CA2728012C - Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life - Google Patents

Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life Download PDF

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Publication number
CA2728012C
CA2728012C CA2728012A CA2728012A CA2728012C CA 2728012 C CA2728012 C CA 2728012C CA 2728012 A CA2728012 A CA 2728012A CA 2728012 A CA2728012 A CA 2728012A CA 2728012 C CA2728012 C CA 2728012C
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CA
Canada
Prior art keywords
modified
fviii
vwf
wild
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2728012A
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English (en)
French (fr)
Other versions
CA2728012A1 (en
Inventor
Thomas Weimer
Stefan Schulte
Hubert Metzner
Ulrich Kronthaler
Holger Lind
Wiegand Lang
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CSL Behring GmbH Deutschland
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CSL Behring GmbH Deutschland
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Publication of CA2728012A1 publication Critical patent/CA2728012A1/en
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2728012A 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life Expired - Fee Related CA2728012C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08011429.1 2008-06-24
EP08011429 2008-06-24
PCT/EP2009/004549 WO2009156137A1 (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

Publications (2)

Publication Number Publication Date
CA2728012A1 CA2728012A1 (en) 2009-12-30
CA2728012C true CA2728012C (en) 2017-10-31

Family

ID=40042814

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2728012A Expired - Fee Related CA2728012C (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

Country Status (12)

Country Link
US (2) US8575104B2 (enExample)
EP (2) EP2865760B1 (enExample)
JP (1) JP5832285B2 (enExample)
KR (2) KR101507718B1 (enExample)
CN (2) CN102076855A (enExample)
AU (1) AU2009262476C1 (enExample)
CA (1) CA2728012C (enExample)
DK (2) DK2865760T3 (enExample)
ES (2) ES2531464T3 (enExample)
PL (1) PL2291523T3 (enExample)
RU (1) RU2528855C2 (enExample)
WO (1) WO2009156137A1 (enExample)

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Also Published As

Publication number Publication date
JP5832285B2 (ja) 2015-12-16
DK2865760T3 (en) 2018-01-15
CN103739712A (zh) 2014-04-23
US20110183907A1 (en) 2011-07-28
AU2009262476C1 (en) 2016-06-02
KR101648734B1 (ko) 2016-08-18
RU2011102366A (ru) 2012-07-27
AU2009262476A1 (en) 2009-12-30
AU2009262476B2 (en) 2014-06-26
US9290561B2 (en) 2016-03-22
ES2531464T3 (es) 2015-03-16
US20140072561A1 (en) 2014-03-13
RU2528855C2 (ru) 2014-09-20
CN102076855A (zh) 2011-05-25
DK2291523T3 (en) 2015-03-23
PL2291523T3 (pl) 2015-05-29
CN103739712B (zh) 2016-10-05
HK1151068A1 (en) 2012-01-20
WO2009156137A1 (en) 2009-12-30
CA2728012A1 (en) 2009-12-30
KR20140090703A (ko) 2014-07-17
EP2291523B1 (en) 2014-12-17
KR101507718B1 (ko) 2015-04-10
KR20110044978A (ko) 2011-05-03
ES2654336T3 (es) 2018-02-13
EP2865760B1 (en) 2017-10-11
EP2865760A1 (en) 2015-04-29
JP2011525363A (ja) 2011-09-22
US8575104B2 (en) 2013-11-05
EP2291523A1 (en) 2011-03-09

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