JP5876031B2 - 化合物 - Google Patents
化合物 Download PDFInfo
- Publication number
- JP5876031B2 JP5876031B2 JP2013501421A JP2013501421A JP5876031B2 JP 5876031 B2 JP5876031 B2 JP 5876031B2 JP 2013501421 A JP2013501421 A JP 2013501421A JP 2013501421 A JP2013501421 A JP 2013501421A JP 5876031 B2 JP5876031 B2 JP 5876031B2
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- indol
- amine
- acetyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 229960002166 vinorelbine tartrate Drugs 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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| US61/419,068 | 2010-12-02 | ||
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| US8598156B2 (en) | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
| WO2012158123A1 (en) * | 2011-05-13 | 2012-11-22 | Agency For Science, Technology And Research | Compounds and methods for treating insulin resistance syndrome |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| SI3689878T1 (sl) | 2011-07-19 | 2021-12-31 | Merck Sharp & Dohme B.V. | 4-imidazopiridazin-1-il-benzamidi in 4-imidazotriazin-1-il-benzamidi kot Btk-zaviralci |
| JP6496246B2 (ja) * | 2012-10-05 | 2019-04-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アルドステロンシンターゼインヒビター関連用途としてのインドリン化合物 |
| WO2014111496A1 (en) * | 2013-01-18 | 2014-07-24 | F. Hoffmann-La Roche Ag | 3-substituted pyrazoles and use as dlk inhibitors |
| US9688662B2 (en) * | 2013-04-04 | 2017-06-27 | Janssen Pharmaceutica Nv | N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors |
| TWI482757B (zh) * | 2013-10-07 | 2015-05-01 | Luminescence Technology Corp | Ｖｅｇｆ－２／３受體及蛋白質酪胺酸激酶抑制劑及其醫藥用途 |
| WO2015056180A1 (en) * | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
| KR20160093062A (ko) | 2013-12-05 | 2016-08-05 | 아세르타 파마. 비.브이. | Pi3k 억제제 및 btk 억제제의 치료적 조합 |
| US10272083B2 (en) | 2014-01-21 | 2019-04-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor |
| EP3116877A1 (en) * | 2014-03-11 | 2017-01-18 | Glaxosmithkline Intellectual Property (No. 2) Limited | Chemical compounds acting as perk inhibitors |
| US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
| PT3179991T (pt) | 2014-08-11 | 2021-11-26 | Acerta Pharma Bv | Combinações terapêuticas de um inibidor de btk e um inibidor de bcl-2 |
| HUE050706T2 (hu) * | 2014-10-24 | 2020-12-28 | Bristol Myers Squibb Co | Indol karboxamid vegyületek, amelyek hasznosak kináz inhibitorokként |
| ES2792036T3 (es) | 2014-11-14 | 2020-11-06 | Nerviano Medical Sciences Srl | Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de cinasa |
| WO2016126026A2 (ko) * | 2015-02-04 | 2016-08-11 | 서울대학교병원 | 당뇨병 치료 조성물 및 이의 용도 |
| SI3317281T1 (sl) | 2015-07-02 | 2020-08-31 | Acerta Pharma B.V. | Trdne oblike in formulacije (s)-4-(8-amino-3-(1-(but-2-inoil)pirolidin -2-il)imidazo(1,5-a)pirazin-1-il)-n-(piridin-2-il)benzamida |
| TW201722957A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產（第二）有限公司 | 化學化合物 |
| WO2017046739A1 (en) * | 2015-09-15 | 2017-03-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Imidazolidinone derivatives as inhibitors of perk |
| JP6746712B2 (ja) * | 2016-04-07 | 2020-08-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節因子として有用な複素環式アミド |
| JP6943876B2 (ja) * | 2016-04-15 | 2021-10-06 | キャンサー・リサーチ・テクノロジー・リミテッドＣａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｔｅｃｈｎｏｌｏｇｙ Ｌｉｍｉｔｅｄ | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
| US11026945B2 (en) * | 2016-04-29 | 2021-06-08 | The Trustees Of The University Of Pennsylvania | Protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitors for prevention and/or treatment of lung injury and/or inflammation |
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| CN111100130B (zh) * | 2018-10-29 | 2022-07-15 | 四川大学 | 4-氨基吡咯并嘧啶衍生物及其制备方法和用途 |
| CN111213632B (zh) * | 2019-11-19 | 2022-03-01 | 长春中医药大学 | 动物药环氧树脂标本制作方法 |
| KR20230035311A (ko) | 2020-06-08 | 2023-03-13 | 할리아 테라퓨틱스, 인코포레이티드 | Nek7 키나제의 억제제 |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| US20240382488A1 (en) | 2021-03-29 | 2024-11-21 | Halia Therapeutics, Inc. | Nek7 inhibitors |
| BR112023019435A2 (pt) | 2021-04-05 | 2023-10-24 | Halia Therapeutics Inc | Inibidores de nek7 |
| WO2023034236A1 (en) * | 2021-08-31 | 2023-03-09 | Wisconsin Alumni Research Foundation | Deuterated inhibitors of rip kinases |
| GB202407386D0 (en) | 2024-05-24 | 2024-07-10 | Apollo Ap45 Ltd | 1H-pyrazolo(4,3-D)pyrimidine derivatives |
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| US20060074102A1 (en) * | 2004-05-14 | 2006-04-06 | Kevin Cusack | Kinase inhibitors as therapeutic agents |
| RS50569B (sr) * | 2004-06-11 | 2010-05-07 | Japan Tobacco Inc. | Derivati 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2h-pirido (2,3-d)pirimidina i slična jedinjenja za lečenje raka |
| US20080255184A1 (en) | 2005-11-04 | 2008-10-16 | Smithkline Beecham Corporation | Thienopyridine B-Raf Kinase Inhibitors |
| JP2009543810A (ja) * | 2006-07-13 | 2009-12-10 | ザイモジェネティクス， インコーポレイテッド | インターロイキン２１およびチロシンキナーゼ阻害剤の併用治療の方法 |
| WO2009151621A1 (en) | 2008-06-13 | 2009-12-17 | Arena Pharmaceuticals, Inc. | Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists |
| ES2536730T3 (es) * | 2008-09-19 | 2015-05-28 | Nerviano Medical Sciences S.R.L. | Derivados de 3,4-dihidro-2H-pirrolo[1,2-a]pirazin-1-ona |
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| WO2011119663A8 (en) | 2012-10-26 |
| UY33288A (es) | 2011-10-31 |
| AU2011232516A1 (en) | 2012-10-04 |
| KR20130018272A (ko) | 2013-02-20 |
| AU2011232516A8 (en) | 2012-12-13 |
| EA201290952A1 (ru) | 2013-04-30 |
| SG183954A1 (en) | 2012-10-30 |
| EP2549868B1 (en) | 2015-01-07 |
| AR080792A1 (es) | 2012-05-09 |
| JP2013534902A (ja) | 2013-09-09 |
| KR101676077B1 (ko) | 2016-11-14 |
| EP2549868A1 (en) | 2013-01-30 |
| CN102917588A (zh) | 2013-02-06 |
| US20120077828A1 (en) | 2012-03-29 |
| MX2012011045A (es) | 2012-11-16 |
| IL222120A (en) | 2015-09-24 |
| WO2011119663A1 (en) | 2011-09-29 |
| AU2011232516B2 (en) | 2014-08-07 |
| CN102917588B (zh) | 2014-10-08 |
| TW201202241A (en) | 2012-01-16 |
| EP2549868A4 (en) | 2013-08-07 |
| EA022325B1 (ru) | 2015-12-30 |
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