BR112014025972A8 - monocloridratos de anamorelina, composições, processo para preparar monocloridrato de anamorelina, método para produzir uma forma de dosagem farmacêutica e forma de dosagem farmacêutica oral - Google Patents

monocloridratos de anamorelina, composições, processo para preparar monocloridrato de anamorelina, método para produzir uma forma de dosagem farmacêutica e forma de dosagem farmacêutica oral

Info

Publication number
BR112014025972A8
BR112014025972A8 BR112014025972A BR112014025972A BR112014025972A8 BR 112014025972 A8 BR112014025972 A8 BR 112014025972A8 BR 112014025972 A BR112014025972 A BR 112014025972A BR 112014025972 A BR112014025972 A BR 112014025972A BR 112014025972 A8 BR112014025972 A8 BR 112014025972A8
Authority
BR
Brazil
Prior art keywords
dosage form
pharmaceutical dosage
anamorelin
compositions
monohydrochlorides
Prior art date
Application number
BR112014025972A
Other languages
English (en)
Other versions
BR112014025972A2 (pt
Inventor
De Groot Eleanor
Yoshiyama Hideyuki
Manini Peter
Pines Seemon
Kuwabe Shin-Itsu
Garcia Rubio Silvina
Yanagimachi Takehiko
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48225135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014025972(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of BR112014025972A2 publication Critical patent/BR112014025972A2/pt
Publication of BR112014025972A8 publication Critical patent/BR112014025972A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

monocloridratos de anamorelina, composições, processo para preparar monocloridrato de anamorelina, método para produzir uma forma de dosagem farmacêutica e forma de dosagem farmacêutica oral. a presente invenção refere-se a formas particuladas de monocloridrato de anamorelina ou uma composição que compreende monocloridrato de anamorelina que tem teor de cloreto controlado, de preferência, isolado em um estado amorfo e/ou particulado fino, a processos para produzir as formas de partículas e composições farmacêuticas que compreendem as formas particuladas.
BR112014025972A 2012-04-20 2013-04-18 monocloridratos de anamorelina, composições, processo para preparar monocloridrato de anamorelina, método para produzir uma forma de dosagem farmacêutica e forma de dosagem farmacêutica oral BR112014025972A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261636108P 2012-04-20 2012-04-20
PCT/US2013/037159 WO2013158874A1 (en) 2012-04-20 2013-04-18 Methods of producing anamorelin hydrochloride having controlled chloride content

Publications (2)

Publication Number Publication Date
BR112014025972A2 BR112014025972A2 (pt) 2017-06-27
BR112014025972A8 true BR112014025972A8 (pt) 2021-06-22

Family

ID=48225135

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014025972A BR112014025972A8 (pt) 2012-04-20 2013-04-18 monocloridratos de anamorelina, composições, processo para preparar monocloridrato de anamorelina, método para produzir uma forma de dosagem farmacêutica e forma de dosagem farmacêutica oral

Country Status (47)

Country Link
US (8) US20140018391A1 (pt)
EP (3) EP3290410B1 (pt)
JP (3) JP6109925B2 (pt)
KR (2) KR101972998B1 (pt)
CN (3) CN110041304A (pt)
AP (1) AP2014008013A0 (pt)
AR (1) AR090725A1 (pt)
AU (1) AU2013249197B2 (pt)
BR (1) BR112014025972A8 (pt)
CA (2) CA3031652C (pt)
CL (1) CL2014002817A1 (pt)
CO (1) CO7131356A2 (pt)
CR (1) CR20140530A (pt)
CY (1) CY1120276T1 (pt)
DK (2) DK2838892T3 (pt)
DO (1) DOP2014000235A (pt)
EA (1) EA031581B1 (pt)
EC (1) ECSP14027739A (pt)
ES (2) ES2658862T3 (pt)
GE (1) GEP20186902B (pt)
HK (2) HK1202863A1 (pt)
HR (1) HRP20180316T1 (pt)
HU (2) HUE035697T2 (pt)
IL (1) IL235064B (pt)
JO (1) JO3353B1 (pt)
LT (1) LT2838892T (pt)
MA (1) MA37524B1 (pt)
MD (1) MD4615C1 (pt)
ME (1) ME02966B (pt)
MX (1) MX354793B (pt)
MY (1) MY170068A (pt)
NI (1) NI201400124A (pt)
NO (1) NO2877697T3 (pt)
NZ (1) NZ700833A (pt)
PE (1) PE20150084A1 (pt)
PH (1) PH12014502351B1 (pt)
PL (2) PL3290410T3 (pt)
PT (2) PT2838892T (pt)
RS (1) RS56869B1 (pt)
SG (2) SG11201406478XA (pt)
SI (2) SI2838892T1 (pt)
TN (1) TN2014000421A1 (pt)
TW (2) TWI589572B (pt)
UA (1) UA116207C2 (pt)
UY (1) UY34753A (pt)
WO (1) WO2013158874A1 (pt)
ZA (1) ZA201408508B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3353B1 (ar) 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي
CN113577074A (zh) * 2014-09-04 2021-11-02 赫尔森保健股份公司 基于阿拉莫林的药物治疗
KR20180086300A (ko) 2015-07-24 2018-07-30 뉴링크 제네틱스 코퍼레이션 1-메틸-d-트립토판의 염 및 프로드러그
CN108239141A (zh) * 2016-12-23 2018-07-03 江苏先声药业有限公司 一种阿拉莫林的制备方法
KR20220054244A (ko) 2019-08-30 2022-05-02 헬신 헬스케어 에스아 개선된 안정성을 갖는 아나모렐린 정제의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73530C2 (uk) * 1999-11-10 2005-08-15 Ново Нордіск А/С Сполука з властивостями вивільнювати гормон росту
CN1882526A (zh) * 2003-09-26 2006-12-20 兰贝克赛实验室有限公司 制备伏格列波糖的方法
EP2298760B1 (en) 2004-06-29 2015-08-05 Helsinn Healthcare S.A. Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
MX2009008561A (es) * 2007-02-13 2010-01-15 Helsinn Therapeutics Us Inc Metodo para tratar trastornos proliferativos celulares utilizando secretagogos.
UA105657C2 (uk) * 2009-02-27 2014-06-10 Хелсінн Терапьютікс (Ю.Ес.), Інк. Поліпшені способи лікування мігрені на основі анамореліну
JO3353B1 (ar) 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي

Also Published As

Publication number Publication date
US9981002B2 (en) 2018-05-29
UY34753A (es) 2013-11-29
WO2013158874A1 (en) 2013-10-24
CR20140530A (es) 2015-03-25
US20190231843A1 (en) 2019-08-01
SG11201406478XA (en) 2014-11-27
JP6616853B2 (ja) 2019-12-04
EP2838892B1 (en) 2017-12-06
AU2013249197B2 (en) 2017-04-06
US20160229889A1 (en) 2016-08-11
KR101972998B1 (ko) 2019-04-29
AU2013249197A1 (en) 2014-10-30
MX2014012178A (es) 2015-08-05
SI3290410T1 (sl) 2020-11-30
NI201400124A (es) 2015-09-21
TWI589572B (zh) 2017-07-01
JO3353B1 (ar) 2019-03-13
HK1202863A1 (en) 2015-10-09
CA2869893C (en) 2019-03-05
US10905737B2 (en) 2021-02-02
CN110041304A (zh) 2019-07-23
LT2838892T (lt) 2018-03-12
CY1120276T1 (el) 2019-07-10
EA201401151A1 (ru) 2015-06-30
GEP20186902B (en) 2018-10-25
JP2018076375A (ja) 2018-05-17
MA37524A1 (fr) 2016-06-30
KR20150013115A (ko) 2015-02-04
CN103857669A (zh) 2014-06-11
PT2838892T (pt) 2018-02-28
DK3517532T3 (da) 2022-01-03
MD4615B1 (ro) 2019-01-31
ZA201408508B (en) 2020-01-29
PH12014502351A1 (en) 2015-01-12
JP6109925B2 (ja) 2017-04-05
ME02966B (me) 2018-07-20
SI2838892T1 (en) 2018-05-31
IL235064A0 (en) 2014-12-31
ECSP14027739A (es) 2015-12-31
US20140018391A1 (en) 2014-01-16
US20160235804A1 (en) 2016-08-18
EP2838892A1 (en) 2015-02-25
JP2015514779A (ja) 2015-05-21
US10300105B2 (en) 2019-05-28
KR102141323B1 (ko) 2020-08-05
MA37524B1 (fr) 2017-04-28
EA031581B1 (ru) 2019-01-31
TWI677494B (zh) 2019-11-21
ES2658862T3 (es) 2018-03-12
MY170068A (en) 2019-07-03
UA116207C2 (uk) 2018-02-26
BR112014025972A2 (pt) 2017-06-27
EP3517532A1 (en) 2019-07-31
MX354793B (es) 2018-03-21
CN103857669B (zh) 2019-06-28
CN110041398A (zh) 2019-07-23
US9956261B2 (en) 2018-05-01
HK1248694A1 (zh) 2018-10-19
PL2838892T3 (pl) 2018-05-30
HUE050865T2 (hu) 2021-01-28
US9872883B2 (en) 2018-01-23
JP6284665B2 (ja) 2018-02-28
HRP20180316T1 (hr) 2018-04-06
PT3517532T (pt) 2021-11-08
DK2838892T3 (en) 2018-03-12
CA2869893A1 (en) 2013-10-24
MD20140122A2 (ro) 2015-05-31
TW201348224A (zh) 2013-12-01
US9403867B2 (en) 2016-08-02
US20190000914A1 (en) 2019-01-03
US20150072934A1 (en) 2015-03-12
EP3290410A1 (en) 2018-03-07
SG10201608488RA (en) 2016-12-29
RS56869B1 (sr) 2018-04-30
MD4615C1 (ro) 2019-08-31
PH12014502351B1 (en) 2015-01-12
EP3517532B1 (en) 2021-10-13
CO7131356A2 (es) 2014-12-01
NZ700833A (en) 2016-01-29
DOP2014000235A (es) 2015-01-31
US20200276259A1 (en) 2020-09-03
CL2014002817A1 (es) 2015-08-14
TW201722928A (zh) 2017-07-01
CA3031652A1 (en) 2013-10-24
KR20190044697A (ko) 2019-04-30
TN2014000421A1 (en) 2016-03-30
HUE035697T2 (en) 2018-05-28
US20160237115A1 (en) 2016-08-18
JP2017101082A (ja) 2017-06-08
IL235064B (en) 2019-09-26
PL3290410T3 (pl) 2021-01-11
US10576122B2 (en) 2020-03-03
CA3031652C (en) 2020-10-27
AR090725A1 (es) 2014-12-03
ES2820354T3 (es) 2021-04-20
AP2014008013A0 (en) 2014-10-31
PE20150084A1 (es) 2015-01-23
EP3290410B1 (en) 2020-07-01
NO2877697T3 (pt) 2018-10-13

