CN104284665B - 吡唑衍生物及其医药用途 - Google Patents

吡唑衍生物及其医药用途 Download PDF

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Publication number
CN104284665B
CN104284665B CN201380024202.3A CN201380024202A CN104284665B CN 104284665 B CN104284665 B CN 104284665B CN 201380024202 A CN201380024202 A CN 201380024202A CN 104284665 B CN104284665 B CN 104284665B
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constipation
compound
group
day
administration
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Chinese (zh)
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CN104284665A (zh
Inventor
伊佐治正幸
竹村理明
伊泽英俊
布袋之彦
宫下格
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Kissei Pharmaceutical Co Ltd
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Kissei Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380024202.3A 2012-05-07 2013-05-02 吡唑衍生物及其医药用途 Active CN104284665B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-105847 2012-05-07
JP2012105847 2012-05-07
PCT/JP2013/062755 WO2013168671A1 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途

Publications (2)

Publication Number Publication Date
CN104284665A CN104284665A (zh) 2015-01-14
CN104284665B true CN104284665B (zh) 2016-11-16

Family

ID=49550709

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CN201380024202.3A Active CN104284665B (zh) 2012-05-07 2013-05-02 吡唑衍生物及其医药用途

Country Status (15)

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US (2) US9273085B2 (enExample)
EP (1) EP2848254B1 (enExample)
JP (2) JP5663699B2 (enExample)
KR (1) KR101868991B1 (enExample)
CN (1) CN104284665B (enExample)
AU (1) AU2013258566B2 (enExample)
BR (1) BR112014027841B1 (enExample)
CA (1) CA2872002C (enExample)
DK (1) DK2848254T3 (enExample)
ES (1) ES2601127T3 (enExample)
MX (1) MX359988B (enExample)
PL (1) PL2848254T3 (enExample)
PT (1) PT2848254T (enExample)
RU (1) RU2602739C2 (enExample)
WO (1) WO2013168671A1 (enExample)

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PL3400944T3 (pl) 2010-11-04 2020-11-16 Albireo Ab Inhibitory ibat w leczeniu chorób wątroby
PL2848254T3 (pl) * 2012-05-07 2017-03-31 Kissei Pharmaceutical Co., Ltd. Pochodne pirazolu i ich zastosowanie w celach medycznych
MX346453B (es) 2013-02-04 2017-03-17 Taisho Pharmaceutical Co Ltd Medicamento profilactico o terapeutico para el estreñimiento.
KR102560954B1 (ko) 2014-06-25 2023-07-31 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
WO2015199146A1 (ja) * 2014-06-25 2015-12-30 味の素株式会社 固形製剤及びその安定化方法
BR112020019624A8 (pt) 2018-03-28 2022-03-03 Avolynt Método para tratar a hipoglicemia pós-prandial
EP3802504B1 (en) 2018-06-05 2023-01-18 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
EP3810084A1 (en) 2018-06-20 2021-04-28 Albireo AB Pharmaceutical formulation of odevixibat
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
DK3921028T3 (da) 2019-02-06 2023-01-23 Albireo Ab Benzothiadiazepinforbindelser og anvendelse deraf som galdesyremodulatorer
CN114761018B (zh) 2019-12-04 2025-12-02 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
DK4069360T3 (da) 2019-12-04 2024-02-26 Albireo Ab Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer
ES2972045T3 (es) 2019-12-04 2024-06-10 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
JP7696897B2 (ja) 2019-12-04 2025-06-23 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CN116157389B (zh) 2020-08-03 2026-02-10 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
WO2022117778A1 (en) 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2011002001A1 (ja) * 2009-07-01 2011-01-06 キッセイ薬品工業株式会社 ピラゾール誘導体とビグアナイド薬との組み合わせ医薬

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137245A (ja) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
MX2008013583A (es) * 2006-04-26 2008-10-31 Genentech Inc Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen.
US8354382B2 (en) 2008-04-16 2013-01-15 Kissei Pharmaceutical Co., Ltd. Hemifumarate of a pyrazole derivative
AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
PL2848254T3 (pl) * 2012-05-07 2017-03-31 Kissei Pharmaceutical Co., Ltd. Pochodne pirazolu i ich zastosowanie w celach medycznych

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2011002001A1 (ja) * 2009-07-01 2011-01-06 キッセイ薬品工業株式会社 ピラゾール誘導体とビグアナイド薬との組み合わせ医薬

Also Published As

Publication number Publication date
BR112014027841B1 (pt) 2022-08-09
RU2602739C2 (ru) 2016-11-20
US9694027B2 (en) 2017-07-04
US20150141631A1 (en) 2015-05-21
EP2848254B1 (en) 2016-08-03
DK2848254T3 (en) 2016-10-31
JPWO2013168671A1 (ja) 2016-01-07
CA2872002C (en) 2019-01-15
PL2848254T3 (pl) 2017-03-31
PT2848254T (pt) 2016-10-05
CA2872002A1 (en) 2013-11-14
US9273085B2 (en) 2016-03-01
WO2013168671A1 (ja) 2013-11-14
JP2015083580A (ja) 2015-04-30
KR101868991B1 (ko) 2018-06-19
BR112014027841A2 (pt) 2017-06-27
AU2013258566B2 (en) 2017-03-16
KR20150013671A (ko) 2015-02-05
JP5663699B2 (ja) 2015-02-04
CN104284665A (zh) 2015-01-14
AU2013258566A1 (en) 2014-11-27
MX359988B (es) 2018-10-18
JP6105546B2 (ja) 2017-03-29
ES2601127T3 (es) 2017-02-14
HK1204773A1 (en) 2015-12-04
US20160129031A1 (en) 2016-05-12
EP2848254A4 (en) 2015-07-15
RU2014149181A (ru) 2016-06-27
MX2014013696A (es) 2015-02-05
EP2848254A1 (en) 2015-03-18
BR112014027841A8 (pt) 2021-09-28

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