CY1120276T1 - Απομονωμενη στερεη μορφη μονοϋδροχλωρικη αναμορελινης με χαμηλη γραμμομοριακη αναλογια χλωριου:αναμορελινης και χαμηλη περιεκτικοτητασε καταλοιπα οργανικου διαλυτη - Google Patents

Απομονωμενη στερεη μορφη μονοϋδροχλωρικη αναμορελινης με χαμηλη γραμμομοριακη αναλογια χλωριου:αναμορελινης και χαμηλη περιεκτικοτητασε καταλοιπα οργανικου διαλυτη

Info

Publication number
CY1120276T1
CY1120276T1 CY20181100270T CY181100270T CY1120276T1 CY 1120276 T1 CY1120276 T1 CY 1120276T1 CY 20181100270 T CY20181100270 T CY 20181100270T CY 181100270 T CY181100270 T CY 181100270T CY 1120276 T1 CY1120276 T1 CY 1120276T1
Authority
CY
Cyprus
Prior art keywords
monohylchloride
grammoric
chamilike
anamorelinin
anamoreline
Prior art date
Application number
CY20181100270T
Other languages
English (en)
Inventor
Shin-Itsu Kuwabe
Takehiko YANAGIMACHI
Hideyuki YOSHIYAMA
Eleanor DE GROOT
Silvina Garcia Rubio
Peter Manini
Seemon Pines
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48225135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120276(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of CY1120276T1 publication Critical patent/CY1120276T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με σωματιδιακές μορφές μονοϋδροχλωρικής αναμορελίνης ή μια σύνθεση που περιλαμβάνει μονοϋδροχλωρική αναμορελίνη η οποία έχει ελεγχόμενη περιεκτικότητα σε χλώριο, κατά προτίμηση απομονωμένη σε μια άμορφη κατάσταση ή/και κατάσταση με λεπτοκομμένα σωματίδια, με διαδικασίες για την παρασκευή των σωματιδιακών μορφών και με φαρμακευτικές συνθέσεις που περιλαμβάνουν τις σωματιδιακές μορφές.
CY20181100270T 2012-04-20 2018-03-05 Απομονωμενη στερεη μορφη μονοϋδροχλωρικη αναμορελινης με χαμηλη γραμμομοριακη αναλογια χλωριου:αναμορελινης και χαμηλη περιεκτικοτητασε καταλοιπα οργανικου διαλυτη CY1120276T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261636108P 2012-04-20 2012-04-20
PCT/US2013/037159 WO2013158874A1 (en) 2012-04-20 2013-04-18 Methods of producing anamorelin hydrochloride having controlled chloride content

Publications (1)

Publication Number Publication Date
CY1120276T1 true CY1120276T1 (el) 2019-07-10

Family

ID=48225135

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100270T CY1120276T1 (el) 2012-04-20 2018-03-05 Απομονωμενη στερεη μορφη μονοϋδροχλωρικη αναμορελινης με χαμηλη γραμμομοριακη αναλογια χλωριου:αναμορελινης και χαμηλη περιεκτικοτητασε καταλοιπα οργανικου διαλυτη

Country Status (47)

Country Link
US (8) US20140018391A1 (el)
EP (3) EP3290410B1 (el)
JP (3) JP6109925B2 (el)
KR (2) KR101972998B1 (el)
CN (3) CN110041304A (el)
AP (1) AP2014008013A0 (el)
AR (1) AR090725A1 (el)
AU (1) AU2013249197B2 (el)
BR (1) BR112014025972A8 (el)
CA (2) CA2869893C (el)
CL (1) CL2014002817A1 (el)
CO (1) CO7131356A2 (el)
CR (1) CR20140530A (el)
CY (1) CY1120276T1 (el)
DK (2) DK2838892T3 (el)
DO (1) DOP2014000235A (el)
EA (1) EA031581B1 (el)
EC (1) ECSP14027739A (el)
ES (2) ES2820354T3 (el)
GE (1) GEP20186902B (el)
HK (2) HK1202863A1 (el)
HR (1) HRP20180316T1 (el)
HU (2) HUE050865T2 (el)
IL (1) IL235064B (el)
JO (1) JO3353B1 (el)
LT (1) LT2838892T (el)
MA (1) MA37524B1 (el)
MD (1) MD4615C1 (el)
ME (1) ME02966B (el)
MX (1) MX354793B (el)
MY (1) MY170068A (el)
NI (1) NI201400124A (el)
NO (1) NO2877697T3 (el)
NZ (1) NZ700833A (el)
PE (1) PE20150084A1 (el)
PH (1) PH12014502351A1 (el)
PL (2) PL3290410T3 (el)
PT (2) PT3517532T (el)
RS (1) RS56869B1 (el)
SG (2) SG10201608488RA (el)
SI (2) SI3290410T1 (el)
TN (1) TN2014000421A1 (el)
TW (2) TWI589572B (el)
UA (1) UA116207C2 (el)
UY (1) UY34753A (el)
WO (1) WO2013158874A1 (el)
ZA (1) ZA201408508B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3353B1 (ar) 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي
US9675600B2 (en) * 2014-09-04 2017-06-13 Helsinn Healthcare Sa Medical treatments based on anamorelin
CR20180023A (es) 2015-07-24 2018-03-20 Newlink Genetics Corp Sales y profármacos de 1-metil-d-triptofano
CN108239141A (zh) * 2016-12-23 2018-07-03 江苏先声药业有限公司 一种阿拉莫林的制备方法
WO2021038519A1 (en) 2019-08-30 2021-03-04 Helsinn Healthcare Sa Methods of manufacturing anamorelin tablets having improved stability

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73530C2 (uk) * 1999-11-10 2005-08-15 Ново Нордіск А/С Сполука з властивостями вивільнювати гормон росту
CN1882526A (zh) * 2003-09-26 2006-12-20 兰贝克赛实验室有限公司 制备伏格列波糖的方法
KR101324340B1 (ko) 2004-06-29 2013-10-31 헬신 세라퓨틱스 (유.에스.) 인크. (3ｒ)-1-(2-메틸알라닐-ｄ-트립토필)-3-(페닐메틸)-3-피페리딘카르복실산 1,2,2-트리메틸하이드라지드의 결정 형태
JP2010518158A (ja) * 2007-02-13 2010-05-27 ヘルシン セラピューティクス（ユー．エス．），インコーポレイティド 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法
UA105657C2 (uk) * 2009-02-27 2014-06-10 Хелсінн Терапьютікс (Ю.Ес.), Інк. Поліпшені способи лікування мігрені на основі анамореліну
JO3353B1 (ar) * 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي

Also Published As

Publication number Publication date
ES2658862T3 (es) 2018-03-12
SI2838892T1 (en) 2018-05-31
DOP2014000235A (es) 2015-01-31
CA2869893A1 (en) 2013-10-24
MA37524A1 (fr) 2016-06-30
TWI677494B (zh) 2019-11-21
CA3031652A1 (en) 2013-10-24
JP6616853B2 (ja) 2019-12-04
PH12014502351B1 (en) 2015-01-12
ME02966B (me) 2018-07-20
US9403867B2 (en) 2016-08-02
TW201722928A (zh) 2017-07-01
US9872883B2 (en) 2018-01-23
US10300105B2 (en) 2019-05-28
KR20150013115A (ko) 2015-02-04
LT2838892T (lt) 2018-03-12
TW201348224A (zh) 2013-12-01
EA201401151A1 (ru) 2015-06-30
DK3517532T3 (da) 2022-01-03
US20190231843A1 (en) 2019-08-01
TWI589572B (zh) 2017-07-01
AP2014008013A0 (en) 2014-10-31
WO2013158874A1 (en) 2013-10-24
KR102141323B1 (ko) 2020-08-05
CN110041304A (zh) 2019-07-23
SG11201406478XA (en) 2014-11-27
SG10201608488RA (en) 2016-12-29
AU2013249197A1 (en) 2014-10-30
MX2014012178A (es) 2015-08-05
US20140018391A1 (en) 2014-01-16
TN2014000421A1 (en) 2016-03-30
JP2018076375A (ja) 2018-05-17
KR101972998B1 (ko) 2019-04-29
NO2877697T3 (el) 2018-10-13
BR112014025972A2 (pt) 2017-06-27
CA3031652C (en) 2020-10-27
JP6284665B2 (ja) 2018-02-28
MD4615C1 (ro) 2019-08-31
EP3290410B1 (en) 2020-07-01
MD4615B1 (ro) 2019-01-31
US20150072934A1 (en) 2015-03-12
US10576122B2 (en) 2020-03-03
US9981002B2 (en) 2018-05-29
EP3517532A1 (en) 2019-07-31
US9956261B2 (en) 2018-05-01
HK1202863A1 (en) 2015-10-09
US20160235804A1 (en) 2016-08-18
MD20140122A2 (ro) 2015-05-31
MX354793B (es) 2018-03-21
NZ700833A (en) 2016-01-29
BR112014025972A8 (pt) 2021-06-22
CA2869893C (en) 2019-03-05
AU2013249197B2 (en) 2017-04-06
EP2838892A1 (en) 2015-02-25
US20160237115A1 (en) 2016-08-18
IL235064B (en) 2019-09-26
UY34753A (es) 2013-11-29
EP2838892B1 (en) 2017-12-06
MY170068A (en) 2019-07-03
US10905737B2 (en) 2021-02-02
ES2820354T3 (es) 2021-04-20
HRP20180316T1 (hr) 2018-04-06
US20200276259A1 (en) 2020-09-03
PT2838892T (pt) 2018-02-28
NI201400124A (es) 2015-09-21
PT3517532T (pt) 2021-11-08
HK1248694A1 (zh) 2018-10-19
GEP20186902B (en) 2018-10-25
DK2838892T3 (en) 2018-03-12
ECSP14027739A (es) 2015-12-31
CR20140530A (es) 2015-03-25
HUE050865T2 (hu) 2021-01-28
JP2017101082A (ja) 2017-06-08
KR20190044697A (ko) 2019-04-30
JO3353B1 (ar) 2019-03-13
US20160229889A1 (en) 2016-08-11
CL2014002817A1 (es) 2015-08-14
EP3517532B1 (en) 2021-10-13
SI3290410T1 (sl) 2020-11-30
RS56869B1 (sr) 2018-04-30
PE20150084A1 (es) 2015-01-23
UA116207C2 (uk) 2018-02-26
PL3290410T3 (pl) 2021-01-11
JP6109925B2 (ja) 2017-04-05
PL2838892T3 (pl) 2018-05-30
CO7131356A2 (es) 2014-12-01
EP3290410A1 (en) 2018-03-07
IL235064A0 (en) 2014-12-31
CN110041398A (zh) 2019-07-23
PH12014502351A1 (en) 2015-01-12
EA031581B1 (ru) 2019-01-31
CN103857669A (zh) 2014-06-11
JP2015514779A (ja) 2015-05-21
CN103857669B (zh) 2019-06-28
AR090725A1 (es) 2014-12-03
US20190000914A1 (en) 2019-01-03
HUE035697T2 (en) 2018-05-28
ZA201408508B (en) 2020-01-29
MA37524B1 (fr) 2017-04-28

Similar Documents

Publication Publication Date Title
CY1120276T1 (el) Απομονωμενη στερεη μορφη μονοϋδροχλωρικη αναμορελινης με χαμηλη γραμμομοριακη αναλογια χλωριου:αναμορελινης και χαμηλη περιεκτικοτητασε καταλοιπα οργανικου διαλυτη
CY1124663T1 (el) Αντιιικα παραγωγα ν4-υδροξυκυτιδινης
CY1119245T1 (el) Φαρμακευτικη συνθεση καρβετοκινης
CY1121862T1 (el) Αντισωματα anti-phf-tau και χρησεις αυτων
CY1118680T1 (el) Φαρμακευτικη συνθεση
CY1119566T1 (el) Αντιϊικες ενωσεις rsv
EA201591137A1 (ru) Ингибиторы mk2 и их применения
TR201811764T4 (tr) Kinaz inhibitörleri olarak aminoheteroaril benzamidleri.
TR201901886T4 (tr) DNA-PK inhibitörleri.
EA201490806A1 (ru) Комбинированный состав двух противовирусных соединений
BR112014013108A2 (pt) compostos tricíclicos fundidos como inibidores da quinase raf
EA201492056A1 (ru) Пиримидиниловые ингибиторы тирозинкиназы
EA201590887A1 (ru) Композиция
JO3154B1 (ar) عوامل مضادة لـ trpv4
CY1124378T1 (el) Ενωσεις για αγωγη του αποκλεισμου επαναμυελινωσης σε παθησεις που συσχετιζονται με την εκφραση της πρωτεϊνης φακελου herv-w
CY1120185T1 (el) Υποκατεστημενα πυριδινικα παραγωγα χρησιμα ως αναστολεις c-fms κινασης
CY1119470T1 (el) Γαλακταγωγες συνθεσεις με βαση φωσφατιδυλοσερινη
CY1120528T1 (el) Παραγωγα βενζοφουρανο-2-σουλφοναμιδιου ως τροποποιητες υποδοχεων χημειοκινων
EA201391643A1 (ru) Составы с замедленным высвобождением парацетамола
EA201391586A1 (ru) ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ
CR20150159A (es) Derivados oxazolidinona 3,4-disustituidos y su uso como inhibidores de potasio calcio activado
TR201908358T4 (tr) BACE inhibitörü olarak bir tetrahidropirrolo[3,4-d][1,3]tiazin-türevi.
EA201492173A1 (ru) Дронедарон для применения при лейшманиозе, в составах и комбинациях для применения при лейшманиозе
EA201591770A1 (ru) Таксоиды - принцип очистки для жидких наполнителей
TR201306238A2 (tr) Dikkat ve konsantrasyon bozukluklarının tedavisine yönelik bir kompozisyon.