JP5784623B2 - 速放性錠剤製剤 - Google Patents
速放性錠剤製剤 Download PDFInfo
- Publication number
- JP5784623B2 JP5784623B2 JP2012539026A JP2012539026A JP5784623B2 JP 5784623 B2 JP5784623 B2 JP 5784623B2 JP 2012539026 A JP2012539026 A JP 2012539026A JP 2012539026 A JP2012539026 A JP 2012539026A JP 5784623 B2 JP5784623 B2 JP 5784623B2
- Authority
- JP
- Japan
- Prior art keywords
- dapagliflozin
- propylene glycol
- magnesium stearate
- glycol hydrate
- starch glycolate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- JVHXJTBJCFBINQ-ADAARDCZSA-N Dapagliflozin Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl JVHXJTBJCFBINQ-ADAARDCZSA-N 0.000 claims description 183
- 229960003834 dapagliflozin Drugs 0.000 claims description 183
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- GOADIQFWSVMMRJ-UPGAGZFNSA-N dapagliflozin propanediol monohydrate Chemical compound O.C[C@H](O)CO.C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl GOADIQFWSVMMRJ-UPGAGZFNSA-N 0.000 claims description 126
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| PE20080697A1 (es) | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
| AP2011005795A0 (en) | 2009-02-13 | 2011-08-31 | Boehringer Ingelheim Int | SGLT-2 inhibitor for treating type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance or hyperglycemia. |
| BRPI1008560B1 (pt) | 2009-02-13 | 2021-08-31 | Boehringer Ingelheim International Gmbh | Composição farmacêutica compreendendo um inibidor de sglt2, um inibidor de dpp-iv e opcionalmente um outro agente antidiabético e usos dos mesmos |
| JP5758900B2 (ja) | 2009-09-30 | 2015-08-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換ベンジルベンゼン誘導体の調製方法 |
| AU2010303123B2 (en) | 2009-09-30 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Method for the preparation of a crystalline form of 1-chloro-4- (Beta-D-glucopyranos-1-yl)-2-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)benzene |
| UY32919A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos |
| EP3315124B1 (en) * | 2009-11-13 | 2021-01-06 | Astrazeneca AB | Bilayer tablet formulations |
| JP5784623B2 (ja) | 2009-11-13 | 2015-09-24 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | 速放性錠剤製剤 |
| US20130035281A1 (en) * | 2011-02-09 | 2013-02-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
| EP2529742B1 (en) * | 2011-06-03 | 2013-11-20 | ratiopharm GmbH | Pharmaceutical composition comprising dapagliflozin and cyclodextrin |
| US9480755B2 (en) * | 2011-06-03 | 2016-11-01 | Ratiopharm Gmbh | Pharmaceutical composition comprising dapagliflozin and cyclodextrin |
| EP2597090A1 (en) * | 2011-11-28 | 2013-05-29 | Sandoz AG | Crystalline dapagliflozin hydrate |
| RS60415B1 (sr) * | 2011-12-27 | 2020-07-31 | Amgen (Europe) GmbH | Formulacije (+)-2-[1-(3-etoksi-4-metoksi-fenil)-2-metansulfonil-etil]-4-acetil aminoizoindolin-1,3-diona |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| TR201202948A2 (tr) | 2012-03-15 | 2012-07-23 | Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. | Dapagliflozin ve uzatılmış salınımlı metaformin içeren tablet formülasyonu. |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| HRP20190101T1 (hr) | 2013-04-05 | 2019-03-08 | Boehringer Ingelheim International Gmbh | Terapeutske uporabe empagliflozina |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CA2812519A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| FI4000608T3 (fi) | 2013-04-18 | 2026-01-21 | Boehringer Ingelheim Int | Farmaseuttinen koostumus, menetelmä hoitamiseksi ja sen käyttöjä |
| WO2014178040A1 (en) | 2013-04-29 | 2014-11-06 | Mapi Pharma Ltd. | Co-crystals of dapagliflozin |
| CA2918570A1 (en) * | 2013-07-22 | 2015-01-29 | Sandoz Ag | Formulations containing amorphous dapagliflozin |
| CN103463090A (zh) * | 2013-09-11 | 2013-12-25 | 深圳翰宇药业股份有限公司 | 西他列汀盐酸二甲双胍复方制剂的制备方法 |
| EP3110402A1 (en) * | 2014-02-28 | 2017-01-04 | Sun Pharmaceutical Industries Ltd | Dapagliflozin compositions |
| CN103976997B (zh) * | 2014-05-13 | 2016-08-17 | 中国药科大学 | 一种降血糖复方缓释胶囊及其制备方法 |
| CN106924208A (zh) * | 2015-12-30 | 2017-07-07 | 深圳翰宇药业股份有限公司 | 一种复方达格列净二甲双胍缓释片及其制备方法 |
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| CN106176718A (zh) * | 2016-08-03 | 2016-12-07 | 上海延安药业有限公司 | 复方卡格列净二甲双胍片 |
| KR20250097990A (ko) | 2016-11-10 | 2025-06-30 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 조성물, 치료 방법 및 이의 용도 |
| WO2018124497A1 (ko) * | 2016-12-30 | 2018-07-05 | 한미약품 주식회사 | 다파글리플로진 l-프롤린과 항당뇨병제를 포함하는 약제학적 복합 제제 |
| CN106924237B (zh) * | 2017-03-03 | 2019-12-03 | 杭州华东医药集团新药研究院有限公司 | 一种含有恩格列净和盐酸二甲双胍的药物组合物 |
| WO2018167589A1 (en) | 2017-03-16 | 2018-09-20 | Inventia Healthcare Private Limited | Pharmaceutical composition comprising dapagliflozin |
| SG10201913562VA (en) * | 2017-04-24 | 2020-03-30 | Samus Therapeutics Inc | Hsp90 inhibitor oral formulations and related methods |
| WO2018200691A2 (en) * | 2017-04-25 | 2018-11-01 | Proteus Digital Health, Inc. | Lisinopril compositions with an ingestible event marker |
| AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
| EP3675830A1 (en) * | 2017-08-30 | 2020-07-08 | Prilenia Neurotherapeutics Ltd. | High concentration dosage forms of pridopidine |
| KR102369679B1 (ko) * | 2017-09-29 | 2022-03-04 | 한미약품 주식회사 | 다파글리플로진 l-프롤린과 메트포르민을 포함하는 약제학적 복합제제 |
| TW201938147A (zh) * | 2017-12-18 | 2019-10-01 | 德商拜耳廠股份有限公司 | 阿卡波糖與甲福明之固定劑量組合錠劑配製物及其製法 |
| BR112020017056A2 (pt) * | 2018-02-21 | 2020-12-15 | Glenmark Pharmaceuticals Limited | Composição farmacêutica compreendendo remogliflozina e um agente antidiabético |
| SG11202011883RA (en) * | 2018-05-31 | 2020-12-30 | Hua Medicine Shanghai Ltd | Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and ppar receptor activator, and preparation methods and uses thereof |
| WO2020089760A1 (en) * | 2018-11-01 | 2020-05-07 | Glenmark Pharmaceuticals Limited | Fixed dose pharmaceutical composition comprising combination of remogliflozin or salt or ester thereof and vildagliptin or salt thereof |
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| EP4431088A1 (en) | 2023-03-06 | 2024-09-18 | Galenicum Health S.L.U. | Pharmaceutical compositions comprising dapagliflozin and metformin |
| EP4427742A1 (en) | 2023-03-06 | 2024-09-11 | Galenicum Health S.L.U. | Pharmaceutical compositions comprising dapagliflozin and metformin |
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