Similar Documents

Publication Publication Date Title
BR112015012469A2 (pt) pó formado de partículas, mais do que 95% em número de ditas partículas exibindo uma circularidade superior ou igual a 0,85, processo para a fabricação de um pó, processo de pulverização térmica e câmara de tratamento para semicondutores
PH12016501122A1 (en) Delayed release compositions of linaclotide
MX2016005446A (es) Intervenciones a base de angiopoyetina para tratar la malaria cerebral.
BR112014025972A8 (pt) monocloridratos de anamorelina, composições, processo para preparar monocloridrato de anamorelina, método para produzir uma forma de dosagem farmacêutica e forma de dosagem farmacêutica oral
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
UA116889C2 (uk) Фармацевтична композиція, що містить суміш ізоформ apg101 (cd95-fc)
IN2013MU03641A (pt)
WO2014068586A3 (en) Solid oral compositions of tolvaptan
MX366829B (es) Composiciones y formas de dosificacion de itraconazol y metodos de uso de las mismas.
BR112018008588A2 (pt) composição, e, processo para preparar uma composição.
EP2983684B8 (en) Essential oil and aloe for treatment and prophylaxis of inflammations caused by demodex, especially marginal blepharitis, a pharmaceutical composition containing essential oil and/or aloe and the use of essential oil and aloe and their compositions for the production of a preparation used in treatment and prophylaxis of the mentioned inflammations
IL245260B (en) Non-aqueous crystalline form of cabazitaxel, process for its preparation and pharmaceutical compositions thereof
MX2016005645A (es) Composicion farmaceutica topica de acitretina.
BR112014011745A2 (pt) composição farmacêutica, e, processo para a fabricação de uma composição farmacêutica de hidrocortisona
TN2015000523A1 (en) Substituted benzoxazoles
IN2013CH05858A (pt)
WO2013129970A3 (ru) Фармацевтический состав, обладающий сосудосуживающим, антиконгестивным, противовоспалительным действием (варианты)
IN2013MU02777A (pt)
IN2013MU03639A (pt)
IN2013CH05769A (pt)
AU2011902761A0 (en) Dernatan sulphate pharmaceutical compositions and process for producing same

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]