|
PT2213661E
(pt)
*
|
2003-09-26 |
2011-12-15 |
Exelixis Inc |
Moduladores de c-met e métodos de uso
|
|
EP1719762B1
(en)
|
2004-02-27 |
2012-06-27 |
Eisai R&D Management Co., Ltd. |
Novel pyridine derivative and pyrimidine derivative (1)
|
|
KR101257343B1
(ko)
|
2004-07-30 |
2013-04-23 |
메틸진 인코포레이티드 |
Vegf 수용체 및 hgf 수용체 신호전달 억제제
|
|
AU2006313456B2
(en)
*
|
2005-05-20 |
2011-06-23 |
Methylgene Inc. |
Inhibitors of VEGF receptor and HGF receptor signaling
|
|
CN101796055B
(zh)
*
|
2005-05-20 |
2013-09-04 |
梅特希尔基因公司 |
Vegf受体和hgf受体信号的抑制剂
|
|
EP1885400A4
(en)
*
|
2005-06-02 |
2011-01-26 |
Galaxy Biotech Llc |
METHOD FOR THE TREATMENT OF BRAIN TUMORS BY ANTIBODIES
|
|
HRP20130719T1
(en)
|
2005-08-24 |
2013-09-30 |
Eisai R&D Management Co., Ltd. |
Novel pyridine derivative and pyrimidine derivative (3)
|
|
BRPI0617863A2
(pt)
|
2005-10-28 |
2011-08-09 |
Irm Llc |
compostos e composições como inibidores da proteìna quinase
|
|
NL2000291C2
(nl)
|
2005-11-10 |
2009-02-17 |
Pfizer Prod Inc |
1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
|
|
JP2009526761A
(ja)
|
2006-01-30 |
2009-07-23 |
アレイ バイオファーマ、インコーポレイテッド |
ヘテロ二環式チオフェン化合物および使用の方法
|
|
BRPI0708615A2
(pt)
|
2006-03-07 |
2011-06-07 |
Array Biopharma Inc |
compostos de pirazol heterobicìclicos e métodos de uso
|
|
AR059922A1
(es)
*
|
2006-04-01 |
2008-05-07 |
Galaxy Biotech Llc |
Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
|
|
CA2651898A1
(en)
|
2006-04-07 |
2007-10-18 |
Develogen Aktiengesellschaft |
Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
|
|
JP2009539878A
(ja)
*
|
2006-06-08 |
2009-11-19 |
アレイ バイオファーマ、インコーポレイテッド |
キノリン化合物および使用方法
|
|
EP1889847A1
(en)
|
2006-07-10 |
2008-02-20 |
DeveloGen Aktiengesellschaft |
Pyrrolopyrimidines for pharmaceutical compositions
|
|
US7683060B2
(en)
|
2006-08-07 |
2010-03-23 |
Incyte Corporation |
Triazolotriazines as kinase inhibitors
|
|
CA2661333C
(en)
|
2006-08-23 |
2014-08-05 |
Eisai R&D Management Co., Ltd. |
Salt of phenoxypyridine derivative or crystal thereof and process for producing the same
|
|
US7790885B2
(en)
|
2006-08-31 |
2010-09-07 |
Eisai R&D Management Co., Ltd. |
Process for preparing phenoxypyridine derivatives
|
|
WO2008049855A2
(en)
*
|
2006-10-27 |
2008-05-02 |
Glaxo Group Limited |
7-azaindole derivatives as c-met kinase inhibitors
|
|
ME02372B
(me)
|
2006-11-22 |
2016-06-20 |
Incyte Holdings Corp |
Imidazotriazini i imidazopiramidini kao inhibitori kinaze
|
|
EP2311807B1
(en)
|
2006-12-08 |
2015-11-11 |
Novartis AG |
Compounds and composition as protein kinase inhibitors
|
|
DE102007026341A1
(de)
|
2007-06-06 |
2008-12-11 |
Merck Patent Gmbh |
Benzoxazolonderivate
|
|
CN101918403A
(zh)
*
|
2007-09-06 |
2010-12-15 |
阵列生物制药公司 |
作为酪氨酸激酶抑制剂的吡唑并吡啶类化合物
|
|
JP2009132660A
(ja)
|
2007-11-30 |
2009-06-18 |
Eisai R & D Management Co Ltd |
食道癌治療用組成物
|
|
BRPI0908573A2
(pt)
|
2008-03-05 |
2012-12-25 |
Methylgene Inc |
inibidores da atividade de proteÍna tirosina quinase
|
|
WO2009143211A2
(en)
|
2008-05-21 |
2009-11-26 |
Incyte Corporation |
Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
|
|
JP4884570B2
(ja)
*
|
2008-08-20 |
2012-02-29 |
ファイザー・インク |
ピロロ[2,3−d]ピリミジン化合物
|
|
MX2011001938A
(es)
|
2008-08-26 |
2011-03-29 |
Boehringer Ingelheim Int |
Tienopirimidinas para composiciones farmaceuticas.
|
|
EP2340244A4
(en)
*
|
2008-10-14 |
2012-07-25 |
Ning Xi |
COMPOUNDS AND APPLICATION PROCEDURES
|
|
DE102009003975A1
(de)
|
2009-01-07 |
2010-07-08 |
Merck Patent Gmbh |
Benzothiazolonderivate
|
|
SG173014A1
(en)
|
2009-01-16 |
2011-08-29 |
Exelixis Inc |
Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
|
|
ES2578990T3
(es)
*
|
2009-03-21 |
2016-08-03 |
Sunshine Lake Pharma Co., Ltd. |
Derivados de amino éster, sales de los mismos y métodos de uso
|
|
EP2245936A1
(en)
|
2009-04-27 |
2010-11-03 |
Bayer CropScience AG |
Use of 4-aza indole derivatives for the reduction of mycotoxin contamination
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
CA2776028C
(en)
*
|
2009-10-15 |
2015-12-01 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
DE102009056886A1
(de)
|
2009-12-03 |
2011-06-09 |
Bayer Schering Pharma Aktiengesellschaft |
cMet-Inhibitoren zur Behandlung der Endometriose
|
|
EA025304B1
(ru)
|
2010-02-03 |
2016-12-30 |
Инсайт Холдингс Корпорейшн |
ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ
|
|
UY33241A
(es)
|
2010-02-26 |
2011-09-30 |
Boehringer Ingelheim Int |
?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
|
|
EP2539343B1
(en)
|
2010-02-26 |
2015-12-30 |
Evotec International GmbH |
Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
|
|
UY33246A
(es)
|
2010-02-26 |
2011-09-30 |
Boehringer Ingelheim Int |
Tienopirimidinas que contienen cicloalquilo para composiciones farmacéuticas
|
|
JP5960688B2
(ja)
|
2010-05-17 |
2016-08-02 |
インコゼン セラピューティクス プライベート リミテッド |
プロテインキナーゼ調節物質としての新規3,5−二置換−3h−[1,2,3]トリアゾロ[4,5−b]ピリジン化合物
|
|
US9073918B2
(en)
|
2010-05-20 |
2015-07-07 |
Takeda Pharmaceutical Company Limited |
Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5
|
|
WO2011162343A1
(ja)
|
2010-06-25 |
2011-12-29 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キナーゼ阻害作用を有する化合物の併用による抗腫瘍剤
|
|
EP2593090B1
(en)
|
2010-07-16 |
2021-10-13 |
Exelixis, Inc. |
C-met modulator pharmaceutical compositions
|
|
CA2812750C
(en)
|
2010-09-27 |
2020-10-06 |
Exelixis, Inc. |
Dual inhibitors of met and vegf for the treatment of castration-resistant prostate cancer and osteoblastic bone metastases
|
|
EP2637692A4
(en)
|
2010-11-12 |
2014-09-10 |
Scott & White Healthcare |
ANTIBODIES TO THE ENDOTHELIAL TUMOR MARKER 8
|
|
JP2014505109A
(ja)
|
2011-02-10 |
2014-02-27 |
エクセリクシス, インク. |
キノリン化合物およびそのような化合物を含有する医薬組成物の調製方法
|
|
US20120252840A1
(en)
|
2011-04-04 |
2012-10-04 |
Exelixis, Inc. |
Method of Treating Cancer
|
|
KR20140025496A
(ko)
|
2011-05-02 |
2014-03-04 |
엑셀리시스, 인코포레이티드 |
암 및 뼈 암 통증의 치료방법
|
|
US8772277B2
(en)
|
2011-08-04 |
2014-07-08 |
Takeda Pharmaceutical Company Limited |
Nitrogen-containing heterocyclic compound
|
|
GEP201606523B
(en)
|
2011-09-22 |
2016-08-10 |
Exelixis Inc |
Method for treating osteoporosis
|
|
KR20140059246A
(ko)
|
2011-09-22 |
2014-05-15 |
화이자 인코포레이티드 |
피롤로피리미딘 및 퓨린 유도체
|
|
DK2768796T3
(da)
*
|
2011-10-20 |
2020-02-24 |
Exelixis Inc |
Fremgangsmåde til fremstilling af quinolin-derivater
|
|
US9586965B2
(en)
|
2012-01-13 |
2017-03-07 |
Acea Biosciences Inc. |
Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
|
|
US9464089B2
(en)
|
2012-01-13 |
2016-10-11 |
Acea Biosciences Inc. |
Heterocyclic compounds and uses thereof
|
|
CA2861010A1
(en)
|
2012-01-13 |
2013-07-18 |
Xiao Xu |
Heterocyclic compounds and uses as anticancer agents
|
|
US9034885B2
(en)
|
2012-01-13 |
2015-05-19 |
Acea Biosciences Inc. |
EGFR modulators and uses thereof
|
|
EP2831073B1
(en)
|
2012-03-30 |
2020-12-09 |
Rhizen Pharmaceuticals S.A. |
Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of c-met protein kinases
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
JP2015515988A
(ja)
|
2012-05-02 |
2015-06-04 |
エクセリクシス, インク. |
溶骨性骨転移を治療するためのmet−vegf二重調節剤
|
|
TWI520962B
(zh)
*
|
2012-06-29 |
2016-02-11 |
|
As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
|
|
CN104507930B
(zh)
*
|
2012-06-29 |
2017-10-10 |
贝达药业股份有限公司 |
作为c‑Met酪氨酸激酶抑制剂的新型稠合吡啶衍生物
|
|
CN103570723B
(zh)
*
|
2012-07-27 |
2016-07-13 |
广西梧州制药(集团)股份有限公司 |
吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途
|
|
MD20150037A2
(ro)
|
2012-11-08 |
2015-11-30 |
Pfizer Inc. |
Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1
|
|
CN102964308B
(zh)
*
|
2012-11-30 |
2015-03-18 |
中国药科大学 |
新型嘧啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
|
|
AU2013364953A1
(en)
|
2012-12-21 |
2015-04-30 |
Eisai R&D Management Co., Ltd. |
Amorphous form of quinoline derivative, and method for producing same
|
|
AU2014232714B2
(en)
|
2013-03-15 |
2018-07-19 |
Exelixis, Inc. |
Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
|
|
BR112015025408A8
(pt)
*
|
2013-04-04 |
2018-07-10 |
Exelixis Inc |
combinações de drogas para tratar câncer
|
|
EP2981263B1
(en)
|
2013-04-04 |
2022-06-29 |
Exelixis, Inc. |
Cabozantinib dosage form and use in the treatment of cancer
|
|
EP2997377B1
(en)
|
2013-05-14 |
2018-07-18 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
|
|
NZ715687A
(en)
|
2013-07-11 |
2019-04-26 |
Acea Biosciences Inc |
Pyrimidine derivatives as kinase inhibitors
|
|
KR102354963B1
(ko)
|
2014-02-14 |
2022-01-21 |
엑셀리시스, 인코포레이티드 |
N-{4-[(6,7-다이메톡시퀴놀린-4-일)옥시]페닐}-n'-(4-플루오로페닐) 사이클로프로판-1,1-다이카복스아마이드의 결정질 고체 형태, 제조 방법 및 사용 방법
|
|
EP3122900A1
(en)
|
2014-03-24 |
2017-02-01 |
F. Hoffmann-La Roche AG |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
EP3134405B1
(en)
|
2014-04-25 |
2019-08-28 |
Pfizer Inc |
Heteroaromatic compounds and their use as dopamine d1 ligands
|
|
EA201691831A1
(ru)
|
2014-04-25 |
2017-02-28 |
Пфайзер Инк. |
Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов
|
|
ES2929888T3
(es)
|
2014-07-31 |
2022-12-02 |
Exelixis Inc |
Procedimiento para preparar cabozantinib marcado con flúor 18 y sus análogos
|
|
BR112017002318A2
(pt)
|
2014-08-05 |
2018-07-17 |
Exelixis, Inc. |
combinações de fármacos para tratar mieloma múltiplo.
|
|
PT3524595T
(pt)
|
2014-08-28 |
2022-09-19 |
Eisai R&D Man Co Ltd |
Derivado de quinolina altamente puro e método para produção do mesmo
|
|
AU2016224583B2
(en)
|
2015-02-25 |
2021-06-03 |
Eisai R&D Management Co., Ltd. |
Method for suppressing bitterness of quinoline derivative
|
|
KR102662228B1
(ko)
|
2015-03-04 |
2024-05-02 |
머크 샤프 앤드 돔 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
|
|
BR112017027227B1
(pt)
|
2015-06-16 |
2023-12-12 |
Eisai R&D Management Co., Ltd |
Agente anti-câncer
|
|
EP3292115B1
(en)
*
|
2015-07-20 |
2019-12-25 |
Betta Pharmaceuticals Co., Ltd. |
Crystalline form of fused pyridine derivative's maleate and uses thereof
|
|
US10844051B2
(en)
|
2015-07-22 |
2020-11-24 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Substituted oxazoles for the treatment of cancer
|
|
JP6553726B2
(ja)
|
2015-08-20 |
2019-07-31 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療剤
|
|
KR20180067584A
(ko)
|
2015-10-09 |
2018-06-20 |
아세아 테라퓨틱스 인코포레이티드 |
피롤로피리미딘 키나아제 억제제의 약학적 염, 물리적 형태 및 조성물, 및 이들의 제조 방법
|
|
GB201520499D0
(en)
|
2015-11-20 |
2016-01-06 |
Medical Res Council Technology |
Compounds
|
|
GB201520500D0
(en)
|
2015-11-20 |
2016-01-06 |
Medical Res Council Technology |
Compounds
|
|
RU2748549C2
(ru)
|
2016-04-15 |
2021-05-26 |
Экселиксис, Инк. |
Способ лечения почечно-клеточного рака с использованием n-(4-(6,7-диметоксихинолин-4-илокси)фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида, (2s)-гидроксибутандиоата
|
|
CN106496232B
(zh)
*
|
2016-09-22 |
2018-11-09 |
南方医科大学 |
一种具有抗肿瘤活性的1-(2-四氢吡喃)-1H-吡唑并[3,4-d]嘧啶类化合物及其制备方法
|
|
JP6581320B2
(ja)
|
2017-02-08 |
2019-09-25 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療用医薬組成物
|
|
AU2017408099A1
(en)
|
2017-04-07 |
2019-11-07 |
ACEA Therapeutics, Inc. |
Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same
|
|
EP3624800A4
(en)
|
2017-05-16 |
2021-02-17 |
Eisai R&D Management Co., Ltd. |
TREATMENT OF HEPATOCELLULAR CARCINOMA
|
|
WO2018228920A1
(en)
|
2017-06-13 |
2018-12-20 |
Bayer Pharma Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives
|
|
EP3638670B1
(en)
|
2017-06-13 |
2021-07-21 |
Bayer Pharma Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives as map4k1 modulators for the treatment of cancer diseases
|
|
EP3638671A1
(en)
|
2017-06-13 |
2020-04-22 |
Bayer Pharma Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives
|
|
US11427578B1
(en)
|
2017-07-18 |
2022-08-30 |
Bayer Pharma Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives
|
|
KR102708177B1
(ko)
|
2018-01-31 |
2024-09-23 |
데시페라 파마슈티칼스, 엘엘씨. |
위장관 기질 종양의 치료를 위한 병용 요법
|
|
IL276398B2
(en)
|
2018-01-31 |
2026-03-01 |
Deciphera Pharmaceuticals Llc |
Combination therapy for mastocytosis
|
|
CN113292537B
(zh)
|
2018-06-15 |
2024-04-05 |
汉达癌症医药责任有限公司 |
激酶抑制剂的盐类及其组合物
|
|
UY38349A
(es)
|
2018-08-30 |
2020-03-31 |
Array Biopharma Inc |
Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
|
|
EP3894406A1
(en)
|
2018-12-11 |
2021-10-20 |
Bayer Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives
|
|
ES2974634T3
(es)
|
2018-12-21 |
2024-06-28 |
Celgene Corp |
Inhibidores de tienopiridinas de RIPK2
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
EP3938363A1
(en)
|
2019-03-11 |
2022-01-19 |
Teva Pharmaceuticals International GmbH |
Solid state forms of ripretinib
|
|
MX2022000103A
(es)
*
|
2019-06-25 |
2022-04-27 |
Sinopsee Therapeutics |
Compuestos para el tratamiento de trastornos oculares.
|
|
PT4013412T
(pt)
|
2019-08-12 |
2026-03-18 |
Deciphera Pharmaceuticals Llc |
Ripretinib para o tratamento de tumores estromais gastrointestinais
|
|
LT4013412T
(lt)
|
2019-08-12 |
2026-03-25 |
Deciphera Pharmaceuticals, Llc |
Ripretinibas, skirtas virškinamojo trakto stromos navikų gydymui
|
|
HRP20231699T1
(hr)
|
2019-12-30 |
2024-05-10 |
Deciphera Pharmaceuticals, Llc |
Formulacije inhibitora amorfne kinaze i postupci njihove primjene
|
|
CN115243681B
(zh)
|
2019-12-30 |
2024-08-16 |
德西费拉制药有限责任公司 |
1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物
|
|
WO2021249913A1
(en)
|
2020-06-09 |
2021-12-16 |
Bayer Aktiengesellschaft |
2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer
|
|
WO2022167627A1
(en)
|
2021-02-05 |
2022-08-11 |
Bayer Aktiengesellschaft |
Map4k1 inhibitors
|
|
CN116836176B
(zh)
*
|
2022-03-23 |
2026-02-24 |
中国科学院上海药物研究所 |
青蒿素类化合物、其制备方法和应用
|
|
CN115160340B
(zh)
*
|
2022-06-07 |
2023-07-21 |
四川大学华西医院 |
一种具有ack1抑制活性的小分子化合物及其应用
|
|
US11779572B1
(en)
|
2022-09-02 |
2023-10-10 |
Deciphera Pharmaceuticals, Llc |
Methods of treating gastrointestinal stromal tumors
|
|
US20260049059A1
(en)
*
|
2022-11-25 |
2026-02-19 |
Synthon B.V. |
A process for preparation of cabozantinib or tivozanib
|
|
TW202444365A
(zh)
|
2023-01-31 |
2024-11-16 |
漢達生技醫藥股份有限公司 |
改良之卡博替尼組合物及其使用方法
|