JP5864829B2 - ビフィドバクテリウム種の溶解産物を敏感肌の処置のために用いる方法 - Google Patents
ビフィドバクテリウム種の溶解産物を敏感肌の処置のために用いる方法 Download PDFInfo
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- JP5864829B2 JP5864829B2 JP2008225836A JP2008225836A JP5864829B2 JP 5864829 B2 JP5864829 B2 JP 5864829B2 JP 2008225836 A JP2008225836 A JP 2008225836A JP 2008225836 A JP2008225836 A JP 2008225836A JP 5864829 B2 JP5864829 B2 JP 5864829B2
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- BJYLYJCXYAMOFT-RSFVBTMBSA-N tacalcitol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@@H](O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RSFVBTMBSA-N 0.000 description 1
- 229960004907 tacalcitol Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 229940068778 tocotrienols Drugs 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
- 239000006208 topical dosage form Substances 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- OHOTVSOGTVKXEL-UHFFFAOYSA-K trisodium;2-[bis(carboxylatomethyl)amino]propanoate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C(C)N(CC([O-])=O)CC([O-])=O OHOTVSOGTVKXEL-UHFFFAOYSA-K 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019159 vitamin B9 Nutrition 0.000 description 1
- 239000011727 vitamin B9 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Birds (AREA)
- Microbiology (AREA)
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- Tropical Medicine & Parasitology (AREA)
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- Toxicology (AREA)
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Description
「アレルギー性」と呼ばれる皮膚と対照的に,敏感肌の反応性は,免疫学的プロセスの問題ではなく,即ちアレルゲンの存在に反応して起きるのではない。
上記のように,本発明に従って,ビフィドバクテリウム属の少なくとも1の微生物の少なくとも1の溶解産物及び/又はその画分が活性剤として使用される。
ビタミンD及びその誘導体,例えばビタミンD3及びビタミンD2,カルシトリオール,カルシポトリオール,タカルシトール,24,25-ジOHビタミンD3,1−OHビタミンD2,及び1,24-ジOHビタミンD2;ビタミンB9及びその誘導体,
過酸化物,例えばベンゾイルパーオキサイド及び過酸化水素,
脱毛防止剤,例えば,ミノキシジル及びその誘導体例えばアミネキシル,
毛髪染料及び毛髪着色剤,例えばアミノフェノール及びその誘導体,例えばパラーフェニレンジアミン(p-PDA),N-フェニルp−PDA,2,5−トルエンジアミンサルフェート,メタ−フェニレンジアミン(m-PDA),3,4−トルエンジアミン及びオルト−フェニレンジアミン(o-PDA),
制汗剤,例えばアルミニウム塩例えば塩酸アルミニウム,
パーマネント髪ウエーブ活性剤例えばチオグリコレート又は水性アンモニア,
チオグリコレート及びその塩,
フェノキシエタノール,
1,2−ペンタンジオール,
芳香のあるアルコール溶液(香料,オードトワレ,アフターシェーブ又はデオドラント),
アントラリン(ジオキシアントラノール),
アントラノイド(例えば欧州特許出願公開第319028号に記載されているもの),
リチウム塩,
脱色素剤(例えば,ハイドロキノン,高濃度のビタミンC,又はコージ酸),
発熱効果を有するある種の痩身活性剤,
ニコチネート及びその誘導体,
カプサイシン,
抗シラミ活性剤(ピレスリン),
抗過形成剤(anti-proliferative agent)例えば5−フルオロウラシル又はメトトレキセート,
抗ウィルス剤,
抗寄生虫剤,
抗菌剤,
抗痒疹剤,
抗脂漏剤,
ある種のサンスクリーン,
プロ着色剤,例えばソラーレン及びメチルアンジェシリン(methylangecilin)及び
それらの混合物。
敏感肌の反応性に関するビフィドバクテリウム溶解産物の効果の評価
試験された製品は,弱酸性の水性媒体中の(超音波で)分解された懸濁物中のビフィドバクテリウムロンガム溶解産物であり,リペアコンプレックスCLR(商)の名前で販売されているものである。活性剤は,この市販品の合計バイオ溶解産物の5%である。
本発明に従う溶解産物の鎮静効果の評価
Hallら(J. Neurosci.1997:17(8):2775〜84)により記載された技術に従って調製された知覚神経の初代培養物
培養培地:
DMEM-HAM F12(インビトロゲン 21331-020)
L-グルタミン2mM(インビトロゲン 25030024)
ペニシリン50IU/ml-ストレプトマイシン50μg/ml(インビトロゲン 15070063)
サプリメント N2(17502-048)
神経成長因子(NGF,インビトロゲン13290.010)
神経栄養因子(Neurotrophin)3(NT-3,Tebu450-03-b)
知覚神経は,37℃かつ湿気で飽和された5%CO2におけるオーブンにおいて,合成培地(defined medium)で96ウェルプレート(1ウェル当たり30000細胞)中で培養された。合成培地は,ニューロンの成長を促進して汚染細胞(contaminant cell)(シュワン(Schwann)細胞及び線維母細胞)の損傷に至らしめる。9日間の培養の後,電気生理学的に成熟したニューロンが神経ペプチドを自然に放出する。
本発明に従う溶解産物の神経反応に対する活性の評価
このテストのために,生存状態に維持されたヒトの皮膚のモデルであって神経媒介物質(物質P「SP」)で刺激されたものが使用された。
対照の皮膚(基本条件:刺激なし,処置なしの皮膚)
10μMの物質Pで刺激された皮膚
物質Pで刺激され,かつ10%の溶解産物で処置された皮膚。
a)浮腫及び毛細血管の直径の変形の組織学的評価
ヘマラン−エオシンで染色した後,組織学的薄片全体上で膨張された血管の数を数えることにより,血管の膨張が評価された(16倍×40倍(16 fields at magnification 40))。この数は血管の総数の上に持ち越され,膨張された血管の百分率を計算する。さらに,血管の管腔により占有された領域の形態学的分析が行われ,血管により占有された平均面積(μm2)を決定する。
浮腫の評価は,半定量的点数を使用して実行された
浮腫なし:0(0点)
非常に穏やかな浮腫:+(1点)
中程度の浮腫:++(2点)
大きな浮腫:+++(3点)
非常に大きな浮腫:++++(4点)
サイトカイニン,例えばTNF,の分泌の変調が調べられた。
8つの皮膚試料で得られた結果から平均が決定された。統計学的分析は,5%のリスクの「減少された偏差」スチューデントテスト又は対応のある試料テストにより行われる。
a)血管変調の評価
これらの結果は,全体として血管拡張及び浮腫の大きくかつ統計学的に有意な減少を伴う溶解産物の鎮静効果を証明する。TNFの放出の有意な減少は,これらの組織学的結果から誘導される。
Claims (16)
- ビフィドバクテリウム属の少なくとも1の微生物の少なくとも1の溶解産物全体の有効量を、敏感肌の場合における皮膚の異常を予防する及び/又は処置するために化粧的に使用する方法(医療行為を除く)であって、前記溶解産物全体が細胞内生物学的成分並びに細胞壁及び細胞膜成分から全体的に形成される、前記方法。
- 前記微生物の溶解産物全体が、敏感肌の場合の無知覚過敏の発現を予防する及び/又は処置することを意図されている、請求項1に記載の方法。
- 前記微生物の溶解産物全体が、皮膚の神経媒介物質の放出を阻害することを意図されている、請求項1又は2に記載の方法。
- ビフィドバクテリウム属の少なくとも1の微生物の少なくとも1の溶解産物全体の有効量を、敏感肌の場合の皮膚の異常を予防する及び/又は処置するための組成物の製造のために使用する方法。
- 前記ビフィドバクテリウム属の微生物が、ビフィドバクテリアロンガム,ビフィドバクテリウムビフィダム,ビフィドバクテリウムブリーブ,ビフィドバクテリウムアニマリス,ビフィドバクテリアラクチス,ビフィドバクテリウムインファンチス,ビフィドバクテリウムアドレッセンチス及びビフィドバクテリウムシュードカテヌラツム及びそれらの混合物から選択される、請求項1〜4のいずれか1項に記載の方法。
- 前記ビフィドバクテリウム属の微生物が、ビフィドバクテリウムロンガムである、請求項1〜5のいずれか1項に記載の方法。
- 前記溶解産物全体が、0.1〜50重量%の微生物由来活性物質を含む、請求項1〜6のいずれか1項に記載の方法。
- 前記溶解産物全体が局所的に投与される、請求項1〜7のいずれか1項に記載の方法。
- 前記溶解産物全体が経口的に投与される、請求項1〜7のいずれか1項に記載の方法。
- 敏感肌の場合の皮膚の異常を処置する及び/又は予防するのに有用である化粧的及び/又は皮膚科学的組成物において,生理学的に許容される媒体中に,ビフィドバクテリウム属の少なくとも1の微生物の少なくとも1の溶解産物全体の少なくとも有効量を、皮膚の刺激を起こすことのできる少なくとも1の化合物と組み合わせて含む組成物であって、前記溶解産物全体が細胞内生物学的成分並びに細胞壁及び細胞膜成分から全体的に形成される、前記組成物。
- 追加のプロバイオチック微生物及び/又はその画分及び/又は少なくとも1の追加のプロバイオチック微生物の溶解産物及び/又はその画分をもまた含む、請求項10に記載の組成物。
- 前記追加のプロバイオチック微生物が、サッカロミセス,ヤロウィア,クルイフェロミセス,トルラスポーラ,スキゾサッカロミセスポンベ,デバロミセス,カンジダ,ピチア,アスペルギルス,ペニシリウム、及びその他の子嚢菌,ビフィドバクテリウム属のバクテリア,バクテロイド、フゾバクテリウム,メリッソコッカス,プロピオニバクテリウム,エンテロコッカス,ラクトコッカス,スタフィロコッカス,ペプトストレプトコッカス,バシルス,ペジオコッカス,ミクロコッカス,ロイコノストック,ワイセラ,アエロコッカス,オエノコッカス,及びラクトバシルス,及びそれらの混合物から選択される、請求項11に記載の組成物。
- 前記追加の微生物が乳酸バクテリアの群から誘導される、請求項11又は12に記載の組成物。
- 前記追加のプロバイオチック微生物及び/又はその画分が、前記組成物の0.0001〜30重量%の割合で存在する、請求項11〜13のいずれか1項に記載の組成物。
- 水性,水性−アルコール性又はオイル状の溶液,溶液タイプの分散物又はローション若しくはセラムタイプの分散物,脂肪相を水性相に(O/W)若しくは逆に(W/O)分散させることにより得られる乳液タイプの液体若しくは半液体の粘稠性のエマルジョン,クリームタイプの柔らかな、半固体の若しくは固体の粘稠性の懸濁物若しくはエマルジョン,水性若しくは無水のゲル,マイクロエマルジョン,マイクロカプセル,マイクロ粒子,又はイオン性及び/又は非イオン性タイプのベシクル分散物の形である、請求項11〜14のいずれか1項に記載の組成物。
- 個人の敏感肌の場合の皮膚異常を予防する及び/又は処置するための化粧方法において、ビフィドバクテリウム属の少なくとも1の微生物の少なくとも1の溶解産物全体の有効量を前記個人へ投与することを少なくとも含む方法(医療行為を除く)であって、前記溶解産物全体が細胞内生物学的成分並びに細胞壁及び細胞膜成分から全体的に形成される、前記方法。
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FR0757352A FR2920305B1 (fr) | 2007-09-04 | 2007-09-04 | Utilisation d'un lysat de bifidobacterium species pour le traitement de peaux sensibles. |
FR0757352 | 2007-09-04 |
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US20130089530A1 (en) * | 2011-10-11 | 2013-04-11 | Microbes, Inc. | Methods and compositions for treating parasitic worm infections in a mammal |
FR2938437B1 (fr) * | 2008-11-19 | 2020-03-27 | Société des Produits Nestlé S.A. | Utilisation cosmetique de microorganisme pour le traitement des peaux grasses |
US20110064777A1 (en) * | 2009-09-11 | 2011-03-17 | Sharad Mohan | Live lactobacillus soap and method for delivering lactobacillus to skin tissue |
FR2951377B1 (fr) * | 2009-10-21 | 2012-06-22 | Oreal | Association d'un lysat de probiotique et d'un derive c-glycoside |
US8470880B2 (en) | 2009-12-15 | 2013-06-25 | Mcneil-Ppc, Inc. | Methods of reducing hair loss and/or facilitating hair growth and/or regrowth |
US8470833B2 (en) * | 2009-12-15 | 2013-06-25 | Mcneil-Ppc, Inc. | Hair growth and/or regrowth compositions |
FR2957788B1 (fr) * | 2010-03-24 | 2012-07-13 | Oreal | Procede cosmetique topique utilisant un microorganisme probiotique vivant |
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EP2033627A3 (fr) | 2012-03-28 |
EP2033627B2 (fr) | 2023-08-02 |
EP2033627B1 (fr) | 2018-04-18 |
FR2920305B1 (fr) | 2010-07-30 |
EP2033627A2 (fr) | 2009-03-11 |
CN101380288A (zh) | 2009-03-11 |
JP2009108031A (ja) | 2009-05-21 |
ES2676307T5 (es) | 2024-03-04 |
CN101380288B (zh) | 2013-01-16 |
US10238897B2 (en) | 2019-03-26 |
ES2676307T3 (es) | 2018-07-18 |
US20090068160A1 (en) | 2009-03-12 |
FR2920305A1 (fr) | 2009-03-06 |
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