JP5358564B2 - 環状ペプチドｃｘｃｒ４アンタゴニスト - Google Patents
環状ペプチドｃｘｃｒ４アンタゴニスト Download PDFInfo
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- JP5358564B2 JP5358564B2 JP2010510418A JP2010510418A JP5358564B2 JP 5358564 B2 JP5358564 B2 JP 5358564B2 JP 2010510418 A JP2010510418 A JP 2010510418A JP 2010510418 A JP2010510418 A JP 2010510418A JP 5358564 B2 JP5358564 B2 JP 5358564B2
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Classifications
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- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
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- Virology (AREA)
- Rheumatology (AREA)
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- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94080207P | 2007-05-30 | 2007-05-30 | |
| US60/940,802 | 2007-05-30 | ||
| US94099607P | 2007-05-31 | 2007-05-31 | |
| US60/940,996 | 2007-05-31 | ||
| PCT/US2008/064177 WO2008150689A1 (en) | 2007-05-30 | 2008-05-20 | Cyclic peptide cxcr4 antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529957A JP2010529957A (ja) | 2010-09-02 |
| JP2010529957A5 JP2010529957A5 (OSRAM) | 2011-07-07 |
| JP5358564B2 true JP5358564B2 (ja) | 2013-12-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2010510418A Expired - Fee Related JP5358564B2 (ja) | 2007-05-30 | 2008-05-20 | 環状ペプチドｃｘｃｒ４アンタゴニスト |
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| EP (2) | EP2160221B1 (OSRAM) |
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| AT (1) | ATE516853T1 (OSRAM) |
| AU (1) | AU2008260326B2 (OSRAM) |
| BR (1) | BRPI0812134A2 (OSRAM) |
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| CL (1) | CL2008001467A1 (OSRAM) |
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| CR (1) | CR11105A (OSRAM) |
| CY (1) | CY1111815T1 (OSRAM) |
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| DO (1) | DOP2009000270A (OSRAM) |
| EA (1) | EA017716B1 (OSRAM) |
| GT (1) | GT200900304A (OSRAM) |
| HR (1) | HRP20110551T1 (OSRAM) |
| IL (1) | IL201685A (OSRAM) |
| JO (1) | JO2776B1 (OSRAM) |
| MA (1) | MA31666B1 (OSRAM) |
| MX (1) | MX2009012952A (OSRAM) |
| MY (1) | MY149432A (OSRAM) |
| NZ (1) | NZ580849A (OSRAM) |
| PE (1) | PE20090299A1 (OSRAM) |
| PL (1) | PL2160221T3 (OSRAM) |
| PT (1) | PT2160221E (OSRAM) |
| TN (1) | TN2009000496A1 (OSRAM) |
| TW (1) | TWI423987B (OSRAM) |
| WO (1) | WO2008150689A1 (OSRAM) |
| ZA (1) | ZA200908345B (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2942798B1 (fr) * | 2009-03-05 | 2011-04-08 | Centre Nat Rech Scient | Peptides utilisables pour le traitement de la leucemie lymphoide chronique |
| IT1397901B1 (it) * | 2010-01-26 | 2013-02-04 | Consiglio Nazionale Ricerche | Peptidi ciclici che legano il recettore cxcr4 e relativi usi in campo medico e diagnostico. |
| JPWO2012118124A1 (ja) * | 2011-03-01 | 2014-07-07 | 国立大学法人京都大学 | 新規ケモカイン受容体拮抗剤 |
| WO2012168336A1 (en) * | 2011-06-07 | 2012-12-13 | Polyphor Ag | Beta - hairpin peptidomimetics as cxc4 antagonists |
| CN104780930A (zh) * | 2011-09-30 | 2015-07-15 | 程云 | 丙型肝炎病毒免疫原性肽或其衍生物在预防或治疗关节炎中的应用 |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| EP2979991A1 (en) | 2014-07-31 | 2016-02-03 | Greif International Holding BV. | Multilayer material, fire protection mat with said multilayer material and transport and storage container assembly comprising said fire protection mat. |
| ES2764840T3 (es) | 2015-01-28 | 2020-06-04 | Univ Bordeaux | Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica |
| WO2017176565A1 (en) | 2016-04-07 | 2017-10-12 | Eli Lilly And Company | Combinations of an anti-b7-h1 antibody and a cxcr4 peptide antagonist for treating a solid tumor |
| CN109922818B (zh) * | 2016-09-06 | 2024-02-20 | 主线生物科学公司 | Cxcr4拮抗剂及使用方法 |
| CN106841624B (zh) * | 2017-01-26 | 2019-02-22 | 庄磊靓 | 抗人cd4和抗人cd184单克隆抗体作为标志物的应用 |
| KR20200043970A (ko) * | 2017-09-05 | 2020-04-28 | 메인라인 바이오사이언스 | 고친화성 cxcr4 선택적 결합 콘쥬게이트 및 그 사용 방법 |
| US11123437B2 (en) | 2017-09-05 | 2021-09-21 | Mainline Biosciences, Inc. | Selective CXCR4 binding peptide conjugate and methods for making and using the same |
| WO2019126796A1 (en) * | 2017-12-21 | 2019-06-27 | Mainline Biosciences Llc | Composition comprising a therapeutic agent and a cxcr4 selective antagonist and methods for using the same |
| JP2021165234A (ja) * | 2018-07-03 | 2021-10-14 | 富士フイルム富山化学株式会社 | Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体 |
| US11639373B2 (en) | 2018-09-12 | 2023-05-02 | Technische Universität München | Therapeutic and diagnostic agents for cancer |
| CA3108450A1 (en) | 2018-09-12 | 2020-03-19 | Technische Universitat Munchen | Cxcr4-targeted diagnostic and therapeutic agents with reduced species selectivity |
| JP7541532B2 (ja) * | 2019-04-18 | 2024-08-28 | プロビンシャル・ヘルス・サービシーズ・オーソリティ | 診断及び治療のための新規な放射性標識されたｃｘｃｒ４を標的とする化合物 |
| EP4097120A4 (en) * | 2020-01-26 | 2024-05-01 | Mainline Biosciences (Shanghai) Co., Ltd. | ISOTOPE-LABELED CXCR4 SELECTIVELY BINDING PEPTIDE CONJUGATE AND METHODS OF MAKING AND USE THEREOF |
| WO2022082312A1 (en) * | 2020-10-21 | 2022-04-28 | Provincial Health Services Authority | Novel cxcr4-targeting compounds |
| TW202235429A (zh) * | 2020-12-25 | 2022-09-16 | 日商中外製藥股份有限公司 | 含ｎ－置換－胺基酸殘基之胜肽化合物的製備方法 |
| CN116615411A (zh) * | 2020-12-25 | 2023-08-18 | 中外制药株式会社 | 包含n-取代氨基酸残基的肽化合物的制造方法 |
| EP4043041A1 (en) | 2021-02-15 | 2022-08-17 | Technische Universität München | Cxcr4-ligands for diagnostic and therapeutic use and precursors thereof |
| CN119325480A (zh) * | 2022-04-20 | 2025-01-17 | 省卫生服务机构 | 靶向cxcr4的化合物及其制备和使用方法 |
| CN115060901A (zh) * | 2022-06-21 | 2022-09-16 | 中国医学科学院基础医学研究所 | 苹果酸酶2在制备矽肺病或肺纤维化相关疾病诊断试剂或治疗药物中的应用 |
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| JP4391123B2 (ja) * | 2002-10-24 | 2009-12-24 | 株式会社オーファンリンク | 新規ｃｘｃｒ４アンタゴニスト |
| CA2643744A1 (en) * | 2006-02-27 | 2007-08-30 | Technische Universitaet Muenchen | Cancer imaging and treatment |
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