JP5826107B2 - 微生物の腸内投与用組成物 - Google Patents
微生物の腸内投与用組成物 Download PDFInfo
- Publication number
- JP5826107B2 JP5826107B2 JP2012108867A JP2012108867A JP5826107B2 JP 5826107 B2 JP5826107 B2 JP 5826107B2 JP 2012108867 A JP2012108867 A JP 2012108867A JP 2012108867 A JP2012108867 A JP 2012108867A JP 5826107 B2 JP5826107 B2 JP 5826107B2
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- JP
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- Prior art keywords
- microorganism
- lactobacillus
- coating
- bifidobacterium
- microorganisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
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- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/032—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
- A23C19/0323—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin using only lactic acid bacteria, e.g. Pediococcus and Leuconostoc species; Bifidobacteria; Microbial starters in general
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
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Description
[圧密化/流動層コーティング]
[工程1]
ステアリン酸マグネシウム(46.74g)、アルファ−トコフェロール(6.46g)および中鎖トリグリセリド(MCT、3.8g)をビーカー中で混合し、その後、混合物が均一になるまでパスタメーカー(アトラス150型(Model Atlas 150)、ファブリク・エン・イタリー・パル(Fabrique En Italie Par)、カンポダルセゴ(Campodarsego)、イタリア(Itali))で混練した。その後、混合物をラフティ(登録商標)L10(CBS 116411)(323g)と混合し、均一でフレーク状になるまでパスタメーカーで混練した。フレーク状材料を800ミクロンの篩に加圧通過させて、粒状粒子を形成した。
アルギン酸ナトリウム(水分含量13%;FMC バイオポリマー(FMC Biopolymer)、フィラデルフィア(Philadelphia)、米国)7.372gを脱イオン水(99.5g)に溶解させて、6%アルギン酸塩溶液を調製した。ステアリン酸マグネシウムで被覆したラフティ(登録商標)L10(工程1で得られたもの、350g)を流動層造粒機(MP−1 マルチ−プロセッサー(MP−1 Multi−Processor)、エアロマティック−フィールダー(Aeromatic−Fielder)、ブーベンドルフ(Bubendorf)、スイス(Switzerland))に入れ、毎分約1.6gの割合で6%アルギン酸塩溶液(106.9g)を底部からスプレーした。最後に、生成物を水分含量が4%未満になるまで乾燥させて、次のような表1に示す粒度分布を有する最終生成物を得た。
[錠剤化]
ポリプラスドンXL10(Polyplasdone XL10)(クロスポビドン)2.80gおよびアビセルpH302(Avicel pH302)(微結晶性セルロース)181.96gを1mmの篩にかけた。実施例1で得られたラフティ(登録商標)L10調製物95.24gを加え、タンブラーミキサーで10分間混合した。
圧壊力:277N(クレーマーUTS4.1(Kraemer UTS4.1)により測定)
壊変時間:7分10秒(USP27による、脱塩水)
加算カウント(Added counts)/錠 90.8*109
実測カウント(Found counts)/錠 89.6*109(残率=99%)
[ブレンド/流動層コーティング]
[工程1]
