DK2865760T3 - Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life - Google Patents

Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life Download PDF

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Publication number
DK2865760T3
DK2865760T3 DK14192277.3T DK14192277T DK2865760T3 DK 2865760 T3 DK2865760 T3 DK 2865760T3 DK 14192277 T DK14192277 T DK 14192277T DK 2865760 T3 DK2865760 T3 DK 2865760T3
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glu
ser
val
ala
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DK14192277.3T
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Danish (da)
English (en)
Inventor
Thomas Weimer
Stefan Schulte
Hubert Metzner
Wiegand Lang
Ulrich Kronthaler
Holger Lind
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Csl Behring Gmbh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK14192277.3T 2008-06-24 2009-06-24 Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life DK2865760T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08011429 2008-06-24
EP09768986.3A EP2291523B1 (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

Publications (1)

Publication Number Publication Date
DK2865760T3 true DK2865760T3 (en) 2018-01-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK14192277.3T DK2865760T3 (en) 2008-06-24 2009-06-24 Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life
DK09768986T DK2291523T3 (en) 2008-06-24 2009-06-24 Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09768986T DK2291523T3 (en) 2008-06-24 2009-06-24 Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life

Country Status (12)

Country Link
US (2) US8575104B2 (enExample)
EP (2) EP2865760B1 (enExample)
JP (1) JP5832285B2 (enExample)
KR (2) KR101507718B1 (enExample)
CN (2) CN102076855A (enExample)
AU (1) AU2009262476C1 (enExample)
CA (1) CA2728012C (enExample)
DK (2) DK2865760T3 (enExample)
ES (2) ES2531464T3 (enExample)
PL (1) PL2291523T3 (enExample)
RU (1) RU2528855C2 (enExample)
WO (1) WO2009156137A1 (enExample)

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Also Published As

Publication number Publication date
JP5832285B2 (ja) 2015-12-16
CN103739712A (zh) 2014-04-23
US20110183907A1 (en) 2011-07-28
AU2009262476C1 (en) 2016-06-02
KR101648734B1 (ko) 2016-08-18
RU2011102366A (ru) 2012-07-27
AU2009262476A1 (en) 2009-12-30
AU2009262476B2 (en) 2014-06-26
US9290561B2 (en) 2016-03-22
ES2531464T3 (es) 2015-03-16
US20140072561A1 (en) 2014-03-13
RU2528855C2 (ru) 2014-09-20
CN102076855A (zh) 2011-05-25
DK2291523T3 (en) 2015-03-23
PL2291523T3 (pl) 2015-05-29
CN103739712B (zh) 2016-10-05
HK1151068A1 (en) 2012-01-20
WO2009156137A1 (en) 2009-12-30
CA2728012A1 (en) 2009-12-30
KR20140090703A (ko) 2014-07-17
EP2291523B1 (en) 2014-12-17
KR101507718B1 (ko) 2015-04-10
KR20110044978A (ko) 2011-05-03
CA2728012C (en) 2017-10-31
ES2654336T3 (es) 2018-02-13
EP2865760B1 (en) 2017-10-11
EP2865760A1 (en) 2015-04-29
JP2011525363A (ja) 2011-09-22
US8575104B2 (en) 2013-11-05
EP2291523A1 (en) 2011-03-09

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