JP5442906B2 - キナーゼインヒビターおよびこれを用いた癌の治療方法 - Google Patents

キナーゼインヒビターおよびこれを用いた癌の治療方法 Download PDF

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JP5442906B2
JP5442906B2 JP2013502966A JP2013502966A JP5442906B2 JP 5442906 B2 JP5442906 B2 JP 5442906B2 JP 2013502966 A JP2013502966 A JP 2013502966A JP 2013502966 A JP2013502966 A JP 2013502966A JP 5442906 B2 JP5442906 B2 JP 5442906B2
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mmol
cancer
indazol
title compound
indoline
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JP2013523784A5 (enExample
JP2013523784A (ja
Inventor
ブレント サンプソン，ピーター
リウ，ヨン
リー，セー−ワン
ティー． フォレスト，ブライアン
ダブリュ． ポールズ，ハインズ
ジー． エドワーズ，ルイーズ
フェーヘル，ミクロス
クマール ビー． パテル，ナレンドラ
ラウファー，ラドスロー
パン，クオホア．
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University Health Network
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University Health Network
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
JP2013502966A 2010-04-06 2011-04-06 キナーゼインヒビターおよびこれを用いた癌の治療方法 Active JP5442906B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32133210P 2010-04-06 2010-04-06
US32132910P 2010-04-06 2010-04-06
US61/321,332 2010-04-06
PCT/CA2010/000518 WO2010115279A1 (en) 2009-04-06 2010-04-06 Kinase inhibitors and method of treating cancer with same
CAPCT/CA2010/000518 2010-04-06
US61/321,329 2010-04-06
PCT/CA2011/000386 WO2011123946A1 (en) 2010-04-06 2011-04-06 Kinase inhibitors and method of treating cancer with same

Publications (3)

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JP2013523784A JP2013523784A (ja) 2013-06-17
JP2013523784A5 JP2013523784A5 (enExample) 2013-07-25
JP5442906B2 true JP5442906B2 (ja) 2014-03-19

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US (9) US8263596B2 (enExample)
EP (2) EP2556071B1 (enExample)
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KR (1) KR101782668B1 (enExample)
CN (1) CN102892766B (enExample)
AU (1) AU2011238384B2 (enExample)
BR (1) BR112012025496B1 (enExample)
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SM (1) SMT201600430B (enExample)
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WO (2) WO2011123947A1 (enExample)

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US8921545B2 (en) 2014-12-30
EA023173B1 (ru) 2016-04-29
CN102892766B (zh) 2015-05-20
TWI516262B (zh) 2016-01-11
SI2556071T1 (sl) 2016-12-30
BR112012025496B1 (pt) 2021-02-23
SG183875A1 (en) 2012-10-30
EP2556071A4 (en) 2013-09-04
CN102892766A (zh) 2013-01-23
US8481533B2 (en) 2013-07-09
US9796703B2 (en) 2017-10-24
NZ602350A (en) 2014-05-30
PT2556071T (pt) 2016-11-22
US8263596B2 (en) 2012-09-11
EP2556070A4 (en) 2013-10-23
CY1118610T1 (el) 2017-07-12
LT2556071T (lt) 2017-01-25
HUE030651T2 (en) 2017-05-29
ES2639757T3 (es) 2017-10-30
KR101782668B1 (ko) 2017-09-27
PL2556071T3 (pl) 2017-02-28
US20130096301A1 (en) 2013-04-18
DK2556071T3 (en) 2016-12-12
JP2013523784A (ja) 2013-06-17
US20180105511A1 (en) 2018-04-19
AU2011238384B2 (en) 2015-02-19
IL221556A (en) 2015-04-30
AU2011238384A1 (en) 2012-09-27
MX2012011516A (es) 2013-03-08
KR20130108065A (ko) 2013-10-02
US20180282306A1 (en) 2018-10-04
WO2011123947A1 (en) 2011-10-13
US20110263598A1 (en) 2011-10-27
US20150133677A1 (en) 2015-05-14
BR112012025496A2 (pt) 2020-08-18
US9139563B2 (en) 2015-09-22
EP2556070A1 (en) 2013-02-13
ME02545B (me) 2017-02-20
ES2603613T3 (es) 2017-02-28
SMT201600430B (it) 2017-01-10
US10077255B2 (en) 2018-09-18
US9907800B2 (en) 2018-03-06
HRP20161498T1 (hr) 2016-12-16
WO2011123946A8 (en) 2011-12-08
US10358436B2 (en) 2019-07-23
US9579327B2 (en) 2017-02-28
EP2556070B1 (en) 2017-06-07
US20140045838A1 (en) 2014-02-13
EA201270752A1 (ru) 2013-04-30
US20160045511A1 (en) 2016-02-18
US20120264800A1 (en) 2012-10-18
US20170226088A1 (en) 2017-08-10
WO2011123946A1 (en) 2011-10-13
TW201134471A (en) 2011-10-16
EP2556071A1 (en) 2013-02-13
WO2011123947A8 (en) 2011-12-22
EP2556071B1 (en) 2016-08-17

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