JP5818356B2 - 皮膚、粘膜、頭皮、及び/若しくは毛髪の処置及び/若しくはケアに有用なペプチド並びに/又は化粧品組成物若しくは医薬組成物におけるその使用 - Google Patents
皮膚、粘膜、頭皮、及び/若しくは毛髪の処置及び/若しくはケアに有用なペプチド並びに/又は化粧品組成物若しくは医薬組成物におけるその使用 Download PDFInfo
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
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Description
人体から発せられる臭気(odor)の性質は、遺伝的体質又はその人体が患っている病態等の内的要因だけでなく、ライフスタイル、食物摂取、喫煙、入浴頻度等の要因にも影響を受ける[Labows JN(1979)“Human odors”Perf.4:12−17 flavor,Senol M.and Fireman P.(1999)“Body odor in dermatologic diagnosis”Cutis 63:107−111]。人体が放つにおい(scent)の成分は特定されており、主に、ヒトの種々の臓器及び/又は細胞から分泌される脂肪酸から形成される揮発性アルデヒド及びそのエステルである。体臭の成分は、人生の種々の段階を通して一定ではない。特に中高年のにおい(smell)の主な原因は、中高年の皮脂腺分泌物に主に見られ且つ加齢に伴う脂肪性の鼻をつく不快な体臭の原因である9−ヘキサデセン酸(9−hexacedenoic acid)から形成される2−ノネナール又は2−オクテナール等の不飽和脂肪酸のアルデヒドである[S.Haze,Y.Gozu,S.Nakamura,Y.Kohno,K.Sawano,H.Ohta and K.Yamazaki(2001)“2−Nonenal newly found in human body odor tends to increase with aging”,J.Invest.Dermatol.116:520−524]。これらのα及びβ不飽和アルデヒドは、酸化ストレス状況下で脂肪酸が受ける脂質過酸化プロセス中に脂肪及び皮膚中で生成する活性炭素種(RCS)である。
本発明を理解し易くするために、本発明において使用されるいくつかの用語の定義を記載する。
本発明の化合物は、一般式(I)
R1−AA1−AA2−AA3−AA4−R2 (I)
その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩で定義され:
AA1が、−Lys−、−Orn−、−Dab−、−Dpr−、−Agl−、−3,4−デヒドロリジン、及び−4,5−デヒドロリジンにより形成される群から選択され;
AA2が−Ala−であり;
AA3が−Asp−、−Ala−、−Asn−、−Glu−、及び−Pro−からなる群から選択され;
AA4が−His−であり;
R1がH、置換又は未置換の非環式脂肪族基、置換又は未置換の脂環基、置換又は未置換のヘテロシクリル、置換又は未置換のヘテロアリールアルキル、置換又は未置換のアリール、置換又は未置換のアラルキル、及びR5−COからなる群から選択され;
R2が−NR3R4、−OR3、及び−SR3からなる群から選択され;
R3及びR4が、独立して、H、置換又は未置換の非環式脂肪族基、置換又は未置換の脂環基、置換又は未置換のヘテロシクリル、置換又は未置換のヘテロアリールアルキル、置換又は未置換のアリール、及び置換又は未置換のアラルキルからなる群から選択され;
R5がH、置換又は未置換の非環式脂肪族基、置換又は未置換の脂環基、置換又は未置換のアリール、置換又は未置換のアラルキル、置換又は未置換のヘテロシクリル、及び置換又は未置換のヘテロアリールアルキルからなる群から選択されることを特徴とする。
H−Dpr−Ala−Ala−His−OH、
H−Dpr−Ala−Ala−His−NH2、
H−Dpr−Ala−Asn−His−OH、
H−Dpr−Ala−Asn−His−NH2、
H−Dpr−Ala−Asp−His−OH、
H−Dpr−Ala−Asp−His−NH2、
H−Dpr−Ala−Glu−His−OH、
H−Dpr−Ala−Glu−His−NH2、
H−Dpr−Ala−Pro−His−OH、
H−Dpr−Ala−Pro−His−NH2、
Palm−Dpr−Ala−Ala−His−OH、
Palm−Dpr−Ala−Ala−His−NH2、
