JP5468899B2 - Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 - Google Patents

Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 Download PDF

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Publication number
JP5468899B2
JP5468899B2 JP2009519767A JP2009519767A JP5468899B2 JP 5468899 B2 JP5468899 B2 JP 5468899B2 JP 2009519767 A JP2009519767 A JP 2009519767A JP 2009519767 A JP2009519767 A JP 2009519767A JP 5468899 B2 JP5468899 B2 JP 5468899B2
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methyl
compound
acrylamide
pyrido
tetrahydro
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Expired - Fee Related
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Japanese (ja)
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JP2010501474A5 (cg-RX-API-DMAC7.html
JP2010501474A (ja
Inventor
ハインツ， ダブリュー． ポールズ，
ジェイラール ラムナウス，
ピーター サンプソン，
アンドラス トロ，
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Affinium Pharmaceuticals Inc
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Affinium Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
JP2009519767A 2006-07-20 2007-07-19 Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 Expired - Fee Related JP5468899B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83205806P 2006-07-20 2006-07-20
US60/832,058 2006-07-20
PCT/CA2007/001277 WO2008009122A1 (en) 2006-07-20 2007-07-19 Acrylamide derivatives as fab i inhibitors

Publications (3)

Publication Number Publication Date
JP2010501474A JP2010501474A (ja) 2010-01-21
JP2010501474A5 JP2010501474A5 (cg-RX-API-DMAC7.html) 2013-09-12
JP5468899B2 true JP5468899B2 (ja) 2014-04-09

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JP2009519767A Expired - Fee Related JP5468899B2 (ja) 2006-07-20 2007-07-19 Ｆａｂｉインヒビターとしてのアクリルアミド誘導体

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Country Link
US (2) US8318720B2 (cg-RX-API-DMAC7.html)
EP (2) EP2687533B1 (cg-RX-API-DMAC7.html)
JP (1) JP5468899B2 (cg-RX-API-DMAC7.html)
CA (1) CA2658506C (cg-RX-API-DMAC7.html)
IL (1) IL196590A (cg-RX-API-DMAC7.html)
WO (1) WO2008009122A1 (cg-RX-API-DMAC7.html)

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JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
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KR102872166B1 (ko) * 2018-11-12 2025-10-15 데비오팜 인터네셔날 에스 에이 항생제 화합물, 이의 제조 방법, 이를 포함하는 약학적 조성물 및 그 용도
JP7383715B2 (ja) 2019-02-14 2023-11-20 デバイオファーム インターナショナル エス．エー． アファビシン製剤、その作製方法及びその使用
EA202290048A1 (ru) 2019-06-14 2022-03-10 Дебиофарм Интернэшнл C.A. Лекарственное средство и его применение для лечения бактериальных инфекций, связанных с биопленкой
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CN112552303B (zh) * 2020-12-14 2021-11-30 承德医学院 嘧啶酮并二氮杂卓类化合物及其盐、其制备方法及医药用途
WO2022187329A1 (en) * 2021-03-03 2022-09-09 The Board Of Trustees Of The University Of Illinois Fabi inhibitors for gram-negative pathogens
KR20240132504A (ko) 2022-01-12 2024-09-03 데날리 테라퓨틱스 인크. (s)-5-벤질-n-(5-메틸-4-옥소-2,3,4,5-테트라하이드로피리도 [3,2-b][1,4]옥사제핀-3-일)-4h-1,2,4-트리아졸-3-카복사미드의 결정질 형태
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US20100130470A1 (en) 2010-05-27
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