JP5762001B2 - プロテアーゼ安定化インスリンアナログ - Google Patents
プロテアーゼ安定化インスリンアナログ Download PDFInfo
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- JP5762001B2 JP5762001B2 JP2010550214A JP2010550214A JP5762001B2 JP 5762001 B2 JP5762001 B2 JP 5762001B2 JP 2010550214 A JP2010550214 A JP 2010550214A JP 2010550214 A JP2010550214 A JP 2010550214A JP 5762001 B2 JP5762001 B2 JP 5762001B2
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- Prior art keywords
- human insulin
- desb30 human
- insulin
- desb27
- desb29
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000930 thermomechanical effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 229950009811 ubenimex Drugs 0.000 description 1
- 229960001130 urapidil Drugs 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 239000000777 urocortin Substances 0.000 description 1
- 229940014499 ursodeoxycholate Drugs 0.000 description 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08102598 | 2008-03-14 | ||
| EP08102598.3 | 2008-03-14 | ||
| PCT/EP2009/053019 WO2009112583A2 (en) | 2008-03-14 | 2009-03-13 | Protease-stabilized insulin analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011512856A JP2011512856A (ja) | 2011-04-28 |
| JP2011512856A5 JP2011512856A5 (enExample) | 2015-04-02 |
| JP5762001B2 true JP5762001B2 (ja) | 2015-08-12 |
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| JP2010550214A Expired - Fee Related JP5762001B2 (ja) | 2008-03-14 | 2009-03-13 | プロテアーゼ安定化インスリンアナログ |
Country Status (6)
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| US (1) | US9260502B2 (enExample) |
| EP (1) | EP2254905B1 (enExample) |
| JP (1) | JP5762001B2 (enExample) |
| CN (1) | CN101970477B (enExample) |
| ES (1) | ES2618073T3 (enExample) |
| WO (1) | WO2009112583A2 (enExample) |
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| US9018161B2 (en) | 2006-09-22 | 2015-04-28 | Novo Nordisk A/S | Protease resistant insulin analogues |
| ES2618073T3 (es) | 2008-03-14 | 2017-06-20 | Novo Nordisk A/S | Análogos de insulina estabilizados frente a proteasas |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| CN102245633A (zh) * | 2008-12-09 | 2011-11-16 | 诺沃—诺迪斯克有限公司 | 新的胰岛素类似物 |
| JP5973427B2 (ja) * | 2010-06-23 | 2016-08-23 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するインスリン類似体 |
| CN102933599A (zh) | 2010-06-23 | 2013-02-13 | 诺沃—诺迪斯克有限公司 | 包含额外的二硫键的人胰岛素 |
| WO2011161125A1 (en) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin derivatives containing additional disulfide bonds |
| EP2836508B1 (en) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulin formulations |
| JP2016525524A (ja) * | 2013-07-24 | 2016-08-25 | ノヴォ ノルディスク アー／エス | 錠剤コアとアニオン性コポリマーコーティングとを含む経口インスリン投与のための医薬組成物 |
| JP6499184B2 (ja) | 2013-10-07 | 2019-04-10 | ノヴォ ノルディスク アー／エス | インスリン類似体の新規な誘導体 |
| MY186251A (en) * | 2014-01-20 | 2021-06-30 | Hanmi Pharm Ind Co Ltd | Long-acting insulin and use thereof |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| JP2018531899A (ja) * | 2015-08-25 | 2018-11-01 | ノヴォ ノルディスク アー／エス | 新規インスリン誘導体及びその医学的使用 |
| CN108026157B (zh) | 2015-08-25 | 2022-11-25 | 诺和诺德股份有限公司 | 新型胰岛素衍生物及其医学用途 |
| CN108026156A (zh) * | 2015-08-25 | 2018-05-11 | 诺和诺德股份有限公司 | 新型胰岛素衍生物及其医学用途 |
| UY36870A (es) * | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| EP3517544B1 (en) | 2016-09-23 | 2025-01-08 | Hanmi Pharm. Co., Ltd. | Insulin analog having reduced binding force to insulin receptor, and use thereof |
| WO2018094388A1 (en) * | 2016-11-21 | 2018-05-24 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| EP3821905B1 (en) | 2016-12-16 | 2022-10-12 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| EP3604328A4 (en) | 2017-03-23 | 2021-01-06 | Hanmi Pharm. Co., Ltd. | INSULIN ANALOGUE COMPLEX WITH REDUCED AFFINITY FOR THE INSULIN RECEPTOR AND USE OF IT |
| AU2018317810A1 (en) | 2017-08-17 | 2020-03-19 | Novo Nordisk A/S | Novel acylated insulin analogues and uses thereof |
| CN117624207A (zh) | 2017-11-09 | 2024-03-01 | 诺和诺德股份有限公司 | 葡萄糖敏感性白蛋白结合衍生物 |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| SG11202106168VA (en) | 2018-12-11 | 2021-07-29 | Sanofi Sa | Insulin analogs having reduced insulin receptor binding affinity |
| CN109735589B (zh) * | 2019-01-02 | 2020-07-10 | 珠海冀百康生物科技有限公司 | 一种胰岛素DesB30的制备方法 |
| EP3946363A2 (en) * | 2019-03-29 | 2022-02-09 | Novo Nordisk A/S | Glucose sensitive insulin derivatives |
| MA58093B1 (fr) | 2019-12-11 | 2024-09-30 | Novo Nordisk A/S | Nouveaux analogues d'insuline et leurs utilisations |
| US20250082758A1 (en) * | 2022-01-26 | 2025-03-13 | Sanofi | Insulin conjugates |
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-
2009
- 2009-03-13 ES ES09721144.5T patent/ES2618073T3/es active Active
- 2009-03-13 EP EP09721144.5A patent/EP2254905B1/en not_active Not-in-force
- 2009-03-13 JP JP2010550214A patent/JP5762001B2/ja not_active Expired - Fee Related
- 2009-03-13 US US12/922,106 patent/US9260502B2/en not_active Expired - Fee Related
- 2009-03-13 CN CN200980109927.6A patent/CN101970477B/zh not_active Expired - Fee Related
- 2009-03-13 WO PCT/EP2009/053019 patent/WO2009112583A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US9260502B2 (en) | 2016-02-16 |
| JP2011512856A (ja) | 2011-04-28 |
| EP2254905B1 (en) | 2016-12-14 |
| CN101970477B (zh) | 2014-12-31 |
| WO2009112583A3 (en) | 2010-01-21 |
| US20110092419A1 (en) | 2011-04-21 |
| WO2009112583A2 (en) | 2009-09-17 |
| ES2618073T3 (es) | 2017-06-20 |
| CN101970477A (zh) | 2011-02-09 |
| EP2254905A2 (en) | 2010-12-01 |
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