JP5832285B2 - 延長されたインビボ半減期を有する第viii因子、フォン・ヴィレブランド因子又はそれらの複合体 - Google Patents

延長されたインビボ半減期を有する第viii因子、フォン・ヴィレブランド因子又はそれらの複合体 Download PDF

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JP5832285B2
JP5832285B2 JP2011515200A JP2011515200A JP5832285B2 JP 5832285 B2 JP5832285 B2 JP 5832285B2 JP 2011515200 A JP2011515200 A JP 2011515200A JP 2011515200 A JP2011515200 A JP 2011515200A JP 5832285 B2 JP5832285 B2 JP 5832285B2
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vwf
fviii
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トーマス・ヴァイマー
シュテファン・シュルテ
フーベルト・メッツナー
ウルリッヒ・クロンタラー
ホルガー・リント
ヴィーガント・ラーング
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ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2011515200A 2008-06-24 2009-06-24 延長されたインビボ半減期を有する第viii因子、フォン・ヴィレブランド因子又はそれらの複合体 Expired - Fee Related JP5832285B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08011429.1 2008-06-24
EP08011429 2008-06-24
PCT/EP2009/004549 WO2009156137A1 (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

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JP2011525363A JP2011525363A (ja) 2011-09-22
JP2011525363A5 JP2011525363A5 (enExample) 2012-07-26
JP5832285B2 true JP5832285B2 (ja) 2015-12-16

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US (2) US8575104B2 (enExample)
EP (2) EP2865760B1 (enExample)
JP (1) JP5832285B2 (enExample)
KR (2) KR101648734B1 (enExample)
CN (2) CN102076855A (enExample)
AU (1) AU2009262476C1 (enExample)
CA (1) CA2728012C (enExample)
DK (2) DK2865760T3 (enExample)
ES (2) ES2654336T3 (enExample)
PL (1) PL2291523T3 (enExample)
RU (1) RU2528855C2 (enExample)
WO (1) WO2009156137A1 (enExample)

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KR101648734B1 (ko) 2016-08-18
US8575104B2 (en) 2013-11-05
KR101507718B1 (ko) 2015-04-10
DK2865760T3 (en) 2018-01-15
CN103739712A (zh) 2014-04-23
CN102076855A (zh) 2011-05-25
ES2531464T3 (es) 2015-03-16
EP2291523B1 (en) 2014-12-17
RU2011102366A (ru) 2012-07-27
RU2528855C2 (ru) 2014-09-20
HK1151068A1 (en) 2012-01-20
US9290561B2 (en) 2016-03-22
PL2291523T3 (pl) 2015-05-29
CA2728012A1 (en) 2009-12-30
CA2728012C (en) 2017-10-31
EP2291523A1 (en) 2011-03-09
AU2009262476B2 (en) 2014-06-26
EP2865760A1 (en) 2015-04-29
JP2011525363A (ja) 2011-09-22
US20110183907A1 (en) 2011-07-28
EP2865760B1 (en) 2017-10-11
ES2654336T3 (es) 2018-02-13
DK2291523T3 (en) 2015-03-23
US20140072561A1 (en) 2014-03-13
AU2009262476A1 (en) 2009-12-30
KR20140090703A (ko) 2014-07-17
WO2009156137A1 (en) 2009-12-30
CN103739712B (zh) 2016-10-05
AU2009262476C1 (en) 2016-06-02
KR20110044978A (ko) 2011-05-03

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