AR122463A2 - Suspensiones de nanopartículas que contienen polímero de carboxivinilo - Google Patents
Suspensiones de nanopartículas que contienen polímero de carboxiviniloInfo
- Publication number
- AR122463A2 AR122463A2 ARP210101199A ARP210101199A AR122463A2 AR 122463 A2 AR122463 A2 AR 122463A2 AR P210101199 A ARP210101199 A AR P210101199A AR P210101199 A ARP210101199 A AR P210101199A AR 122463 A2 AR122463 A2 AR 122463A2
- Authority
- AR
- Argentina
- Prior art keywords
- carboxyvinyl polymer
- concentration
- compound
- soluble particulate
- galactomannan
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Las composiciones de suspensión poseen un polímero de carboxivinilo tal como un carbómero, un galactomanano tal como guar, y un compuesto borato. Un compuesto particulado moderadamente soluble tal como nepafenac también se incluye en las composiciones. El compuesto particulado moderadamente soluble posee un tamaño de particular pequeño para aumentar la biodisponibilidad del compuesto. Reivindicación 1: Una composición de suspensión oftálmica acuosa que se administra de modo tópico caracterizada porque comprende: un polímero de carboxivinilo en una concentración de 0,1 a 0,5% p/v; un galactomanano en una concentración de 0,1 a 0,4% p/v; borato en una concentración de 0,4 a 2,0% p/v; y un compuesto particulado moderadamente soluble, que posee una solubilidad en agua a 25ºC de 0,001 a 0,1% p/v y un tamaño de partícula de 50 a 700 nm. Reivindicación 14: Una composición de acuerdo con la reivindicación 1, caracterizada porque dicho polímero de carboxivinilo es carbómero, dicho galactomanano es guar, dicho borato es ácido bórico, y dicho compuesto particulado moderadamente soluble es nepafenac a una concentración de 0,1 hasta 1,0% p/v.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26636809P | 2009-12-03 | 2009-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR122463A2 true AR122463A2 (es) | 2022-09-14 |
Family
ID=43425837
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104470A AR080572A1 (es) | 2009-12-03 | 2010-12-03 | Suspensiones de nanoparticulas que contienen polimero de carboxivinilo |
ARP210101199A AR122463A2 (es) | 2009-12-03 | 2021-05-03 | Suspensiones de nanopartículas que contienen polímero de carboxivinilo |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100104470A AR080572A1 (es) | 2009-12-03 | 2010-12-03 | Suspensiones de nanoparticulas que contienen polimero de carboxivinilo |
Country Status (27)
Country | Link |
---|---|
US (3) | US8921337B2 (es) |
EP (3) | EP2965749B1 (es) |
JP (3) | JP5864433B2 (es) |
KR (2) | KR101543613B1 (es) |
CN (1) | CN102724965B (es) |
AR (2) | AR080572A1 (es) |
AU (1) | AU2010326099B2 (es) |
BR (1) | BR112012013503B8 (es) |
CA (1) | CA2781254C (es) |
CL (1) | CL2012001402A1 (es) |
CY (1) | CY1120585T1 (es) |
DK (3) | DK2506831T3 (es) |
ES (3) | ES2684752T3 (es) |
HK (3) | HK1170164A1 (es) |
HR (2) | HRP20140016T1 (es) |
HU (2) | HUE025838T2 (es) |
LT (1) | LT2965749T (es) |
MX (1) | MX2012006231A (es) |
PL (3) | PL2965749T3 (es) |
PT (3) | PT2965749T (es) |
RS (2) | RS53085B (es) |
RU (1) | RU2571078C2 (es) |
SI (3) | SI2965749T1 (es) |
TW (1) | TWI486178B (es) |
UY (1) | UY33081A (es) |
WO (1) | WO2011068872A2 (es) |
ZA (1) | ZA201203770B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8435631B2 (en) * | 2010-04-15 | 2013-05-07 | Ppg Industries Ohio, Inc. | Microporous material |
MX347598B (es) * | 2010-07-20 | 2017-05-03 | C-Ip S A * | Suspension de compuesto que contiene boro. |
TW201336527A (zh) * | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
US20160051503A1 (en) * | 2012-08-31 | 2016-02-25 | Bausch & Lomb Incorporated | Ophthalmic compositions with omega-3 fatty acids |
US9630909B2 (en) | 2013-06-27 | 2017-04-25 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
US20150191647A1 (en) * | 2014-01-07 | 2015-07-09 | Trican Well Service Ltd. | Stability of viscous fluids in low salinity environments |
PT3721868T (pt) | 2015-01-26 | 2022-08-12 | Bausch & Lomb | Composição para suspensão oftálmica |
CN108367026A (zh) * | 2015-06-18 | 2018-08-03 | 常规制药股份公司 | 抗微生物配制品 |
TW201938141A (zh) * | 2018-02-21 | 2019-10-01 | 瑞士商諾華公司 | 基於脂質的眼用乳劑 |
US11730699B2 (en) | 2018-02-21 | 2023-08-22 | Alcon Inc. | Lipid-based ophthalmic emulsion |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3864183A (en) * | 1972-11-21 | 1975-02-04 | Tokyo Hat | Method for producing pen core from filament tows |
US4313949A (en) | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
IL80298A (en) | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
US5188826A (en) | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
US5461081A (en) | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5429824A (en) | 1992-12-15 | 1995-07-04 | Eastman Kodak Company | Use of tyloxapole as a nanoparticle stabilizer and dispersant |
US5475034A (en) | 1994-06-06 | 1995-12-12 | Alcon Laboratories, Inc. | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
FR2761959B1 (fr) * | 1997-04-15 | 1999-05-21 | Oreal | Ensemble de conditionnement et d'application d'un produit fluide |
CN1229110C (zh) * | 1997-07-29 | 2005-11-30 | 阿尔康实验室公司 | 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物 |
IT1306123B1 (it) | 1999-04-02 | 2001-05-30 | Technopharma Sa | Soluzione oftalmica viscosizzata con azione detergente sulle lenti acontatto. |
ITMI991453A1 (it) | 1999-07-01 | 2001-01-01 | Farmila Farma Milano | Composizioni oftalmiche in forma di gel acquosi |
CA2395331C (en) | 1999-12-23 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions providing enhanced drug concentrations |
PE20020146A1 (es) | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
TNSN03137A1 (en) | 2001-06-22 | 2005-12-23 | Pfizer Prod Inc | PHARMACEUTICAL COMPOSITIONS COMPRISING LOW SOLUBILITY AND / OR ACID SENSITIVE DRUGS AND NEUTRALIZED ACID POLYMERS. |
EP1448209A2 (en) | 2001-10-23 | 2004-08-25 | Ranbaxy Laboratories, Ltd. | A process for the preparation of pharmaceutical compositions for topical delivery of cyclooxygenase-2 enzyme inhibitors |
US7045121B2 (en) | 2001-12-14 | 2006-05-16 | Allergan, Inc. | Ophthalmic compositions for lubricating eyes and methods for making and using same |
AU2003213210A1 (en) | 2002-02-22 | 2003-09-09 | Pharmacia Corporation | Ophthalmic formulation with gum system |
US7947295B2 (en) | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
ATE444732T1 (de) | 2003-08-07 | 2009-10-15 | Allergan Inc | Zusammensetzungen zur abgabe von therapeutika in die augen und verfahren zu ihrer herstellung und verwendung |
FR2865648B1 (fr) | 2004-02-03 | 2006-06-30 | Philippe Perovitch | Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede |
TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
US20080145430A1 (en) | 2004-12-08 | 2008-06-19 | Santipharp Panmai | Ophthalmic Nanoparticulate Formulation Of A Cyclooxygenase-2 Selective Inhibitor |
TWI393567B (zh) | 2005-03-31 | 2013-04-21 | Bausch & Lomb | 治療乾眼之組合物及相關之製造方法及使用方法 |
JP4257860B2 (ja) * | 2005-04-19 | 2009-04-22 | 中得工業株式会社 | 化粧材の塗布具 |
CA2607014A1 (en) * | 2005-05-10 | 2006-11-16 | Alcon, Inc. | Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders |
ES2322200T3 (es) | 2005-05-10 | 2009-06-17 | Alcon, Inc. | Formulaciones en suspension que comprenden un principio activo, un tensioactivo poloxamero o meroxapol y un glicol, su uso para la fabricacion de un medicamento para tratar trastornos oftalmicos. |
US20060292203A1 (en) | 2005-06-08 | 2006-12-28 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
JP5112669B2 (ja) | 2005-09-30 | 2013-01-09 | 富山化学工業株式会社 | 難溶性薬物のナノ微粒子を含有する水性懸濁液剤 |
WO2007058935A2 (en) | 2005-11-14 | 2007-05-24 | Bausch & Lomb Incorporated | Ophthalmic composition for dry eye therapy |
US20070299124A1 (en) | 2006-01-25 | 2007-12-27 | Ousler George W Iii | Formulations and methods for treating dry eye |
US20070297981A1 (en) | 2006-01-25 | 2007-12-27 | Ousler George W Iii | Formulations and methods for treating dry eye |
US20080039398A1 (en) | 2006-01-25 | 2008-02-14 | Ousler George W Iii | Formulations and methods for treating dry eye |
EP1981491A4 (en) | 2006-01-25 | 2009-09-23 | Aciex Inc | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT |
US20080181957A1 (en) | 2006-06-23 | 2008-07-31 | Min Wei | Increased amorphous stability of poorly water soluble drugs by nanosizing |
US20080260837A1 (en) | 2007-04-20 | 2008-10-23 | Qpharma, L.L.C. | Physically stable aqueous suspensions of active pharmaceuticals |
JP2010528014A (ja) | 2007-05-24 | 2010-08-19 | アーシエックス セラピューティックス, インコーポレイテッド | ドライアイを処置するための処方物および方法 |
BRPI0910717A2 (pt) * | 2008-04-26 | 2015-09-29 | Alcon Res Ltd | sistema polimérico de lágrima artificial |
JP4395189B1 (ja) * | 2008-08-29 | 2010-01-06 | 株式会社ソリトン | 塗布具 |
KR20110113199A (ko) | 2009-02-05 | 2011-10-14 | 알콘 리서치, 리미티드 | 구아의 정제 방법 |
JP5716960B2 (ja) * | 2011-05-23 | 2015-05-13 | オーベクス株式会社 | 塗布体用素材の製造方法及び塗布体用素材並びに塗布体及び塗布具 |
-
2010
- 2010-12-01 AU AU2010326099A patent/AU2010326099B2/en active Active
- 2010-12-01 DK DK10787650.0T patent/DK2506831T3/da active
- 2010-12-01 SI SI201031730T patent/SI2965749T1/sl unknown
- 2010-12-01 ES ES15179323.9T patent/ES2684752T3/es active Active
- 2010-12-01 MX MX2012006231A patent/MX2012006231A/es active IP Right Grant
- 2010-12-01 HU HUE13152584A patent/HUE025838T2/en unknown
- 2010-12-01 JP JP2012542157A patent/JP5864433B2/ja active Active
- 2010-12-01 US US12/957,864 patent/US8921337B2/en active Active
- 2010-12-01 KR KR1020127017237A patent/KR101543613B1/ko active IP Right Grant
- 2010-12-01 RS RS20130564A patent/RS53085B/en unknown
- 2010-12-01 KR KR1020157013045A patent/KR101809484B1/ko active IP Right Grant
- 2010-12-01 RU RU2012127675/15A patent/RU2571078C2/ru active
- 2010-12-01 EP EP15179323.9A patent/EP2965749B1/en active Active
- 2010-12-01 DK DK15179323.9T patent/DK2965749T3/en active
- 2010-12-01 LT LTEP15179323.9T patent/LT2965749T/lt unknown
- 2010-12-01 ES ES13152584.2T patent/ES2550942T3/es active Active
- 2010-12-01 PL PL15179323T patent/PL2965749T3/pl unknown
- 2010-12-01 WO PCT/US2010/058563 patent/WO2011068872A2/en active Application Filing
- 2010-12-01 PT PT15179323T patent/PT2965749T/pt unknown
- 2010-12-01 SI SI201031043T patent/SI2586426T1/sl unknown
- 2010-12-01 ES ES10787650.0T patent/ES2441420T3/es active Active
- 2010-12-01 CA CA2781254A patent/CA2781254C/en active Active
- 2010-12-01 EP EP13152584.2A patent/EP2586426B1/en active Active
- 2010-12-01 SI SI201030454T patent/SI2506831T1/sl unknown
- 2010-12-01 CN CN201080054514.5A patent/CN102724965B/zh active Active
- 2010-12-01 HU HUE15179323A patent/HUE038821T2/hu unknown
- 2010-12-01 BR BR112012013503A patent/BR112012013503B8/pt active IP Right Grant
- 2010-12-01 PT PT131525842T patent/PT2586426E/pt unknown
- 2010-12-01 EP EP10787650.0A patent/EP2506831B1/en active Active
- 2010-12-01 RS RS20180836A patent/RS57465B1/sr unknown
- 2010-12-01 PL PL13152584T patent/PL2586426T3/pl unknown
- 2010-12-01 PL PL10787650T patent/PL2506831T3/pl unknown
- 2010-12-01 PT PT107876500T patent/PT2506831E/pt unknown
- 2010-12-01 DK DK13152584.2T patent/DK2586426T3/en active
- 2010-12-02 TW TW099141906A patent/TWI486178B/zh active
- 2010-12-03 AR ARP100104470A patent/AR080572A1/es not_active Application Discontinuation
- 2010-12-03 UY UY0001033081A patent/UY33081A/es not_active Application Discontinuation
-
2012
- 2012-05-23 ZA ZA2012/03770A patent/ZA201203770B/en unknown
- 2012-05-30 CL CL2012001402A patent/CL2012001402A1/es unknown
- 2012-10-31 HK HK12110924.6A patent/HK1170164A1/xx unknown
- 2012-10-31 HK HK13106027.9A patent/HK1178802A1/xx unknown
-
2014
- 2014-01-07 HR HRP20140016AT patent/HRP20140016T1/hr unknown
- 2014-11-12 US US14/539,996 patent/US9662398B2/en active Active
-
2015
- 2015-01-05 JP JP2015000073A patent/JP6055849B2/ja active Active
-
2016
- 2016-03-22 JP JP2016056630A patent/JP2016106155A/ja active Pending
- 2016-05-04 HK HK16105087.5A patent/HK1217091A1/zh unknown
- 2016-10-04 US US15/284,930 patent/US20170020818A1/en not_active Abandoned
-
2018
- 2018-08-21 HR HRP20181337TT patent/HRP20181337T1/hr unknown
- 2018-08-22 CY CY20181100875T patent/CY1120585T1/el unknown
-
2021
- 2021-05-03 AR ARP210101199A patent/AR122463A2/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR122463A2 (es) | Suspensiones de nanopartículas que contienen polímero de carboxivinilo | |
BR112015008186A2 (pt) | formulação de um anticorpo estável e de baixa viscosidade | |
AR122746A2 (es) | Una formulación farmacéutica líquida estable de anticuerpo | |
BR112012026338A2 (pt) | novos derivados de 3,3-dimetil tetrahidroquinolina | |
BR112015004984A2 (pt) | formulações aquosas estáveis de adalimumab | |
MX2014013315A (es) | Nanoparticulas farmaceuticas que muestran la mejora del transporte de la mucosa. | |
NZ628398A (en) | Stable preservative-free mydriatic and anti-inflammatory solutions for injection | |
EP2528602A4 (en) | FORMULAS FROM BENDAMUSTIN | |
BR112012013847A2 (pt) | novos derivados de indolinona ciclopropano | |
NI201500073A (es) | Dispersión sólida con solubilidad mejorada que comprende un derivado de tetrazol como ingrediente activo. | |
DOP2012000281A (es) | Composiciones farmaceuticas y metodos para su elaboracion | |
BR112013028449A2 (pt) | composições compreendendo partículas de hidrogel | |
BR112014006248A2 (pt) | compostos de triazolopiridina como inibidores de pde10a | |
PH12014501937A1 (en) | Pharmaceutical composition containing an antivirally active dihydroquinazoline derivative | |
AR094012A1 (es) | Composiciones estables con peroxido para el cuidado oral | |
AR082049A1 (es) | Formulaciones liquidas de rupatadina fumarato | |
BR112015009603A2 (pt) | novos derivados de pirazina | |
PE20130374A1 (es) | Composicion farmaceutica que comprende ibuprofeno | |
EA201490573A1 (ru) | Соединение бензотиазолона | |
EA201490363A1 (ru) | Новые составы на основе (триметоксифениламино)пиримидинилов | |
AR101060A1 (es) | Conjugados de fviii | |
CY1122694T1 (el) | Φαρμακοτεχνικη μορφη η οποια περιεχει κουρκουμινη | |
EA201370198A1 (ru) | КЛАТРАТНЫЕ КОМПЛЕКСЫ β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ (ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, ОБЛАДАЮЩИЕ ПРОТИВОВИРУСНЫМ ДЕЙСТВИЕМ, И СПОСОБЫ ИХ ПОЛУЧЕНИЯ | |
BR112015010469A2 (pt) | derivados de imidazopiridina | |
CN105519579A (zh) | 一种煤矿巷道用消毒剂 |