JP5663699B2 - ピラゾール誘導体及びその医薬用途 - Google Patents

ピラゾール誘導体及びその医薬用途 Download PDF

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Publication number
JP5663699B2
JP5663699B2 JP2014514708A JP2014514708A JP5663699B2 JP 5663699 B2 JP5663699 B2 JP 5663699B2 JP 2014514708 A JP2014514708 A JP 2014514708A JP 2014514708 A JP2014514708 A JP 2014514708A JP 5663699 B2 JP5663699 B2 JP 5663699B2
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constipation
day
compound
administration
stool
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Japanese (ja)
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JPWO2013168671A1 (ja
Inventor
伊佐治　正幸
正幸 伊佐治
理明 竹村
理明 竹村
英俊 伊澤
英俊 伊澤
之彦 布袋
之彦 布袋
格 宮下
格 宮下
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Kissei Pharmaceutical Co Ltd
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Kissei Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014514708A 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途 Active JP5663699B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014514708A JP5663699B2 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012105847 2012-05-07
JP2012105847 2012-05-07
PCT/JP2013/062755 WO2013168671A1 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途
JP2014514708A JP5663699B2 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途

Related Child Applications (1)

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JP2014245645A Division JP6105546B2 (ja) 2012-05-07 2014-12-04 ピラゾール誘導体及びその医薬用途

Publications (2)

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JP5663699B2 true JP5663699B2 (ja) 2015-02-04
JPWO2013168671A1 JPWO2013168671A1 (ja) 2016-01-07

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JP2014514708A Active JP5663699B2 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途
JP2014245645A Active JP6105546B2 (ja) 2012-05-07 2014-12-04 ピラゾール誘導体及びその医薬用途

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US (2) US9273085B2 (enExample)
EP (1) EP2848254B1 (enExample)
JP (2) JP5663699B2 (enExample)
KR (1) KR101868991B1 (enExample)
CN (1) CN104284665B (enExample)
AU (1) AU2013258566B2 (enExample)
BR (1) BR112014027841B1 (enExample)
CA (1) CA2872002C (enExample)
DK (1) DK2848254T3 (enExample)
ES (1) ES2601127T3 (enExample)
MX (1) MX359988B (enExample)
PL (1) PL2848254T3 (enExample)
PT (1) PT2848254T (enExample)
RU (1) RU2602739C2 (enExample)
WO (1) WO2013168671A1 (enExample)

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MX386489B (es) 2010-11-04 2025-03-19 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepaticas.
US9273085B2 (en) * 2012-05-07 2016-03-01 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative and use thereof for medical purposes
MY176162A (en) 2013-02-04 2020-07-24 Taisho Pharmaceutical Co Ltd Prophylactic or therapeutic drug for constipation
KR20220082931A (ko) 2014-06-25 2022-06-17 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
JP6581082B2 (ja) * 2014-06-25 2019-09-25 Ｅａファーマ株式会社 固形製剤及びその安定化方法
BR112020019624A8 (pt) 2018-03-28 2022-03-03 Avolynt Método para tratar a hipoglicemia pós-prandial
ES2942443T3 (es) 2018-06-05 2023-06-01 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores de ácidos biliares
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
PT3810581T (pt) 2018-06-20 2025-03-05 Albireo Ab Modificações cristalinas de odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
PL3921028T3 (pl) 2019-02-06 2023-02-13 Albireo Ab Związki benzotiadiazepinowe i ich zastosowanie jako modulatory kwasów żółciowych
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
IL293379B1 (en) 2019-12-04 2025-12-01 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CA3158276A1 (en) 2019-12-04 2021-06-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
EP4069247B1 (en) 2019-12-04 2025-03-26 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
CN114761080B (zh) 2019-12-04 2024-07-23 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
ES3002777T3 (en) 2020-08-03 2025-03-07 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
EP4243831A1 (en) 2020-11-12 2023-09-20 Albireo AB Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
BR112023010799A2 (pt) 2020-12-04 2023-10-03 Albireo Ab Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2009128421A1 (ja) * 2008-04-16 2009-10-22 キッセイ薬品工業株式会社 ピラゾール誘導体の１／２フマル酸塩

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137245A (ja) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
CL2007001166A1 (es) * 2006-04-26 2008-01-25 Piramed Ltd Compuestos derivados de pirimidina condensada, inhibidores de pi3-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicion farmaceutica
JPWO2011002001A1 (ja) * 2009-07-01 2012-12-13 キッセイ薬品工業株式会社 ピラゾール誘導体とビグアナイド薬との組み合わせ医薬
AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
US9273085B2 (en) * 2012-05-07 2016-03-01 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative and use thereof for medical purposes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2009128421A1 (ja) * 2008-04-16 2009-10-22 キッセイ薬品工業株式会社 ピラゾール誘導体の１／２フマル酸塩

Non-Patent Citations (2)

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Title
JPN6014047874; Ｄｉａｂｅｔｅｓ　Ｊｏｕｒｎａｌ Ｖｏｌ．３１，　Ｎｏ．３, 2003, ｐ．８６-９１ *
JPN6014047875; モダンフィジシャン Ｖｏｌ．１８，　Ｎｏ．６, 1998, ｐ．７１７-７１９ *

Also Published As

Publication number Publication date
RU2602739C2 (ru) 2016-11-20
ES2601127T3 (es) 2017-02-14
RU2014149181A (ru) 2016-06-27
KR101868991B1 (ko) 2018-06-19
DK2848254T3 (en) 2016-10-31
WO2013168671A1 (ja) 2013-11-14
EP2848254A1 (en) 2015-03-18
BR112014027841A2 (pt) 2017-06-27
EP2848254B1 (en) 2016-08-03
PT2848254T (pt) 2016-10-05
JP6105546B2 (ja) 2017-03-29
US9273085B2 (en) 2016-03-01
CA2872002A1 (en) 2013-11-14
CN104284665B (zh) 2016-11-16
EP2848254A4 (en) 2015-07-15
BR112014027841B1 (pt) 2022-08-09
AU2013258566A1 (en) 2014-11-27
AU2013258566B2 (en) 2017-03-16
US20150141631A1 (en) 2015-05-21
MX2014013696A (es) 2015-02-05
HK1204773A1 (en) 2015-12-04
CA2872002C (en) 2019-01-15
PL2848254T3 (pl) 2017-03-31
JPWO2013168671A1 (ja) 2016-01-07
KR20150013671A (ko) 2015-02-05
BR112014027841A8 (pt) 2021-09-28
US9694027B2 (en) 2017-07-04
MX359988B (es) 2018-10-18
US20160129031A1 (en) 2016-05-12
CN104284665A (zh) 2015-01-14
JP2015083580A (ja) 2015-04-30

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