DK2865760T3 - Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life - Google Patents

Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life Download PDF

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Publication number
DK2865760T3
DK2865760T3 DK14192277.3T DK14192277T DK2865760T3 DK 2865760 T3 DK2865760 T3 DK 2865760T3 DK 14192277 T DK14192277 T DK 14192277T DK 2865760 T3 DK2865760 T3 DK 2865760T3
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glu
ser
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ala
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DK14192277.3T
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Danish (da)
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Thomas Weimer
Stefan Schulte
Hubert Metzner
Wiegand Lang
Ulrich Kronthaler
Holger Lind
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Csl Behring Gmbh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK14192277.3T 2008-06-24 2009-06-24 Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life DK2865760T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08011429 2008-06-24
EP09768986.3A EP2291523B1 (en) 2008-06-24 2009-06-24 Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life

Publications (1)

Publication Number Publication Date
DK2865760T3 true DK2865760T3 (en) 2018-01-15

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Application Number Title Priority Date Filing Date
DK14192277.3T DK2865760T3 (en) 2008-06-24 2009-06-24 Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life
DK09768986T DK2291523T3 (en) 2008-06-24 2009-06-24 Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09768986T DK2291523T3 (en) 2008-06-24 2009-06-24 Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life

Country Status (12)

Country Link
US (2) US8575104B2 (enExample)
EP (2) EP2865760B1 (enExample)
JP (1) JP5832285B2 (enExample)
KR (2) KR101648734B1 (enExample)
CN (2) CN102076855A (enExample)
AU (1) AU2009262476C1 (enExample)
CA (1) CA2728012C (enExample)
DK (2) DK2865760T3 (enExample)
ES (2) ES2654336T3 (enExample)
PL (1) PL2291523T3 (enExample)
RU (1) RU2528855C2 (enExample)
WO (1) WO2009156137A1 (enExample)

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Also Published As

Publication number Publication date
KR101648734B1 (ko) 2016-08-18
US8575104B2 (en) 2013-11-05
KR101507718B1 (ko) 2015-04-10
CN103739712A (zh) 2014-04-23
CN102076855A (zh) 2011-05-25
ES2531464T3 (es) 2015-03-16
EP2291523B1 (en) 2014-12-17
RU2011102366A (ru) 2012-07-27
RU2528855C2 (ru) 2014-09-20
HK1151068A1 (en) 2012-01-20
US9290561B2 (en) 2016-03-22
PL2291523T3 (pl) 2015-05-29
CA2728012A1 (en) 2009-12-30
CA2728012C (en) 2017-10-31
EP2291523A1 (en) 2011-03-09
AU2009262476B2 (en) 2014-06-26
EP2865760A1 (en) 2015-04-29
JP2011525363A (ja) 2011-09-22
US20110183907A1 (en) 2011-07-28
EP2865760B1 (en) 2017-10-11
ES2654336T3 (es) 2018-02-13
DK2291523T3 (en) 2015-03-23
US20140072561A1 (en) 2014-03-13
AU2009262476A1 (en) 2009-12-30
KR20140090703A (ko) 2014-07-17
JP5832285B2 (ja) 2015-12-16
WO2009156137A1 (en) 2009-12-30
CN103739712B (zh) 2016-10-05
AU2009262476C1 (en) 2016-06-02
KR20110044978A (ko) 2011-05-03

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