CA2872002C - Pyrazole derivative and use thereof for medical purposes - Google Patents
Pyrazole derivative and use thereof for medical purposes Download PDFInfo
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- CA2872002C CA2872002C CA2872002A CA2872002A CA2872002C CA 2872002 C CA2872002 C CA 2872002C CA 2872002 A CA2872002 A CA 2872002A CA 2872002 A CA2872002 A CA 2872002A CA 2872002 C CA2872002 C CA 2872002C
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- constipation
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- 238000007911 parenteral administration Methods 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 208000028591 pheochromocytoma Diseases 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000002325 prokinetic agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229960003863 prucalopride Drugs 0.000 description 1
- ZPMNHBXQOOVQJL-UHFFFAOYSA-N prucalopride Chemical compound C1CN(CCCOC)CCC1NC(=O)C1=CC(Cl)=C(N)C2=C1OCC2 ZPMNHBXQOOVQJL-UHFFFAOYSA-N 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000016160 smooth muscle contraction Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- GOZDTZWAMGHLDY-UHFFFAOYSA-L sodium picosulfate Chemical compound [Na+].[Na+].C1=CC(OS(=O)(=O)[O-])=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OS([O-])(=O)=O)C=C1 GOZDTZWAMGHLDY-UHFFFAOYSA-L 0.000 description 1
- 229960005077 sodium picosulfate Drugs 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001148 spastic effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960005345 trimebutine Drugs 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 description 1
- 201000007954 uterine fibroid Diseases 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-105847 | 2012-05-07 | ||
| JP2012105847 | 2012-05-07 | ||
| PCT/JP2013/062755 WO2013168671A1 (ja) | 2012-05-07 | 2013-05-02 | ピラゾール誘導体及びその医薬用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2872002A1 CA2872002A1 (en) | 2013-11-14 |
| CA2872002C true CA2872002C (en) | 2019-01-15 |
Family
ID=49550709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2872002A Active CA2872002C (en) | 2012-05-07 | 2013-05-02 | Pyrazole derivative and use thereof for medical purposes |
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| EP (1) | EP2848254B1 (enExample) |
| JP (2) | JP5663699B2 (enExample) |
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| CN (1) | CN104284665B (enExample) |
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| PT (1) | PT2848254T (enExample) |
| RU (1) | RU2602739C2 (enExample) |
| WO (1) | WO2013168671A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012064266A1 (en) | 2010-11-04 | 2012-05-18 | Albireo Ab | Ibat inhibitors for the treatment of liver diseases |
| PT2848254T (pt) * | 2012-05-07 | 2016-10-05 | Kissei Pharmaceutical | Derivado de pirazol e utilização do mesmo para propósitos médicos |
| RU2648467C2 (ru) | 2013-02-04 | 2018-03-26 | Тайсо Фармасьютикал Ко., Лтд. | Профилактическое или терапевтическое лекарственное средство для лечения запора |
| US20170143738A1 (en) * | 2014-06-25 | 2017-05-25 | Ea Pharma Co., Ltd. | Solid formulation and method for stabilizing the same |
| KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| WO2019191352A1 (en) | 2018-03-28 | 2019-10-03 | Avolynt | Method for treating post-prandial hypoglycemia |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| AU2020218908B2 (en) | 2019-02-06 | 2025-01-23 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CA3158181A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3158184A1 (en) | 2019-12-04 | 2021-08-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| DK4069360T3 (da) | 2019-12-04 | 2024-02-26 | Albireo Ab | Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer |
| CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| JP2024500309A (ja) | 2020-12-04 | 2024-01-09 | アルビレオ エービー | ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| CA2650295C (en) * | 2006-04-26 | 2015-12-29 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them |
| BRPI0821773B8 (pt) * | 2007-12-27 | 2021-05-25 | Kissei Pharmaceutical | monossebacato cristalino de bis[3-(3-{4-[3-(beta-dglicopiranosilóxi)-5-isopropil-1h-pirazol-4-ilmetil]-3-metilfenóxi}propilamino)-2,2-dimetil-propionamida], composição farmacêutica e medicamento compreendendo o dito composto |
| WO2009128421A1 (ja) * | 2008-04-16 | 2009-10-22 | キッセイ薬品工業株式会社 | ピラゾール誘導体の１／２フマル酸塩 |
| TW201105336A (en) * | 2009-07-01 | 2011-02-16 | Kissei Pharmaceutical | Combined medicine of pyrazole derivative and biguanide drug |
| AR087701A1 (es) | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| PT2848254T (pt) * | 2012-05-07 | 2016-10-05 | Kissei Pharmaceutical | Derivado de pirazol e utilização do mesmo para propósitos médicos |
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2013
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- 2013-05-02 JP JP2014514708A patent/JP5663699B2/ja active Active
- 2013-05-02 US US14/399,093 patent/US9273085B2/en active Active
- 2013-05-02 RU RU2014149181/15A patent/RU2602739C2/ru active
- 2013-05-02 CN CN201380024202.3A patent/CN104284665B/zh active Active
- 2013-05-02 MX MX2014013696A patent/MX359988B/es active IP Right Grant
- 2013-05-02 DK DK13787714.8T patent/DK2848254T3/en active
- 2013-05-02 KR KR1020147033887A patent/KR101868991B1/ko active Active
- 2013-05-02 ES ES13787714.8T patent/ES2601127T3/es active Active
- 2013-05-02 PL PL13787714T patent/PL2848254T3/pl unknown
- 2013-05-02 AU AU2013258566A patent/AU2013258566B2/en active Active
- 2013-05-02 CA CA2872002A patent/CA2872002C/en active Active
- 2013-05-02 EP EP13787714.8A patent/EP2848254B1/en active Active
- 2013-05-02 WO PCT/JP2013/062755 patent/WO2013168671A1/ja not_active Ceased
- 2013-05-02 BR BR112014027841-5A patent/BR112014027841B1/pt active IP Right Grant
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2014
- 2014-12-04 JP JP2014245645A patent/JP6105546B2/ja active Active
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2016
- 2016-01-14 US US14/995,489 patent/US9694027B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104284665B (zh) | 2016-11-16 |
| US20160129031A1 (en) | 2016-05-12 |
| DK2848254T3 (en) | 2016-10-31 |
| EP2848254B1 (en) | 2016-08-03 |
| PL2848254T3 (pl) | 2017-03-31 |
| AU2013258566B2 (en) | 2017-03-16 |
| ES2601127T3 (es) | 2017-02-14 |
| MX359988B (es) | 2018-10-18 |
| MX2014013696A (es) | 2015-02-05 |
| JPWO2013168671A1 (ja) | 2016-01-07 |
| BR112014027841B1 (pt) | 2022-08-09 |
| HK1204773A1 (en) | 2015-12-04 |
| BR112014027841A8 (pt) | 2021-09-28 |
| EP2848254A1 (en) | 2015-03-18 |
| US9694027B2 (en) | 2017-07-04 |
| EP2848254A4 (en) | 2015-07-15 |
| WO2013168671A1 (ja) | 2013-11-14 |
| AU2013258566A1 (en) | 2014-11-27 |
| KR20150013671A (ko) | 2015-02-05 |
| PT2848254T (pt) | 2016-10-05 |
| BR112014027841A2 (pt) | 2017-06-27 |
| CN104284665A (zh) | 2015-01-14 |
| RU2602739C2 (ru) | 2016-11-20 |
| JP5663699B2 (ja) | 2015-02-04 |
| US9273085B2 (en) | 2016-03-01 |
| KR101868991B1 (ko) | 2018-06-19 |
| CA2872002A1 (en) | 2013-11-14 |
| JP2015083580A (ja) | 2015-04-30 |
| JP6105546B2 (ja) | 2017-03-29 |
| US20150141631A1 (en) | 2015-05-21 |
| RU2014149181A (ru) | 2016-06-27 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20171207 |