JP5762001B2 - プロテアーゼ安定化インスリンアナログ - Google Patents

プロテアーゼ安定化インスリンアナログ Download PDF

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Publication number
JP5762001B2
JP5762001B2 JP2010550214A JP2010550214A JP5762001B2 JP 5762001 B2 JP5762001 B2 JP 5762001B2 JP 2010550214 A JP2010550214 A JP 2010550214A JP 2010550214 A JP2010550214 A JP 2010550214A JP 5762001 B2 JP5762001 B2 JP 5762001B2
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JP
Japan
Prior art keywords
human insulin
desb30 human
insulin
desb27
desb29
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2010550214A
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English (en)
Japanese (ja)
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JP2011512856A (ja
JP2011512856A5 (enExample
Inventor
ペーター クレステン ニールセン,
ペーター クレステン ニールセン,
フランチセク フバレク,
フランチセク フバレク,
インガー ラウトルップ−ラーセン,
インガー ラウトルップ−ラーセン,
ペル バルシュミット,
ペル バルシュミット,
スヴェンド ルドヴィーセン,
スヴェンド ルドヴィーセン,
トマス ボールム キェルセン,
トマス ボールム キェルセン,
Original Assignee
ノボ・ノルデイスク・エー/エス
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Publication of JP2011512856A5 publication Critical patent/JP2011512856A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010550214A 2008-03-14 2009-03-13 プロテアーゼ安定化インスリンアナログ Expired - Fee Related JP5762001B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08102598 2008-03-14
EP08102598.3 2008-03-14
PCT/EP2009/053019 WO2009112583A2 (en) 2008-03-14 2009-03-13 Protease-stabilized insulin analogues

Publications (3)

Publication Number Publication Date
JP2011512856A JP2011512856A (ja) 2011-04-28
JP2011512856A5 JP2011512856A5 (enExample) 2015-04-02
JP5762001B2 true JP5762001B2 (ja) 2015-08-12

Family

ID=40756161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010550214A Expired - Fee Related JP5762001B2 (ja) 2008-03-14 2009-03-13 プロテアーゼ安定化インスリンアナログ

Country Status (6)

Country Link
US (1) US9260502B2 (enExample)
EP (1) EP2254905B1 (enExample)
JP (1) JP5762001B2 (enExample)
CN (1) CN101970477B (enExample)
ES (1) ES2618073T3 (enExample)
WO (1) WO2009112583A2 (enExample)

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CN101970477B (zh) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
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WO2018174668A2 (ko) 2017-03-23 2018-09-27 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
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KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
TW202039437A (zh) * 2018-12-11 2020-11-01 法商賽諾菲公司 肽黏合劑
CN109735589B (zh) * 2019-01-02 2020-07-10 珠海冀百康生物科技有限公司 一种胰岛素DesB30的制备方法
TWI717245B (zh) * 2019-03-29 2021-01-21 丹麥商諾佛 儂迪克股份有限公司 葡萄糖敏感型胰島素衍生物
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EP2254905B1 (en) 2016-12-14
US20110092419A1 (en) 2011-04-21
EP2254905A2 (en) 2010-12-01
CN101970477A (zh) 2011-02-09
WO2009112583A2 (en) 2009-09-17
ES2618073T3 (es) 2017-06-20
US9260502B2 (en) 2016-02-16
WO2009112583A3 (en) 2010-01-21
CN101970477B (zh) 2014-12-31

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