Palm−Dpr−Ala−Asn−His−OH、
Palm−Dpr−Ala−Asn−His−NH2、
Palm−Dpr−Ala−Asp−His−OH、
Palm−Dpr−Ala−Asp−His−NH2、
Palm−Dpr−Ala−Glu−His−OH、
Palm−Dpr−Ala−Glu−His−NH2、
Palm−Dpr−Ala−Pro−His−OH、
Palm−Dpr−Ala−Pro−His−NH2、
H−Orn−Ala−Pro−His−OH、
H−Lys−Ala−Pro−His−OH、
H−Dab−Ala−Pro−His−OH、
H−Agl−Ala−Pro−His−OH、
H−Orn−Ala−Ala−His−OH、
H−Lys−Ala−Ala−His−OH、
H−Dab−Ala−Ala−His−OH、
H−Agl−Ala−Ala−His−OH、
H−Dpr−Ala−Pro−His−CONH−(CH2)15−CH3、
H−Dpr−Ala−Ala−His−CONH−(CH2)15−CH3、
H−4,5−デヒドロLys−Ala−Pro−His−OH、
H−3,4−デヒドロLys−Ala−Pro−His−OH、
Ac−Dpr−Ala−Pro−His−OH、及び
Ac−Dpr−Ala−Ala−His−OH;
これらの立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩。
本発明のペプチド、その立体異性体、又はその化粧品学的若しくは薬学的に許容される塩の合成は、先行技術に公知の常法、例えば固相ペプチド合成法[Stewart JM and Young J.D.(1984)“Solid Phase Peptide Synthesis,2nd edition”Pierce Chemical Company,Rockford,Illinois;Bodanzsky M.and Bodanzsky A.(1984)“The practice of Peptide Synthesis”Springer Verlag,New York,Lloyd Williams P.,Albericio F.and Giralt E.(1997)“Chemical Approaches to the Synthesis of Peptides and Proteins”CRC,Boca Raton,FL,USA]、溶液中での合成、固相合成法と酵素的合成溶液法の組合せ、又は[Kullmann W.(1980)“Proteases as catalysts for enzymic syntheses of opioid peptides”J.Biol.Chem.255:8234−8238]に従って行うことができる。ペプチドの獲得は、所望の配列を生産するための遺伝子操作されていてもいなくてもよい菌種の発酵、あるいは、少なくとも所望の配列を含むペプチド断片を放出させる動物タンパク質又は植物タンパク質の制御加水分解、好ましくは植物タンパク質の制御加水分解でも可能である。
N末端が保護されてC末端がフリーのアミノ酸をN末端がフリーでC末端が保護されているか固体支持体に結合されているアミノ酸上でカップリングさせる工程;
N末端の保護基を除去する工程;
カップリング及びN末端保護基の除去の連続操作を繰り返して所望のペプチド配列を得る工程;
C末端の保護基を除去するか固体支持体から切断する工程;
を含む。
本発明のペプチドは、ペプチド含有組成物の形態でペプチドを哺乳動物、好ましくはヒト、の体におけるその作用部位と接触させる任意の手段により、RCSを捕捉するように投与され得る。
本発明の別の態様は、皮膚、粘膜、頭皮、及び/又は毛髪を処置及び/又はケアするための化粧品組成物又は医薬組成物の製造における、一般式(I)で表されるペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩の少なくとも1つの使用に関する。
全ての試薬及び溶媒は合成用の品質であり、更なる処理をせずに用いる。
アミノ酸に用いる略語は、Eur J.Biochem.(1984)138:9−37及びJ.Chem(1989)264:633−673に詳説されているIUPAC−IUB生化学命名法委員会の規則に従う。
全ての合成プロセスを、多孔性ポリエチレンのディスクを備えたポリプロピレンシリンジ中又は多孔板を備えたパイレックス(登録商標)製反応器中で行う。溶媒及び可溶性試薬は吸引により除去する。Fmoc基は、ピペリジン−DMF(2:8、v/v)(1×1分、1×5分、5mL/g樹脂)を用いて取り除く[Lloyd Williams P., Albericio F. and Giralt E.(1997) “Chemical Approaches to the Synthesis of Peptides and Proteins” CRC, Boca Raton, FL, USA]。脱保護段階、カップリング段階、及び再脱保護段階の間での洗浄は、DMFを各回10mL溶媒/g樹脂で用いて行った(3×1分)。カップリング反応は、3mL溶媒/g樹脂で行った。カップリングの調節はニンヒドリン試験[E. Kaiser, RL Colescott, CD Bossing and Cook P.I.(1970) “Color test for detection of free terminal amino groups in the solid phase synthesis of peptides” Anal. Biochem. 34:595−598]又はクロラニル[Christensen T.(1979) “A qualitative test for monitoring coupling completeness in solid−phase peptide synthesis using Chloranil” Acta Chem Scand. 33B:763−766]を用いて行った。全ての合成変換及び洗浄は室温で行った。
Fmoc−AA1−AA2−AA3−AA4−O−2−ClTrt樹脂の調製
5.45gのFmoc−L−His(Trt)−OH又は5.45gのFmoc−D−His(Trt)−OH(8.8mmol;1equiv)を、55mlのDCMに投入して溶解させ、そこに乾燥2クロロトリチル樹脂(5.5g、8.8mmol)上で1.3mLのDIEA(7.6mmol、0.86equiv)を添加した。これらを5分間撹拌した後、2.5mLのIDEA(14.6mmol、1.66equiv)を添加した。これを40分間反応させた。残りの4.4mLのMeOHで処理して塩化物基をブロックした。
Fmoc−AA1−AA2−AA3−AA4−AM−MBHA樹脂の調製
官能化されたFmoc−AM−MBHA樹脂6.85g(0.73mmol/g;5mmol)を、Fmoc基を除去するために、記載されている一般的プロトコールに従いピペリジン−DMFで処理した。この脱保護した樹脂に、DMFを溶媒として用いて1時間、DIPCDI(3.85mL、25mmol;5equiv)及びHOBt(3.85g、25mmol;5equiv)存在下で15.49gのFmoc−L−His(Trt)−OH又は15.49gのFmoc−D−His(Trt)−OH(25mmol;5equiv)を導入した。
N末端Fmoc保護基を切断するための一般的プロセス
実施例1及び2で得られたペプチジル樹脂のFmocN末端基を、一般的方法に記載したように脱保護した(20%ピペリジンを含むDMF、1×5分+1×20分)。ペプチジル樹脂の洗浄をDMF(5×1分)、DCM(4×1分)、ジエチルエーテル(4×1分)を用いて行い、真空下で乾燥させた。
高分子支持体からの切断プロセス:AA1−AA2−AA3−AA4−OH、Ac−AA1−AA2−AA3−AA4−OH、Palm−AA1−AA2−AA3−AA4−OH、H−AA1−AA2−AA3−AA4−NH2、Ac−AA1−AA2−AA3−AA4−NH2、及びPalm−AA1−AA2−AA3−AA4−NH2の調製
実施例3で得た乾燥ペプチジル樹脂200mgを、室温で撹拌しながら2時間、5mlのTFA−TIS−H2O(90:5:5)で処理した。ろ液を50mlの冷ジエチルエーテルに回収し、多孔性ポリエチレンディスクを付けたポリプロピレン製シリンジを用いて濾過し、50mLのジエチルエーテルで5回洗浄した。最終沈殿物を真空下で乾燥させた。
4−ヒドロキシ−2−ノネナールの消去アッセイ
ペプチドから濃度2mMの溶液を10mMのPBS緩衝液中に調製し、濃度100μMのアルデヒドを含むアセトニトリル溶液も調製した。同じ体積のペプチド溶液及びアルデヒドを混合し、37℃で24時間反応させた。反応混合物中に残ったアルデヒドの含有量をHPLC分析することでRCSの消去効率を測定した。
2−ノネナール消去アッセイ
ペプチドから濃度2mMの溶液を10mMのPBS緩衝液中に調製し、濃度100μMのアルデヒドを含むアセトニトリル溶液も調製した。同じ体積のペプチド溶液及びアルデヒドを混合し、37℃で24時間反応させた。反応混合物中に残ったアルデヒドの含有量をHPLC分析することでRCSの消去効率を測定した。
H−L−Dpr−D−Ala−L−Pro−L−His−OH及びH−L−Dp− L−Ala−L−Pro−L−His−OHの培養ヒトケラチノサイトにおける光保護効率試験
ヒトのケラチノサイトを96ウェルプレートで24時間培養液中に維持して単層を形成させ、1mg/mlのH−L−Dpr−D−Ala−L−Pro−L−His−OH、H−L−Dpr−L−Ala−L−Pro−L−His−OH、又はリン酸緩衝生理食塩水(対照)と共に37℃にて1時間、湿った5%CO2空気下で暗黒下にて細胞をプレインキュベートした。その後、室温で150分間、37J/cm2のエネルギーで太陽をシミュレートしたランプを細胞に照射した。対照プレートは同じ時間、室温で暗黒下に維持した。照射期間後、細胞培地を新鮮な培地と交換し、細胞を更に24時間インキュベートした。
DNA分解保護能力の試験
ヒトメラノサイトの一次培養物(105細胞/プレート)を、37℃で2時間、1.0μg/mLのH−L−Dpr−D−Ala−L−Pro−L−His−OHで処理した。その後、培養物に、4℃で3分以下、1.0J/cm2のUVAを照射し、DNAに誘導された損傷の程度をアルカリコメットアッセイ[De Meo M.,Laget M.,Castegnaro M.and Dumenil G.(1991)“Genotoxic activity of potassium permanganate in acidic solutions”Mutat.Res 260:295−306]で決定した。
H−L−Dpr−D−Ala−L−Ala−L−His−OHを含むフェイシャルクリーム組成物
製造
・相Aの原料を混合して70℃に加熱する。
・相Bの原料を混合して70℃に加熱する。
・ホモジナイザー(シルバーソン社(Silverson)製)で5分間撹拌しながら、相Cを相Bに添加する。
・均質化しながら、相B及びCの混合物に徐々に相Aを添加し、均質化を15分間維持する。
・穏やかに撹拌しながら30〜35℃に冷却し始める。50℃の時に相Dを添加する。撹拌を続ける。35〜38℃の時、予め可溶化させた相E及びFを添加する。
Claims (15)
- 一般式(I)
R1−AA1−AA2−AA3−AA4−R2 (I)
で表されるペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩であって:
AA1が−Lys−、−Orn−、−Dab−、−Dpr−、−Agl−、−3,4−デヒドロリジン、及び−4,5−デヒドロリジンからなる群から選択され;
AA2が−Ala−であり;
AA3が−Asp−、−Ala−、−Asn−、−Glu−、及び−Pro−からなる群から選択され;
AA4が−His−であり;
R1がH及びR5−CO−からなる群から選択され;
R2が−NR3R4、−OR3、及び−SR3からなる群から選択され;
R3及びR4がHであり;
R5がH、未置換のC1−C24アルキル、未置換のC2−C24アルケニル、未置換のC2−C24アルキニル、未置換のC3−C24シクロアルキル、未置換のC5−C24シクロアルケニル、及び未置換のC5−C24シクロアルキニルからなる群から選択される;
ことを特徴とする、ペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩。 - R1がH、アセチル、ラウロイル、ミリストイル、又はパルミトイルであり、AA1が−L−Dpr−であり、AA2が−D−Ala−であり、AA3が−L−Ala−であり、AA4が−L−Hisであり、R2が−NR3R4又は−OR3(式中、R3及びR4 がHである)であることを特徴とする、請求項1に記載のペプチド。
- R1がH、アセチル、ラウロイル、ミリストイル、又はパルミトイルであり、AA1が−L−Dpr−であり、AA2が−D−Ala−であり、AA3が−L−Pro−であり、AA4が−L−Hisであり、R2が−NR3R4又は−OR3(式中、R3及びR4 がHである)であることを特徴とする、請求項1に記載のペプチド。
- R1がH、アセチル、ラウロイル、ミリストイル、又はパルミトイルであり、AA1が−L−Dpr−であり、AA2が−L−Ala−であり、AA3が−L−Pro−であり、AA4が−L−His−であり、R2が−NR3R4又は−OR3(式中、R3及びR4 がHである)であることを特徴とする、請求項1に記載のペプチド。
- 皮膚、粘膜、頭皮、及び/又は毛髪を処置及び/又はケアするための、一般式(I)
R1−AA1−AA2−AA3−AA4−R2 (I)
