JP5497451B2 - 創傷治癒・皮膚再建材 - Google Patents
創傷治癒・皮膚再建材 Download PDFInfo
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- JP5497451B2 JP5497451B2 JP2009544707A JP2009544707A JP5497451B2 JP 5497451 B2 JP5497451 B2 JP 5497451B2 JP 2009544707 A JP2009544707 A JP 2009544707A JP 2009544707 A JP2009544707 A JP 2009544707A JP 5497451 B2 JP5497451 B2 JP 5497451B2
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- Prior art keywords
- wound
- skin
- growth factor
- wound healing
- factor
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 46
- 150000001413 amino acids Chemical group 0.000 claims description 21
- 231100000241 scar Toxicity 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 206010027145 Melanocytic naevus Diseases 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 6
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- 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims description 6
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- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 6
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims description 6
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 6
- 102000004890 Interleukin-8 Human genes 0.000 claims description 6
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Description
2 真皮層
3 皮下組織
((XY)l−(ZY)m)n (I)
((YX)l−(YZ)m)n (II)
((ZY)l−(XY)m)n (III)
((YZ)l−(YX)m)n (IV)
(式(I)〜(IV)中、Xは酸性アミノ酸、Yは疎水性アミノ酸、Zは塩基性アミノ酸を表し、l、mおよびnは共に整数(n×(l+m)<200)である。)
また、そのN末端はアセチル化されていてもよく、C末端はアミド化されていてもよい。
(a)マウス皮膚創傷モデルの作製
実験動物として、NTaC:NIHS−Foxn1<nu>系ヌードマウス(雌性、体重〜20g)30匹を用いた。マウスは、本実験中、約17〜26℃、湿度30〜70%、12時間の明暗サイクル、最低1時間に10回の換気、1日1回の給餌と、自由に飲水できる条件下で飼育した。
(b−1)遠心チューブを冷水浴に置き、30分間超音波処理し、1分間ボルテックスミキサーにかけ、室温で遠心分離(3000rpm、1分)して気泡を除去した。すべての気泡を除去できるまで、ボルテックス処理と遠心分離を繰り返すことにより、1%PuraMatrix(登録商標)の水溶液を調製し、処置群−1に用いた。
(a)で作製した皮膚創傷モデルマウス30匹を各群10匹の3群にわけ、外科処置後に表1の設定で処置を行った。外科手術(創傷作製)の日を0日目とした。創傷部の観察は、0日目の処置直前(図1)、7日目(図2)、14日目(図3)、21日目(図4)および28日目(図5)に行なった。
3群のヌードマウスの皮膚の創傷治癒のパラメーターを評価するために、組織病理学試験を行った。
0=再上皮化なし。
1=部分的な再上皮化。(創傷表面は上皮によって完全に覆われてはいない。)
2=全創傷面にわたる再上皮化であるが、上皮組織は、多重層(基底層、有棘層、顆粒層)を有する重層扁平上皮ではない。
3=重層扁平上皮および角質化を伴う全創傷面にわたる再上皮化であるが、アポトーシス細胞または壊死細胞または異常角化症の形態の出現頻度が高い組織修復の跡、または多重有糸分裂像、または不規則な厚さまたは不規則な層(過形成)がみられる。
4=重層扁平上皮の角質化による組織修復、再構成を伴った正常範囲内での完全な再上皮化(ただ正常でない点としては治癒部真皮内に毛包および腺組織がみられない点がある)。
0=正常真皮と比較して減少した血管分布像。
1=正常範囲内の真皮血管分布像。
2=真皮または創傷部の毛細血管の突出の極わずかな増加。この突出の増加は、おそらく、数の増加、膨張(うっ血または充血)およびサイズの増大による。
3=真皮または創傷部におけるよく発達した毛細血管の軽度の増加。
4=真皮または創傷部におけるよく発達した毛細血管の中程度の増加。
0=炎症細胞の増加なし(ヌードマウスの真皮での正常範囲内)。
1=炎症細胞の極少ない増加。炎症は多発性で血管周囲にある傾向。
2=炎症細胞の軽度の増加。炎症は多発性で血管周囲にある傾向。
3=炎症細胞の中程度の増加。
4=炎症細胞の顕著な増加。
0=創傷における線維増殖および/またはコラーゲンなし。
1=創傷の肉芽組織における最小から軽度の線維増殖。
2=創傷全体に渡って中程度の線維増殖およびコラーゲンが存在
3=創傷の浅部に正常な真皮コラーゲンに類似した密度の高いコラーゲンが存在
4=創傷全体に渡って密度の高いコラーゲン。相対的にわずかな線維芽細胞があり、コラーゲンがわずかに正常真皮よりも密度が高い。
創傷部の上皮下のコラーゲンの厚さ(μm)は、対物マイクロメータ(×10)で校正した接眼マイクロメータを用いてコラーゲンの最も厚い部分で測定した。
Claims (3)
- 配列番号1記載のアミノ酸配列を有する自己組織化ペプチドおよびbFGFを含有する創傷治癒・皮膚再建材。
- 前記創傷治癒・皮膚再建材が、皮膚陥凹、にきび、にきび跡陥凹、肥厚性瘢痕、ケロイド、母斑、色素性母斑治療における陥凹部の新たな皮膚の形成のためのものである請求項1記載の創傷治癒・皮膚再建材。
- さらに、ヨウ素、塩化リゾチーム、ジメチルイソプロピルアズレン、トレチノイントコフェリル、精製白糖・ポピドンヨード、アルプロスタジルアルファデクス、アニスアルコール、サリチル酸イソアミル、α,α−ジメチルフェニルエチルアルコール、バグダノール、ヘリオナール、スルファジン銀、ブクラデシンナトリウム、アルプロスタジルアルファデクス、硫酸ゲンタマイシン、塩酸テトラサイクリン、フシジン酸ナトリウム、ムピロシンカルシウム水和物および安息香酸イソアミルからなる群から選択される低分子薬剤、血清、血漿、血小板、多血小板血漿、フィブリン、フィブリノーゲン、プロトロンビン、トロンビン、トロンボプラスチン、プラスミノゲン、アルブミンおよびコレステロールからなる群から選択される血液成分、および/または血小板由来増殖因子(PDGF)、トランスフォーミング成長因子−α(TGF−α)、トランスフォーミング成長因子−β(TGF−β)、インスリン様増殖因子(IGF)、コロニー刺激因子(CSF)、インターロイキン−8(IL−8)、ケラチノサイト増殖因子(KGF)、上皮細胞成長因子(EGF)、インスリン、ハイドロコーチゾン、ウロガストロン、血小板由来創傷治癒因子(PDWHF)、血管内皮細胞増殖因子(VEGF)、神経成長因子(NGF)、肝細胞増殖因子(HGF)、脳由来神経栄養因子(BDNF)、血小板因子IV(PF IV)、骨形成タンパク質(BMP)および成長分化因子(GDF)からなる群から選択される生理活性物質を含む請求項1または2記載の創傷治癒・皮膚再建材。
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JP2009544707A JP5497451B2 (ja) | 2007-12-05 | 2008-12-04 | 創傷治癒・皮膚再建材 |
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PCT/JP2008/072047 WO2009072556A1 (ja) | 2007-12-05 | 2008-12-04 | 創傷治癒・皮膚再建材 |
JP2009544707A JP5497451B2 (ja) | 2007-12-05 | 2008-12-04 | 創傷治癒・皮膚再建材 |
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JP2014043213A Pending JP2014139201A (ja) | 2007-12-05 | 2014-03-05 | 創傷治癒・皮膚再建材 |
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US (2) | US20110002880A1 (ja) |
EP (1) | EP2229960B1 (ja) |
JP (2) | JP5497451B2 (ja) |
ES (1) | ES2534770T3 (ja) |
WO (1) | WO2009072556A1 (ja) |
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US9162005B2 (en) | 2005-04-25 | 2015-10-20 | Arch Biosurgery, Inc. | Compositions for prevention of adhesions and other barrier applications |
BRPI0920030B1 (pt) | 2008-10-06 | 2019-03-26 | 3-D Matrix, Ltd. | Agente de oclusão do tecido, agentes hemostáticos, preventivos e de oclusão ou escleroterapia relacionados, e infusão do tecido mucosal |
JP5732691B2 (ja) * | 2010-01-14 | 2015-06-10 | 学校法人同志社 | インスリン製剤 |
JP2012082180A (ja) * | 2010-10-14 | 2012-04-26 | Nagoya Univ | 骨再生用自己組織化ペプチドハイドロゲル |
WO2012070971A1 (ru) * | 2010-11-22 | 2012-05-31 | Farber Boris Slavinovich | Косметологическая и фармацевтическая композиция для омоложения и восстанов- ления кожи, в том числе после хирургических операций |
KR101318031B1 (ko) | 2011-08-17 | 2013-10-14 | 강원대학교산학협력단 | 염증성 및 자가면역성 질환 치료용 약학 조성물 |
US20140329914A1 (en) * | 2011-09-02 | 2014-11-06 | 3-D Matrix Ltd. | Amphiphilic Peptides for Thoracic Air Leakage Occlusion |
US11260072B2 (en) | 2011-09-07 | 2022-03-01 | 3-D Matrix, Ltd. | MicroRNA-based methods and assays for osteocarcinoma |
US10905708B2 (en) | 2011-09-07 | 2021-02-02 | 3-D Matrix, Ltd. | MicroRNA-based methods and assays for osteocarcinoma |
US20150105336A1 (en) * | 2012-03-09 | 2015-04-16 | 3-D Matrix, Ltd. | Mucosa-elevating agent |
EP2869903B1 (en) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Fill-finish process for peptide solutions |
EP2928513B1 (en) * | 2012-12-07 | 2018-06-06 | Kansas State University Research Foundation | Peptide-albumin hydrogel properties and its applications |
KR20160003651A (ko) * | 2013-03-14 | 2016-01-11 | 가부시끼가이샤 쓰리디 매트릭스 | 위장 폐색 예방용 물질 |
ES2756531T3 (es) * | 2013-08-22 | 2020-04-27 | Arch Biosurgery Inc | Mallas implantables para controlar el movimiento de fluidos |
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JPWO2009072556A1 (ja) | 2011-04-28 |
EP2229960B1 (en) | 2015-04-08 |
ES2534770T3 (es) | 2015-04-28 |
EP2229960A1 (en) | 2010-09-22 |
US20130296239A1 (en) | 2013-11-07 |
EP2229960A4 (en) | 2013-02-20 |
JP2014139201A (ja) | 2014-07-31 |
WO2009072556A1 (ja) | 2009-06-11 |
US20110002880A1 (en) | 2011-01-06 |
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