)C[S@@](=O)CC=C XUHLIQGRKRUKPH-DYEAUMGKSA-N 0.000 claims abstract description 28
- 235000015295 alliin Nutrition 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 17
- 238000010521 absorption reaction Methods 0.000 claims abstract description 6
- 229940124532 absorption promoter Drugs 0.000 claims abstract description 5
- 239000003623 enhancer Substances 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 description 41
- 238000012360 testing method Methods 0.000 description 39
- 230000000694 effects Effects 0.000 description 11
- 238000013461 design Methods 0.000 description 9
- 230000037406 food intake Effects 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000000692 Student's t-test Methods 0.000 description 5
- 238000012353 t test Methods 0.000 description 5
- 229940029982 garlic powder Drugs 0.000 description 4
- 238000004898 kneading Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000001550 time effect Effects 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- FUTHBNRZCFKVQZ-YUMQZZPRSA-N (2s)-2-amino-5-[[(1r)-1-carboxy-2-prop-2-enylsulfanylethyl]amino]-5-oxopentanoic acid Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(O)=O)CSCC=C FUTHBNRZCFKVQZ-YUMQZZPRSA-N 0.000 description 1
- MUFSTXJBHAEIBT-UHFFFAOYSA-N 2-amino-5-[(1-carboxy-2-prop-1-enylsulfanylethyl)amino]-5-oxopentanoic acid Chemical compound CC=CSCC(C(O)=O)NC(=O)CCC(N)C(O)=O MUFSTXJBHAEIBT-UHFFFAOYSA-N 0.000 description 1
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 description 1
- 108010092760 Alliin lyase Proteins 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 235000010081 allicin Nutrition 0.000 description 1
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 235000021471 food effect Nutrition 0.000 description 1
- FUTHBNRZCFKVQZ-UHFFFAOYSA-N gamma-L-Glutamyl-S-allyl-L-cysteine Natural products OC(=O)C(N)CCC(=O)NC(C(O)=O)CSCC=C FUTHBNRZCFKVQZ-UHFFFAOYSA-N 0.000 description 1
- 108010039146 gamma-glutamyl-S-allylcysteine Proteins 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000012898 one-sample t-test Methods 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L35/00—Food or foodstuffs not provided for in groups A23L5/00 – A23L33/00; Preparation or treatment thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Toxicology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seeds, Soups, And Other Foods (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
[2]にんにく卵黄が、にんにく卵黄粉末である、[1]に記載のS−アリルシステイン(SAC)及びアリインの吸収促進剤。
加熱加工処理を行うと、処理の程度(温度・期間)によって、果肉色が、白〜琥珀色〜黒に変化する。S−アリルシステインは、琥珀色の時に最も含有量が高く、黒くなるまで加熱すると減少する。一方、琥珀色の時より刺激が少なく、食べやすくなる。
にんにくを混練しながら減圧状態で80〜100度に加熱し、粉末状になるまで撹拌を続け、SAC、アリインの濃度がにんにく卵黄粉末と同等となるようにデキストリンを加えて調製した。
にんにく70〜90重量部を混練しながら減圧状態で80から100℃に加熱し、混練後に常圧にし、65℃以下の温度で卵黄10〜30重量部加え混練をしながら減圧、80〜100℃まで昇温し粉末状になるまで撹拌しにんにく卵黄粉末を得た。
高速液体クロマトグラム分析法
(カラム:4.6×150mm、Inertsil ODS−45μm)
移動相:リン酸バッファー pH2.6/メタノール=85/15
検出器:UV205nm
高速液体クロマトグラム分析法
(カラム:4.6×150mm、Inertsil ODS−45μm)
移動相:リン酸バッファー pH2.6/メタノール=85/15
検出器:UV205nm
アリイン濃度AUC0−8hについて、クロスオーバーの順序効果、時期効果を検討したところ時期効果は有意であったが、順序効果は有意でなく、クロスオーバーデザインは適切であった。
実測値では、クロスオーバーデザインは不適切であったことから、第I期のみの結果から、試験食品1のCmaxは611.33±197.41ng/mL、試験食品2のCmaxは503.04±126.11ng/mLであり、試験食品1摂取の方が高い値を示したが、有意差は認められなかった(2標本t検定)。その時のTmaxは試験食品1及び2ともに摂取後2時間であった。
実測値では、試験食品1のCmaxは799.45± 266.72ng/mL、試験食品2のCmaxは910.14±217.74ng/mLであり、試験食品2の方が高い値を示したが、有意差は認められなかった(1標本t検定)。その時のTmaxは試験食品1及び2ともに摂取後1時間であった。
主要評価項目のSAC濃度AUC0−8hは、実測値ではクロスオーバーデザインは適切ではなかったが、変化量でのSAC濃度ΔAUC0−8hでは、クロスオーバーデザインは適切であり、試験食品2は試験食品1よりもΔAUC0−8hは有意に高かった。
Claims (2)
- にんにく卵黄を含む、S−アリルシステイン(SAC)及びアリインの吸収促進剤。
- にんにく卵黄が、にんにく卵黄粉末である、請求項1に記載のS−アリルシステイン(SAC)及びアリインの吸収促進剤。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016115985A JP6154939B1 (ja) | 2016-06-10 | 2016-06-10 | ニンニク成分の吸収促進剤 |
TW106118511A TWI666025B (zh) | 2016-06-10 | 2017-06-05 | 大蒜成分的吸收促進劑 |
CN201780035805.1A CN109310726B (zh) | 2016-06-10 | 2017-06-05 | 大蒜成分的吸收促进剂 |
US16/308,333 US20190282652A1 (en) | 2016-06-10 | 2017-06-05 | Absorption promoter for garlic components |
KR1020197000402A KR102345940B1 (ko) | 2016-06-10 | 2017-06-05 | 마늘 성분의 흡수 촉진제 |
PCT/JP2017/020799 WO2017213076A1 (ja) | 2016-06-10 | 2017-06-05 | ニンニク成分の吸収促進剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016115985A JP6154939B1 (ja) | 2016-06-10 | 2016-06-10 | ニンニク成分の吸収促進剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP6154939B1 true JP6154939B1 (ja) | 2017-06-28 |
JP2017218437A JP2017218437A (ja) | 2017-12-14 |
Family
ID=59218549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016115985A Active JP6154939B1 (ja) | 2016-06-10 | 2016-06-10 | ニンニク成分の吸収促進剤 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20190282652A1 (ja) |
JP (1) | JP6154939B1 (ja) |
KR (1) | KR102345940B1 (ja) |
CN (1) | CN109310726B (ja) |
TW (1) | TWI666025B (ja) |
WO (1) | WO2017213076A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6154939B1 (ja) * | 2016-06-10 | 2017-06-28 | 株式会社健康家族 | ニンニク成分の吸収促進剤 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005168321A (ja) * | 2003-12-08 | 2005-06-30 | Ichiro Yamada | にんにく卵黄に水溶性有機イオウ化合物s−アリルシステインを配合した製品とその製造方法。 |
JP2006176421A (ja) * | 2004-12-21 | 2006-07-06 | Kenko Kazoku:Kk | ニンニク卵黄を含有する脳機能及び/又は血液流動性改善用組成物 |
JP2006182776A (ja) * | 2004-12-02 | 2006-07-13 | Kenko Kazoku:Kk | ニンニク卵黄を含有する高血圧の予防及び/又は治療用組成物 |
JP2013021997A (ja) * | 2011-07-25 | 2013-02-04 | Miraikan Co Ltd | ニンニク卵黄の製造方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100412424B1 (ko) | 2000-04-12 | 2003-12-24 | 학교법인고려중앙학원 | 마늘추출물의 전립선암 및 방광암 예방 및 치료제로서의용도 |
KR20100027537A (ko) * | 2008-09-02 | 2010-03-11 | 최돈열 | 홍삼 및 난황이 함유된 마늘환 건강보조식품의 제조장치 및방법 |
KR101188746B1 (ko) * | 2009-09-23 | 2012-10-11 | 주식회사파마킹 | 에스-알릴-엘-시스테인을 유효성분으로 포함하는 위장질환 예방 또는 치료용 조성물 |
JP2012110320A (ja) * | 2010-11-05 | 2012-06-14 | Momoya Co Ltd | ニンニク抽出水溶液の利用法 |
KR101029133B1 (ko) * | 2010-11-19 | 2011-04-13 | 최돈열 | 홍삼 및 난황이 함유된 마늘환 건강보조식품의 제조방법 |
KR20130039309A (ko) * | 2011-10-11 | 2013-04-19 | 김선미 | 마늘과 난황의 복합 활성물질를 건강개선 기능성 약효제로 포함하는 식품조성물과 그 제조방법. |
JP6154939B1 (ja) * | 2016-06-10 | 2017-06-28 | 株式会社健康家族 | ニンニク成分の吸収促進剤 |
-
2016
- 2016-06-10 JP JP2016115985A patent/JP6154939B1/ja active Active
-
2017
- 2017-06-05 KR KR1020197000402A patent/KR102345940B1/ko active IP Right Grant
- 2017-06-05 TW TW106118511A patent/TWI666025B/zh active
- 2017-06-05 US US16/308,333 patent/US20190282652A1/en not_active Abandoned
- 2017-06-05 WO PCT/JP2017/020799 patent/WO2017213076A1/ja active Application Filing
- 2017-06-05 CN CN201780035805.1A patent/CN109310726B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005168321A (ja) * | 2003-12-08 | 2005-06-30 | Ichiro Yamada | にんにく卵黄に水溶性有機イオウ化合物s−アリルシステインを配合した製品とその製造方法。 |
JP2006182776A (ja) * | 2004-12-02 | 2006-07-13 | Kenko Kazoku:Kk | ニンニク卵黄を含有する高血圧の予防及び/又は治療用組成物 |
JP2006176421A (ja) * | 2004-12-21 | 2006-07-06 | Kenko Kazoku:Kk | ニンニク卵黄を含有する脳機能及び/又は血液流動性改善用組成物 |
JP2013021997A (ja) * | 2011-07-25 | 2013-02-04 | Miraikan Co Ltd | ニンニク卵黄の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2017213076A1 (ja) | 2017-12-14 |
KR20190017886A (ko) | 2019-02-20 |
CN109310726B (zh) | 2020-04-21 |
KR102345940B1 (ko) | 2021-12-30 |
JP2017218437A (ja) | 2017-12-14 |
TW201742631A (zh) | 2017-12-16 |
CN109310726A (zh) | 2019-02-05 |
TWI666025B (zh) | 2019-07-21 |
US20190282652A1 (en) | 2019-09-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10765752B2 (en) | Solid composition comprising iron for use in iron deficient conditions | |
JP4854199B2 (ja) | 液化酒粕を再発酵して得られる機能性素材 | |
JP2006149325A (ja) | 醗酵黒ニンニク及びこれを用いるペースト状食品並びにこれらの製造方法 | |
JP4830066B2 (ja) | 生キノコエキス製造方法、エキス及びエキス配合物 | |
JP2014045693A (ja) | 黒ニンニクエキスの製造およびその用途 | |
JP2004269361A (ja) | 成長ホルモン分泌促進組成物 | |
JP6154939B1 (ja) | ニンニク成分の吸収促進剤 | |
JP2007029020A (ja) | 黒酢健康食品とその製造方法 | |
JPH04338336A (ja) | 抗肥満剤 | |
JP2013255512A (ja) | コラーゲン吸収促進用組成物 | |
KR101178860B1 (ko) | 미세조류 단백질 가수분해물을 포함하는 천연조미료 및 이의 제조방법 | |
CN1593191A (zh) | 一种花粉、蜂王浆食品及其制备方法 | |
JP2011115046A (ja) | コラーゲン吸収促進用組成物 | |
JP6697245B2 (ja) | 持久力向上剤 | |
JP2008118994A (ja) | コンニャク粉の液状化による低カロリーコンニャク飲料、低カロリー食品、自然化粧品の製造方法 | |
JP2002017296A (ja) | アミノ酸・糖組成物含有食品 | |
JP2002291439A (ja) | 香辛性材料を原料とした食品または製剤 | |
CN105995875A (zh) | 一种富硒型固态复合调味料及其制备方法 | |
JP2923196B2 (ja) | 中華麺風味付与剤及びその製造方法 | |
JP2007063184A (ja) | 血清コレステロール低下剤及びその製造方法 | |
JP6424025B2 (ja) | 小麦ふすま含有製剤 | |
JP2008173101A (ja) | 乾燥納豆粉末加工食品 | |
WO2015022930A1 (ja) | ホタテ貝外套膜のタンパク質分解物を有効成分とする脂質吸収促進剤及びこれを含む飲食品 | |
JP2022105586A (ja) | S-アリルシステインの製造方法 | |
JPH0217151B2 (ja) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170404 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170530 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170602 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6154939 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |