CY1120585T1 - Εναιωρηματα νανοσωματιδιων που περιεχουν πολυμερες καρβοξυβινυλιου - Google Patents
Εναιωρηματα νανοσωματιδιων που περιεχουν πολυμερες καρβοξυβινυλιουInfo
- Publication number
- CY1120585T1 CY1120585T1 CY20181100875T CY181100875T CY1120585T1 CY 1120585 T1 CY1120585 T1 CY 1120585T1 CY 20181100875 T CY20181100875 T CY 20181100875T CY 181100875 T CY181100875 T CY 181100875T CY 1120585 T1 CY1120585 T1 CY 1120585T1
- Authority
- CY
- Cyprus
- Prior art keywords
- carboxyvinyl polymer
- suspensions containing
- compound
- nanoparticle suspensions
- containing carboxyvinyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση γενικά αναφέρεται σε εναιώρημα συνθέσεων που έχουν ένα πολυμερές καρβοξυβινυλίου όπως είναι ένα καρβομερές, μια γαλακτομαννάνη όπως είναι το γκουαρ, και μια ένωση βορικού. Μια ελάχιστα διαλυτή σωματιδιακή ένωση όπως είναι η νεπαφενάκη επίσης περιλαμβάνεται στις συνθέσεις. Η ελάχιστα διαλυτή σωματιδιακή ένωση έχει ένα μικρό μέγεθος σωματιδίων προκειμένου να ενισχύει την βιοδιαθεσιμότητα της ένωσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26636809P | 2009-12-03 | 2009-12-03 | |
EP13152584.2A EP2586426B1 (en) | 2009-12-03 | 2010-12-01 | Carboxyvinyl polymer-containing nanoparticle suspensions |
EP10787650.0A EP2506831B1 (en) | 2009-12-03 | 2010-12-01 | Carboxyvinyl polymer-containing nanoparticle suspensions |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1120585T1 true CY1120585T1 (el) | 2019-07-10 |
Family
ID=43425837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100875T CY1120585T1 (el) | 2009-12-03 | 2018-08-22 | Εναιωρηματα νανοσωματιδιων που περιεχουν πολυμερες καρβοξυβινυλιου |
Country Status (27)
Country | Link |
---|---|
US (3) | US8921337B2 (el) |
EP (3) | EP2965749B1 (el) |
JP (3) | JP5864433B2 (el) |
KR (2) | KR101543613B1 (el) |
CN (1) | CN102724965B (el) |
AR (2) | AR080572A1 (el) |
AU (1) | AU2010326099B2 (el) |
BR (1) | BR112012013503B8 (el) |
CA (1) | CA2781254C (el) |
CL (1) | CL2012001402A1 (el) |
CY (1) | CY1120585T1 (el) |
DK (3) | DK2506831T3 (el) |
ES (3) | ES2550942T3 (el) |
HK (3) | HK1170164A1 (el) |
HR (2) | HRP20140016T1 (el) |
HU (2) | HUE038821T2 (el) |
LT (1) | LT2965749T (el) |
MX (1) | MX2012006231A (el) |
PL (3) | PL2586426T3 (el) |
PT (3) | PT2965749T (el) |
RS (2) | RS57465B1 (el) |
RU (1) | RU2571078C2 (el) |
SI (3) | SI2506831T1 (el) |
TW (1) | TWI486178B (el) |
UY (1) | UY33081A (el) |
WO (1) | WO2011068872A2 (el) |
ZA (1) | ZA201203770B (el) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8435631B2 (en) * | 2010-04-15 | 2013-05-07 | Ppg Industries Ohio, Inc. | Microporous material |
US10287414B2 (en) * | 2010-07-20 | 2019-05-14 | C-Ip S.A. | Boron compound suspension |
TW201336527A (zh) * | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
CN104602670A (zh) * | 2012-08-31 | 2015-05-06 | 博士伦公司 | 含有ω-3 脂肪酸的眼用组合物 |
WO2014207769A1 (en) | 2013-06-27 | 2014-12-31 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
US20150191647A1 (en) * | 2014-01-07 | 2015-07-09 | Trican Well Service Ltd. | Stability of viscous fluids in low salinity environments |
PL4082531T3 (pl) | 2015-01-26 | 2024-04-08 | Bausch & Lomb Incorporated | Oftalmiczna kompozycja zawiesinowa |
EP3310363A4 (en) * | 2015-06-18 | 2019-02-13 | Common Pharma, Inc | ANTIMICROBIAL FORMULATIONS |
US11730699B2 (en) | 2018-02-21 | 2023-08-22 | Alcon Inc. | Lipid-based ophthalmic emulsion |
TW201938141A (zh) * | 2018-02-21 | 2019-10-01 | 瑞士商諾華公司 | 基於脂質的眼用乳劑 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3864183A (en) * | 1972-11-21 | 1975-02-04 | Tokyo Hat | Method for producing pen core from filament tows |
US4313949A (en) | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
IL80298A (en) | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
US5192535A (en) | 1988-02-08 | 1993-03-09 | Insite Vision Incorporated | Ophthalmic suspensions |
US5188826A (en) | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
US5461081A (en) | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5429824A (en) | 1992-12-15 | 1995-07-04 | Eastman Kodak Company | Use of tyloxapole as a nanoparticle stabilizer and dispersant |
US5475034A (en) | 1994-06-06 | 1995-12-12 | Alcon Laboratories, Inc. | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
FR2761959B1 (fr) * | 1997-04-15 | 1999-05-21 | Oreal | Ensemble de conditionnement et d'application d'un produit fluide |
CN100408100C (zh) | 1997-07-29 | 2008-08-06 | 阿尔康实验室公司 | 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物 |
IT1306123B1 (it) | 1999-04-02 | 2001-05-30 | Technopharma Sa | Soluzione oftalmica viscosizzata con azione detergente sulle lenti acontatto. |
ITMI991453A1 (it) | 1999-07-01 | 2001-01-01 | Farmila Farma Milano | Composizioni oftalmiche in forma di gel acquosi |
DZ3227A1 (fr) | 1999-12-23 | 2001-07-05 | Pfizer Prod Inc | Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees |
PE20020146A1 (es) | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
IL158991A0 (en) | 2001-06-22 | 2004-05-12 | Pfizer Prod Inc | Pharmaceutical compositions comprising low-solubility and/or acid sensitive drugs and neutralized acidic polymers |
EP1448209A2 (en) | 2001-10-23 | 2004-08-25 | Ranbaxy Laboratories, Ltd. | A process for the preparation of pharmaceutical compositions for topical delivery of cyclooxygenase-2 enzyme inhibitors |
US7045121B2 (en) | 2001-12-14 | 2006-05-16 | Allergan, Inc. | Ophthalmic compositions for lubricating eyes and methods for making and using same |
AU2003213210A1 (en) * | 2002-02-22 | 2003-09-09 | Pharmacia Corporation | Ophthalmic formulation with gum system |
TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
US7947295B2 (en) | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
ATE444732T1 (de) | 2003-08-07 | 2009-10-15 | Allergan Inc | Zusammensetzungen zur abgabe von therapeutika in die augen und verfahren zu ihrer herstellung und verwendung |
FR2865648B1 (fr) | 2004-02-03 | 2006-06-30 | Philippe Perovitch | Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede |
TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
US20080145430A1 (en) | 2004-12-08 | 2008-06-19 | Santipharp Panmai | Ophthalmic Nanoparticulate Formulation Of A Cyclooxygenase-2 Selective Inhibitor |
TWI393567B (zh) | 2005-03-31 | 2013-04-21 | Bausch & Lomb | 治療乾眼之組合物及相關之製造方法及使用方法 |
JP4257860B2 (ja) * | 2005-04-19 | 2009-04-22 | 中得工業株式会社 | 化粧材の塗布具 |
AU2006244244B2 (en) | 2005-05-10 | 2010-11-04 | Alcon, Inc. | Suspension formulations comprising an active principle, a poloxamer or meroxapol surfactant and a glycol, its use for the manufacture of a medicament for treating ophthalmic disorders |
AU2006244245B2 (en) * | 2005-05-10 | 2010-11-18 | Alcon, Inc. | Ophthalmic suspension comprising an ophthalmic drug, a poloxamine and a glycol tonicity-adjusting agent, use of said composition for the manufacture of a medicament for treating ophthalmic disorders |
BRPI0606172A2 (pt) | 2005-06-08 | 2009-06-02 | Targegen Inc | métodos e composições para o tratamento de distúrbios oculares |
JP5112669B2 (ja) | 2005-09-30 | 2013-01-09 | 富山化学工業株式会社 | 難溶性薬物のナノ微粒子を含有する水性懸濁液剤 |
US20070110812A1 (en) | 2005-11-14 | 2007-05-17 | Bausch & Lomb Incorporated | Ophthalmic composition for dry eye therapy |
US20070297981A1 (en) | 2006-01-25 | 2007-12-27 | Ousler George W Iii | Formulations and methods for treating dry eye |
EP1981491A4 (en) | 2006-01-25 | 2009-09-23 | Aciex Inc | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT |
US20070299124A1 (en) | 2006-01-25 | 2007-12-27 | Ousler George W Iii | Formulations and methods for treating dry eye |
US20080039398A1 (en) | 2006-01-25 | 2008-02-14 | Ousler George W Iii | Formulations and methods for treating dry eye |
WO2008002485A2 (en) | 2006-06-23 | 2008-01-03 | Alza Corporation | Increased amorphous stability of poorly water soluble drugs by nanosizing |
US20080260837A1 (en) | 2007-04-20 | 2008-10-23 | Qpharma, L.L.C. | Physically stable aqueous suspensions of active pharmaceuticals |
WO2008153746A1 (en) | 2007-05-24 | 2008-12-18 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
CA2722508C (en) * | 2008-04-26 | 2016-08-16 | Alcon Research Ltd. | Polymeric artificial tear system |
JP4395189B1 (ja) * | 2008-08-29 | 2010-01-06 | 株式会社ソリトン | 塗布具 |
SG173581A1 (en) | 2009-02-05 | 2011-09-29 | Alcon Res Ltd | Process for purifying guar |
JP5716960B2 (ja) * | 2011-05-23 | 2015-05-13 | オーベクス株式会社 | 塗布体用素材の製造方法及び塗布体用素材並びに塗布体及び塗布具 |
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2010
- 2010-12-01 AU AU2010326099A patent/AU2010326099B2/en active Active
- 2010-12-01 PT PT15179323T patent/PT2965749T/pt unknown
- 2010-12-01 SI SI201030454T patent/SI2506831T1/sl unknown
- 2010-12-01 KR KR1020127017237A patent/KR101543613B1/ko active IP Right Grant
- 2010-12-01 PL PL13152584T patent/PL2586426T3/pl unknown
- 2010-12-01 RS RS20180836A patent/RS57465B1/sr unknown
- 2010-12-01 HU HUE15179323A patent/HUE038821T2/hu unknown
- 2010-12-01 DK DK10787650.0T patent/DK2506831T3/da active
- 2010-12-01 RS RS20130564A patent/RS53085B/en unknown
- 2010-12-01 JP JP2012542157A patent/JP5864433B2/ja active Active
- 2010-12-01 DK DK15179323.9T patent/DK2965749T3/en active
- 2010-12-01 ES ES13152584.2T patent/ES2550942T3/es active Active
- 2010-12-01 EP EP15179323.9A patent/EP2965749B1/en active Active
- 2010-12-01 ES ES15179323.9T patent/ES2684752T3/es active Active
- 2010-12-01 PL PL15179323T patent/PL2965749T3/pl unknown
- 2010-12-01 CA CA2781254A patent/CA2781254C/en active Active
- 2010-12-01 RU RU2012127675/15A patent/RU2571078C2/ru active
- 2010-12-01 ES ES10787650.0T patent/ES2441420T3/es active Active
- 2010-12-01 HU HUE13152584A patent/HUE025838T2/en unknown
- 2010-12-01 SI SI201031730T patent/SI2965749T1/sl unknown
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