JP5537946B2 - Igf−irを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬 - Google Patents
Igf−irを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬 Download PDFInfo
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- JP5537946B2 JP5537946B2 JP2009538410A JP2009538410A JP5537946B2 JP 5537946 B2 JP5537946 B2 JP 5537946B2 JP 2009538410 A JP2009538410 A JP 2009538410A JP 2009538410 A JP2009538410 A JP 2009538410A JP 5537946 B2 JP5537946 B2 JP 5537946B2
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- igf
- protein
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- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A61K38/18—Growth factors; Growth regulators
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/765—Serum albumin, e.g. HSA
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
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- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86060506P | 2006-11-22 | 2006-11-22 | |
| US60/860,605 | 2006-11-22 | ||
| US87966607P | 2007-01-09 | 2007-01-09 | |
| US60/879,666 | 2007-01-09 | ||
| PCT/US2007/024316 WO2008066752A2 (en) | 2006-11-22 | 2007-11-21 | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010510315A JP2010510315A (ja) | 2010-04-02 |
| JP2010510315A5 JP2010510315A5 (https=) | 2010-09-02 |
| JP5537946B2 true JP5537946B2 (ja) | 2014-07-02 |
Family
ID=39468472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009538410A Expired - Fee Related JP5537946B2 (ja) | 2006-11-22 | 2007-11-21 | Igf−irを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8470332B2 (https=) |
| EP (3) | EP2727936B1 (https=) |
| JP (1) | JP5537946B2 (https=) |
| KR (1) | KR20090110295A (https=) |
| AU (1) | AU2007325838B2 (https=) |
| BR (1) | BRPI0719597A2 (https=) |
| CA (1) | CA2670471A1 (https=) |
| CO (1) | CO6390070A2 (https=) |
| IL (1) | IL198872A0 (https=) |
| MX (1) | MX2009005466A (https=) |
| WO (1) | WO2008066752A2 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1711196A4 (en) | 2003-12-05 | 2011-09-14 | Bristol Myers Squibb Co | INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS |
| MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| EP2111228B1 (en) * | 2007-02-02 | 2011-07-20 | Bristol-Myers Squibb Company | 10Fn3 domain for use in treating diseases associated with inappropriate angiogenesis |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US8633297B2 (en) | 2007-10-31 | 2014-01-21 | Medimmune, Llc | Protein scaffolds |
| US9885050B2 (en) | 2007-11-08 | 2018-02-06 | The University Of Chicago | Molecular affinity clamp technology and uses thereof |
| AU2009213141A1 (en) * | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind EGFR |
| WO2009142773A2 (en) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
| NZ591543A (en) * | 2008-09-30 | 2012-11-30 | Abbott Lab | Improved antibody libraries |
| BRPI0921469B1 (pt) * | 2008-11-03 | 2022-01-18 | Molecular Partners Ag | Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| ES2410579T5 (es) | 2008-12-16 | 2021-10-04 | Novartis Ag | Sistemas de despliegue de levaduras |
| ES2691717T3 (es) | 2009-10-30 | 2018-11-28 | Novartis Ag | Bibliotecas universales del dominio de unión del lado inferior de tipo iii de la fibronectina de tipo III |
| EP2336155A1 (en) | 2009-12-21 | 2011-06-22 | Centre National de la Recherche Scientifique (CNRS) | Antimicrobial peptides |
| ES2759015T3 (es) | 2010-02-10 | 2020-05-07 | Mayo Found Medical Education & Res | Métodos y materiales para tratar el cáncer |
| JP2013520426A (ja) | 2010-02-18 | 2013-06-06 | ブリストル−マイヤーズ スクイブ カンパニー | Il−23に結合する、フィブロネクチンをベースとする足場ドメインタンパク質 |
| WO2011130324A1 (en) | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
| EP2558491B1 (en) | 2010-04-13 | 2018-07-04 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind pcsk9 |
| TW201138808A (en) * | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
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| EP2727936A1 (en) | 2014-05-07 |
| US20100121033A1 (en) | 2010-05-13 |
| WO2008066752A3 (en) | 2009-03-05 |
| WO2008066752A8 (en) | 2009-07-09 |
| IL198872A0 (en) | 2011-08-01 |
| EP2121743B1 (en) | 2015-06-03 |
| AU2007325838A2 (en) | 2010-06-24 |
| US20170190761A1 (en) | 2017-07-06 |
| EP3156415A1 (en) | 2017-04-19 |
| US10221232B2 (en) | 2019-03-05 |
| CO6390070A2 (es) | 2012-02-29 |
| US8470332B2 (en) | 2013-06-25 |
| MX2009005466A (es) | 2009-08-17 |
| EP2727936B1 (en) | 2016-09-07 |
| US11149077B2 (en) | 2021-10-19 |
| BRPI0719597A2 (pt) | 2013-12-17 |
| AU2007325838A1 (en) | 2008-06-05 |
| AU2007325838B2 (en) | 2013-09-19 |
| WO2008066752A2 (en) | 2008-06-05 |
| US20150252097A1 (en) | 2015-09-10 |
| JP2010510315A (ja) | 2010-04-02 |
| EP2121743A2 (en) | 2009-11-25 |
| US20130310317A1 (en) | 2013-11-21 |
| CA2670471A1 (en) | 2008-06-05 |
| KR20090110295A (ko) | 2009-10-21 |
| US20190202894A1 (en) | 2019-07-04 |
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