JP5368701B2 - ｃ−Ｍｅｔモジュレーター及び使用方法 - Google Patents
ｃ−Ｍｅｔモジュレーター及び使用方法 Download PDFInfo
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- JP5368701B2 JP5368701B2 JP2007520386A JP2007520386A JP5368701B2 JP 5368701 B2 JP5368701 B2 JP 5368701B2 JP 2007520386 A JP2007520386 A JP 2007520386A JP 2007520386 A JP2007520386 A JP 2007520386A JP 5368701 B2 JP5368701 B2 JP 5368701B2
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- alkyl
- optionally substituted
- compound
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- 230000000694 effects Effects 0.000 claims abstract description 60
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- 102000020233 phosphotransferase Human genes 0.000 claims abstract description 50
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 117
- 239000003795 chemical substances by application Substances 0.000 claims description 51
- 125000000623 heterocyclic group Chemical group 0.000 claims description 47
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 39
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims description 37
- 125000003118 aryl group Chemical group 0.000 claims description 35
- 229910052757 nitrogen Inorganic materials 0.000 claims description 25
- 229910052736 halogen Inorganic materials 0.000 claims description 20
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- 125000003107 substituted aryl group Chemical group 0.000 claims description 20
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- 238000012216 screening Methods 0.000 claims description 11
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 8
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- 229910052731 fluorine Inorganic materials 0.000 claims description 4
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- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Natural products C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims 4
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 24
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 23
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- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 20
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 20
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- 150000003254 radicals Chemical class 0.000 description 18
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 16
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- 239000003446 ligand Substances 0.000 description 16
- 235000018102 proteins Nutrition 0.000 description 16
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- 102000001253 Protein Kinase Human genes 0.000 description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 15
- 108060006633 protein kinase Proteins 0.000 description 15
- 239000000741 silica gel Substances 0.000 description 15
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 14
- 235000011152 sodium sulphate Nutrition 0.000 description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 13
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
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- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58497704P | 2004-07-02 | 2004-07-02 | |
| US60/584,977 | 2004-07-02 | ||
| PCT/US2005/023364 WO2006014325A2 (en) | 2004-07-02 | 2005-07-01 | C-met modulators and method of use |
Publications (3)
| Publication Number | Publication Date |
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| JP2008505181A JP2008505181A (ja) | 2008-02-21 |
| JP2008505181A5 JP2008505181A5 (https=) | 2008-08-21 |
| JP5368701B2 true JP5368701B2 (ja) | 2013-12-18 |
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| JP2007520386A Expired - Fee Related JP5368701B2 (ja) | 2004-07-02 | 2005-07-01 | ｃ−Ｍｅｔモジュレーター及び使用方法 |
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| Country | Link |
|---|---|
| US (1) | US7977345B2 (https=) |
| EP (1) | EP1773826A4 (https=) |
| JP (1) | JP5368701B2 (https=) |
| AU (1) | AU2005270068B2 (https=) |
| CA (1) | CA2572331A1 (https=) |
| WO (1) | WO2006014325A2 (https=) |
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| WO2021249913A1 (en) | 2020-06-09 | 2021-12-16 | Bayer Aktiengesellschaft | 2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer |
| WO2022167627A1 (en) | 2021-02-05 | 2022-08-11 | Bayer Aktiengesellschaft | Map4k1 inhibitors |
| CN116836176B (zh) * | 2022-03-23 | 2026-02-24 | 中国科学院上海药物研究所 | 青蒿素类化合物、其制备方法和应用 |
| CN115160340B (zh) * | 2022-06-07 | 2023-07-21 | 四川大学华西医院 | 一种具有ack1抑制活性的小分子化合物及其应用 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| US20260049059A1 (en) * | 2022-11-25 | 2026-02-19 | Synthon B.V. | A process for preparation of cabozantinib or tivozanib |
| TW202444365A (zh) | 2023-01-31 | 2024-11-16 | 漢達生技醫藥股份有限公司 | 改良之卡博替尼組合物及其使用方法 |
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|---|---|---|---|---|
| US3149111A (en) * | 1961-09-29 | 1964-09-15 | Burroughs Wellcome Co | Dinitrophenylmercaptopurines |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| GB9604361D0 (en) | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| JP2004509059A (ja) * | 1999-06-03 | 2004-03-25 | アボット・ラボラトリーズ | 細胞接着抑制性抗炎症化合物 |
| EP1243582A4 (en) * | 1999-12-24 | 2003-06-04 | Kirin Brewery | CHINOLINE AND CHINAZOLINE DERIVATIVES AND MEDICATIONS CONTAINING THEM |
| DE60137273D1 (de) * | 2000-10-20 | 2009-02-12 | Eisai R&D Man Co Ltd | Verfahren zur Herstellung von 4-Phenoxy chinolin Derivaten |
| EP2258366B1 (en) * | 2001-06-22 | 2013-04-03 | Kirin Pharma Kabushiki Kaisha | Quinoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same |
| JP4224979B2 (ja) * | 2002-04-09 | 2009-02-18 | 大正製薬株式会社 | インターロイキン１２抑制剤 |
| EP1501829B1 (en) * | 2002-05-06 | 2010-11-24 | Vertex Pharmaceuticals Incorporated | Thiadiazoles or oxadiazoles and their use as inhibitors of jak protein kinase |
| GB0219746D0 (en) | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
| CA2531485C (en) | 2003-07-07 | 2013-03-26 | Merck Patent Gmbh | Malonamide derivatives |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
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- 2005-07-01 CA CA002572331A patent/CA2572331A1/en not_active Abandoned
- 2005-07-01 JP JP2007520386A patent/JP5368701B2/ja not_active Expired - Fee Related
- 2005-07-01 EP EP05763620A patent/EP1773826A4/en not_active Withdrawn
- 2005-07-01 WO PCT/US2005/023364 patent/WO2006014325A2/en not_active Ceased
- 2005-07-01 AU AU2005270068A patent/AU2005270068B2/en not_active Ceased
- 2005-07-01 US US11/571,140 patent/US7977345B2/en not_active Expired - Fee Related
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| WO2006014325A3 (en) | 2007-03-01 |
| US7977345B2 (en) | 2011-07-12 |
| AU2005270068A1 (en) | 2006-02-09 |
| CA2572331A1 (en) | 2006-02-09 |
| AU2005270068B2 (en) | 2012-04-19 |
| WO2006014325A2 (en) | 2006-02-09 |
| EP1773826A4 (en) | 2009-06-03 |
| JP2008505181A (ja) | 2008-02-21 |
| US20070179130A1 (en) | 2007-08-02 |
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