JP5974012B2 - 突然変異体スムースンド及びその使用方法 - Google Patents

突然変異体スムースンド及びその使用方法 Download PDF

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Publication number
JP5974012B2
JP5974012B2 JP2013532905A JP2013532905A JP5974012B2 JP 5974012 B2 JP5974012 B2 JP 5974012B2 JP 2013532905 A JP2013532905 A JP 2013532905A JP 2013532905 A JP2013532905 A JP 2013532905A JP 5974012 B2 JP5974012 B2 JP 5974012B2
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antibody
smo
antibodies
amino acid
mutant
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JP2014503180A (ja
JP2014503180A5 (enExample
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フレデリック・ジ・ド・サウヴァージ
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013532905A 2010-10-05 2011-10-05 突然変異体スムースンド及びその使用方法 Expired - Fee Related JP5974012B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38999510P 2010-10-05 2010-10-05
US61/389,995 2010-10-05
PCT/US2011/054877 WO2012047968A2 (en) 2010-10-05 2011-10-05 Mutant smoothened and methods of using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016139313A Division JP2016214249A (ja) 2010-10-05 2016-07-14 突然変異体スムースンド及びその使用方法

Publications (3)

Publication Number Publication Date
JP2014503180A JP2014503180A (ja) 2014-02-13
JP2014503180A5 JP2014503180A5 (enExample) 2014-11-27
JP5974012B2 true JP5974012B2 (ja) 2016-08-23

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JP2013532905A Expired - Fee Related JP5974012B2 (ja) 2010-10-05 2011-10-05 突然変異体スムースンド及びその使用方法
JP2016139313A Pending JP2016214249A (ja) 2010-10-05 2016-07-14 突然変異体スムースンド及びその使用方法

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Country Status (8)

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US (2) US8481680B2 (enExample)
EP (1) EP2625197B1 (enExample)
JP (2) JP5974012B2 (enExample)
AU (1) AU2011312205B2 (enExample)
CA (1) CA2813738A1 (enExample)
DK (1) DK2625197T3 (enExample)
ES (1) ES2588981T3 (enExample)
WO (1) WO2012047968A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2473522T3 (en) 2009-09-02 2016-11-28 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
ES2588981T3 (es) 2010-10-05 2016-11-08 Genentech, Inc. Smoothened mutante y métodos de uso de la misma
US9708299B2 (en) 2011-01-03 2017-07-18 Genentech, Inc. Hedgehog antagonists having zinc binding moieties
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
WO2015116902A1 (en) 2014-01-31 2015-08-06 Genentech, Inc. G-protein coupled receptors in hedgehog signaling
AU2015214264B2 (en) 2014-02-04 2018-12-20 Curis, Inc. Mutant Smoothened and methods of using the same
US10330683B2 (en) 2015-02-04 2019-06-25 Genentech, Inc. Mutant smoothened and methods of using the same
JP2019509721A (ja) 2016-02-04 2019-04-11 キュリス，インコーポレイテッド 突然変異体スムースンド及びその使用方法
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
BR112021000340A2 (pt) * 2018-07-11 2021-04-13 Hedgehog, Inc. Epítopo específico para proteína smo, anticorpo ou fragmento do mesmo, molécula de ácido nucléico, vetor, célula hospedeira, composição de vacina, composição farmacêutica, uso do anticorpo, método para quantificar proteína smo, método para prover informação quanto ao diagnóstico de doença e kit para quantificar proteína smo
WO2020013644A1 (ko) * 2018-07-11 2020-01-16 고려대학교 산학협력단 Smo 단백질의 특이적 에피토프, 이를 인지하는 항체 및 이를 포함하는 조성물
WO2023101438A1 (ko) * 2021-11-30 2023-06-08 주식회사 헤지호그 Smo 인간 항체

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