BRPI0813271A2 - Síntese regiosseletiva catalisada por cobre de benzimidazóis e azabenzimidazóis - Google Patents
Síntese regiosseletiva catalisada por cobre de benzimidazóis e azabenzimidazóisInfo
- Publication number
- BRPI0813271A2 BRPI0813271A2 BRPI0813271-2A2A BRPI0813271A BRPI0813271A2 BR PI0813271 A2 BRPI0813271 A2 BR PI0813271A2 BR PI0813271 A BRPI0813271 A BR PI0813271A BR PI0813271 A2 BRPI0813271 A2 BR PI0813271A2
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- regososlective
- benzymidazous
- azabenzimidazous
- catalized
- Prior art date
Links
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 229910052802 copper Inorganic materials 0.000 title abstract 2
- 239000010949 copper Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- -1 N-substituted benzimidazoles Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290800 | 2007-06-26 | ||
| PCT/EP2008/004639 WO2009000413A1 (en) | 2007-06-26 | 2008-06-11 | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0813271A2 true BRPI0813271A2 (pt) | 2014-12-30 |
Family
ID=38646504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813271-2A2A BRPI0813271A2 (pt) | 2007-06-26 | 2008-06-11 | Síntese regiosseletiva catalisada por cobre de benzimidazóis e azabenzimidazóis |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8735586B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2173721B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5492770B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100023907A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101687815A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE539063T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008267444A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0813271A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2691857A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL202823A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009013753A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009000413A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| DK2519522T3 (en) | 2009-12-30 | 2014-12-08 | Arqule Inc | SUBSTITUTED IDAZOPYRIDINYL AMINOPYRIDINE COMPOUNDS |
| KR101477156B1 (ko) | 2010-08-25 | 2014-12-29 | (주)네오팜 | 신규한 헤테로고리 화합물 및 이를 이용한 염증성 질환 치료용 조성물 |
| PL2624696T3 (pl) | 2010-10-06 | 2017-07-31 | Glaxosmithkline Llc | Pochodne benzimidazolu jako inhibitory kinazy PI3 |
| JP6001049B2 (ja) | 2011-03-31 | 2016-10-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｍｐｓ−１キナーゼ阻害剤としての置換ベンズイミダゾール類 |
| JP6046710B2 (ja) | 2011-06-24 | 2016-12-21 | アーキュール，インコーポレイティド | 置換されたイミダゾピリジニル−アミノピリジン化合物 |
| WO2012177852A1 (en) | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| BR112014031584A2 (pt) * | 2012-06-22 | 2017-06-27 | Sumitomo Chemical Co | composto heterocíclico fundido |
| CN102924460B (zh) * | 2012-11-05 | 2015-12-16 | 南京师范大学 | 一种4H-吡咯并[1,2-a]苯并咪唑衍生物及其合成方法和应用 |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
| CN103130811B (zh) * | 2013-03-11 | 2015-02-25 | 河南师范大学 | 一种5,6-二氢吡唑并[1,5-c]喹唑啉类化合物的合成方法 |
| WO2014140365A1 (en) * | 2013-03-15 | 2014-09-18 | Syngenta Participations Ag | Microbicidally active imidazopyridine derivatives |
| WO2014151380A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,6-substituted benzimidazoles as flap modulators |
| WO2014151367A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,5-substituted benzimidazoles as flap modulators |
| HRP20200854T1 (hr) | 2013-06-21 | 2020-08-21 | Zenith Epigenetics Ltd. | Novi biciklički inhibitori bromodomene |
| WO2015004534A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| JP6542212B2 (ja) | 2013-07-31 | 2019-07-10 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての新規キナゾリノン |
| JP6502939B2 (ja) | 2013-11-22 | 2019-04-17 | シーエル バイオサイエンシズ リミティド ライアビリティ カンパニー | 骨粗鬆症の処置及び予防のためのガストリン拮抗薬 |
| CN103965136B (zh) * | 2014-05-07 | 2016-09-07 | 苏州波菲特新材料科技有限公司 | 一种制备n-甲基噻唑啉-2-酮类化合物的方法 |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
| WO2016097863A1 (en) | 2014-12-17 | 2016-06-23 | Zenith Epigenetics Corp. | Inhibitors of bromodomains |
| AU2016356694B2 (en) | 2015-11-20 | 2021-07-29 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| CN106519250A (zh) * | 2016-09-29 | 2017-03-22 | 辽宁石油化工大学 | 含氮小分子有机配体调节荧光发射性质的一维链状铜配位聚合物的制备方法 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| CN120987917A (zh) | 2016-12-29 | 2025-11-21 | 箕星药业香港有限公司 | 金属酶抑制剂化合物 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| JP7191298B2 (ja) | 2017-04-26 | 2022-12-19 | バジリア・ファルマスーチカ・インターナショナル・アーゲー，アルシュヴィル | フラザノベンズイミダゾール類及びその結晶形の調製方法 |
| ES3008911T3 (en) | 2017-07-11 | 2025-03-25 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| CA3075880A1 (en) | 2017-09-15 | 2019-03-21 | Forma Therapeutics, Inc. | Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors |
| GB201800688D0 (en) | 2018-01-16 | 2018-02-28 | Redag Crop Prot Ltd | Agricultural chemicals |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| MX2023013508A (es) | 2018-06-29 | 2023-12-13 | Forma Therapeutics Inc | Inhibicion de la proteina de union a creb (cbp). |
| HUE066335T2 (hu) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére |
| CA3126224A1 (en) | 2019-01-08 | 2020-07-16 | Phasebio Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US12441703B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| EP3937940A4 (en) | 2019-03-15 | 2022-12-21 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (creb) |
| CN110982806B (zh) * | 2019-08-30 | 2022-09-02 | 浙江工业大学 | 一种蛋白质芳基衍生物及其制备方法 |
| PT4069691T (pt) | 2019-12-06 | 2024-12-18 | Vertex Pharma | Tetrahidrofuranos substituídos como moduladores dos canais de sódio |
| CN111206260B (zh) * | 2020-02-12 | 2022-03-22 | 齐鲁工业大学 | 一种吡啶并[1,2-a]苯并咪唑类化合物的电化学合成方法 |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| GEAP202416430A (en) | 2021-06-04 | 2024-03-25 | Vertex Pharma | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4481344B2 (ja) * | 2005-12-19 | 2010-06-16 | ラクオリア創薬株式会社 | クロマン置換ベンゾイミダゾール誘導体及び酸ポンプ阻害剤としてのそれらの使用 |
| MX2009005264A (es) * | 2006-12-06 | 2009-05-28 | Boehringer Ingelheim Int | Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos. |
-
2008
- 2008-06-11 AT AT08759158T patent/ATE539063T1/de active
- 2008-06-11 EP EP08759158A patent/EP2173721B1/en not_active Not-in-force
- 2008-06-11 KR KR1020097027120A patent/KR20100023907A/ko not_active Withdrawn
- 2008-06-11 BR BRPI0813271-2A2A patent/BRPI0813271A2/pt not_active IP Right Cessation
- 2008-06-11 AU AU2008267444A patent/AU2008267444A1/en not_active Abandoned
- 2008-06-11 CN CN200880021896A patent/CN101687815A/zh active Pending
- 2008-06-11 MX MX2009013753A patent/MX2009013753A/es active IP Right Grant
- 2008-06-11 WO PCT/EP2008/004639 patent/WO2009000413A1/en not_active Ceased
- 2008-06-11 JP JP2010513710A patent/JP5492770B2/ja not_active Expired - Fee Related
- 2008-06-11 CA CA002691857A patent/CA2691857A1/en not_active Abandoned
-
2009
- 2009-12-17 IL IL202823A patent/IL202823A0/en unknown
- 2009-12-22 US US12/644,401 patent/US8735586B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010531313A (ja) | 2010-09-24 |
| ATE539063T1 (de) | 2012-01-15 |
| AU2008267444A1 (en) | 2008-12-31 |
| US8735586B2 (en) | 2014-05-27 |
| EP2173721B1 (en) | 2011-12-28 |
| IL202823A0 (en) | 2010-06-30 |
| CN101687815A (zh) | 2010-03-31 |
| JP5492770B2 (ja) | 2014-05-14 |
| MX2009013753A (es) | 2010-01-26 |
| CA2691857A1 (en) | 2008-12-31 |
| KR20100023907A (ko) | 2010-03-04 |
| WO2009000413A1 (en) | 2008-12-31 |
| EP2173721A1 (en) | 2010-04-14 |
| US20100261909A1 (en) | 2010-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |