JP5945400B2 - 検出光学系および走査型顕微鏡 - Google Patents
検出光学系および走査型顕微鏡 Download PDFInfo
- Publication number
- JP5945400B2 JP5945400B2 JP2011252674A JP2011252674A JP5945400B2 JP 5945400 B2 JP5945400 B2 JP 5945400B2 JP 2011252674 A JP2011252674 A JP 2011252674A JP 2011252674 A JP2011252674 A JP 2011252674A JP 5945400 B2 JP5945400 B2 JP 5945400B2
- Authority
- JP
- Japan
- Prior art keywords
- light
- diffraction grating
- wavelength
- vph diffraction
- specimen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001514 detection method Methods 0.000 title claims description 109
- 230000003287 optical effect Effects 0.000 title claims description 84
- 238000006073 displacement reaction Methods 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 5
- 230000003595 spectral effect Effects 0.000 description 16
- 238000000034 method Methods 0.000 description 10
- 238000003384 imaging method Methods 0.000 description 8
- NCGICGYLBXGBGN-UHFFFAOYSA-N 3-morpholin-4-yl-1-oxa-3-azonia-2-azanidacyclopent-3-en-5-imine;hydrochloride Chemical compound Cl.[N-]1OC(=N)C=[N+]1N1CCOCC1 NCGICGYLBXGBGN-UHFFFAOYSA-N 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000010287 polarization Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000002073 fluorescence micrograph Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/021—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using plane or convex mirrors, parallel phase plates, or particular reflectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0237—Adjustable, e.g. focussing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/06—Scanning arrangements arrangements for order-selection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J3/18—Generating the spectrum; Monochromators using diffraction elements, e.g. grating
- G01J3/1838—Holographic gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011252674A JP5945400B2 (ja) | 2011-11-18 | 2011-11-18 | 検出光学系および走査型顕微鏡 |
| US13/669,634 US8885162B2 (en) | 2011-11-18 | 2012-11-06 | Detection optical system and scanning microscope |
| EP12007625.2A EP2594979B1 (en) | 2011-11-18 | 2012-11-09 | Detection optical system and scanning microscope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011252674A JP5945400B2 (ja) | 2011-11-18 | 2011-11-18 | 検出光学系および走査型顕微鏡 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013109082A JP2013109082A (ja) | 2013-06-06 |
| JP2013109082A5 JP2013109082A5 (enExample) | 2014-12-18 |
| JP5945400B2 true JP5945400B2 (ja) | 2016-07-05 |
Family
ID=47323809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011252674A Expired - Fee Related JP5945400B2 (ja) | 2011-11-18 | 2011-11-18 | 検出光学系および走査型顕微鏡 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US8885162B2 (enExample) |
| EP (1) | EP2594979B1 (enExample) |
| JP (1) | JP5945400B2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022025728A1 (ko) * | 2020-07-30 | 2022-02-03 | 주식회사 스킨어세이 | 분광기 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5945400B2 (ja) * | 2011-11-18 | 2016-07-05 | オリンパス株式会社 | 検出光学系および走査型顕微鏡 |
| JP6408796B2 (ja) | 2014-06-11 | 2018-10-17 | オリンパス株式会社 | レーザ顕微鏡装置 |
| JP6456617B2 (ja) * | 2014-07-15 | 2019-01-23 | オリンパス株式会社 | 顕微鏡装置 |
| KR102240270B1 (ko) | 2014-07-21 | 2021-04-14 | 삼성전자주식회사 | 광 변환 모듈 및 광학 측정 시스템 |
| WO2016061710A1 (zh) * | 2014-10-21 | 2016-04-28 | 清华大学 | 一种快速宽视场体全息荧光显微成像系统 |
| CN105352923B (zh) * | 2014-10-21 | 2018-08-03 | 清华大学 | 一种快速宽视场体全息荧光显微成像系统 |
| JP6375239B2 (ja) * | 2015-02-05 | 2018-08-15 | オリンパス株式会社 | レーザ顕微鏡装置 |
| KR101884118B1 (ko) * | 2017-03-14 | 2018-07-31 | 한양대학교 산학협력단 | 투과 회절 격자 기반 분광기 |
| DE102017127122B4 (de) * | 2017-11-17 | 2022-05-05 | Endress+Hauser Conducta Gmbh+Co. Kg | Spektrometrisches Messgerät |
| TR202010646A1 (tr) * | 2020-07-06 | 2022-01-21 | Orta Dogu Teknik Ueniversitesi | Deği̇şken kirinim opti̇k elemanli opti̇k spektrometre |
| US20230304922A1 (en) | 2022-03-23 | 2023-09-28 | Tetsuroh Tatebe | Spectroscope and analysis system |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3600093A (en) * | 1969-11-10 | 1971-08-17 | Sperry Rand Corp | Continuously blazed optical monochromator |
