WO2009072556A1 - 創傷治癒・皮膚再建材 - Google Patents

創傷治癒・皮膚再建材 Download PDF

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Publication number
WO2009072556A1
WO2009072556A1 PCT/JP2008/072047 JP2008072047W WO2009072556A1 WO 2009072556 A1 WO2009072556 A1 WO 2009072556A1 JP 2008072047 W JP2008072047 W JP 2008072047W WO 2009072556 A1 WO2009072556 A1 WO 2009072556A1
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
wound healing
reconstruction material
skin reconstruction
amino acids
Prior art date
Application number
PCT/JP2008/072047
Other languages
English (en)
French (fr)
Inventor
Kentaro Takamura
Jiro Takei
Original Assignee
3-D Matrix, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3-D Matrix, Ltd. filed Critical 3-D Matrix, Ltd.
Priority to JP2009544707A priority Critical patent/JP5497451B2/ja
Priority to EP08857996.6A priority patent/EP2229960B1/en
Priority to ES08857996.6T priority patent/ES2534770T3/es
Priority to US12/746,520 priority patent/US20110002880A1/en
Publication of WO2009072556A1 publication Critical patent/WO2009072556A1/ja
Priority to US13/724,519 priority patent/US20130296239A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Abstract

　本発明は、ペプチドを含有する創傷治癒・皮膚再建材であって、該ペプチドが、親水性アミノ酸と疎水性アミノ酸とが交互に結合し、アミノ酸残基８～２００を有する両親媒性のペプチドであり、一価のイオンの存在下、水溶液中で安定なβシート構造を示す自己組織化ペプチドである創傷治癒・皮膚再建材に関する。本発明の創傷治癒・皮膚再建材は、哺乳動物の創傷部を自然治癒よりも早く、かつ瘢痕を残さずに治癒させ、ウイルスなどの感染性の懸念がない。
PCT/JP2008/072047 2007-12-05 2008-12-04 創傷治癒・皮膚再建材 WO2009072556A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009544707A JP5497451B2 (ja) 2007-12-05 2008-12-04 創傷治癒・皮膚再建材
EP08857996.6A EP2229960B1 (en) 2007-12-05 2008-12-04 Wound healing/skin reconstruction material
ES08857996.6T ES2534770T3 (es) 2007-12-05 2008-12-04 Material para la curación de heridas y la reconstrucción de la piel
US12/746,520 US20110002880A1 (en) 2007-12-05 2008-12-04 Material For Wound Healing and Skin Reconstruction
US13/724,519 US20130296239A1 (en) 2007-12-05 2012-12-21 Material for Wound Healing and Skin Reconstruction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-314640 2007-12-05
JP2007314640 2007-12-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/746,520 A-371-Of-International US20110002880A1 (en) 2007-12-05 2008-12-04 Material For Wound Healing and Skin Reconstruction
US13/724,519 Division US20130296239A1 (en) 2007-12-05 2012-12-21 Material for Wound Healing and Skin Reconstruction

Publications (1)

Publication Number Publication Date
WO2009072556A1 true WO2009072556A1 (ja) 2009-06-11

Family

ID=40717733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072047 WO2009072556A1 (ja) 2007-12-05 2008-12-04 創傷治癒・皮膚再建材

Country Status (5)

Country Link
US (2) US20110002880A1 (ja)
EP (1) EP2229960B1 (ja)
JP (2) JP5497451B2 (ja)
ES (1) ES2534770T3 (ja)
WO (1) WO2009072556A1 (ja)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011087024A1 (ja) * 2010-01-14 2011-07-21 学校法人同志社 インスリン製剤
JP2012082180A (ja) * 2010-10-14 2012-04-26 Nagoya Univ 骨再生用自己組織化ペプチドハイドロゲル
WO2012070971A1 (ru) * 2010-11-22 2012-05-31 Farber Boris Slavinovich Косметологическая и фармацевтическая композиция для омоложения и восстанов- ления кожи, в том числе после хирургических операций
WO2013030673A3 (en) * 2011-09-02 2013-10-31 3-D Matrix Ltd. Amphiphilic peptides for thoracic air leakage occlusion
JP2016515113A (ja) * 2013-03-14 2016-05-26 株式会社スリー・ディー・マトリックス 消化管閉塞の予防のための材料
CN109010906A (zh) * 2018-08-16 2018-12-18 陈明远 一种促进术后伤口局部止血及促进术后创面上皮化的生物胶水及其工作方法
US10245299B2 (en) 2014-03-10 2019-04-02 3-D Matrix, Ltd. Autoassembling peptides for the treatment of pulmonary bulla
CN110201000A (zh) * 2019-07-11 2019-09-06 广东海洋大学 一种具有促进创伤愈合作用的方格星虫酶解蛋白肽粉的制备方法及其应用
US10576123B2 (en) 2008-10-06 2020-03-03 3-D Matrix, Ltd. Tissue occluding agent comprising an IEIKIEIKIEIKI peptide
US10654893B2 (en) 2014-03-10 2020-05-19 3-D Matrix, Ltd. Self-assembling peptide compositions
US10793307B2 (en) 2012-07-06 2020-10-06 3-D Matrix, Ltd. Fill-finish process for peptide solutions
US10814038B2 (en) 2016-01-06 2020-10-27 3-D Matrix, Ltd. Combination compositions
US10905708B2 (en) 2011-09-07 2021-02-02 3-D Matrix, Ltd. MicroRNA-based methods and assays for osteocarcinoma
US11090398B2 (en) 2014-03-10 2021-08-17 3-D Matrix, Ltd. Sterilization and filtration of peptide compositions
US11260072B2 (en) 2011-09-07 2022-03-01 3-D Matrix, Ltd. MicroRNA-based methods and assays for osteocarcinoma
EP4041185A4 (en) * 2019-10-11 2024-01-17 Elc Man Llc COSMETIC SKIN REMODELING PROCESSES
JP7442196B2 (ja) 2018-07-03 2024-03-04 株式会社スリー・ディー・マトリックス イオン性自己組織化ペプチド

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JPWO2013133413A1 (ja) * 2012-03-09 2015-07-30 株式会社スリー・ディー・マトリックス 粘膜隆起剤
CA2886109A1 (en) * 2012-12-07 2014-06-12 Kansas State University Research Foundation Peptide-albumin hydrogel properties and its applications
ES2756531T3 (es) 2013-08-22 2020-04-27 Arch Biosurgery Inc Mallas implantables para controlar el movimiento de fluidos
WO2016004213A2 (en) * 2014-07-01 2016-01-07 Vicus Therapeutics, Llc Hydrogels for treating and ameliorating cancers and potentiating the immune system and methods of making and using them
WO2016004216A2 (en) * 2014-07-01 2016-01-07 Vicus Therapeutics, Llc Hydrogels for treating and ameliorating infections and methods of making and using them
US9820953B2 (en) * 2016-02-26 2017-11-21 Omni Bioceutical Innovations, Inc. Compositions of bioactive fulvate fractions and uses thereof
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
CN109136165A (zh) * 2018-10-16 2019-01-04 罗忠礼 一种自组装短肽在皮肤组织创伤中快速修复的应用
EP4090350A1 (en) * 2020-01-13 2022-11-23 Arch Biosurgery, Inc. Self-assembling peptide gel formulation and methods of use
CN113698452B (zh) * 2021-08-23 2023-08-18 四川丽妍工坊生物科技有限公司 一种促皮肤修复肽、制备方法及其应用
CN115369144A (zh) * 2022-06-15 2022-11-22 山东大学 一种多功能海洋贝肉多肽自组装超分子材料及其制备方法和应用

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11801281B2 (en) 2008-10-06 2023-10-31 3-D Matrix, Ltd. Tissue occluding agent comprising an ieikieikieiki peptide
US10576123B2 (en) 2008-10-06 2020-03-03 3-D Matrix, Ltd. Tissue occluding agent comprising an IEIKIEIKIEIKI peptide
US10596225B2 (en) 2008-10-06 2020-03-24 3-D Matrix, Ltd. Tissue occluding agent comprising an IEIKIEIKIEIKI peptide
JP2011162537A (ja) * 2010-01-14 2011-08-25 Doshisha インスリン製剤
WO2011087024A1 (ja) * 2010-01-14 2011-07-21 学校法人同志社 インスリン製剤
JP2012082180A (ja) * 2010-10-14 2012-04-26 Nagoya Univ 骨再生用自己組織化ペプチドハイドロゲル
WO2012070971A1 (ru) * 2010-11-22 2012-05-31 Farber Boris Slavinovich Косметологическая и фармацевтическая композиция для омоложения и восстанов- ления кожи, в том числе после хирургических операций
WO2013030673A3 (en) * 2011-09-02 2013-10-31 3-D Matrix Ltd. Amphiphilic peptides for thoracic air leakage occlusion
US11260072B2 (en) 2011-09-07 2022-03-01 3-D Matrix, Ltd. MicroRNA-based methods and assays for osteocarcinoma
US10905708B2 (en) 2011-09-07 2021-02-02 3-D Matrix, Ltd. MicroRNA-based methods and assays for osteocarcinoma
US10793307B2 (en) 2012-07-06 2020-10-06 3-D Matrix, Ltd. Fill-finish process for peptide solutions
JP2016515113A (ja) * 2013-03-14 2016-05-26 株式会社スリー・ディー・マトリックス 消化管閉塞の予防のための材料
US10654893B2 (en) 2014-03-10 2020-05-19 3-D Matrix, Ltd. Self-assembling peptide compositions
US11090398B2 (en) 2014-03-10 2021-08-17 3-D Matrix, Ltd. Sterilization and filtration of peptide compositions
US10245299B2 (en) 2014-03-10 2019-04-02 3-D Matrix, Ltd. Autoassembling peptides for the treatment of pulmonary bulla
US10814038B2 (en) 2016-01-06 2020-10-27 3-D Matrix, Ltd. Combination compositions
JP7442196B2 (ja) 2018-07-03 2024-03-04 株式会社スリー・ディー・マトリックス イオン性自己組織化ペプチド
CN109010906B (zh) * 2018-08-16 2021-05-14 陈明远 一种促进术后伤口局部止血及促进术后创面上皮化的生物胶水及其工作方法
CN109010906A (zh) * 2018-08-16 2018-12-18 陈明远 一种促进术后伤口局部止血及促进术后创面上皮化的生物胶水及其工作方法
CN110201000A (zh) * 2019-07-11 2019-09-06 广东海洋大学 一种具有促进创伤愈合作用的方格星虫酶解蛋白肽粉的制备方法及其应用
EP4041185A4 (en) * 2019-10-11 2024-01-17 Elc Man Llc COSMETIC SKIN REMODELING PROCESSES

Also Published As

Publication number Publication date
EP2229960A1 (en) 2010-09-22
JPWO2009072556A1 (ja) 2011-04-28
EP2229960B1 (en) 2015-04-08
EP2229960A4 (en) 2013-02-20
JP5497451B2 (ja) 2014-05-21
US20110002880A1 (en) 2011-01-06
ES2534770T3 (es) 2015-04-28
US20130296239A1 (en) 2013-11-07
JP2014139201A (ja) 2014-07-31

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