ラフティ(登録商標)L10(272g)およびステアリン酸マグネシウム(48g)を1リットル瓶に入れ、45RPMで20分間振盪した(タービュラT2C(Turbula T2C)、ウィリー A.バコーフェン(Willy A. Bachofen)、バーゼル(Basel)、スイス)。
アルギン酸ナトリウム(水分含量13%;FMC バイオポリマー、フィラデルフィア、米国)6.321gを脱イオン水(85.3g)に溶解させて、6%アルギン酸塩溶液を調製した。工程1で得られた生成物(300g)を流動層造粒機(MP−1 マルチ−プロセッサー、エアロマティック−フィールダー、ブーベンドルフ、スイス)に入れ、毎分0.86〜1.6gの割合で6%アルギン酸塩溶液(91.65g)を底部からスプレーした。最後に、アルギン酸塩およびステアリン酸マグネシウムで被覆したラフティ(登録商標)L10を水分含量が4%未満になるまで乾燥させて、次のような表4に示す粒度分布を有する最終生成物を得た。
[錠剤化]
ポリプラスドンXL10(クロスポビドン)0.98g、アビセルPH302(微結晶性セルロース)55.09gおよび実施例3で得られたラフティ(登録商標)L10調製物41.93gを1mmの篩に通し、タンブラーミキサーで10分間混合した。
圧壊力:254.4N(クレーマーUTS4.1により測定)
壊変時間:52分02秒(USP27による、脱塩水)
[工程1]
ラフティ(登録商標)L10(272g)およびステアリン酸マグネシウム(48g)を1リットル瓶に入れ、45RPMで20分間振盪した(タービュラT2C、ウィリー A.バコーフェン、バーゼル、スイス)。
ペクチン(ゲヌー(登録商標)ペクチンUSP/100(GENU(登録商標)pectin USP/100)、水分含量8.83%;CP ケルコ(CP Kelco)、リレ・スケンスベド(Lille Skensved)、デンマーク(Denmark))16.45gを脱イオン水(483.55g)に溶解させて、3%ペクチン溶液を調製した。工程1で得られた生成物(360g)を流動層造粒機(MP−1 マルチ−プロセッサー、エアロマティック−フィールダー、ブーベンドルフ、スイス)に入れ、毎分約1.5gの割合で3%ペクチン(216g)を上部からスプレーした。最後に、ペクチンおよびステアリン酸マグネシウムで被覆したラフティ(登録商標)L10を水分含量が4%未満になるまで乾燥させた。生成物の主要フラクション(301g)は造粒機の容器に貯留されたが、少量の白っぽい物質のフラクション(59g)がフィルターに残った。色(ステアリン酸マグネシウム:白、ラフティ:茶色がかった色)に基づけば、フィルター内の物質は大部分がステアリン酸マグネシウムであった。
[圧密化/流動層コーティング]
[工程1]
ステアリン酸カルシウム(61.5g)、アルファ−トコフェロール(8.5g)および中鎖トリグリセリド(MCT、5g)をビーカー中で混合し、その後、混合物が均一になるまでパスタメーカー(アトラス150型、ファブリク・エン・イタリー・パル、カンポダルセゴ、イタリア)で混練した。その後、混合物をラフティ(登録商標)L10(425g)と混合し、均一でフレーク状になるまでパスタメーカーで混練した。混合物を錠剤プレス機で圧密化し、その錠剤を粉砕して1mmの篩に通した。この工程を計4回繰り返した。最後の回に、混合物を500ミクロンの篩に加圧通過させて、粒状粒子を形成した。
アルギン酸ナトリウム(水分含量13%;FMC バイオポリマー、フィラデルフィア、米国)33gを脱イオン水(538.9g)に溶解させて、アルギン酸塩溶液を調製した。ステアリン酸マグネシウムで被覆したラフティ(登録商標)L10(工程1で得られたもの、350g)を流動層造粒機(MP−1 マルチ−プロセッサー、エアロマティック−フィールダー、ブーベンドルフ、スイス)に入れ、毎分約2.3gの割合でアルギン酸塩溶液(142.9g)を底部からスプレーした。最後に、生成物を水分含量が4%未満になるまで乾燥させた。材料全体の8.1%を占める850ミクロン超のフラクションを除去した。残りの材料の粒度分布を表10に示す。
[ブレンド/流動層コーティング]
[工程1]
ラフティ(登録商標)L10(272g)およびステアリン酸マグネシウム(48g)を1リットル瓶に入れ、45RPMで20分間振盪した(タービュラT2C、ウィリー A.バコーフェン、バーゼル、スイス)。
アルギン酸ナトリウム(水分含量13%;FMC バイオポリマー、フィラデルフィア、米国)6.321gを脱イオン水(176.9g)に溶解させて、3%アルギン酸塩溶液を調製した。塩化カルシウム5gを脱イオン水(95g)に溶解させて5%の塩化カルシウムを調製した。工程1で得られた生成物(300g)を流動層造粒機(MP−1 マルチ−プロセッサー、エアロマティック−フィールダー、ブーベンドルフ、スイス)に入れ、毎分1〜3gの割合で3%アルギン酸塩溶液(180g)を、また、毎分0.5〜2gの割合で5%塩化カルシウム溶液(27g)を上部からスプレーした。最後に、アルギン酸塩およびステアリン酸マグネシウムで被覆したラフティ(登録商標)L10を水分含量が4%未満になるまで乾燥させて、次のような表12に示す粒度分布を有する最終生成物を得た。
[錠剤化]
ポリプラスドンXL10(クロスポビドン)0.98g、アビセルPH302(微結晶性セルロース)55.09gおよび実施例6で得られたラフティ(登録商標)L10調製物41.93gを1mmの篩に通し、タンブラーミキサーで10分間混合した。
圧壊力:254.4N(クレーマーUTS4.1による測定)
これらの試行の目的は、ラフティのパイロット規模での製剤と方法、また、生産規模とした場合の可能な推定が有効であることを実証することであった。
表14に示すように、オイルの量に対するプレミックスの感度を調べるため、3回の試行を行った。
粉末混合物(ラフティL10/プレミックス)も、次の表15に示す処方で、高剪断ミキサーを用いて調製した。
使用圧:5〜20kN、パス数:2
得られた生成物はいずれも、良好ないし極めて良好な流動特性を有しており、良好な特性の錠剤の製造に容易に使用される。生成物の密度は高く、包装に好都合である。
Claims (13)
- 微生物を含む固体組成物の製造方法であって、前記微生物を中鎖または長鎖脂肪酸の塩とブレンドして、粉末混合物を調製する第1の工程と、前記粉末混合物に、コーティング物質が水に溶解又は懸濁した溶液又は懸濁液をコーティングし、生成物を乾燥させてコーティングを施す第2の工程とを含む方法。
- 前記ブレンド工程で使用する前記微生物が、マトリックス材料でコーティングされているか、または、マトリックス材料に内包されている請求項1に記載の方法。
- 前記マトリックス材料が、タンパク質、マルトデキストリン、トレハロースおよび/またはアスコルビン酸から選択される請求項2に記載の方法。
- 前記コーティング物質がアルギン酸塩である請求項1〜3のいずれか一項に記載の方法。
- 前記コーティングが、アルギン酸塩水溶液をスプレーすることによって、前記粉末混合物に施される請求項4に記載の方法。
- 前記中鎖または長鎖脂肪酸の塩が、ステアリン酸マグネシウムである請求項1〜5のいずれか一項に記載の方法。
- 前記中鎖または長鎖脂肪酸の塩が、ステアリン酸カルシウムである請求項1〜5のいずれか一項に記載の方法。
- 前記微生物がプロバイオティックまたはその混合物である請求項1〜7のいずれか一項に記載の方法。
- 前記微生物が凍結乾燥調製物である請求項1〜8のいずれか一項に記載の方法。
- 前記微生物が、ビフィドバクテリウム属(Bifidobacterium)、乳酸桿菌属(Lactobacillus)、プロピオニバクテリウム属(Propionibacterium)または腸球菌属(Enterococcus)である請求項1〜9のいずれか一項に記載の方法。
- 前記微生物が、ビフィドバクテリウムインファンティス(Bifidobacterium infantis)、ビフィドバクテリウムロングム(Bifidobacterium longum)、ビフィドバクテリウムアニマリス(Bifidobacterium animalis)、ビフィドバクテリウムラクティス(Bifidobacterium lactis)、ラクトバチルスアシドフィルス(Lactobacillus acidophilus)、ラクトバチルスラムノスス(Lactobacillus rhamnosus)、ラクトバチルスカゼイ(Lactobacillus casei)、ラクトバチルスパラカゼイ(Lactobacillus paracasei)およびラクトバチルスヘルベティクス(Lactobacillus helveticus)からなる群より選択される請求項1〜9のいずれか一項に記載の方法。
- 前記微生物が、ラクトバチルスアシドフィルス株CBS116411、ビフィドバクテリウムアニマリスおよびラクトバチルスカゼイCBS116412からなる群より選択される請求項11に記載の方法。
- 固体微生物組成物の、流動性の向上および/または吸湿性の低減のための請求項1〜12のいずれか一項に記載の方法。
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JP5576606B2 (ja) | 2014-08-20 |
ES2368344T3 (es) | 2011-11-16 |
ATE515198T1 (de) | 2011-07-15 |
US8697126B2 (en) | 2014-04-15 |
WO2006122965A1 (en) | 2006-11-23 |
CN101257804A (zh) | 2008-09-03 |
JP2012175977A (ja) | 2012-09-13 |
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