JP5389905B2 - α−７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 - Google Patents

α−７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 Download PDF

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JP5389905B2
JP5389905B2 JP2011506374A JP2011506374A JP5389905B2 JP 5389905 B2 JP5389905 B2 JP 5389905B2 JP 2011506374 A JP2011506374 A JP 2011506374A JP 2011506374 A JP2011506374 A JP 2011506374A JP 5389905 B2 JP5389905 B2 JP 5389905B2
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mmol
methyl
amine
pyrimidinyl
octane
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JP2011518831A (ja
JP2011518831A5 (enExample
Inventor
ジェイムズ・エイチ・クック・ザ・セカンド
イバー・エム・マクドナルド
ダルトン・キング
リチャード・イー・ウォルソン
ネンフイ・ワン
クリスティアナ・アイ・イウアグ
クリストファー・エフ・ズシ
ジョン・イー・マコー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
JP2011506374A 2008-04-23 2009-04-20 α−７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 Expired - Fee Related JP5389905B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4721108P 2008-04-23 2008-04-23
US61/047,211 2008-04-23
US12/423,299 US7863291B2 (en) 2008-04-23 2009-04-14 Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US12/423,299 2009-04-14
PCT/US2009/041076 WO2009131926A1 (en) 2008-04-23 2009-04-20 Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands

Publications (3)

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JP2011518831A JP2011518831A (ja) 2011-06-30
JP2011518831A5 JP2011518831A5 (enExample) 2012-05-17
JP5389905B2 true JP5389905B2 (ja) 2014-01-15

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US (1) US7863291B2 (enExample)
EP (1) EP2271650B1 (enExample)
JP (1) JP5389905B2 (enExample)
KR (1) KR20110015565A (enExample)
CN (1) CN102066384B (enExample)
AR (1) AR071215A1 (enExample)
AU (1) AU2009239575B2 (enExample)
BR (1) BRPI0911542A2 (enExample)
CA (1) CA2722325A1 (enExample)
CL (1) CL2009000975A1 (enExample)
CO (1) CO6300941A2 (enExample)
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DK (1) DK2271650T3 (enExample)
EA (1) EA017628B1 (enExample)
ES (1) ES2553753T3 (enExample)
HR (1) HRP20151111T1 (enExample)
HU (1) HUE028302T2 (enExample)
IL (1) IL208673A (enExample)
MX (1) MX2010011374A (enExample)
NZ (1) NZ588649A (enExample)
PE (1) PE20091977A1 (enExample)
PL (1) PL2271650T3 (enExample)
PT (1) PT2271650E (enExample)
SI (1) SI2271650T1 (enExample)
TW (1) TWI431007B (enExample)
WO (1) WO2009131926A1 (enExample)
ZA (1) ZA201007527B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509405A (ja) * 2009-10-29 2013-03-14 ブリストル−マイヤーズ スクイブ カンパニー α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物

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TW200948812A (en) 2009-12-01
IL208673A0 (en) 2010-12-30
EA017628B1 (ru) 2013-01-30
PT2271650E (pt) 2015-12-01
MX2010011374A (es) 2010-11-12
BRPI0911542A2 (pt) 2015-10-13
CL2009000975A1 (es) 2011-02-18
CN102066384A (zh) 2011-05-18
CN102066384B (zh) 2014-07-30
EP2271650A1 (en) 2011-01-12
US7863291B2 (en) 2011-01-04
HRP20151111T1 (hr) 2015-12-18
NZ588649A (en) 2012-05-25
CO6300941A2 (es) 2011-07-21
AU2009239575B2 (en) 2014-02-20
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