| DE10038049A1 (de) * | 2000-08-02 | 2002-02-14 | Leica Microsystems | Optische Anordnung zur Selektion und Detektion des Spektalbereichs eines Lichtstrahls |
| US6583873B1 (en) * | 2000-09-25 | 2003-06-24 | The Carnegie Institution Of Washington | Optical devices having a wavelength-tunable dispersion assembly that has a volume dispersive diffraction grating |
| TW538258B (en) * | 2002-07-16 | 2003-06-21 | Ind Tech Res Inst | Grating interferometer device with tunable resolution |
| TWI245473B (en) * | 2003-06-30 | 2005-12-11 | Delta Electronics Inc | Tunable laser source and wavelength selecting method thereof |
| JP4646506B2 (ja) * | 2003-09-11 | 2011-03-09 | オリンパス株式会社 | レーザ走査型顕微鏡 |
| JP4633386B2 (ja) * | 2004-05-25 | 2011-02-16 | オリンパス株式会社 | 走査型レーザ顕微鏡及びそれを用いたデータ取得方法 |
| JP4804727B2 (ja) | 2004-06-24 | 2011-11-02 | オリンパス株式会社 | 光走査型共焦点顕微鏡 |
| JP4645173B2 (ja) * | 2004-11-26 | 2011-03-09 | 株式会社ニコン | 分光器、及びこれを備えている顕微分光装置 |
| DE102005042890B4 (de) * | 2005-09-09 | 2007-05-31 | Leica Microsystems Cms Gmbh | Konfokalmikroskop und Verfahren zur Detektion mit einem Konfokalmikroskop |
| US7564547B2 (en) | 2005-11-07 | 2009-07-21 | Wafermasters, Inc. | Spectroscopy system |
| US20070160325A1 (en) * | 2006-01-11 | 2007-07-12 | Hyungbin Son | Angle-tunable transmissive grating |
| KR100817726B1 (ko) * | 2008-01-18 | 2008-03-31 | 주식회사 나노베이스 | 파장 가변 장치 및 그 방법 |
| KR100885537B1 (ko) * | 2008-09-03 | 2009-02-26 | 주식회사 나노베이스 | 파장 가변 분광계 및 그 파장 가변 방법 |
| JP2011197351A (ja) * | 2010-03-19 | 2011-10-06 | Olympus Corp | 反射型回折格子、及び、それを用いた分光器及びパルス整形器 |
| JP5541972B2 (ja) * | 2010-06-09 | 2014-07-09 | オリンパス株式会社 | 走査型共焦点顕微鏡 |
| JP5965099B2 (ja) * | 2010-11-05 | 2016-08-03 | 住友電気工業株式会社 | 光学装置およびその調整方法 |
| JP5945400B2 (ja) * | 2011-11-18 | 2016-07-05 | オリンパス株式会社 | 検出光学系および走査型顕微鏡 |
-
2011
- 2011-11-18 JP JP2011252674A patent/JP5945400B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-06 US US13/669,634 patent/US8885162B2/en active Active
- 2012-11-09 EP EP12007625.2A patent/EP2594979B1/en not_active Not-in-force
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022025728A1 (ko) * | 2020-07-30 | 2022-02-03 | 주식회사 스킨어세이 | 분광기 |
| US12326363B2 (en) | 2020-07-30 | 2025-06-10 | Answeray Inc. | Spectroscope |
Also Published As
| Publication number | Publication date |
|---|---|
| US8885162B2 (en) | 2014-11-11 |
| EP2594979B1 (en) | 2019-03-27 |
| US20130128268A1 (en) | 2013-05-23 |
| JP2013109082A (ja) | 2013-06-06 |
| EP2594979A1 (en) | 2013-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5945400B2 (ja) | 検出光学系および走査型顕微鏡 | |
| JP4315794B2 (ja) | 共焦点顕微鏡 | |
| JP5541972B2 (ja) | 走査型共焦点顕微鏡 | |
| JP5541978B2 (ja) | レーザ走査型顕微鏡 | |
| JP2013109082A5 (enExample) | ||
| US11686928B2 (en) | Light microscope | |
| JP4434882B2 (ja) | レーザ走査型蛍光観察装置 | |
| JP4414665B2 (ja) | 走査型レーザ顕微鏡 | |
| US20050024721A1 (en) | Scanning microscope | |
| JP4645173B2 (ja) | 分光器、及びこれを備えている顕微分光装置 | |
| JP4331454B2 (ja) | 走査型レーザ顕微鏡 | |
| JP5371362B2 (ja) | レーザ顕微鏡装置 | |
| JP4311936B2 (ja) | レーザ走査型顕微鏡 | |
| JP2006023745A (ja) | 位相フィルタ、光学装置及びラスタ顕微鏡 | |
| JP5861873B2 (ja) | 分光器及び顕微分光システム | |
| JP2017219400A (ja) | レーザ顕微鏡 | |
| JP5576649B2 (ja) | 分光器、及び、それを備えた光学装置 | |
| JP5787151B2 (ja) | 分光ユニット及び走査型顕微鏡 | |
| JP2005345561A (ja) | 走査型レーザ顕微鏡装置 | |
| JP2005181891A (ja) | レーザ顕微鏡 | |
| JP2011058953A (ja) | 検出装置、それを備えた光学装置 | |
| JP5583515B2 (ja) | レーザ顕微鏡用照明装置およびレーザ顕微鏡 | |
| JP2002277744A (ja) | 走査型光学顕微鏡 | |
| JP2006276840A (ja) | 顕微鏡装置、その制御装置、及びプログラム | |
| JP2013200329A (ja) | 顕微鏡システム |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141029 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141029 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20150827 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150915 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151113 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160510 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160530 |
|
| R151 | Written notification of patent or utility model registration |
Ref document number: 5945400 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R151 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |