DE60234193D1 - Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungen - Google Patents
Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungenInfo
- Publication number
- DE60234193D1 DE60234193D1 DE60234193T DE60234193T DE60234193D1 DE 60234193 D1 DE60234193 D1 DE 60234193D1 DE 60234193 T DE60234193 T DE 60234193T DE 60234193 T DE60234193 T DE 60234193T DE 60234193 D1 DE60234193 D1 DE 60234193D1
- Authority
- DE
- Germany
- Prior art keywords
- geneva
- bindings
- disulphide
- constructed
- factor viii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29857801P | 2001-06-14 | 2001-06-14 | |
PCT/US2002/019017 WO2002103024A2 (en) | 2001-06-14 | 2002-06-14 | Stabilized proteins with engineered disulfide bonds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60234193D1 true DE60234193D1 (de) | 2009-12-10 |
Family
ID=23151124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60234193T Expired - Lifetime DE60234193D1 (de) | 2001-06-14 | 2002-06-14 | Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US7205278B2 (de) |
EP (2) | EP1421539B1 (de) |
JP (2) | JP4361786B2 (de) |
AU (1) | AU2002310438B2 (de) |
CA (1) | CA2450732A1 (de) |
DE (1) | DE60234193D1 (de) |
ES (1) | ES2331909T3 (de) |
WO (1) | WO2002103024A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002310438B2 (en) * | 2001-06-14 | 2008-05-01 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
EP1502921A1 (de) * | 2003-07-29 | 2005-02-02 | ZLB Behring GmbH | Rekombinanter mutierter menschlicher Factor VIII (FVIII) mit verbesserter Stabilität |
CA2547569C (en) * | 2003-12-03 | 2013-04-16 | University Of Rochester | Recombinant factor viii having increased specific activity |
US20060019893A1 (en) * | 2004-07-02 | 2006-01-26 | Genentech, Inc. | Factor VIIa variants |
KR101654011B1 (ko) | 2004-11-12 | 2016-09-05 | 바이엘 헬스케어 엘엘씨 | Fviii의 부위 지향 변형 |
AU2006233638A1 (en) * | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation Factor VIII with enhanced stability and its derivates |
GB0514779D0 (en) * | 2005-07-19 | 2005-08-24 | Celltech R&D Ltd | Biological products |
EP1816201A1 (de) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät |
EP2081589B1 (de) * | 2006-11-16 | 2010-10-06 | Crucell Holland B.V. | Komplementierung von faktor xi-mangel durch faktor v-mutanten |
US8754194B2 (en) | 2006-12-22 | 2014-06-17 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
KR20100113478A (ko) * | 2007-11-01 | 2010-10-21 | 유니버시티 오브 로체스터 | 증가된 안정성을 갖는 재조합 인자 ⅴⅰⅰⅰ |
EP2291523B1 (de) | 2008-06-24 | 2014-12-17 | CSL Behring GmbH | Faktor VIII, Von-Willebrand-Faktor oder Komplexe davon mit verlängerter in-vivo-Halbwertzeit |
ES2542202T3 (es) * | 2009-01-22 | 2015-08-03 | Novo Nordisk Health Care Ag | Compuestos de hormonas de crecimiento estables |
WO2011053169A1 (en) * | 2009-10-30 | 2011-05-05 | Agresearch Limited | Modified oil encapsulating proteins and uses thereof |
AU2011208620B2 (en) | 2010-01-22 | 2015-04-16 | Novo Nordisk Health Care Ag | Stable growth hormone compounds |
JP5875527B2 (ja) | 2010-01-22 | 2016-03-02 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | in−vivoにおける効力が延長された成長ホルモン |
JP2013532176A (ja) * | 2010-07-15 | 2013-08-15 | ノヴォ ノルディスク アー/エス | 安定化させた第viii因子バリアント |
WO2012010516A1 (en) * | 2010-07-22 | 2012-01-26 | Novo Nordisk Health Care Ag | Growth hormone conjugates |
PL2814502T3 (pl) | 2012-02-15 | 2018-02-28 | Csl Behring Gmbh | Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIII |
ES2755104T3 (es) | 2012-05-17 | 2020-04-21 | Ra Pharmaceuticals Inc | Inhibidores peptídicos y peptidomiméticos |
JP2016518321A (ja) * | 2013-03-15 | 2016-06-23 | バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC | 組み換え因子viii配合物 |
JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
WO2015066700A2 (en) | 2013-11-04 | 2015-05-07 | The Regents Of The University Of California | Therapy for treatment or prevention of conditions associated with bleeding or hypocoagulation |
EP3164150B1 (de) | 2014-07-02 | 2020-11-04 | CSL Behring Lengnau AG | Modifizierter von-willebrand-faktor |
KR20170125941A (ko) | 2015-03-06 | 2017-11-15 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | 개선된 반감기를 갖는 변형된 폰 빌레브란트 인자 |
EP3298036B1 (de) | 2015-05-22 | 2022-04-06 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
RU2017145014A (ru) | 2015-05-22 | 2019-06-24 | Цсл Беринг Ленгнау Аг | Усеченные полипептиды фактора фон виллебранда для лечения гемофилии |
CN104974228B (zh) * | 2015-06-15 | 2017-10-17 | 四川合泰新光生物科技有限公司 | 一种小分子多肽zy4及其应用 |
MX2018008337A (es) | 2016-01-07 | 2018-09-17 | CSL Behring Lengnau AG | Factor de von willebrand truncado mutado. |
RU2018128613A (ru) | 2016-01-07 | 2020-02-07 | Цсл Беринг Ленгнау Аг | Мутированный фактор фон виллебранда |
EP3538133B1 (de) | 2016-11-11 | 2021-02-17 | CSL Behring Lengnau AG | Verkürzte von-willebrand-faktor-polypeptide zur behandlung von hämophilie |
TW201828974A (zh) | 2016-11-11 | 2018-08-16 | 瑞士商Csl貝林重組技能公司 | 用於血管外施予以治療或預防凝血疾病之截短型類血友病因子(von Willebrand factor)多肽類 |
US11788081B2 (en) | 2018-04-19 | 2023-10-17 | Stichting Vu | Protein macrocyclization |
EP3810647A4 (de) * | 2018-04-26 | 2022-08-17 | The University of North Carolina at Chapel Hill | Verfahren und zusammensetzungen zur behandlung von hämophilie |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5214033A (en) | 1983-03-31 | 1993-05-25 | Scripps Clinic & Research Foundation | Factor VIII coagulant polypeptides |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
AU5772886A (en) | 1985-04-12 | 1986-11-05 | Genetics Institute Inc. | Novel procoagulant proteins |
US5250421A (en) | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
US5198349A (en) | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
US5422260A (en) | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
US4853871A (en) * | 1987-04-06 | 1989-08-01 | Genex Corporation | Computer-based method for designing stablized proteins |
US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
US5827821A (en) * | 1987-12-10 | 1998-10-27 | The Burnham Institute | Conformationally stabilized cell adhesion peptides |
US5009889A (en) | 1987-12-31 | 1991-04-23 | Oklahoma Medical Research Foundation | Treatment of dysfunctional vascular endothelium using activated protein C |
US4852871A (en) * | 1988-12-02 | 1989-08-01 | John Perko | Hand exercise device |
US5082767A (en) | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
US5610137A (en) | 1990-12-20 | 1997-03-11 | The Uab Research Foundation | Transgenic, cross-linked hemoglobin |
US5661008A (en) | 1991-03-15 | 1997-08-26 | Kabi Pharmacia Ab | Recombinant human factor VIII derivatives |
US5114148A (en) * | 1991-07-09 | 1992-05-19 | Liu Ming Zen | Puzzle device |
US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
US5364771A (en) | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5453937A (en) | 1993-04-28 | 1995-09-26 | Immunex Corporation | Method and system for protein modeling |
US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
DE4418635C2 (de) * | 1994-05-27 | 1997-07-24 | Immuno Ag | Pharmazeutische Zusammensetzung zur Vorbeugung und Behandlung von Blutgerinnungsstörungen |
US5681746A (en) * | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
US5543149A (en) * | 1995-03-01 | 1996-08-06 | Rubin; Stan M. | Treatment for insect bites |
US5935568A (en) | 1995-05-18 | 1999-08-10 | National Jewish Medical & Research Center | Gene therapy for effector cell regulation |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
US20040092442A1 (en) * | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
US6262238B1 (en) * | 1997-01-14 | 2001-07-17 | Roche Diagnostic, Gmbh | Process for modifying the stability of antibodies |
EE9900343A (et) | 1997-02-07 | 2000-02-15 | Merck & Co., Inc. | Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon |
US6358703B1 (en) | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
AU2002310438B2 (en) * | 2001-06-14 | 2008-05-01 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
-
2002
- 2002-06-14 AU AU2002310438A patent/AU2002310438B2/en not_active Ceased
- 2002-06-14 EP EP02737516A patent/EP1421539B1/de not_active Expired - Fee Related
- 2002-06-14 US US10/172,712 patent/US7205278B2/en not_active Expired - Fee Related
- 2002-06-14 WO PCT/US2002/019017 patent/WO2002103024A2/en active Application Filing
- 2002-06-14 CA CA002450732A patent/CA2450732A1/en not_active Abandoned
- 2002-06-14 ES ES02737516T patent/ES2331909T3/es not_active Expired - Lifetime
- 2002-06-14 EP EP09159506A patent/EP2110385A1/de not_active Withdrawn
- 2002-06-14 DE DE60234193T patent/DE60234193D1/de not_active Expired - Lifetime
- 2002-06-14 JP JP2003505346A patent/JP4361786B2/ja not_active Expired - Fee Related
-
2007
- 2007-01-25 US US11/627,197 patent/US7928199B2/en not_active Expired - Fee Related
-
2008
- 2008-05-12 JP JP2008124202A patent/JP2008271975A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2008271975A (ja) | 2008-11-13 |
US7928199B2 (en) | 2011-04-19 |
EP1421539A4 (de) | 2005-11-09 |
JP2005500831A (ja) | 2005-01-13 |
US7205278B2 (en) | 2007-04-17 |
EP2110385A8 (de) | 2010-06-02 |
EP1421539B1 (de) | 2009-10-28 |
AU2002310438B2 (en) | 2008-05-01 |
EP1421539A2 (de) | 2004-05-26 |
WO2002103024A3 (en) | 2004-03-18 |
US20030125232A1 (en) | 2003-07-03 |
EP2110385A1 (de) | 2009-10-21 |
WO2002103024A2 (en) | 2002-12-27 |
US20070276128A1 (en) | 2007-11-29 |
JP4361786B2 (ja) | 2009-11-11 |
CA2450732A1 (en) | 2002-12-27 |
ES2331909T3 (es) | 2010-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |