JP5728082B2 - トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液 - Google Patents

トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液 Download PDF

Info

Publication number
JP5728082B2
JP5728082B2 JP2013516553A JP2013516553A JP5728082B2 JP 5728082 B2 JP5728082 B2 JP 5728082B2 JP 2013516553 A JP2013516553 A JP 2013516553A JP 2013516553 A JP2013516553 A JP 2013516553A JP 5728082 B2 JP5728082 B2 JP 5728082B2
Authority
JP
Japan
Prior art keywords
composition
viscosity
xanthan gum
sodium
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013516553A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013529632A (ja
JP2013529632A5 (https=
Inventor
バグワティ ピー． カブラ，
バグワティ ピー． カブラ，
Original Assignee
アルコン リサーチ， リミテッド
アルコン リサーチ， リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルコン リサーチ， リミテッド, アルコン リサーチ， リミテッド filed Critical アルコン リサーチ， リミテッド
Publication of JP2013529632A publication Critical patent/JP2013529632A/ja
Publication of JP2013529632A5 publication Critical patent/JP2013529632A5/ja
Application granted granted Critical
Publication of JP5728082B2 publication Critical patent/JP5728082B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2013516553A 2010-06-23 2010-06-23 トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液 Expired - Fee Related JP5728082B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/039618 WO2011162752A1 (en) 2010-06-23 2010-06-23 Topical ophthalmic suspensions containing tobramycin and dexamethasone

Publications (3)

Publication Number Publication Date
JP2013529632A JP2013529632A (ja) 2013-07-22
JP2013529632A5 JP2013529632A5 (https=) 2013-08-29
JP5728082B2 true JP5728082B2 (ja) 2015-06-03

Family

ID=44080140

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013516553A Expired - Fee Related JP5728082B2 (ja) 2010-06-23 2010-06-23 トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液

Country Status (10)

Country Link
EP (1) EP2585037A1 (https=)
JP (1) JP5728082B2 (https=)
KR (1) KR20130094280A (https=)
CN (1) CN102946855B (https=)
AU (1) AU2010356098B2 (https=)
BR (1) BR112012033052A2 (https=)
CA (1) CA2801731A1 (https=)
MX (1) MX2012015051A (https=)
WO (1) WO2011162752A1 (https=)
ZA (1) ZA201209240B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201208080D0 (en) 2012-05-09 2012-06-20 Norton Healthcare Ltd Tobramycin formulation
JP6527315B2 (ja) * 2014-08-08 2019-06-05 Ｄｓｐ五協フード＆ケミカル株式会社 速溶性増粘剤、咀嚼・嚥下困難者用増粘剤及び咀嚼・嚥下困難者用飲食品
CN109260219B (zh) * 2018-11-30 2021-03-09 山东省药学科学院 一种关节腔注射制剂及其应用
IT202000002296A1 (it) * 2020-02-06 2021-08-06 Sifi Spa Formulazioni topiche oftalmiche a base di xantano con ridotta posologia
WO2021229433A1 (en) * 2020-05-12 2021-11-18 Probiotical S.P.A. Compositions comprising bacterial strains and use thereof for the treatment of ocular diseases and lesions
IT202200000821A1 (it) * 2022-01-19 2023-07-19 Sifi Spa Formulazioni topiche oftalmiche a base di xantano con ridotta posologia
CN115006412B (zh) * 2022-05-20 2023-11-10 北京诺康达医药科技股份有限公司 一种复方妥布霉素滴眼液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136177A (en) 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US5149694A (en) 1988-03-09 1992-09-22 Alcon Laboratories, Inc. Combination of tobramycin and dexamethasone for topical ophthalmic use
DK0999825T3 (da) * 1997-07-29 2004-02-09 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6174524B1 (en) 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
EP1069913B1 (en) * 1998-04-07 2003-07-23 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
PL199321B1 (pl) 2000-07-28 2008-09-30 Alcon Inc Kompozycje farmaceutyczne zawierające tobramycynę i gumę ksantanową

Also Published As

Publication number Publication date
EP2585037A1 (en) 2013-05-01
KR20130094280A (ko) 2013-08-23
CN102946855B (zh) 2016-01-06
CN102946855A (zh) 2013-02-27
ZA201209240B (en) 2014-02-26
JP2013529632A (ja) 2013-07-22
WO2011162752A1 (en) 2011-12-29
CA2801731A1 (en) 2011-12-29
AU2010356098B2 (en) 2014-08-14
MX2012015051A (es) 2013-02-15
AU2010356098A1 (en) 2013-01-10
BR112012033052A2 (pt) 2019-09-24

Similar Documents

Publication Publication Date Title
US8450287B2 (en) Topical ophthalmic compositions containing tobramycin and dexamethasone
JP5728082B2 (ja) トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液
JP4545927B2 (ja) キサンタンガムを含有するゲル化眼科用組成物
US20110105450A1 (en) Ophthalmic formulations of fluticasone and methods of use
CA2760140C (en) Topical solution formulations containing a corticosteroid and a cyclodextrin
JPH11510497A (ja) Ｏ−カルボキシアルキルキトサンを含む配合物及び眼科領域での使用方法
TW201701882A (zh) 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑
WO2010107689A1 (en) Ophthalmic formulations of cetirizine and methods of use
US20070110812A1 (en) Ophthalmic composition for dry eye therapy
TW202342108A (zh) 多劑量眼用組成物
JP2001501194A (ja) ゲル形成性医薬組成物
CN111107838B (zh) 用于治疗干眼症的含有瑞巴派特的滴眼剂组合物及其增溶和稳定化方法
JP6522592B2 (ja) １ｈ−インドール−１−カルボキサミド誘導体を含有する局所水性眼科用組成物および眼疾患の治療へのその使用
JP2808378B2 (ja) 水性懸濁液剤の製造法
CN116847826A (zh) 包含左氧氟沙星和酮咯酸的眼用组合物、其制备方法和用途
EP4337167A2 (en) Ophthalmic pharmaceutical composition comprising atropine
CA2835013C (en) Eye drops for treatment of conjunctivochalasis
WO2022238250A1 (en) Ophthalmic pharmaceutical composition comprising atropine
JP2017178880A (ja) 人工涙液型点眼剤組成物
HK40101857A (zh) 包含左氧氟沙星和酮咯酸的眼用组合物、其制备方法和用途
MXJL05000034A (es) Una formulacion oftalmica topica y su uso.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130610

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130610

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140725

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141023

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150331

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150403

R150 Certificate of patent or registration of utility model

Ref document number: 5728082

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees