EA201290952A1 - Химические соединения - Google Patents

Химические соединения

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EA201290952A1
EA201290952A1 EA201290952A EA201290952A EA201290952A1 EA 201290952 A1 EA201290952 A1 EA 201290952A1 EA 201290952 A EA201290952 A EA 201290952A EA 201290952 A EA201290952 A EA 201290952A EA 201290952 A1 EA201290952 A1 EA 201290952A1
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disease
compound
cancer
activity
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EA201290952A
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EA022325B1 (ru
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Джеффри Майкл Акстен
Сет Уилсон Грант
Дирк А. Хирдинг
Хесус Рауль Медина
Стюарт Пол Ромерил
Дзун Танг
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ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
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Publication of EA201290952A1 publication Critical patent/EA201290952A1/ru
Publication of EA022325B1 publication Critical patent/EA022325B1/ru

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Abstract

Изобретение относится к замещенным производным индолина. В частности, изобретение относится к соединениям согласно формуле (I)в которых R, Rи Rопределены в описании. Соединения по изобретению являются ингибиторами PERK и могут быть использованы в лечении рака, глазных заболеваний и заболеваний, связанных с путями ответов на активированные нескрученные белки, таких как болезнь Альцгеймера, инсульт, диабет типа 1, болезнь Паркинсона, болезнь Гентингтона, боковой амиотрофический склероз, инфаркт миокарда, сердечно-сосудистое заболевание, атеросклероз и аритмии, более конкретно, рак молочной железы, толстой кишки, поджелудочной железы и легкого. Соответственно, изобретение также относится к фармацевтическим композициям, включающим соединение по изобретению. Изобретение также относится к способам ингибирования активности PERK и лечения нарушений, связанных с этой активностью, с использованием соединения по изобретению или фармацевтической композиции, включающей соединение по изобретению.
EA201290952A 2010-03-25 2011-03-23 Производные индолина как ингибиторы perk EA022325B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US31747610P 2010-03-25 2010-03-25
US35286310P 2010-06-09 2010-06-09
US38148010P 2010-09-10 2010-09-10
US38815110P 2010-09-30 2010-09-30
US41906810P 2010-12-02 2010-12-02
PCT/US2011/029511 WO2011119663A1 (en) 2010-03-25 2011-03-23 Chemical compounds

Publications (2)

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EA201290952A1 true EA201290952A1 (ru) 2013-04-30
EA022325B1 EA022325B1 (ru) 2015-12-30

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EA201290952A EA022325B1 (ru) 2010-03-25 2011-03-23 Производные индолина как ингибиторы perk

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US (1) US20120077828A1 (ru)
EP (1) EP2549868B1 (ru)
JP (1) JP5876031B2 (ru)
KR (1) KR101676077B1 (ru)
CN (1) CN102917588B (ru)
AR (1) AR080792A1 (ru)
AU (1) AU2011232516B2 (ru)
EA (1) EA022325B1 (ru)
ES (1) ES2530955T3 (ru)
IL (1) IL222120A (ru)
MX (1) MX2012011045A (ru)
SG (1) SG183954A1 (ru)
TW (1) TW201202241A (ru)
UY (1) UY33288A (ru)
WO (1) WO2011119663A1 (ru)

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WO2011119663A8 (en) 2012-10-26
EP2549868B1 (en) 2015-01-07
US20120077828A1 (en) 2012-03-29
AU2011232516B2 (en) 2014-08-07
KR20130018272A (ko) 2013-02-20
AU2011232516A8 (en) 2012-12-13
AR080792A1 (es) 2012-05-09
JP5876031B2 (ja) 2016-03-02
TW201202241A (en) 2012-01-16
JP2013534902A (ja) 2013-09-09
ES2530955T3 (es) 2015-03-09
SG183954A1 (en) 2012-10-30
AU2011232516A1 (en) 2012-10-04
CN102917588A (zh) 2013-02-06
UY33288A (es) 2011-10-31
WO2011119663A1 (en) 2011-09-29
IL222120A (en) 2015-09-24
EA022325B1 (ru) 2015-12-30
MX2012011045A (es) 2012-11-16
EP2549868A4 (en) 2013-08-07
CN102917588B (zh) 2014-10-08
EP2549868A1 (en) 2013-01-30

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