JP5583586B2 - グリコール酸の生産のための固定化微生物ニトリラーゼの改善 - Google Patents

グリコール酸の生産のための固定化微生物ニトリラーゼの改善 Download PDF

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JP5583586B2
JP5583586B2 JP2010532268A JP2010532268A JP5583586B2 JP 5583586 B2 JP5583586 B2 JP 5583586B2 JP 2010532268 A JP2010532268 A JP 2010532268A JP 2010532268 A JP2010532268 A JP 2010532268A JP 5583586 B2 JP5583586 B2 JP 5583586B2
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nitrilase
glutaraldehyde
catalyst
enzyme
seq
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JP2011501970A (ja
JP2011501970A5 (enExample
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ロバート・ディコージモ
アリー・ベン−バサト
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EIDP Inc
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EI Du Pont de Nemours and Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010532268A 2007-10-31 2008-10-31 グリコール酸の生産のための固定化微生物ニトリラーゼの改善 Active JP5583586B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/930,744 2007-10-31
US11/930,744 US7741088B2 (en) 2007-10-31 2007-10-31 Immobilized microbial nitrilase for production of glycolic acid
PCT/US2008/081952 WO2009059104A1 (en) 2007-10-31 2008-10-31 Improvement in immobilized microbial nitrilase for production of glycolic acid

Publications (3)

Publication Number Publication Date
JP2011501970A JP2011501970A (ja) 2011-01-20
JP2011501970A5 JP2011501970A5 (enExample) 2011-12-15
JP5583586B2 true JP5583586B2 (ja) 2014-09-03

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JP2010532268A Active JP5583586B2 (ja) 2007-10-31 2008-10-31 グリコール酸の生産のための固定化微生物ニトリラーゼの改善

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US (2) US7741088B2 (enExample)
EP (1) EP2215226B9 (enExample)
JP (1) JP5583586B2 (enExample)
CN (1) CN102016018B (enExample)
DK (1) DK2215226T3 (enExample)
ES (1) ES2562791T3 (enExample)
PL (1) PL2215226T3 (enExample)
WO (1) WO2009059104A1 (enExample)

Families Citing this family (9)

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EP2480661A1 (en) * 2009-09-24 2012-08-01 UCB Pharma, S.A. Bacterial host strain
CA2796158C (en) 2010-04-14 2022-06-14 Strategic Enzyme Applications, Inc. Process for producing phosphinothricin employing nitrilases
WO2012003336A2 (en) 2010-06-30 2012-01-05 Codexis, Inc. Chemically modified carbonic anhydrases useful in carbon capture systems
WO2012048865A2 (de) * 2010-10-12 2012-04-19 C-Lecta Gmbh Nitrilasen
EP3354742A1 (en) 2017-01-26 2018-08-01 Metabolic Explorer Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid
CN108486088B (zh) 2018-02-14 2021-02-02 浙江工业大学 腈水解酶突变体及其应用
CN113195727A (zh) * 2018-10-18 2021-07-30 巴斯夫欧洲公司 用于产生丙烯酸或其盐的方法
CN112063607B (zh) * 2020-10-09 2021-12-07 浙江工业大学 一种腈水解酶突变体及其在催化合成2-氯烟酸中的应用
CN119570649A (zh) * 2024-07-12 2025-03-07 北京衍微科技有限公司 含红球菌发酵液的复合催化剂及其用途

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US2175805A (en) 1937-06-08 1939-10-10 Du Pont Stabilized organic nitrile and process of making
US2890238A (en) 1957-01-31 1959-06-09 Dow Chemical Co Preparation of glyconitrile
FR2245585B1 (enExample) * 1973-09-19 1976-05-14 Anvar
DK146942C (da) 1978-04-19 1984-07-30 Novo Industri As Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
US4355105A (en) * 1981-03-30 1982-10-19 Miles Laboratories, Inc. Glutaraldehyde/polyethylenimine immobilization of whole microbial cells
JPS6156086A (ja) 1984-08-27 1986-03-20 Asahi Chem Ind Co Ltd α−オキシ酸およびその塩の微生物学的製造法
US5187301A (en) 1989-10-26 1993-02-16 W. R. Grace & Co.-Conn. Preparation of iminodiacetonitrile from glycolonitrile
DE69131217T2 (de) * 1990-03-30 1999-09-23 Mitsubishi Rayon Co., Ltd. Verfahren zur Herstellung von R(-)Mandelsäure und deren Derivaten
JP2974737B2 (ja) * 1990-08-16 1999-11-10 三菱レイヨン株式会社 光学活性乳酸の製造法
DE69126762T2 (de) 1990-11-14 1997-10-23 Nitto Chemical Industry Co Ltd Biologisches Verfahren zur Herstellung von Alpha-Hydroxyamid und Alpha-Hydroxysäure
JP2676568B2 (ja) * 1991-06-26 1997-11-17 日東化学工業株式会社 Ｒ（−）−マンデル酸およびその誘導体の製造法
US5846762A (en) 1992-08-26 1998-12-08 Lockheed Martin Energy Research Systems, Inc. Structurally stable gel bead containing entrapped enzyme and method for manufacture thereof
JP3218133B2 (ja) 1993-02-03 2001-10-15 三菱レイヨン株式会社 フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法
JP2720140B2 (ja) 1993-02-03 1998-02-25 日東化学工業株式会社 フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法
JP3354688B2 (ja) 1994-01-28 2002-12-09 三菱レイヨン株式会社 微生物によるα−ヒドロキシ酸またはα−ヒドロキシアミドの製造法
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
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JP3154646B2 (ja) 1995-07-19 2001-04-09 三菱レイヨン株式会社 グリコール酸の微生物学的製造法
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DE102005015570A1 (de) 2005-04-05 2006-10-12 Robert Bosch Gmbh Druckregelventil
CN101278047B (zh) 2005-09-30 2012-12-12 诺维信公司 酶的固定化

Also Published As

Publication number Publication date
PL2215226T3 (pl) 2016-06-30
US20090111148A1 (en) 2009-04-30
ES2562791T3 (es) 2016-03-08
DK2215226T3 (en) 2016-03-07
JP2011501970A (ja) 2011-01-20
EP2215226A1 (en) 2010-08-11
WO2009059104A1 (en) 2009-05-07
US7741088B2 (en) 2010-06-22
US7867748B2 (en) 2011-01-11
CN102016018A (zh) 2011-04-13
EP2215226B9 (en) 2016-03-02
CN102016018B (zh) 2013-09-25
ES2562791T9 (es) 2016-04-18
EP2215226B1 (en) 2015-12-02
US20100136656A1 (en) 2010-06-03

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