JP5360075B2 - 胃食物受容能障害治療薬 - Google Patents
胃食物受容能障害治療薬 Download PDFInfo
- Publication number
- JP5360075B2 JP5360075B2 JP2011000499A JP2011000499A JP5360075B2 JP 5360075 B2 JP5360075 B2 JP 5360075B2 JP 2011000499 A JP2011000499 A JP 2011000499A JP 2011000499 A JP2011000499 A JP 2011000499A JP 5360075 B2 JP5360075 B2 JP 5360075B2
- Authority
- JP
- Japan
- Prior art keywords
- gastric
- compound
- food
- acid addition
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002496 gastric effect Effects 0.000 title claims description 19
- 235000013305 food Nutrition 0.000 title claims description 14
- 239000003814 drug Substances 0.000 title description 6
- 229940079593 drug Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 15
- 235000012054 meals Nutrition 0.000 claims description 13
- 210000002784 stomach Anatomy 0.000 claims description 7
- 206010059186 Early satiety Diseases 0.000 claims description 5
- 230000003187 abdominal effect Effects 0.000 claims description 5
- 206010016766 flatulence Diseases 0.000 claims description 5
- TWHZNAUBXFZMCA-UHFFFAOYSA-N Acotiamide Chemical compound C1=C(OC)C(OC)=CC(O)=C1C(=O)NC1=NC(C(=O)NCCN(C(C)C)C(C)C)=CS1 TWHZNAUBXFZMCA-UHFFFAOYSA-N 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000002040 relaxant effect Effects 0.000 claims description 2
- 238000012360 testing method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 230000009471 action Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 238000001647 drug administration Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000008447 perception Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- -1 4,5-dimethoxy-2-hydroxybenzoyl Chemical group 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- DCSUBABJRXZOMT-IRLDBZIGSA-N cisapride Chemical compound C([C@@H]([C@@H](CC1)NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)OC)N1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-IRLDBZIGSA-N 0.000 description 4
- 229960005132 cisapride Drugs 0.000 description 4
- DCSUBABJRXZOMT-UHFFFAOYSA-N cisapride Natural products C1CC(NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)C(OC)CN1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-UHFFFAOYSA-N 0.000 description 4
- 230000010339 dilation Effects 0.000 description 4
- 210000002599 gastric fundus Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 125000000335 thiazolyl group Chemical group 0.000 description 3
- UMEHMORTTSHRSD-UHFFFAOYSA-N 2-[(2-chloro-4,5-dimethoxybenzoyl)amino]-n-[2-[di(propan-2-yl)amino]ethyl]-1,3-thiazole-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC(Cl)=C1C(=O)NC1=NC(C(=O)NCCN(C(C)C)C(C)C)=CS1 UMEHMORTTSHRSD-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010065713 Gastric Fistula Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 230000030136 gastric emptying Effects 0.000 description 2
- 230000030135 gastric motility Effects 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 150000002688 maleic acid derivatives Chemical class 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RAIPHJJURHTUIC-UHFFFAOYSA-N 1,3-thiazol-2-amine Chemical class NC1=NC=CS1 RAIPHJJURHTUIC-UHFFFAOYSA-N 0.000 description 1
- RQGAQSHTOLJBCQ-UHFFFAOYSA-N 2-[(3,4-dimethoxybenzoyl)amino]-n-[2-[di(propan-2-yl)amino]ethyl]-1,3-thiazole-4-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=NC(C(=O)NCCN(C(C)C)C(C)C)=CS1 RQGAQSHTOLJBCQ-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- FSRLGULMGJGKGI-BTJKTKAUSA-N Trimebutine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=CC=1C(CC)(N(C)C)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 FSRLGULMGJGKGI-BTJKTKAUSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- JUGOREOARAHOCO-UHFFFAOYSA-M acetylcholine chloride Chemical compound [Cl-].CC(=O)OCC[N+](C)(C)C JUGOREOARAHOCO-UHFFFAOYSA-M 0.000 description 1
- 229960004266 acetylcholine chloride Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002973 anti-dopamine Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000064 cholinergic agonist Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000037020 contractile activity Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229960001253 domperidone Drugs 0.000 description 1
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 description 1
- 239000002804 dopamine agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960004503 metoclopramide Drugs 0.000 description 1
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- RVZZUQVNJYUUGU-UHFFFAOYSA-N n-[2-[di(propan-2-yl)amino]ethyl]-5-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]furan-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC(O)=C1C(=O)NC1=CC(C(=O)NCCN(C(C)C)C(C)C)=CO1 RVZZUQVNJYUUGU-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003402 opiate agonist Substances 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 description 1
- 239000000387 serotonin 5-HT4 receptor agonist Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960005345 trimebutine Drugs 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
これら従来の消化管運動障害治療薬は、動物実験において、胃運動の改善、すなわち胃幽門部の収縮能の有無を基準にスクリーニングされており、臨床的には、胃内容物の排出遅延の改善効果が判断されていた。
しかしながら、最近、胃内容物の排出促進効果だけでは、食物摂取後の早期満腹感や上腹部鼓腸等に対して充分な効果が得られないことが判明し、これらの症状を改善するためには胃運動の改善、すなわち胃の食物排出能ではなく、胃底部の弛緩、すなわち胃の食物受容能障害を改善する必要があることが判明した(非特許文献1)。
で表される化合物又はその酸付加塩を有効成分とする胃食物受容能障害治療薬を提供するものである。
また本発明は、上記一般式(1)の化合物又はその酸付加塩の、胃食物受容能障害治療薬製造のための使用を提供するものである。
さらに本発明は、上記一般式(1)の化合物又はその酸付加塩の有効量を投与することを特徴とする胃食物受容能障害の処置方法を提供するものである。
前記WO96/36619及び特開平10−212271号においては、化合物(1)が胃幽門前庭部における収縮能を有することが示されている。これに対し、本発明者はイヌを対象としたバロスタット試験により、化合物(1)が優れた食物受容能改善作用、すなわち胃収縮能でなく、食後の胃底部弛緩作用を有することを見出したものである。かかる作用により、化合物(1)又はその酸付加塩を投与すれば、早期満腹感、上腹部鼓腸等の症状が有意に改善される。
化合物(1)又はその酸付加塩の投与量は年齢、体重、症状、治療効果、投与方法、投与期間により異なるが、通常、経口投与の場合には0.1〜2000mg/日、好ましくは50〜1000mg/日の投与範囲で1日1〜3回に分けて投与する。
(1)方法
雄性雑種成犬の胃体部前壁中央に胃ろう管(KN−365,D−14−C,夏目製作所)を慢性的に装着し、エアバッグの挿入に用いた。
胃ろう管を慢性縫着したイヌを18時間以上絶食させ、実験開始前に胃ろう管を開放し、生理食塩液を注入して胃内を洗浄した。必要に応じてこの作業は2〜3回繰り返した。市販のポリエチレン袋を加工したエアバッグ(最大容積:約750mL)を胃ろう管より挿入しシリコン栓にて固定し、バロスタット装置(ISOBAR-3,G & J Electronics Inc.)に接続し無拘束状態で測定を開始した。エアバッグ容量変化をレコーダおよびコンピューターに記録した。
