MX337722B - Uso de nuevos inhibidores de pan-cdk para tratar tumores. - Google Patents
Uso de nuevos inhibidores de pan-cdk para tratar tumores.Info
- Publication number
- MX337722B MX337722B MX2012011427A MX2012011427A MX337722B MX 337722 B MX337722 B MX 337722B MX 2012011427 A MX2012011427 A MX 2012011427A MX 2012011427 A MX2012011427 A MX 2012011427A MX 337722 B MX337722 B MX 337722B
- Authority
- MX
- Mexico
- Prior art keywords
- treating tumors
- cdk inhibitors
- novel pan
- pan
- novel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere al uso de derivados seleccionados de anilinopirimidina sustituidos con sulfoximina de la fórmula (I) para tratar tumores (Ver Formula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010014426A DE102010014426A1 (de) | 2010-04-01 | 2010-04-01 | Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
PCT/EP2011/054733 WO2011120922A1 (de) | 2010-04-01 | 2011-03-28 | Verwendung neuer pan-cdk-inhibitoren zur behandlung von tumoren |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012011427A MX2012011427A (es) | 2013-03-05 |
MX337722B true MX337722B (es) | 2016-03-16 |
Family
ID=43858236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011427A MX337722B (es) | 2010-04-01 | 2011-03-28 | Uso de nuevos inhibidores de pan-cdk para tratar tumores. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20130210846A1 (es) |
EP (1) | EP2552450A1 (es) |
JP (1) | JP5816259B2 (es) |
KR (1) | KR20130014678A (es) |
CN (1) | CN102834100A (es) |
AU (1) | AU2011234654B2 (es) |
BR (1) | BR112012024422A2 (es) |
CA (1) | CA2794996A1 (es) |
CL (1) | CL2012002753A1 (es) |
CR (1) | CR20120502A (es) |
DE (1) | DE102010014426A1 (es) |
DO (1) | DOP2012000260A (es) |
EC (1) | ECSP12012198A (es) |
MA (1) | MA34098B1 (es) |
MX (1) | MX337722B (es) |
NZ (1) | NZ602710A (es) |
SG (2) | SG183925A1 (es) |
TN (1) | TN2012000469A1 (es) |
UA (1) | UA108494C2 (es) |
WO (1) | WO2011120922A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201491732A1 (ru) * | 2012-03-21 | 2015-08-31 | Байер Интеллектуэль Проперти Гмбх | Применение (rs)-s-циклопропил-s-(4-{[4-{[(1r,2r)-2-гидрокси-1-метилпропил]окси}-5-(трифторметил)пиримидин-2-ил]амино}фенил)сульфоксимида для лечения специфических опухолей |
BR112015021550A2 (pt) * | 2013-03-07 | 2017-07-18 | Bayer Pharma AG | uso de (rs)-s-ciclopropil-s-(4-{[4-{[(1r, 2r)-2-hidróxi-1-metilpropil]oxi}-5-(trifluorometil)pirimidin-2-il]amino}fenil)sulfóximida para tratamento de tumores específicos |
PL2968294T3 (pl) * | 2013-03-13 | 2019-10-31 | Oncoceutics Inc | 7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu |
WO2014173815A1 (en) * | 2013-04-23 | 2014-10-30 | Bayer Pharma Aktiengesellschaft | Use of (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5- (trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide for the treatment of specific tumours |
JP2016526540A (ja) * | 2013-06-21 | 2016-09-05 | バイエル ファーマ アクチエンゲゼルシャフト | 置換ベンジルピラゾール |
WO2015071231A1 (de) * | 2013-11-14 | 2015-05-21 | Bayer Pharma Aktiengesellschaft | Kombinationen von (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluormethyl)pyrimidin-2-yl]amino}phenyl)sulfoximid zur behandlung von tumoren |
CN109283279B (zh) * | 2017-07-21 | 2019-11-01 | 南京正大天晴制药有限公司 | 通过高效液相色谱法分离测定雷替曲塞及其对映异构体的方法 |
CN109283263B (zh) * | 2017-07-21 | 2019-06-25 | 南京正大天晴制药有限公司 | 用于雷替曲塞合成质量控制的检测分析方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4029650A1 (de) | 1990-09-19 | 1992-03-26 | Hoechst Ag | 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide |
AU744986B2 (en) | 1997-07-12 | 2002-03-07 | Cancer Research Technology Limited | Cyclin dependent kinase inhibiting purine derivatives |
US6440965B1 (en) | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
ES2270612T3 (es) | 1998-08-29 | 2007-04-01 | Astrazeneca Ab | Compuestos de pirimidina. |
GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
JP4291135B2 (ja) | 2001-05-29 | 2009-07-08 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Cdk阻害性ピリミジン、それらの製造および薬剤としての使用 |
EP1483260A1 (de) | 2002-03-11 | 2004-12-08 | Schering Aktiengesellschaft | Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel |
DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
DE102005062742A1 (de) * | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel |
DE102006027156A1 (de) * | 2006-06-08 | 2007-12-13 | Bayer Schering Pharma Ag | Sulfimide als Proteinkinaseinhibitoren |
EP1878726A1 (en) * | 2006-07-12 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Substituted sulphoximines as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same and uses of the same |
EP2022785A1 (en) * | 2007-06-20 | 2009-02-11 | Bayer Schering Pharma Aktiengesellschaft | Alkynylpyrimidines as Tie2 kinase inhibitors |
US20090203709A1 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical Dosage Form For Oral Administration Of Tyrosine Kinase Inhibitor |
EP2179991A1 (de) * | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
-
2010
- 2010-04-01 DE DE102010014426A patent/DE102010014426A1/de not_active Withdrawn
-
2011
- 2011-03-28 MX MX2012011427A patent/MX337722B/es active IP Right Grant
- 2011-03-28 MA MA35265A patent/MA34098B1/fr unknown
- 2011-03-28 UA UAA201212233A patent/UA108494C2/uk unknown
- 2011-03-28 SG SG2012065819A patent/SG183925A1/en unknown
- 2011-03-28 BR BR112012024422A patent/BR112012024422A2/pt not_active IP Right Cessation
- 2011-03-28 AU AU2011234654A patent/AU2011234654B2/en not_active Ceased
- 2011-03-28 EP EP11710224A patent/EP2552450A1/de not_active Withdrawn
- 2011-03-28 CN CN2011800166124A patent/CN102834100A/zh active Pending
- 2011-03-28 NZ NZ602710A patent/NZ602710A/en not_active IP Right Cessation
- 2011-03-28 SG SG10201502566SA patent/SG10201502566SA/en unknown
- 2011-03-28 CA CA2794996A patent/CA2794996A1/en not_active Abandoned
- 2011-03-28 US US13/638,833 patent/US20130210846A1/en not_active Abandoned
- 2011-03-28 KR KR1020127025684A patent/KR20130014678A/ko not_active Application Discontinuation
- 2011-03-28 WO PCT/EP2011/054733 patent/WO2011120922A1/de active Application Filing
- 2011-03-28 JP JP2013501789A patent/JP5816259B2/ja not_active Expired - Fee Related
-
2012
- 2012-09-27 TN TNP2012000469A patent/TN2012000469A1/en unknown
- 2012-10-01 DO DO2012000260A patent/DOP2012000260A/es unknown
- 2012-10-01 CL CL2012002753A patent/CL2012002753A1/es unknown
- 2012-10-01 CR CR20120502A patent/CR20120502A/es unknown
- 2012-10-01 EC ECSP12012198 patent/ECSP12012198A/es unknown
Also Published As
Publication number | Publication date |
---|---|
TN2012000469A1 (en) | 2014-01-30 |
CL2012002753A1 (es) | 2013-01-18 |
EP2552450A1 (de) | 2013-02-06 |
UA108494C2 (uk) | 2015-05-12 |
CR20120502A (es) | 2012-11-20 |
SG183925A1 (en) | 2012-10-30 |
ECSP12012198A (es) | 2012-10-30 |
WO2011120922A1 (de) | 2011-10-06 |
AU2011234654A1 (en) | 2012-10-25 |
CA2794996A1 (en) | 2011-10-06 |
BR112012024422A2 (pt) | 2016-05-31 |
AU2011234654B2 (en) | 2015-08-06 |
NZ602710A (en) | 2014-05-30 |
DE102010014426A1 (de) | 2011-10-06 |
MX2012011427A (es) | 2013-03-05 |
DOP2012000260A (es) | 2013-03-31 |
SG10201502566SA (en) | 2015-05-28 |
MA34098B1 (fr) | 2013-03-05 |
US20130210846A1 (en) | 2013-08-15 |
KR20130014678A (ko) | 2013-02-08 |
JP5816259B2 (ja) | 2015-11-18 |
JP2013523680A (ja) | 2013-06-17 |
CN102834100A (zh) | 2012-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |