JP5461712B2 - Ｎ−（ブロモアセチル）−３，３−ジニトロアゼチジンの合成及び単離法並びにそれを含む組成物 - Google Patents

Ｎ−（ブロモアセチル）−３，３−ジニトロアゼチジンの合成及び単離法並びにそれを含む組成物 Download PDF

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JP5461712B2
JP5461712B2 JP2012552884A JP2012552884A JP5461712B2 JP 5461712 B2 JP5461712 B2 JP 5461712B2 JP 2012552884 A JP2012552884 A JP 2012552884A JP 2012552884 A JP2012552884 A JP 2012552884A JP 5461712 B2 JP5461712 B2 JP 5461712B2
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abdnaz
solvent
dnaz
dichloromethane
water
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Japanese (ja)
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JP2013518925A5 (OSRAM
JP2013518925A (ja
Inventor
ストラースラー，ニコラス・エイ
カニゾー，ルイス・エフ
リー，ピン
クレーマー，マイケル・ピー
ローゼンバーグ，デヴィッド・エム
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Northrop Grumman Innovation Systems LLC
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Alliant Techsystems Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2012552884A 2010-02-09 2011-01-18 Ｎ−（ブロモアセチル）−３，３−ジニトロアゼチジンの合成及び単離法並びにそれを含む組成物 Active JP5461712B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/702,782 2010-02-09
US12/702,782 US8471041B2 (en) 2010-02-09 2010-02-09 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
PCT/US2011/021500 WO2011100090A1 (en) 2010-02-09 2011-01-18 Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same

Publications (3)

Publication Number Publication Date
JP2013518925A JP2013518925A (ja) 2013-05-23
JP2013518925A5 JP2013518925A5 (OSRAM) 2013-08-29
JP5461712B2 true JP5461712B2 (ja) 2014-04-02

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JP2012552884A Active JP5461712B2 (ja) 2010-02-09 2011-01-18 Ｎ−（ブロモアセチル）−３，３−ジニトロアゼチジンの合成及び単離法並びにそれを含む組成物

Country Status (12)

Country Link
US (1) US8471041B2 (OSRAM)
EP (1) EP2534131B1 (OSRAM)
JP (1) JP5461712B2 (OSRAM)
KR (1) KR101456438B1 (OSRAM)
CN (1) CN102762535B (OSRAM)
AU (1) AU2011216176B2 (OSRAM)
CA (1) CA2788459C (OSRAM)
DK (1) DK2534131T3 (OSRAM)
ES (1) ES2460040T3 (OSRAM)
IL (1) IL221141A (OSRAM)
MX (1) MX2012008989A (OSRAM)
WO (1) WO2011100090A1 (OSRAM)

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US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
EP2763667B1 (en) 2011-10-07 2022-10-26 EpicentRx, Inc. Organonitro thioether compounds and medical uses thereof
WO2013052803A2 (en) 2011-10-07 2013-04-11 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
AU2017207304B2 (en) 2016-01-11 2022-05-26 Epicentrx, Inc. Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
CA3040479A1 (en) 2016-10-14 2018-04-19 Epicentrx, Inc. Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
IL311727A (en) 2017-07-07 2024-05-01 Epicentrx Inc Preparations for intravenous administration of medical substances
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
TW202313001A (zh) * 2021-06-09 2023-04-01 美商埃皮辛特瑞科斯公司 結晶abdnaz組合物及其製造及使用方法
WO2024145484A1 (en) 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

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Also Published As

Publication number Publication date
US8471041B2 (en) 2013-06-25
KR101456438B1 (ko) 2014-10-31
AU2011216176A1 (en) 2012-08-23
WO2011100090A1 (en) 2011-08-18
DK2534131T3 (da) 2014-04-07
IL221141A0 (en) 2012-09-24
KR20130053385A (ko) 2013-05-23
US20110195947A1 (en) 2011-08-11
EP2534131B1 (en) 2014-03-19
CN102762535B (zh) 2014-09-03
AU2011216176B2 (en) 2013-11-14
EP2534131A1 (en) 2012-12-19
IL221141A (en) 2016-08-31
CA2788459C (en) 2016-01-05
CN102762535A (zh) 2012-10-31
MX2012008989A (es) 2012-08-23
ES2460040T3 (es) 2014-05-13
JP2013518925A (ja) 2013-05-23
CA2788459A1 (en) 2011-08-18

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