DK2291523T3 - Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life - Google Patents
Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life Download PDFInfo
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- DK2291523T3 DK2291523T3 DK09768986T DK09768986T DK2291523T3 DK 2291523 T3 DK2291523 T3 DK 2291523T3 DK 09768986 T DK09768986 T DK 09768986T DK 09768986 T DK09768986 T DK 09768986T DK 2291523 T3 DK2291523 T3 DK 2291523T3
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
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- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
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- Microbiology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08011429 | 2008-06-24 | ||
| PCT/EP2009/004549 WO2009156137A1 (en) | 2008-06-24 | 2009-06-24 | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2291523T3 true DK2291523T3 (en) | 2015-03-23 |
Family
ID=40042814
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09768986T DK2291523T3 (en) | 2008-06-24 | 2009-06-24 | Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life |
| DK14192277.3T DK2865760T3 (en) | 2008-06-24 | 2009-06-24 | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14192277.3T DK2865760T3 (en) | 2008-06-24 | 2009-06-24 | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8575104B2 (enExample) |
| EP (2) | EP2865760B1 (enExample) |
| JP (1) | JP5832285B2 (enExample) |
| KR (2) | KR101507718B1 (enExample) |
| CN (2) | CN103739712B (enExample) |
| AU (1) | AU2009262476C1 (enExample) |
| CA (1) | CA2728012C (enExample) |
| DK (2) | DK2291523T3 (enExample) |
| ES (2) | ES2531464T3 (enExample) |
| PL (1) | PL2291523T3 (enExample) |
| RU (1) | RU2528855C2 (enExample) |
| WO (1) | WO2009156137A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプramのチエツク方法 |
| RU2528855C2 (ru) | 2008-06-24 | 2014-09-20 | Цсл Беринг Гмбх | Модифицированный фактор виллебранда с удлиненным полупериодом существования in vivo, его применения и способы получения |
| US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| WO2011060242A2 (en) | 2009-11-13 | 2011-05-19 | Talecris Biotherapeutics, Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
| US20130040888A1 (en) | 2010-02-16 | 2013-02-14 | Novo Nordisk A/S | Factor VIII Molecules With Reduced VWF Binding |
| US9493543B2 (en) | 2010-02-16 | 2016-11-15 | Novo Nordisk A/S | Factor VIII fusion protein |
| CN102812039B (zh) * | 2010-02-16 | 2016-01-20 | 诺沃—诺迪斯克有限公司 | 缀合蛋白质 |
| WO2011150284A2 (en) | 2010-05-26 | 2011-12-01 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| EP3412305B1 (en) | 2011-06-10 | 2021-01-06 | Baxalta GmbH | Treatment of coagulation disease by administration of recombinant vwf |
| RS59670B1 (sr) * | 2012-01-12 | 2020-01-31 | Bioverativ Therapeutics Inc | Himerni polipeptidi faktora viii i njihove upotrebe |
| EP2814955A1 (en) * | 2012-02-14 | 2014-12-24 | Portola Pharmaceuticals, Inc. | Process for making recombinant antidote to factor xa inhibitor |
| DK3564260T5 (da) | 2012-02-15 | 2024-09-02 | Bioverativ Therapeutics Inc | Faktor viii-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf |
| EP2814502B1 (en) | 2012-02-15 | 2017-09-13 | CSL Behring GmbH | Von willebrand factor variants having improved factor viii binding affinity |
| EA201491388A1 (ru) * | 2012-02-15 | 2015-01-30 | Байоджен Айдек Ма Инк. | Рекомбинантные белки фактора viii |
| WO2013083858A1 (en) | 2012-04-24 | 2013-06-13 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
| CN104661674A (zh) * | 2012-07-11 | 2015-05-27 | 阿穆尼克斯运营公司 | 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途 |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| US10231993B2 (en) | 2013-06-27 | 2019-03-19 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
| WO2014210558A1 (en) * | 2013-06-28 | 2014-12-31 | Biogen Idec Ma Inc. | Thrombin cleavable linker with xten and its uses thereof |
| EP3013359A4 (en) * | 2013-06-28 | 2017-01-25 | Biogen MA Inc. | Thrombin cleavable linker |
| WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
| WO2015066769A1 (en) | 2013-11-08 | 2015-05-14 | Csl Ltd. | New method to concentrate von willebrand factor or complexes thereof |
| CN114736305B (zh) * | 2014-01-10 | 2023-05-05 | 比奥贝拉蒂治疗公司 | 因子viii嵌合蛋白及其用途 |
| WO2015188224A1 (en) | 2014-06-13 | 2015-12-17 | Csl Limited | Improved production of recombinant von willebrand factor in a bioreactor |
| DE102014011653A1 (de) * | 2014-06-20 | 2015-12-24 | Ulrich Loos | Nachweis von Autoantikörpern gegen den TSH-Rezeptor |
| US10253088B2 (en) | 2014-07-02 | 2019-04-09 | CSL Behring Lengnau AG | Modified von Willebrand Factor |
| US10626164B2 (en) | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
| MX388739B (es) * | 2015-02-06 | 2025-03-20 | Univ North Carolina Chapel Hill | Casetes optimizados de expresión del gen humano del factor viii de coagulación y su uso. |
| CA2978374A1 (en) | 2015-03-06 | 2016-09-15 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
| KR20180012303A (ko) | 2015-05-22 | 2018-02-05 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | 변형된 폰 빌레브란트 인자의 제조 방법 |
| EP3297656B1 (en) | 2015-05-22 | 2020-01-08 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| MX2018001497A (es) | 2015-08-03 | 2018-05-15 | Bioverativ Therapeutics Inc | Proteinas de fusion de factor ix y metodos para producirlas y usarlas. |
| WO2017112895A1 (en) * | 2015-12-23 | 2017-06-29 | Haplomics, Inc. | F8 gene repair |
| CA3010720A1 (en) * | 2016-01-07 | 2017-07-13 | Csl Behring Recombinant Facility Ag | Mutated truncated von willebrand factor |
| DK3400238T3 (da) * | 2016-01-07 | 2021-07-26 | CSL Behring Lengnau AG | Muteret von willebrand faktor |
| US12171808B2 (en) * | 2016-05-20 | 2024-12-24 | Octapharma Ag | Glycosylated VWF fusion proteins with improved pharmacokinetics |
| KR102175878B1 (ko) * | 2016-06-24 | 2020-11-06 | 재단법인 목암생명과학연구소 | Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도 |
| SG10201912360SA (en) | 2016-11-11 | 2020-02-27 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| US11890327B2 (en) | 2016-11-11 | 2024-02-06 | CSL Behring Lengnau AG | Truncated von Willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| IL308416B2 (en) | 2016-12-02 | 2025-08-01 | Bioverativ Therapeutics Inc | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| CA3068098A1 (en) | 2017-06-22 | 2018-12-27 | CSL Behring Lengnau AG | Modulation of fviii immunogenicity by truncated vwf |
| BR112020000321A2 (pt) | 2017-07-07 | 2020-07-14 | Baxalta Incorporated | método para tratamento de sangramento gastrointestinal em um sujeito com doença de von willebrand. |
| FI3648787T3 (fi) * | 2017-07-07 | 2025-01-20 | Takeda Pharmaceuticals Co | Elektiiviseen leikkaustoimenpiteeseen osallistuvien vaikeaa von willebrandin tautia sairastavien potilaiden hoito antamalla rekombinanttia vwf:ää |
| CA3072003A1 (en) | 2017-08-23 | 2019-02-28 | Csl Behring Gmbh | Method for virus filtration of von willebrand factor |
| MA52630B1 (fr) | 2018-05-18 | 2025-07-31 | Bioverativ Therapeutics Inc. | Procédés de traitement de l'hémophilie a |
| EP3897831A1 (en) * | 2018-12-23 | 2021-10-27 | CSL Behring LLC | Donor t-cells with kill switch |
| US12128090B2 (en) | 2019-02-01 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Methods of prophylactic treatment using recombinant VWF (rVWF) |
| CN111592591B (zh) * | 2020-06-17 | 2021-12-14 | 博雅生物制药集团股份有限公司 | 一种人血管性血友病因子/人凝血因子ⅷ复合物的制备方法及产物和应用 |
| CN117720671B (zh) * | 2024-01-30 | 2024-06-14 | 南通大学 | 具有自组装性能的重复结构单元重组蛋白ⅠAⅠB-ⅠAⅠBrQTY及应用 |
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| US4970300A (en) | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
| FR2673632A1 (fr) | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
| AU6029594A (en) | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| JPH11501506A (ja) | 1994-12-12 | 1999-02-09 | ベス イスラエル デアコネス メディカル センター | キメラ型サイトカインおよびその利用 |
| WO1997003193A1 (en) | 1995-07-11 | 1997-01-30 | Chiron Corporation | Novel factor viii:c polypeptide analogs with altered metal-binding properties |
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| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| US20040092442A1 (en) | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
| ATE502958T1 (de) | 1996-04-24 | 2011-04-15 | Univ Michigan | Gegen inaktivierung resistenter faktor viii |
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| EP1079805B1 (en) | 1998-04-27 | 2004-11-24 | Opperbas Holding B.V. | Pharmaceutical composition comprising factor viii and neutral liposomes |
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| EP1351986A2 (en) | 2001-01-12 | 2003-10-15 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii |
| WO2002103024A2 (en) | 2001-06-14 | 2002-12-27 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
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| AU2004251145C1 (en) | 2003-06-12 | 2011-04-14 | Eli Lilly And Company | GLP-1 analog fusion proteins |
| EP1502921A1 (en) * | 2003-07-29 | 2005-02-02 | ZLB Behring GmbH | Recombinant mutated human factor VIII (FVIII) with improved stability |
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| RU2370276C2 (ru) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ |
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| RU2528855C2 (ru) | 2008-06-24 | 2014-09-20 | Цсл Беринг Гмбх | Модифицированный фактор виллебранда с удлиненным полупериодом существования in vivo, его применения и способы получения |
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| WO2013083858A1 (en) | 2012-04-24 | 2013-06-13 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
-
2009
- 2009-06-24 RU RU2011102366/10A patent/RU2528855C2/ru active
- 2009-06-24 JP JP2011515200A patent/JP5832285B2/ja not_active Expired - Fee Related
- 2009-06-24 EP EP14192277.3A patent/EP2865760B1/en not_active Not-in-force
- 2009-06-24 KR KR1020117001530A patent/KR101507718B1/ko not_active Expired - Fee Related
- 2009-06-24 DK DK09768986T patent/DK2291523T3/en active
- 2009-06-24 AU AU2009262476A patent/AU2009262476C1/en not_active Ceased
- 2009-06-24 CN CN201310596839.1A patent/CN103739712B/zh not_active Expired - Fee Related
- 2009-06-24 CA CA2728012A patent/CA2728012C/en not_active Expired - Fee Related
- 2009-06-24 US US13/000,938 patent/US8575104B2/en not_active Expired - Fee Related
- 2009-06-24 ES ES09768986.3T patent/ES2531464T3/es active Active
- 2009-06-24 ES ES14192277.3T patent/ES2654336T3/es active Active
- 2009-06-24 CN CN200980123818XA patent/CN102076855A/zh active Pending
- 2009-06-24 WO PCT/EP2009/004549 patent/WO2009156137A1/en not_active Ceased
- 2009-06-24 DK DK14192277.3T patent/DK2865760T3/en active
- 2009-06-24 KR KR1020147018123A patent/KR101648734B1/ko not_active Expired - Fee Related
- 2009-06-24 PL PL09768986T patent/PL2291523T3/pl unknown
- 2009-06-24 EP EP09768986.3A patent/EP2291523B1/en active Active
-
2013
- 2013-09-17 US US14/028,869 patent/US9290561B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR101507718B1 (ko) | 2015-04-10 |
| JP2011525363A (ja) | 2011-09-22 |
| US20110183907A1 (en) | 2011-07-28 |
| KR20140090703A (ko) | 2014-07-17 |
| KR20110044978A (ko) | 2011-05-03 |
| ES2654336T3 (es) | 2018-02-13 |
| CN103739712A (zh) | 2014-04-23 |
| AU2009262476C1 (en) | 2016-06-02 |
| JP5832285B2 (ja) | 2015-12-16 |
| EP2865760B1 (en) | 2017-10-11 |
| EP2291523B1 (en) | 2014-12-17 |
| EP2865760A1 (en) | 2015-04-29 |
| HK1151068A1 (en) | 2012-01-20 |
| CN102076855A (zh) | 2011-05-25 |
| PL2291523T3 (pl) | 2015-05-29 |
| ES2531464T3 (es) | 2015-03-16 |
| AU2009262476B2 (en) | 2014-06-26 |
| US20140072561A1 (en) | 2014-03-13 |
| US9290561B2 (en) | 2016-03-22 |
| RU2011102366A (ru) | 2012-07-27 |
| RU2528855C2 (ru) | 2014-09-20 |
| KR101648734B1 (ko) | 2016-08-18 |
| AU2009262476A1 (en) | 2009-12-30 |
| DK2865760T3 (en) | 2018-01-15 |
| CA2728012C (en) | 2017-10-31 |
| WO2009156137A1 (en) | 2009-12-30 |
| CA2728012A1 (en) | 2009-12-30 |
| EP2291523A1 (en) | 2011-03-09 |
| US8575104B2 (en) | 2013-11-05 |
| CN103739712B (zh) | 2016-10-05 |
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