JP5492770B2 - ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成 - Google Patents

ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成 Download PDF

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JP5492770B2
JP5492770B2 JP2010513710A JP2010513710A JP5492770B2 JP 5492770 B2 JP5492770 B2 JP 5492770B2 JP 2010513710 A JP2010513710 A JP 2010513710A JP 2010513710 A JP2010513710 A JP 2010513710A JP 5492770 B2 JP5492770 B2 JP 5492770B2
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phenyl
unsubstituted
benzimidazole
independently
methyl
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Japanese (ja)
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JP2010531313A (ja
JP2010531313A5 (cg-RX-API-DMAC7.html
Inventor
ホルヘ・アロンソ
アンドレーアス・リンデンシュミット
マルク・ナツァーレ
マティーアス・ウルマン
ニス・ハールラント
オマール・ルカイク
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2010513710A 2007-06-26 2008-06-11 ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成 Expired - Fee Related JP5492770B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07290800.7 2007-06-26
EP07290800 2007-06-26
PCT/EP2008/004639 WO2009000413A1 (en) 2007-06-26 2008-06-11 A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

Publications (3)

Publication Number Publication Date
JP2010531313A JP2010531313A (ja) 2010-09-24
JP2010531313A5 JP2010531313A5 (cg-RX-API-DMAC7.html) 2011-07-07
JP5492770B2 true JP5492770B2 (ja) 2014-05-14

Family

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Family Applications (1)

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JP2010513710A Expired - Fee Related JP5492770B2 (ja) 2007-06-26 2008-06-11 ベンゾイミダゾール及びアザベンゾイミダゾールの位置選択的銅触媒合成

Country Status (12)

Country Link
US (1) US8735586B2 (cg-RX-API-DMAC7.html)
EP (1) EP2173721B1 (cg-RX-API-DMAC7.html)
JP (1) JP5492770B2 (cg-RX-API-DMAC7.html)
KR (1) KR20100023907A (cg-RX-API-DMAC7.html)
CN (1) CN101687815A (cg-RX-API-DMAC7.html)
AT (1) ATE539063T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008267444A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0813271A2 (cg-RX-API-DMAC7.html)
CA (1) CA2691857A1 (cg-RX-API-DMAC7.html)
IL (1) IL202823A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009013753A (cg-RX-API-DMAC7.html)
WO (1) WO2009000413A1 (cg-RX-API-DMAC7.html)

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PL2624696T3 (pl) 2010-10-06 2017-07-31 Glaxosmithkline Llc Pochodne benzimidazolu jako inhibitory kinazy PI3
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JP6502939B2 (ja) 2013-11-22 2019-04-17 シーエル バイオサイエンシズ リミティド ライアビリティ カンパニー 骨粗鬆症の処置及び予防のためのガストリン拮抗薬
CN103965136B (zh) * 2014-05-07 2016-09-07 苏州波菲特新材料科技有限公司 一种制备n-甲基噻唑啉-2-酮类化合物的方法
US10710992B2 (en) 2014-12-01 2020-07-14 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
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Publication number Publication date
JP2010531313A (ja) 2010-09-24
ATE539063T1 (de) 2012-01-15
AU2008267444A1 (en) 2008-12-31
BRPI0813271A2 (pt) 2014-12-30
US8735586B2 (en) 2014-05-27
EP2173721B1 (en) 2011-12-28
IL202823A0 (en) 2010-06-30
CN101687815A (zh) 2010-03-31
MX2009013753A (es) 2010-01-26
CA2691857A1 (en) 2008-12-31
KR20100023907A (ko) 2010-03-04
WO2009000413A1 (en) 2008-12-31
EP2173721A1 (en) 2010-04-14
US20100261909A1 (en) 2010-10-14

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