JP5840148B2 - 変性させることなく可溶性組換えインターフェロンタンパク質を産生する方法 - Google Patents
変性させることなく可溶性組換えインターフェロンタンパク質を産生する方法 Download PDFInfo
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- JP5840148B2 JP5840148B2 JP2012556223A JP2012556223A JP5840148B2 JP 5840148 B2 JP5840148 B2 JP 5840148B2 JP 2012556223 A JP2012556223 A JP 2012556223A JP 2012556223 A JP2012556223 A JP 2012556223A JP 5840148 B2 JP5840148 B2 JP 5840148B2
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US31067110P | 2010-03-04 | 2010-03-04 | |
| US61/310,671 | 2010-03-04 | ||
| PCT/US2011/026921 WO2011109556A2 (en) | 2010-03-04 | 2011-03-02 | Method for producing soluble recombinant interferon protein without denaturing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524775A JP2013524775A (ja) | 2013-06-20 |
| JP2013524775A5 JP2013524775A5 (enExample) | 2014-04-17 |
| JP5840148B2 true JP5840148B2 (ja) | 2016-01-06 |
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| JP (1) | JP5840148B2 (enExample) |
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| CN (1) | CN102906108B (enExample) |
| AU (1) | AU2011223627B2 (enExample) |
| BR (1) | BR112012022292A2 (enExample) |
| CA (1) | CA2791361C (enExample) |
| CL (1) | CL2012002378A1 (enExample) |
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| MX (1) | MX2012010148A (enExample) |
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| PE (1) | PE20130557A1 (enExample) |
| RU (1) | RU2573909C2 (enExample) |
| WO (1) | WO2011109556A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011109556A2 (en) | 2010-03-04 | 2011-09-09 | Pfenex Inc. | Method for producing soluble recombinant interferon protein without denaturing |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| CN106967175A (zh) * | 2013-05-15 | 2017-07-21 | 复旦大学 | 长效干扰素及其制备方法和用途 |
| LT6164B (lt) | 2013-10-15 | 2015-06-25 | Uab Biotechnologinės Farmacijos Centras "Biotechpharma" | Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas |
| CN107099569B (zh) * | 2017-06-30 | 2021-05-07 | 北京生物制品研究所有限责任公司 | 一种规模化发酵生产重组人干扰素β1b蛋白的方法 |
| JP2023530095A (ja) * | 2020-06-09 | 2023-07-13 | アイコサバックス， インコーポレイテッド | ウイルス様粒子を作製する方法 |
| CN116120424A (zh) * | 2022-06-06 | 2023-05-16 | 江苏靶标生物医药研究所有限公司 | 一种干扰素α2b可溶性重组表达和分离纯化方法及其应用 |
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| WO2011109556A2 (en) | 2010-03-04 | 2011-09-09 | Pfenex Inc. | Method for producing soluble recombinant interferon protein without denaturing |
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-
2011
- 2011-03-02 WO PCT/US2011/026921 patent/WO2011109556A2/en not_active Ceased
- 2011-03-02 AU AU2011223627A patent/AU2011223627B2/en not_active Ceased
- 2011-03-02 NZ NZ602255A patent/NZ602255A/en not_active IP Right Cessation
- 2011-03-02 JP JP2012556223A patent/JP5840148B2/ja not_active Expired - Fee Related
- 2011-03-02 RU RU2012141653/10A patent/RU2573909C2/ru not_active IP Right Cessation
- 2011-03-02 EP EP11751317.6A patent/EP2542574B1/en not_active Not-in-force
- 2011-03-02 PE PE2012001389A patent/PE20130557A1/es not_active Application Discontinuation
- 2011-03-02 BR BR112012022292A patent/BR112012022292A2/pt not_active IP Right Cessation
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2012
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2015
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| BR112012022292A2 (pt) | 2017-01-10 |
| AU2011223627A1 (en) | 2012-09-27 |
| WO2011109556A3 (en) | 2012-01-12 |
| MX2012010148A (es) | 2013-01-22 |
| CA2791361C (en) | 2018-06-12 |
| EP2542574A4 (en) | 2014-01-29 |
| US20110217784A1 (en) | 2011-09-08 |
| CO6592086A2 (es) | 2013-01-02 |
| CN102906108A (zh) | 2013-01-30 |
| PE20130557A1 (es) | 2013-05-19 |
| EP2542574B1 (en) | 2017-08-09 |
| JP2013524775A (ja) | 2013-06-20 |
| WO2011109556A2 (en) | 2011-09-09 |
| US20160032345A1 (en) | 2016-02-04 |
| KR101857825B1 (ko) | 2018-05-14 |
| CL2012002378A1 (es) | 2014-01-10 |
| NZ602255A (en) | 2014-04-30 |
| ES2639398T3 (es) | 2017-10-26 |
| KR20130018743A (ko) | 2013-02-25 |
| CA2791361A1 (en) | 2011-09-09 |
| EP2542574A2 (en) | 2013-01-09 |
| AU2011223627B2 (en) | 2015-06-18 |
| RU2573909C2 (ru) | 2016-01-27 |
| RU2012141653A (ru) | 2014-04-10 |
| US9187543B2 (en) | 2015-11-17 |
| US9611499B2 (en) | 2017-04-04 |
| CN102906108B (zh) | 2016-01-20 |
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