JP5468899B2 - Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 - Google Patents

Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 Download PDF

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Publication number
JP5468899B2
JP5468899B2 JP2009519767A JP2009519767A JP5468899B2 JP 5468899 B2 JP5468899 B2 JP 5468899B2 JP 2009519767 A JP2009519767 A JP 2009519767A JP 2009519767 A JP2009519767 A JP 2009519767A JP 5468899 B2 JP5468899 B2 JP 5468899B2
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Prior art keywords
methyl
compound
acrylamide
pyrido
tetrahydro
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Expired - Fee Related
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Japanese (ja)
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JP2010501474A5 (enExample
JP2010501474A (ja
Inventor
ハインツ， ダブリュー． ポールズ，
ジェイラール ラムナウス，
ピーター サンプソン，
アンドラス トロ，
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Affinium Pharmaceuticals Inc
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Affinium Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
JP2009519767A 2006-07-20 2007-07-19 Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 Expired - Fee Related JP5468899B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83205806P 2006-07-20 2006-07-20
US60/832,058 2006-07-20
PCT/CA2007/001277 WO2008009122A1 (en) 2006-07-20 2007-07-19 Acrylamide derivatives as fab i inhibitors

Publications (3)

Publication Number Publication Date
JP2010501474A JP2010501474A (ja) 2010-01-21
JP2010501474A5 JP2010501474A5 (enExample) 2013-09-12
JP5468899B2 true JP5468899B2 (ja) 2014-04-09

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JP2009519767A Expired - Fee Related JP5468899B2 (ja) 2006-07-20 2007-07-19 Ｆａｂｉインヒビターとしてのアクリルアミド誘導体

Country Status (6)

Country Link
US (2) US8318720B2 (enExample)
EP (2) EP2687533B1 (enExample)
JP (1) JP5468899B2 (enExample)
CA (1) CA2658506C (enExample)
IL (1) IL196590A (enExample)
WO (1) WO2008009122A1 (enExample)

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US10913730B2 (en) 2016-10-10 2021-02-09 Dong-A Socio Holdings Co., Ltd. Heteroaryl compounds and their use as Mer inhibitors
HUE058802T2 (hu) 2016-12-09 2022-09-28 Denali Therapeutics Inc RIPK1 inhibitorokként alkalmas vegyületek
CA3119390A1 (en) * 2018-11-12 2020-05-22 Debiopharm International S.A. Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof
MY203711A (en) 2019-02-14 2024-07-15 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
JP7418475B2 (ja) 2019-06-14 2024-01-19 デバイオファーム インターナショナル エス．エー． バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用
MX2022007412A (es) * 2019-12-19 2022-09-19 Debiopharm Int Sa Compuestos novedosos y sus usos.
CN112552303B (zh) * 2020-12-14 2021-11-30 承德医学院 嘧啶酮并二氮杂卓类化合物及其盐、其制备方法及医药用途
WO2022187329A1 (en) * 2021-03-03 2022-09-09 The Board Of Trustees Of The University Of Illinois Fabi inhibitors for gram-negative pathogens
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US20100130470A1 (en) 2010-05-27
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IL196590A (en) 2017-03-30
US8895545B2 (en) 2014-11-25
CA2658506A1 (en) 2008-01-24
WO2008009122A1 (en) 2008-01-24
IL196590A0 (en) 2009-11-18
US20130237523A1 (en) 2013-09-12
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EP2687533A2 (en) 2014-01-22
EP2054422B1 (en) 2017-06-14
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US8318720B2 (en) 2012-11-27
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