JP2013529632A5 - - Google Patents
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- Publication number
- JP2013529632A5 JP2013529632A5 JP2013516553A JP2013516553A JP2013529632A5 JP 2013529632 A5 JP2013529632 A5 JP 2013529632A5 JP 2013516553 A JP2013516553 A JP 2013516553A JP 2013516553 A JP2013516553 A JP 2013516553A JP 2013529632 A5 JP2013529632 A5 JP 2013529632A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- sodium
- chloride
- ionizable species
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 49
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 239000000230 xanthan gum Substances 0.000 claims description 9
- 229920001285 xanthan gum Polymers 0.000 claims description 9
- 229940082509 xanthan gum Drugs 0.000 claims description 9
- 235000010493 xanthan gum Nutrition 0.000 claims description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 8
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 8
- 235000011152 sodium sulphate Nutrition 0.000 claims description 8
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims description 8
- 229960000707 tobramycin Drugs 0.000 claims description 8
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 5
- 229960003957 dexamethasone Drugs 0.000 claims description 5
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 229910052796 boron Inorganic materials 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- 235000011148 calcium chloride Nutrition 0.000 claims description 4
- 239000003792 electrolyte Substances 0.000 claims description 4
- 230000004968 inflammatory condition Effects 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 4
- 235000011147 magnesium chloride Nutrition 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000001103 potassium chloride Substances 0.000 claims description 4
- 235000011164 potassium chloride Nutrition 0.000 claims description 4
- 239000001508 potassium citrate Substances 0.000 claims description 4
- 229960002635 potassium citrate Drugs 0.000 claims description 4
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 4
- 235000011082 potassium citrates Nutrition 0.000 claims description 4
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 4
- 235000011009 potassium phosphates Nutrition 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 235000002639 sodium chloride Nutrition 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- 235000011083 sodium citrates Nutrition 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 235000011008 sodium phosphates Nutrition 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 4
- 230000006196 deacetylation Effects 0.000 description 2
- 238000003381 deacetylation reaction Methods 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000000850 deacetylating effect Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/039618 WO2011162752A1 (en) | 2010-06-23 | 2010-06-23 | Topical ophthalmic suspensions containing tobramycin and dexamethasone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529632A JP2013529632A (ja) | 2013-07-22 |
| JP2013529632A5 true JP2013529632A5 (https=) | 2013-08-29 |
| JP5728082B2 JP5728082B2 (ja) | 2015-06-03 |
Family
ID=44080140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516553A Expired - Fee Related JP5728082B2 (ja) | 2010-06-23 | 2010-06-23 | トブラマイシンおよびデキサメタゾンを含む局所用眼用懸濁液 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2585037A1 (https=) |
| JP (1) | JP5728082B2 (https=) |
| KR (1) | KR20130094280A (https=) |
| CN (1) | CN102946855B (https=) |
| AU (1) | AU2010356098B2 (https=) |
| BR (1) | BR112012033052A2 (https=) |
| CA (1) | CA2801731A1 (https=) |
| MX (1) | MX2012015051A (https=) |
| WO (1) | WO2011162752A1 (https=) |
| ZA (1) | ZA201209240B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201208080D0 (en) * | 2012-05-09 | 2012-06-20 | Norton Healthcare Ltd | Tobramycin formulation |
| JP6527315B2 (ja) * | 2014-08-08 | 2019-06-05 | Ｄｓｐ五協フード＆ケミカル株式会社 | 速溶性増粘剤、咀嚼・嚥下困難者用増粘剤及び咀嚼・嚥下困難者用飲食品 |
| CN109260219B (zh) * | 2018-11-30 | 2021-03-09 | 山东省药学科学院 | 一种关节腔注射制剂及其应用 |
| IT202000002296A1 (it) * | 2020-02-06 | 2021-08-06 | Sifi Spa | Formulazioni topiche oftalmiche a base di xantano con ridotta posologia |
| ES2993434T3 (en) * | 2020-05-12 | 2024-12-30 | Probiotical Spa | Compositions comprising bacterial strains and use thereof for use in the treatment of ocular diseases and lesions |
| IT202200000821A1 (it) * | 2022-01-19 | 2023-07-19 | Sifi Spa | Formulazioni topiche oftalmiche a base di xantano con ridotta posologia |
| CN115006412B (zh) * | 2022-05-20 | 2023-11-10 | 北京诺康达医药科技股份有限公司 | 一种复方妥布霉素滴眼液及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136177A (en) | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Xanthan gum therapeutic compositions |
| US5149694A (en) | 1988-03-09 | 1992-09-22 | Alcon Laboratories, Inc. | Combination of tobramycin and dexamethasone for topical ophthalmic use |
| DE69839355T2 (de) * | 1997-07-29 | 2009-06-04 | Alcon Laboratories, Inc., Fort Worth | Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat |
| US6174524B1 (en) | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| DE69909768T2 (de) * | 1998-04-07 | 2004-06-17 | Alcon Manufacturing Ltd., Fort Worth | Xanthangummi enthaltende gelbildende ophthalmische zusammensetzungen |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| BR0112787B1 (pt) | 2000-07-28 | 2013-03-05 | composiÇço de soluÇço topicamente administrÁvel. |
-
2010
- 2010-06-23 EP EP10726406.1A patent/EP2585037A1/en not_active Withdrawn
- 2010-06-23 BR BR112012033052A patent/BR112012033052A2/pt not_active IP Right Cessation
- 2010-06-23 CN CN201080067666.9A patent/CN102946855B/zh not_active Expired - Fee Related
- 2010-06-23 AU AU2010356098A patent/AU2010356098B2/en not_active Ceased
- 2010-06-23 MX MX2012015051A patent/MX2012015051A/es active IP Right Grant
- 2010-06-23 WO PCT/US2010/039618 patent/WO2011162752A1/en not_active Ceased
- 2010-06-23 CA CA2801731A patent/CA2801731A1/en not_active Abandoned
- 2010-06-23 KR KR1020137000258A patent/KR20130094280A/ko not_active Abandoned
- 2010-06-23 JP JP2013516553A patent/JP5728082B2/ja not_active Expired - Fee Related
-
2012
- 2012-12-06 ZA ZA2012/09240A patent/ZA201209240B/en unknown
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