で表されるペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩の使用であって:
AA1が−Lys−、−Orn−、−Dab−、−Dpr−、−Agl−、−3,4−デヒドロリジン、及び−4,5−デヒドロリジンからなる群から選択され;
AA2が−Ala−であり;
AA3が−Asp−、−Ala−、−Asn−、−Glu−、及び−Pro−からなる群から選択され;
AA4が−His−であり;
R1がH及びR5−CO−からなる群から選択され;
R2が−NR3R4、−OR3、及び−SR3からなる群から選択され;
R3及びR4がHであり;
R5がH、未置換のC1−C24アルキル、未置換のC2−C24アルケニル、未置換のC2−C24アルキニル、未置換のC3−C24シクロアルキル、未置換のC5−C24シクロアルケニル、及び未置換のC5−C24シクロアルキニルからなる群から選択される;
ことを特徴とする、ペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩の皮膚、粘膜、頭皮及び/又は毛髪の処置及び/又はケアのための化粧品的又は薬学的組成物の調製物における
使用。 - RCS生成により生じる皮膚、粘膜、頭皮、及び/又は毛髪の状態、障害、及び/又は病態を処置及び/又はケアするための、請求項5に記載の使用。
- 前記処置及び/又はケアが、皮膚、粘膜、頭皮、及び/又は毛髪における、光保護、細胞DNAの保護、及び/又は細胞DNAの修復である、請求項5〜6のいずれか一項に記載の使用。
- 前記処置及び/又は皮膚のケアが、老化、光老化、セルライト、及び/又は体臭の徴候を低減、遅延、及び/又は防止するためになされる、請求項5〜7のいずれか一項に記載の使用。
- 固相又は液相で行われることを特徴とする、請求項1〜4のいずれか一項に記載の一般式(I)で表されるペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩の製造プロセス。
- 化粧品学的又は薬学的有効量の、請求項1〜4のいずれか一項に記載の少なくとも1つの一般式(I)で表されるペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩及び少なくとも1つの化粧品学的又は薬学的に許容される補形剤又は原料を含む、化粧品組成物又は医薬組成物。
- 前記一般式(I)で表されるペプチド、その立体異性体、それらの混合物、又はその化粧品学的若しくは薬学的に許容される塩が、リポソーム、混合リポソーム、オレオソーム、ミリカプセル、マイクロカプセル、ナノカプセル、スポンジ、シクロデキストリン、小胞、ミセル、界面活性剤の混合ミセル、界面活性剤−リン脂質混合ミセル、ミリスフェア、マイクロスフェア、ナノスフェア、リポスフェア、マイクロエマルション、ナノエマルション、ミリ粒子、マイクロ粒子、ナノ粒子、及び固体脂質ナノ粒子からなる群から選択される送達系又は化粧品学的若しくは薬学的に許容される徐放系に組み込まれる、及び/又は、タルク、ベントナイト、シリカ、でんぷん、及びマルトデキストリンからなる群から選択される化粧品学的又は薬学的に許容される固体有機ポリマー又は固体支持体に吸着されることを特徴とする、請求項10に記載の組成物。
- クリーム、複合エマルション、無水組成物、水成分散液、油、乳液、バルサム、フォーム、ローション、ゲル、クリームゲル、ヒドロアルコール溶液、ハイドログリコリック溶液、リニメント、血清、石けん、シャンプー、コンディショナー、血清、軟膏、ムース、ポマード、パウダー、バー、ペンシル、スプレー、カプセル、ゼラチンカプセル、錠剤、糖衣錠、顆粒形態、チューインガム、溶液、懸濁液、エマルション、シロップ剤、多糖膜、ゼリー、及びゼラチンからなる群から選択される製剤の形態であることを特徴とする、請求項10〜11のいずれか一項に記載の組成物。
- コンシーラー、メイクアップファンデーション、メイクアップ落とし用ローション、メイクアップ落とし用乳液、アイシャドー、口紅、リップグロス、リッププロテクター、及びパウダーからなる群から選択される製品に組み込まれることを特徴とする、請求項10〜12のいずれか一項に記載の組成物。
- 前記一般式(I)で表されるペプチド、その立体異性体、それらの混合物、又は化粧品学的若しくは薬学的に許容される塩が、布地、不織布、又は医療器具に組み込まれることを特徴とする、請求項10〜12のいずれか一項に記載の組成物。
- 他のRCSスカベンジャー、MMP抑制剤、メラニン合成の刺激剤又は抑制剤、美白剤又は脱色剤(depigmenting agent)、着色促進剤(propigmenting agent)、セルフタンニング剤、老化防止剤、NO合成阻害剤、5α還元酵素阻害剤、リジルヒドロキシラーゼ及び/又はプロリルヒドロキシラーゼの阻害剤、酸化防止剤、フリーラジカルスカベンジャー、抗糖化剤、抗ヒスタミン剤、制吐薬、抗ウイルス薬、抗寄生虫薬、乳化剤、皮膚軟化剤、有機溶媒、液体推進薬、スキンコンディショナー、湿潤剤、水分保持物質、アルファヒドロキシ酸、ベータヒドロキシ酸、モイスチャライザー、表皮加水分解酵素、ビタミン、顔料又は着色剤、色素、ゲル化ポリマー、増粘剤、界面活性剤、柔軟剤、抗シワ剤、目の下のタルミを低減又は処置できる剤、剥脱剤、抗微生物剤、抗真菌剤、静真菌剤、殺菌剤、静菌剤、真皮又は表皮の巨大分子合成を刺激する且つ/又はその分解を阻害若しくは防止できる剤、コラーゲン合成刺激剤、エラスチン合成刺激剤、デコリン合成刺激剤、ラミニン合成刺激剤、デフェンシン合成刺激剤、シャペロン合成刺激剤、アクアポリン合成刺激剤、ヒアルロン酸合成刺激剤、フィブロネクチン合成刺激剤、サーチュイン合成刺激剤、角質層の脂質及び成分の合成刺激剤、コラーゲン分解抑制剤、エラスチン分解抑制剤、セリンプロテアーゼ阻害剤、線維芽細胞増殖刺激剤、ケラチノサイト増殖刺激剤、脂肪細胞増殖刺激剤、メラノサイト増殖刺激剤、ケラチノサイト分化刺激剤、脂肪細胞分化刺激剤、アセチルコリンエステラーゼ阻害剤、皮膚弛緩剤、グリコサミノグリカン合成刺激剤、抗過角化症剤、コメド溶解剤(comedolytic agent)、抗乾癬剤、DNA修復剤、DNA保護剤、安定剤、抗掻痒剤、敏感肌を処置及び/又はケアするための剤、固化剤、抗皮膚線条剤、結合剤、皮脂生成制御剤、脂肪分解剤又はリポリーシス刺激剤、抗セルライト剤、制汗剤、治癒刺激剤、コアジュバント治癒剤、再上皮化刺激剤、コアジュバント再上皮化剤、サイトカイン増殖因子、鎮静剤、抗炎症薬、麻酔薬、毛細血管循環及び/又は微小循環に作用する剤、血管新生刺激薬、血管透過性抑制剤、静脈強壮剤、細胞代謝に作用する剤、真皮−表皮接合部改善剤、発毛・育毛誘導剤、発毛・育毛を抑制剤又は遅延する剤、保存剤、芳香剤、キレート化剤、植物エキス、精油、海洋エキス、バイオ発酵プロセスから得られる剤、鉱物塩、細胞抽出物、並びに日焼け止め、紫外線A及び/又はBに有効な有機又は無機光保護剤、又はこれらの混合物からなる群から選択される化粧品学的又は薬学的有効量の少なくとも1つの原料を更に含むことを特徴とする、請求項10〜14のいずれか一項に記載の組成物。
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MX2011003511A (es) | 2011-08-04 |
KR101656540B1 (ko) | 2016-09-09 |
BRPI0913831B1 (pt) | 2021-01-26 |
AU2009300037B9 (en) | 2014-08-21 |
TWI474838B (zh) | 2015-03-01 |
BRPI0913831A2 (pt) | 2017-06-20 |
ES2342754A1 (es) | 2010-07-13 |
KR20110069131A (ko) | 2011-06-22 |
BRPI0913831B8 (pt) | 2021-05-25 |
EP2331560A1 (en) | 2011-06-15 |
JP2012504566A (ja) | 2012-02-23 |
EP2331560B1 (en) | 2019-05-08 |
US8710010B2 (en) | 2014-04-29 |
CN102203115B (zh) | 2015-05-13 |
ES2342754B1 (es) | 2011-05-11 |
TW201018492A (en) | 2010-05-16 |
AU2009300037A1 (en) | 2010-04-08 |
WO2010037553A1 (en) | 2010-04-08 |
CA2739386A1 (en) | 2010-04-08 |
ES2733338T3 (es) | 2019-11-28 |
CN102203115A (zh) | 2011-09-28 |
AU2009300037B2 (en) | 2014-07-10 |
US20110195102A1 (en) | 2011-08-11 |
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