JP5816259B2 - 腫瘍治療用の新規なpan−CDK阻害剤の使用 - Google Patents

腫瘍治療用の新規なpan−CDK阻害剤の使用 Download PDF

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Publication number
JP5816259B2
JP5816259B2 JP2013501789A JP2013501789A JP5816259B2 JP 5816259 B2 JP5816259 B2 JP 5816259B2 JP 2013501789 A JP2013501789 A JP 2013501789A JP 2013501789 A JP2013501789 A JP 2013501789A JP 5816259 B2 JP5816259 B2 JP 5816259B2
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cancer
amino
trifluoromethyl
hydroxy
phenyl
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Japanese (ja)
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JP2013523680A5 (OSRAM
JP2013523680A (ja
Inventor
ウルリッヒ・リュッキング
ゲルハルト・ジーマイスター
アンツェ・マルグレート・ヴェングナー
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013501789A 2010-04-01 2011-03-28 腫瘍治療用の新規なpan−CDK阻害剤の使用 Expired - Fee Related JP5816259B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010014426.6 2010-04-01
DE102010014426A DE102010014426A1 (de) 2010-04-01 2010-04-01 Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
PCT/EP2011/054733 WO2011120922A1 (de) 2010-04-01 2011-03-28 Verwendung neuer pan-cdk-inhibitoren zur behandlung von tumoren

Publications (3)

Publication Number Publication Date
JP2013523680A JP2013523680A (ja) 2013-06-17
JP2013523680A5 JP2013523680A5 (OSRAM) 2014-05-15
JP5816259B2 true JP5816259B2 (ja) 2015-11-18

Family

ID=43858236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013501789A Expired - Fee Related JP5816259B2 (ja) 2010-04-01 2011-03-28 腫瘍治療用の新規なpan−CDK阻害剤の使用

Country Status (21)

Country Link
US (1) US20130210846A1 (OSRAM)
EP (1) EP2552450A1 (OSRAM)
JP (1) JP5816259B2 (OSRAM)
KR (1) KR20130014678A (OSRAM)
CN (1) CN102834100A (OSRAM)
AU (1) AU2011234654B2 (OSRAM)
BR (1) BR112012024422A2 (OSRAM)
CA (1) CA2794996A1 (OSRAM)
CL (1) CL2012002753A1 (OSRAM)
CR (1) CR20120502A (OSRAM)
DE (1) DE102010014426A1 (OSRAM)
DO (1) DOP2012000260A (OSRAM)
EC (1) ECSP12012198A (OSRAM)
MA (1) MA34098B1 (OSRAM)
MX (1) MX337722B (OSRAM)
NZ (1) NZ602710A (OSRAM)
PH (1) PH12012501945A1 (OSRAM)
SG (2) SG10201502566SA (OSRAM)
TN (1) TN2012000469A1 (OSRAM)
UA (1) UA108494C2 (OSRAM)
WO (1) WO2011120922A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014011240A (es) * 2012-03-21 2014-10-15 Bayer Ip Gmbh Uso de (rs)-s-ciclopropil-s-(4-{[4-{[(1r, 2r)-2-hidroxi-1-metilpro pil]oxi}-5-(trifluorometil)pirimidin-2-il]amino}fenil)sulfoximida para el tratamiento de tumores especificos.
JP2016513619A (ja) * 2013-03-07 2016-05-16 バイエル ファーマ アクチエンゲゼルシャフト 特定の腫瘍を治療するための(rs)−s−シクロプロピル−s−(4−{[4−{[(1r,2r)−2−ヒドロキシ−1−メチルプロピル]オキシ}−5−(トリフルオロメチル)ピリミジン−2−イル]アミノ}フェニル)スルホキシイミドの使用
BR112015023256A2 (pt) * 2013-03-13 2017-07-18 Oncoceutics Inc terapia de combinação com 7-benzil-10-(2-metil-benzil)-2,6,7,8,9,10-hexaidroimidazol[1,2-a]pirido[4,3-d]pirimidin-5(3h)-ona.
WO2014173815A1 (en) * 2013-04-23 2014-10-30 Bayer Pharma Aktiengesellschaft Use of (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5- (trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide for the treatment of specific tumours
CN105452236A (zh) * 2013-06-21 2016-03-30 拜耳制药股份公司 取代的苄基吡唑
WO2015071231A1 (de) * 2013-11-14 2015-05-21 Bayer Pharma Aktiengesellschaft Kombinationen von (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluormethyl)pyrimidin-2-yl]amino}phenyl)sulfoximid zur behandlung von tumoren
CN109283279B (zh) * 2017-07-21 2019-11-01 南京正大天晴制药有限公司 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法
CN109283263B (zh) * 2017-07-21 2019-06-25 南京正大天晴制药有限公司 用于雷替曲塞合成质量控制的检测分析方法
CA3202990A1 (en) * 2020-11-27 2022-06-02 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Aminoheteroaryl kinase inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4029650A1 (de) 1990-09-19 1992-03-26 Hoechst Ag 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
CA2294244A1 (en) 1997-07-12 1999-01-21 Cancer Research Campaign Technology Limited Cyclin dependent kinase inhibiting purine derivatives
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
JP2002523498A (ja) 1998-08-29 2002-07-30 アストラゼネカ・アクチエボラーグ ピリミジン化合物
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
HRP20031081A2 (en) 2001-05-29 2005-10-31 Schering Aktiengesellschaft Cdk inhibiting pyrimidines, production thereof and their use as medicaments
AU2003212282A1 (en) 2002-03-11 2003-09-22 Schering Aktiengesellschaft Cdk inhibiting 2-heteroaryl pyrimidine, the production thereof, and use thereof as a medicament
DE10349423A1 (de) * 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
DE102005062742A1 (de) * 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
DE102006027156A1 (de) * 2006-06-08 2007-12-13 Bayer Schering Pharma Ag Sulfimide als Proteinkinaseinhibitoren
EP1878726A1 (en) * 2006-07-12 2008-01-16 Bayer Schering Pharma Aktiengesellschaft Substituted sulphoximines as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same and uses of the same
EP2022785A1 (en) * 2007-06-20 2009-02-11 Bayer Schering Pharma Aktiengesellschaft Alkynylpyrimidines as Tie2 kinase inhibitors
WO2009100176A2 (en) * 2008-02-07 2009-08-13 Abbott Laboratories Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
EP2179991A1 (de) * 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel

Also Published As

Publication number Publication date
PH12012501945A1 (en) 2017-08-09
US20130210846A1 (en) 2013-08-15
CR20120502A (es) 2012-11-20
DE102010014426A1 (de) 2011-10-06
BR112012024422A2 (pt) 2016-05-31
KR20130014678A (ko) 2013-02-08
UA108494C2 (uk) 2015-05-12
EP2552450A1 (de) 2013-02-06
NZ602710A (en) 2014-05-30
CL2012002753A1 (es) 2013-01-18
TN2012000469A1 (en) 2014-01-30
SG183925A1 (en) 2012-10-30
WO2011120922A1 (de) 2011-10-06
MX337722B (es) 2016-03-16
MA34098B1 (fr) 2013-03-05
JP2013523680A (ja) 2013-06-17
ECSP12012198A (es) 2012-10-30
CA2794996A1 (en) 2011-10-06
DOP2012000260A (es) 2013-03-31
AU2011234654A1 (en) 2012-10-25
AU2011234654B2 (en) 2015-08-06
MX2012011427A (es) 2013-03-05
SG10201502566SA (en) 2015-05-28
CN102834100A (zh) 2012-12-19

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