CO6241137A2 - Antagonistas ciclicos de peptido cxcr4 - Google Patents
Antagonistas ciclicos de peptido cxcr4Info
- Publication number
- CO6241137A2 CO6241137A2 CO09135750A CO09135750A CO6241137A2 CO 6241137 A2 CO6241137 A2 CO 6241137A2 CO 09135750 A CO09135750 A CO 09135750A CO 09135750 A CO09135750 A CO 09135750A CO 6241137 A2 CO6241137 A2 CO 6241137A2
- Authority
- CO
- Colombia
- Prior art keywords
- glu
- group
- asp
- dglu
- side chain
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 title 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000000899 L-alpha-glutamyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 150000003951 lactams Chemical class 0.000 abstract 5
- -1 n-hexanoyl Chemical group 0.000 abstract 5
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 abstract 5
- 125000000030 D-alanine group Chemical group [H]N([H])[C@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 3
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004077 D-glutamic acid group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(N([H])[H])=O 0.000 abstract 2
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 2
- 125000003798 L-tyrosyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 2
- QCXJEYYXVJIFCE-UHFFFAOYSA-N para-acetamidobenzoic acid Natural products CC(=O)NC1=CC=C(C(O)=O)C=C1 QCXJEYYXVJIFCE-UHFFFAOYSA-N 0.000 abstract 2
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 1
- 125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002435 L-phenylalanyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 244000075898 Lantana strigocamara Species 0.000 abstract 1
- DTERQYGMUDWYAZ-UHFFFAOYSA-N N-acetyl-N-thioacetyl-Lysine Natural products CC(=O)NCCCCC(N)C(O)=O DTERQYGMUDWYAZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94080207P | 2007-05-30 | 2007-05-30 | |
| US94099607P | 2007-05-31 | 2007-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6241137A2 true CO6241137A2 (es) | 2011-01-20 |
Family
ID=39831600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09135750A CO6241137A2 (es) | 2007-05-30 | 2009-11-27 | Antagonistas ciclicos de peptido cxcr4 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US7691813B2 (OSRAM) |
| EP (2) | EP2160221B1 (OSRAM) |
| JP (1) | JP5358564B2 (OSRAM) |
| KR (2) | KR101169846B1 (OSRAM) |
| CN (1) | CN101678213B (OSRAM) |
| AR (1) | AR066648A1 (OSRAM) |
| AT (1) | ATE516853T1 (OSRAM) |
| AU (1) | AU2008260326B2 (OSRAM) |
| BR (1) | BRPI0812134A2 (OSRAM) |
| CA (1) | CA2688574C (OSRAM) |
| CL (1) | CL2008001467A1 (OSRAM) |
| CO (1) | CO6241137A2 (OSRAM) |
| CR (1) | CR11105A (OSRAM) |
| CY (1) | CY1111815T1 (OSRAM) |
| DK (1) | DK2160221T3 (OSRAM) |
| DO (1) | DOP2009000270A (OSRAM) |
| EA (1) | EA017716B1 (OSRAM) |
| GT (1) | GT200900304A (OSRAM) |
| HR (1) | HRP20110551T1 (OSRAM) |
| IL (1) | IL201685A (OSRAM) |
| JO (1) | JO2776B1 (OSRAM) |
| MA (1) | MA31666B1 (OSRAM) |
| MX (1) | MX2009012952A (OSRAM) |
| MY (1) | MY149432A (OSRAM) |
| NZ (1) | NZ580849A (OSRAM) |
| PE (1) | PE20090299A1 (OSRAM) |
| PL (1) | PL2160221T3 (OSRAM) |
| PT (1) | PT2160221E (OSRAM) |
| TN (1) | TN2009000496A1 (OSRAM) |
| TW (1) | TWI423987B (OSRAM) |
| WO (1) | WO2008150689A1 (OSRAM) |
| ZA (1) | ZA200908345B (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2942798B1 (fr) | 2009-03-05 | 2011-04-08 | Centre Nat Rech Scient | Peptides utilisables pour le traitement de la leucemie lymphoide chronique |
| IT1397901B1 (it) * | 2010-01-26 | 2013-02-04 | Consiglio Nazionale Ricerche | Peptidi ciclici che legano il recettore cxcr4 e relativi usi in campo medico e diagnostico. |
| JPWO2012118124A1 (ja) * | 2011-03-01 | 2014-07-07 | 国立大学法人京都大学 | 新規ケモカイン受容体拮抗剤 |
| CA2838037C (en) * | 2011-06-07 | 2019-09-17 | Polyphor Ag | Beta-hairpin peptidomimetics as cxc4 antagonists |
| WO2013044500A1 (zh) * | 2011-09-30 | 2013-04-04 | Cheng Yun | 丙型肝炎病毒免疫原性肽或其衍生物在预防或治疗关节炎中的应用 |
| EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| EP2979991A1 (en) | 2014-07-31 | 2016-02-03 | Greif International Holding BV. | Multilayer material, fire protection mat with said multilayer material and transport and storage container assembly comprising said fire protection mat. |
| ES2764840T3 (es) | 2015-01-28 | 2020-06-04 | Univ Bordeaux | Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica |
| WO2017176565A1 (en) | 2016-04-07 | 2017-10-12 | Eli Lilly And Company | Combinations of an anti-b7-h1 antibody and a cxcr4 peptide antagonist for treating a solid tumor |
| CN109922818B (zh) * | 2016-09-06 | 2024-02-20 | 主线生物科学公司 | Cxcr4拮抗剂及使用方法 |
| CN106841624B (zh) * | 2017-01-26 | 2019-02-22 | 庄磊靓 | 抗人cd4和抗人cd184单克隆抗体作为标志物的应用 |
| CA3065086A1 (en) * | 2017-09-05 | 2019-03-14 | Mainline Biosciences | High affinity cxcr4 selective binding conjugate and method for using the same |
| US11123437B2 (en) * | 2017-09-05 | 2021-09-21 | Mainline Biosciences, Inc. | Selective CXCR4 binding peptide conjugate and methods for making and using the same |
| US11771736B2 (en) * | 2017-12-21 | 2023-10-03 | Mainline Biosciences (Shanghai) Co., Ltd. | Composition comprising a therapeutic agent and a CXCR4 selective antagonist and methods for using the same |
| JP2021165234A (ja) * | 2018-07-03 | 2021-10-14 | 富士フイルム富山化学株式会社 | Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体 |
| EA202190755A1 (ru) | 2018-09-12 | 2021-06-11 | Технише Универзитет Мюнхен | Агенты для терапии и диагностики рака |
| WO2020053256A1 (en) | 2018-09-12 | 2020-03-19 | Technische Universität München | Cxcr4-targeted diagnostic and therapeutic agents with reduced species selectivity |
| US20220218852A1 (en) * | 2019-04-18 | 2022-07-14 | Provincial Health Services Authority | Novel radiolabelled cxcr4-targeting compounds for diagnosis and therapy |
| WO2021150258A1 (en) * | 2020-01-26 | 2021-07-29 | Mainline Biosciences Llc | Isotopically labelled selective cxcr4 binding peptide conjugate and methods for making and using the same |
| EP4232459A4 (en) * | 2020-10-21 | 2024-12-04 | Provincial Health Services Authority | NEW COMPOUNDS TARGETING CXCR4 |
| US20240124517A1 (en) * | 2020-12-25 | 2024-04-18 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide compound containing n-substituted-amino acid residue |
| CN116615411A (zh) * | 2020-12-25 | 2023-08-18 | 中外制药株式会社 | 包含n-取代氨基酸残基的肽化合物的制造方法 |