試験食の胃内投与により胃底部弛緩反応が発現し、エアバッグ容量は増加した。その後、増大したエアバッグ容量は時間の経過と共に減少した。
試験食投与後すなわち薬物投与前5分間の平均エアバッグ容量に対し、薬物投与後のエアバッグ容量の変化を表1に示した。溶媒投与後5分間のエアバッグ容量は39.2mL減少した。一方、化合物a塩酸塩の投与は胃の弛緩を増大させ、エアバッグ容量を50.8mL増加させた。その効果は、シサプリドの効果を上回るものであった。
実施例1の方法に準じて化合物bのマレイン酸塩、化合物cの塩酸塩及び化合物dのマレイン酸塩についてバロスタット試験を行った。その結果、表2に示すように化合物b、c及びdも優れた胃食物受容能改善作用を示した。
(1)記録方法
Rome II基準に準拠したFunctional Dyspepsia患者を一晩(12時間以上)絶食させた。化合物a塩酸塩300mgあるいはプラセボは治験責任医師が経口投与する。30分後に、二重管腔ポリビニール製粘着プラスチック・バッグ(Medtronic-Synetics Medecal Ltd, Enfield, UK)(1100mL、最大径17cm)を小さく折りたたんで口または鼻から導入し、粘着テープにより被験者の顎で止める。胃底のバッグの位置は、X線透視により確認した。
30分間の適応期間後、バック内圧を毎分1mmHg増加し、最小侵襲性胃内拡張圧(MDP)、すなわちバッグ内容積が30mL以上となる最低圧力を測定した。この圧力は腹腔内圧を平衡化させる。その後、段階的等圧膨張により、MDPから2mmHgずつ増加させた。各段階は対応する胃内容積を記録しながら、2分間持続させた。患者には、各膨張段階の終りに、膨張刺激によって上腹部に感じる感覚を、言葉による説明を付した0〜6の図式評価スケールを用いてスコア化してもらった。これら膨張手段は、バッグ内容積が1000mLになるか、被験者が不快感または苦痛(スコア:5または6)を訴えた時点で終了した。
さらに30分の適応期間をおいた後、90分間、圧力レベルをMDP+2mmHgに設定した。30分後、混合流動食(200mL、300kcal、タンパク質13%、炭水化物39%、NutridrinkTM、Nutricia)を経口摂取させた。その後さらに60分間にわたって胃緊張度を測定した。
2分間の各膨張期間について、記録値を平均してバルーン内容積を求めた。知覚及び不快感の閾値は、各膨張段階に対応する知覚スコアを分析することにより求める。知覚閾値は知覚スコアが1以上になる最初の圧力、不快感閾値は知覚スコアが5以上になる最初の圧力と定義する。
食前・食後の胃緊張を評価するため、5分間隔で連続的に平均バルーン容積を求めた。最大弛緩度は、平均食前容積と食後最大容積及び食後5分毎に測定した平均容積の差として求めた。
0=疼痛なし
1=わずかな痛覚あり
2=軽度痛覚あり
3=中等度の痛覚あり
4=高度の痛覚あり
5=不快
6=苦痛あり
食後の胃の最大弛緩度、すなわち食物受容能の結果を表3に示す。
Claims (1)
- 2−〔N−(4,5−ジメトキシ−2−ヒドロキシベンゾイル)アミノ〕−4−〔(2−ジイソプロピルアミノエチル)アミノカルボニル〕−1,3−チアゾール又はその酸付加塩を有効成分とし、食後の胃底部弛緩作用により食後の早期満腹感及び上腹部鼓腸を改善する胃食物受容能改善薬であって、該化合物を50〜1000mg/日の投与範囲で1日1〜3回に分けて経口投与するものである胃食物受容能改善薬。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011000499A JP5360075B2 (ja) | 2002-04-08 | 2011-01-05 | 胃食物受容能障害治療薬 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002104894 | 2002-04-08 | ||
JP2002104894 | 2002-04-08 | ||
JP2011000499A JP5360075B2 (ja) | 2002-04-08 | 2011-01-05 | 胃食物受容能障害治療薬 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003581777A Division JP5281226B2 (ja) | 2002-04-08 | 2003-04-08 | 胃食物受容能障害治療薬 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011068692A JP2011068692A (ja) | 2011-04-07 |
JP2011068692A5 JP2011068692A5 (ja) | 2012-08-09 |
JP5360075B2 true JP5360075B2 (ja) | 2013-12-04 |
Family
ID=28786350
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003581777A Expired - Lifetime JP5281226B2 (ja) | 2002-04-08 | 2003-04-08 | 胃食物受容能障害治療薬 |
JP2011000499A Expired - Lifetime JP5360075B2 (ja) | 2002-04-08 | 2011-01-05 | 胃食物受容能障害治療薬 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003581777A Expired - Lifetime JP5281226B2 (ja) | 2002-04-08 | 2003-04-08 | 胃食物受容能障害治療薬 |
Country Status (14)
Country | Link |
---|---|
US (4) | US20050176788A1 (ja) |
EP (2) | EP2301540A1 (ja) |
JP (2) | JP5281226B2 (ja) |
KR (4) | KR101423284B1 (ja) |
CN (2) | CN102125551B (ja) |
AT (1) | ATE522214T1 (ja) |
AU (1) | AU2003236326B2 (ja) |
CA (1) | CA2481916C (ja) |
CY (1) | CY1112057T1 (ja) |
DK (1) | DK1493441T3 (ja) |
ES (1) | ES2368732T3 (ja) |
PT (1) | PT1493441E (ja) |
SI (1) | SI1493441T1 (ja) |
WO (1) | WO2003084537A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104447612A (zh) * | 2013-09-16 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 阿考替胺水合物晶型及其制备方法和用途 |
CN103980226A (zh) * | 2014-05-10 | 2014-08-13 | 杭州新博思生物医药有限公司 | 盐酸阿考替胺水合物晶型及其制备方法 |
CN105315225A (zh) * | 2014-07-07 | 2016-02-10 | 中美华世通生物医药科技(武汉)有限公司 | 阿考替胺的酸加成盐及其制备方法 |
CN104045606B (zh) * | 2014-07-11 | 2015-09-30 | 杭州新博思生物医药有限公司 | 一锅法制备阿考替胺盐酸盐的方法 |
CN109988121B (zh) * | 2019-04-28 | 2023-01-03 | 梯尔希(南京)药物研发有限公司 | 一种阿考替胺衍生物的制备方法 |
TW202321237A (zh) | 2021-07-14 | 2023-06-01 | 美商纜圖藥品公司 | Map4k1抑制劑 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE254609T1 (de) * | 1995-05-18 | 2003-12-15 | Zeria Pharm Co Ltd | Aminothiazolderivate, sie enthaltende arzneimittel und zwischenprodukte in der herstellung dieser verbindungen |
JPH10212271A (ja) * | 1997-01-31 | 1998-08-11 | Zeria Pharmaceut Co Ltd | N−置換ベンゾイルアミン誘導体、それを含有する医薬及び該化合物の製造中間体 |
ES2198719T3 (es) * | 1997-06-24 | 2004-02-01 | Zeria Pharmaceutical Co., Ltd. | Procedimiento de produccion de los derivados de 2-hidroxibenzamida. |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
WO2000030640A1 (en) * | 1998-11-23 | 2000-06-02 | Janssen Pharmaceutica N.V. | Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia |
TR200103430T2 (tr) * | 1999-06-02 | 2002-06-21 | Janssen Pharmaceutica N.V. | Aminoalkil ile ikame edilmiş (benzodioksan, benzofuran veya benzopiran) türevleri |
NZ518579A (en) * | 1999-11-23 | 2003-09-26 | Janssen Pharmaceutica Nv | Use of 5HT3 agonists for relaxing the fundus-a cause of gastrointestinal disorder |
GB0002336D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
ATE343384T1 (de) * | 2000-09-08 | 2006-11-15 | Zeria Pharm Co Ltd | Pharmazeutische zusammensetzungen enthaltend aminothiazole derivate zur behandlung von motorischen störungen des dickdarms |
US6986882B2 (en) * | 2002-01-17 | 2006-01-17 | Astrazeneca Ab | Therapy for functional dyspepsia |
-
2003
- 2003-04-08 WO PCT/JP2003/004445 patent/WO2003084537A1/ja active Application Filing
- 2003-04-08 KR KR1020137022604A patent/KR101423284B1/ko active IP Right Review Request
- 2003-04-08 ES ES03745958T patent/ES2368732T3/es not_active Expired - Lifetime
- 2003-04-08 JP JP2003581777A patent/JP5281226B2/ja not_active Expired - Lifetime
- 2003-04-08 AT AT03745958T patent/ATE522214T1/de active
- 2003-04-08 CN CN201010611741.5A patent/CN102125551B/zh not_active Expired - Lifetime
- 2003-04-08 CN CNA038079755A patent/CN1646123A/zh active Pending
- 2003-04-08 EP EP10010621A patent/EP2301540A1/en not_active Withdrawn
- 2003-04-08 KR KR10-2004-7015764A patent/KR20050002925A/ko active Application Filing
- 2003-04-08 DK DK03745958.3T patent/DK1493441T3/da active
- 2003-04-08 PT PT03745958T patent/PT1493441E/pt unknown
- 2003-04-08 EP EP03745958A patent/EP1493441B1/en not_active Expired - Lifetime
- 2003-04-08 AU AU2003236326A patent/AU2003236326B2/en not_active Expired
- 2003-04-08 SI SI200332073T patent/SI1493441T1/sl unknown
- 2003-04-08 US US10/509,335 patent/US20050176788A1/en not_active Abandoned
- 2003-04-08 CA CA2481916A patent/CA2481916C/en not_active Expired - Lifetime
- 2003-04-08 KR KR1020127005319A patent/KR20120037035A/ko active Application Filing
- 2003-04-08 KR KR1020117000220A patent/KR20110010837A/ko active Application Filing
-
2009
- 2009-02-17 US US12/372,234 patent/US20090156652A1/en not_active Abandoned
-
2011
- 2011-01-05 JP JP2011000499A patent/JP5360075B2/ja not_active Expired - Lifetime
- 2011-11-16 CY CY20111101103T patent/CY1112057T1/el unknown
-
2014
- 2014-12-22 US US14/579,102 patent/US20150141475A1/en not_active Abandoned
-
2020
- 2020-08-20 US US16/998,637 patent/US20200375954A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2011068692A (ja) | 2011-04-07 |
PT1493441E (pt) | 2011-09-28 |
CA2481916A1 (en) | 2003-10-16 |
ATE522214T1 (de) | 2011-09-15 |
KR20120037035A (ko) | 2012-04-18 |
ES2368732T3 (es) | 2011-11-21 |
AU2003236326B2 (en) | 2008-02-28 |
EP1493441B1 (en) | 2011-08-31 |
US20150141475A1 (en) | 2015-05-21 |
SI1493441T1 (sl) | 2011-12-30 |
KR20110010837A (ko) | 2011-02-07 |
AU2003236326A1 (en) | 2003-10-20 |
US20050176788A1 (en) | 2005-08-11 |
EP1493441A1 (en) | 2005-01-05 |
DK1493441T3 (da) | 2011-10-17 |
CN1646123A (zh) | 2005-07-27 |
EP1493441A4 (en) | 2007-10-17 |
CN102125551A (zh) | 2011-07-20 |
US20090156652A1 (en) | 2009-06-18 |
CA2481916C (en) | 2013-02-26 |
CN102125551B (zh) | 2015-07-22 |
WO2003084537A1 (fr) | 2003-10-16 |
JP5281226B2 (ja) | 2013-09-04 |
EP2301540A1 (en) | 2011-03-30 |
JPWO2003084537A1 (ja) | 2005-08-11 |
CY1112057T1 (el) | 2015-11-04 |
KR20130101162A (ko) | 2013-09-12 |
US20200375954A1 (en) | 2020-12-03 |
KR20050002925A (ko) | 2005-01-10 |
KR101423284B1 (ko) | 2014-07-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5360075B2 (ja) | 胃食物受容能障害治療薬 | |
TWI314053B (en) | Use of compounds that are effective as selective opiate receptor modulators | |
KR101868991B1 (ko) | 피라졸 유도체 및 그 의약용도 | |
CN1341018A (zh) | 用于预防和治疗内脏痛的加巴喷丁衍生物 | |
HU201675B (en) | Process for producing oral pharmaceutical compositions with unappetizing effect | |
JP4876367B2 (ja) | アミノチアゾール誘導体を有効成分とする大腸運動不全治療剤 | |
AU2010212467A1 (en) | 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno(2,3-D) pyrimidine in the treatment of functional bowel disorder | |
AU2003255712B2 (en) | 4-(2-fluorophenyl)-6-methyl-2(1-piperazinyl)thieno(2,3-D) pyrimidine in the treatment of functional bowel disorder | |
WO2003022290A1 (fr) | Compositions pharmaceutiques pour traiter la neuropathie diabetique | |
JP2021172639A (ja) | 医薬組成物 | |
JP2899740B2 (ja) | 炎症性腸疾患治療剤 | |
JP4598674B2 (ja) | 統合失調症治療剤 | |
JP5142991B2 (ja) | 1−(3−クロロフェニル)−3−アルキルピペラジンを含む食欲障害治療用医薬組成物 | |
JPH0753363A (ja) | 頻尿治療剤 | |
JP2005314313A (ja) | 過敏性腸症候群を予防又は治療するための医薬 | |
JPH07291861A (ja) | 炎症性腸疾患予防治療剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120626 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130402 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130417 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130806 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130819 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5360075 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |