JP5855568B2 - 癌の治療法 - Google Patents

癌の治療法 Download PDF

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Publication number
JP5855568B2
JP5855568B2 JP2012529881A JP2012529881A JP5855568B2 JP 5855568 B2 JP5855568 B2 JP 5855568B2 JP 2012529881 A JP2012529881 A JP 2012529881A JP 2012529881 A JP2012529881 A JP 2012529881A JP 5855568 B2 JP5855568 B2 JP 5855568B2
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Japan
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composition
cdp
cancer
conjugate
particle
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Expired - Fee Related
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JP2012529881A
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Japanese (ja)
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JP2013504630A5 (enExample
JP2013504630A (ja
Inventor
ユン イェン，
ユン イェン，
トーマス シュレップ，
トーマス シュレップ，
ジョン ライアン，
ジョン ライアン，
マーク デイビス，
マーク デイビス，
ジェイムス シー． オリバー，
ジェイムス シー． オリバー，
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セルリアン・ファーマ・インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012529881A 2009-09-15 2010-09-15 癌の治療法 Expired - Fee Related JP5855568B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US24275209P 2009-09-15 2009-09-15
US61/242,752 2009-09-15
US31703910P 2010-03-24 2010-03-24
US61/317,039 2010-03-24
US33215010P 2010-05-06 2010-05-06
US61/332,150 2010-05-06
US38185110P 2010-09-10 2010-09-10
US61/381,851 2010-09-10
PCT/US2010/048973 WO2011034954A1 (en) 2009-09-15 2010-09-15 Treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014223985A Division JP2015025020A (ja) 2009-09-15 2014-11-04 癌の治療法

Publications (3)

Publication Number Publication Date
JP2013504630A JP2013504630A (ja) 2013-02-07
JP2013504630A5 JP2013504630A5 (enExample) 2013-10-17
JP5855568B2 true JP5855568B2 (ja) 2016-02-09

Family

ID=43758997

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2012529881A Expired - Fee Related JP5855568B2 (ja) 2009-09-15 2010-09-15 癌の治療法
JP2014223985A Withdrawn JP2015025020A (ja) 2009-09-15 2014-11-04 癌の治療法
JP2016045695A Pending JP2016106143A (ja) 2009-09-15 2016-03-09 癌の治療法
JP2017196769A Withdrawn JP2017226708A (ja) 2009-09-15 2017-10-10 癌の治療法
JP2020109574A Pending JP2020164547A (ja) 2009-09-15 2020-06-25 癌の治療法
JP2022135758A Withdrawn JP2022166327A (ja) 2009-09-15 2022-08-29 癌の治療法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2014223985A Withdrawn JP2015025020A (ja) 2009-09-15 2014-11-04 癌の治療法
JP2016045695A Pending JP2016106143A (ja) 2009-09-15 2016-03-09 癌の治療法
JP2017196769A Withdrawn JP2017226708A (ja) 2009-09-15 2017-10-10 癌の治療法
JP2020109574A Pending JP2020164547A (ja) 2009-09-15 2020-06-25 癌の治療法
JP2022135758A Withdrawn JP2022166327A (ja) 2009-09-15 2022-08-29 癌の治療法

Country Status (11)

Country Link
US (5) US20110160159A1 (enExample)
EP (1) EP2477985B1 (enExample)
JP (6) JP5855568B2 (enExample)
CN (1) CN102666533A (enExample)
AU (1) AU2010295646B2 (enExample)
BR (1) BR112012005594A2 (enExample)
CA (2) CA2774015A1 (enExample)
EA (1) EA201200486A1 (enExample)
IL (1) IL218575A0 (enExample)
MX (2) MX366955B (enExample)
WO (1) WO2011034954A1 (enExample)

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AU2010295646A1 (en) 2012-04-05
EP2477985B1 (en) 2018-11-07
US20160058875A1 (en) 2016-03-03
BR112012005594A2 (pt) 2015-09-08
US20110160159A1 (en) 2011-06-30
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