JP5420534B2 - モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン - Google Patents

モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン Download PDF

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Publication number
JP5420534B2
JP5420534B2 JP2010510560A JP2010510560A JP5420534B2 JP 5420534 B2 JP5420534 B2 JP 5420534B2 JP 2010510560 A JP2010510560 A JP 2010510560A JP 2010510560 A JP2010510560 A JP 2010510560A JP 5420534 B2 JP5420534 B2 JP 5420534B2
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Japan
Prior art keywords
compound
pharmaceutically acceptable
solvate
substituted
acceptable salt
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Expired - Fee Related
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JP2010510560A
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English (en)
Japanese (ja)
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JP2010529045A (ja
JP2010529045A5 (https=
Inventor
シャオ，リミング
ワン，フェンジャン
マルコム，スコット，クリストファー
ヒューイッド，マイケル，チャールス
マ，ジアンゴ
リブ，セス
バーニー，マーク，エー．
キャンベル，ウナ
エンジェル，シャロン，レイ
ハーディー，ラリー，ウェンデル
コーシュ，パトリック
シュライバー，ルディ
スペア，ケリー，エル．
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Sumitomo Pharma America Inc
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Sunovion Pharmaceuticals Inc
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Publication of JP2010529045A5 publication Critical patent/JP2010529045A5/ja
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010510560A 2007-05-31 2008-06-02 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン Expired - Fee Related JP5420534B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94124207P 2007-05-31 2007-05-31
US60/941,242 2007-05-31
PCT/US2008/065571 WO2008151156A1 (en) 2007-05-31 2008-06-02 Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors

Related Child Applications (1)

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JP2013239442A Division JP2014062108A (ja) 2007-05-31 2013-11-20 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

Publications (3)

Publication Number Publication Date
JP2010529045A JP2010529045A (ja) 2010-08-26
JP2010529045A5 JP2010529045A5 (https=) 2011-05-26
JP5420534B2 true JP5420534B2 (ja) 2014-02-19

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Family Applications (3)

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JP2010510560A Expired - Fee Related JP5420534B2 (ja) 2007-05-31 2008-06-02 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP2013239442A Withdrawn JP2014062108A (ja) 2007-05-31 2013-11-20 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP2015225509A Pending JP2016065085A (ja) 2007-05-31 2015-11-18 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

Family Applications After (2)

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JP2013239442A Withdrawn JP2014062108A (ja) 2007-05-31 2013-11-20 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP2015225509A Pending JP2016065085A (ja) 2007-05-31 2015-11-18 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

Country Status (14)

Country Link
US (3) US8669291B2 (https=)
EP (3) EP3296289A3 (https=)
JP (3) JP5420534B2 (https=)
KR (1) KR101581289B1 (https=)
CN (3) CN101686672A (https=)
AU (1) AU2008259841B2 (https=)
BR (1) BRPI0811639A2 (https=)
CA (1) CA2688493C (https=)
IL (1) IL202405A (https=)
MX (1) MX2009012685A (https=)
NZ (1) NZ580429A (https=)
RU (1) RU2470011C2 (https=)
WO (1) WO2008151156A1 (https=)
ZA (1) ZA200907171B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014062108A (ja) * 2007-05-31 2014-04-10 Sunovion Pharmaceuticals Inc モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

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US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
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US9381170B2 (en) * 2013-01-30 2016-07-05 MediSynergics, LLC Cycloalkyl-diamines for neurodegenerative disorders
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WO2021241982A1 (ko) 2020-05-29 2021-12-02 재단법인 대구경북첨단의료산업진흥재단 N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
CN116057049A (zh) 2020-05-29 2023-05-02 大邱庆北尖端医疗产业振兴财团 甲酰胺衍生物和含其作为活性成分的用于预防或治疗精神疾病的药物组合物
CN116157124A (zh) 2020-05-29 2023-05-23 大邱庆北尖端医疗产业振兴财团 磺胺衍生物和含其作为活性成分的用于预防或治疗精神疾病的药物组合物
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