JP5688877B2 - 癌疾患の治療用キナゾリン誘導体 - Google Patents
癌疾患の治療用キナゾリン誘導体 Download PDFInfo
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- JP5688877B2 JP5688877B2 JP2008539440A JP2008539440A JP5688877B2 JP 5688877 B2 JP5688877 B2 JP 5688877B2 JP 2008539440 A JP2008539440 A JP 2008539440A JP 2008539440 A JP2008539440 A JP 2008539440A JP 5688877 B2 JP5688877 B2 JP 5688877B2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Chemistry (AREA)
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| PCT/EP2006/068313 WO2007054550A1 (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
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| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
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| DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| PL1948180T3 (pl) * | 2005-11-11 | 2013-09-30 | Boehringer Ingelheim Int | Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2 |
| JP5688877B2 (ja) | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
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| WO2010130757A1 (en) | 2009-05-14 | 2010-11-18 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of oncological and fibrotic diseases |
| SI2451445T1 (sl) | 2009-07-06 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino |
| EP2509592A1 (en) * | 2009-12-07 | 2012-10-17 | Boehringer Ingelheim International GmbH | Bibw 2992 for use in the treatment of triple negative breast cancer |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| US20130289056A1 (en) * | 2010-08-26 | 2013-10-31 | Boehringer Ingelheim International Gmbh | Methods of administering an egfr inhibitor |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
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| US8828391B2 (en) * | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| CN104736155B (zh) | 2012-05-14 | 2018-01-02 | 杭州德润玉成生物科技有限公司 | 双环化合物作为激酶的抑制剂 |
| CN103755688B (zh) | 2013-12-24 | 2015-11-18 | 江苏奥赛康药业股份有限公司 | 一种阿法替尼化合物的制备方法 |
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- 2006-11-09 EP EP06819379A patent/EP1948179A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| US20150272954A1 (en) | 2015-10-01 |
| CA2833706C (en) | 2014-10-21 |
| US20170112835A1 (en) | 2017-04-27 |
| JP5695680B2 (ja) | 2015-04-08 |
| CA2833852C (en) | 2014-10-21 |
| US9539258B2 (en) | 2017-01-10 |
| JP2013064024A (ja) | 2013-04-11 |
| EP3173084A1 (en) | 2017-05-31 |
| US20180360834A1 (en) | 2018-12-20 |
| CA2833706A1 (en) | 2007-05-18 |
| CA2833852A1 (en) | 2007-05-18 |
| EP3173084B1 (en) | 2019-10-23 |
| US8404697B2 (en) | 2013-03-26 |
| JP2009515851A (ja) | 2009-04-16 |
| US20090306044A1 (en) | 2009-12-10 |
| US20130178487A1 (en) | 2013-07-11 |
| CA2629244A1 (en) | 2007-05-18 |
| US9089571B2 (en) | 2015-07-28 |
| CA2629244C (en) | 2014-08-05 |
| WO2007054550A1 (en) | 2007-05-18 |
| EP1948179A1 (en) | 2008-07-30 |
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