| EP4043041A1 (en) | 2021-02-15 | 2022-08-17 | Technische Universität München | Cxcr4-ligands for diagnostic and therapeutic use and precursors thereof |
| JP2025513489A (ja) * | 2022-04-20 | 2025-04-24 | プロビンシャル・ヘルス・サービシーズ・オーソリティ | Ｃｘｃｒ４標的化合物、およびその作製方法、およびその使用方法 |
| CN115060901A (zh) * | 2022-06-21 | 2022-09-16 | 中国医学科学院基础医学研究所 | 苹果酸酶2在制备矽肺病或肺纤维化相关疾病诊断试剂或治疗药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4391123B2 (ja) * | 2002-10-24 | 2009-12-24 | 株式会社オーファンリンク | 新規ｃｘｃｒ４アンタゴニスト |
| US8628750B2 (en) * | 2006-02-27 | 2014-01-14 | Technische Universitat Munchen | Cancer imaging and treatment |
-
2008
- 2008-05-20 EA EA200971129A patent/EA017716B1/ru not_active IP Right Cessation
- 2008-05-20 EP EP08769524A patent/EP2160221B1/en active Active
- 2008-05-20 TW TW097118554A patent/TWI423987B/zh not_active IP Right Cessation
- 2008-05-20 MX MX2009012952A patent/MX2009012952A/es active IP Right Grant
- 2008-05-20 WO PCT/US2008/064177 patent/WO2008150689A1/en not_active Ceased
- 2008-05-20 HR HR20110551T patent/HRP20110551T1/hr unknown
- 2008-05-20 NZ NZ580849A patent/NZ580849A/en not_active IP Right Cessation
- 2008-05-20 KR KR1020097024829A patent/KR101169846B1/ko not_active Expired - Fee Related
- 2008-05-20 AT AT08769524T patent/ATE516853T1/de active
- 2008-05-20 AU AU2008260326A patent/AU2008260326B2/en not_active Ceased
- 2008-05-20 DK DK08769524.3T patent/DK2160221T3/da active
- 2008-05-20 BR BRPI0812134-6A2A patent/BRPI0812134A2/pt not_active IP Right Cessation
- 2008-05-20 AR ARP080102137A patent/AR066648A1/es unknown
- 2008-05-20 US US12/123,574 patent/US7691813B2/en not_active Ceased
- 2008-05-20 JP JP2010510418A patent/JP5358564B2/ja not_active Expired - Fee Related
- 2008-05-20 PT PT08769524T patent/PT2160221E/pt unknown
- 2008-05-20 PL PL08769524T patent/PL2160221T3/pl unknown
- 2008-05-20 CL CL2008001467A patent/CL2008001467A1/es unknown
- 2008-05-20 EP EP11172401A patent/EP2377579A1/en not_active Withdrawn
- 2008-05-20 KR KR1020117026680A patent/KR101319740B1/ko not_active Expired - Fee Related
- 2008-05-20 PE PE2008000868A patent/PE20090299A1/es not_active Application Discontinuation
- 2008-05-20 CN CN2008800178577A patent/CN101678213B/zh not_active Expired - Fee Related
- 2008-05-20 JO JO2008229A patent/JO2776B1/en active
- 2008-05-20 CA CA2688574A patent/CA2688574C/en not_active Expired - Fee Related
- 2008-05-20 MY MYPI20095053A patent/MY149432A/en unknown
-
2009
- 2009-10-22 IL IL201685A patent/IL201685A/en not_active IP Right Cessation
- 2009-11-10 CR CR11105A patent/CR11105A/es not_active Application Discontinuation
- 2009-11-25 ZA ZA2009/08345A patent/ZA200908345B/en unknown
- 2009-11-26 GT GT200900304A patent/GT200900304A/es unknown
- 2009-11-26 TN TNP2009000496A patent/TN2009000496A1/fr unknown
- 2009-11-27 CO CO09135750A patent/CO6241137A2/es active IP Right Grant
- 2009-11-27 DO DO2009000270A patent/DOP2009000270A/es unknown
- 2009-12-21 MA MA32439A patent/MA31666B1/fr unknown
-
2010
- 2010-01-25 US US12/692,788 patent/US20100130409A1/en not_active Abandoned
- 2010-09-10 US US12/807,694 patent/USRE42274E1/en not_active Expired - Fee Related
-
2011
- 2011-09-07 CY CY20111100861T patent/CY1111815T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |