PL2160221T3 - Cykliczne peptydy antagonistyczne wobec CXCR4 - Google Patents

Cykliczne peptydy antagonistyczne wobec CXCR4

Info

Publication number
PL2160221T3
PL2160221T3 PL08769524T PL08769524T PL2160221T3 PL 2160221 T3 PL2160221 T3 PL 2160221T3 PL 08769524 T PL08769524 T PL 08769524T PL 08769524 T PL08769524 T PL 08769524T PL 2160221 T3 PL2160221 T3 PL 2160221T3
Authority
PL
Poland
Prior art keywords
cyclic peptide
cxcr4 antagonists
peptide cxcr4
antagonists
cyclic
Prior art date
Application number
PL08769524T
Other languages
English (en)
Inventor
Wayne David Kohn
Sheng-Bin Peng
Liang Zeng Yan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39831600&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2160221(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PL2160221T3 publication Critical patent/PL2160221T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL08769524T 2007-05-30 2008-05-20 Cykliczne peptydy antagonistyczne wobec CXCR4 PL2160221T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94080207P 2007-05-30 2007-05-30
US94099607P 2007-05-31 2007-05-31
EP08769524A EP2160221B1 (en) 2007-05-30 2008-05-20 Cyclic peptide cxcr4 antagonists
PCT/US2008/064177 WO2008150689A1 (en) 2007-05-30 2008-05-20 Cyclic peptide cxcr4 antagonists

Publications (1)

Publication Number Publication Date
PL2160221T3 true PL2160221T3 (pl) 2011-12-30

Family

ID=39831600

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08769524T PL2160221T3 (pl) 2007-05-30 2008-05-20 Cykliczne peptydy antagonistyczne wobec CXCR4

Country Status (32)

Country Link
US (3) US7691813B2 (pl)
EP (2) EP2160221B1 (pl)
JP (1) JP5358564B2 (pl)
KR (2) KR101169846B1 (pl)
CN (1) CN101678213B (pl)
AR (1) AR066648A1 (pl)
AT (1) ATE516853T1 (pl)
AU (1) AU2008260326B2 (pl)
BR (1) BRPI0812134A2 (pl)
CA (1) CA2688574C (pl)
CL (1) CL2008001467A1 (pl)
CO (1) CO6241137A2 (pl)
CR (1) CR11105A (pl)
CY (1) CY1111815T1 (pl)
DK (1) DK2160221T3 (pl)
DO (1) DOP2009000270A (pl)
EA (1) EA017716B1 (pl)
GT (1) GT200900304A (pl)
HR (1) HRP20110551T1 (pl)
IL (1) IL201685A (pl)
JO (1) JO2776B1 (pl)
MA (1) MA31666B1 (pl)
MX (1) MX2009012952A (pl)
MY (1) MY149432A (pl)
NZ (1) NZ580849A (pl)
PE (1) PE20090299A1 (pl)
PL (1) PL2160221T3 (pl)
PT (1) PT2160221E (pl)
TN (1) TN2009000496A1 (pl)
TW (1) TWI423987B (pl)
WO (1) WO2008150689A1 (pl)
ZA (1) ZA200908345B (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2942798B1 (fr) 2009-03-05 2011-04-08 Centre Nat Rech Scient Peptides utilisables pour le traitement de la leucemie lymphoide chronique
IT1397901B1 (it) * 2010-01-26 2013-02-04 Consiglio Nazionale Ricerche Peptidi ciclici che legano il recettore cxcr4 e relativi usi in campo medico e diagnostico.
JPWO2012118124A1 (ja) * 2011-03-01 2014-07-07 国立大学法人京都大学 新規ケモカイン受容体拮抗剤
CA2838037C (en) * 2011-06-07 2019-09-17 Polyphor Ag Beta-hairpin peptidomimetics as cxc4 antagonists
WO2013044500A1 (zh) * 2011-09-30 2013-04-04 Cheng Yun 丙型肝炎病毒免疫原性肽或其衍生物在预防或治疗关节炎中的应用
EP2771484A1 (en) 2011-10-28 2014-09-03 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
EP2979991A1 (en) 2014-07-31 2016-02-03 Greif International Holding BV. Multilayer material, fire protection mat with said multilayer material and transport and storage container assembly comprising said fire protection mat.
ES2764840T3 (es) 2015-01-28 2020-06-04 Univ Bordeaux Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica
WO2017176565A1 (en) 2016-04-07 2017-10-12 Eli Lilly And Company Combinations of an anti-b7-h1 antibody and a cxcr4 peptide antagonist for treating a solid tumor
CN109922818B (zh) * 2016-09-06 2024-02-20 主线生物科学公司 Cxcr4拮抗剂及使用方法
CN106841624B (zh) * 2017-01-26 2019-02-22 庄磊靓 抗人cd4和抗人cd184单克隆抗体作为标志物的应用
CA3065086A1 (en) * 2017-09-05 2019-03-14 Mainline Biosciences High affinity cxcr4 selective binding conjugate and method for using the same
US11123437B2 (en) * 2017-09-05 2021-09-21 Mainline Biosciences, Inc. Selective CXCR4 binding peptide conjugate and methods for making and using the same
US11771736B2 (en) * 2017-12-21 2023-10-03 Mainline Biosciences (Shanghai) Co., Ltd. Composition comprising a therapeutic agent and a CXCR4 selective antagonist and methods for using the same
JP2021165234A (ja) * 2018-07-03 2021-10-14 富士フイルム富山化学株式会社 Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体
EA202190755A1 (ru) 2018-09-12 2021-06-11 Технише Универзитет Мюнхен Агенты для терапии и диагностики рака
WO2020053256A1 (en) 2018-09-12 2020-03-19 Technische Universität München Cxcr4-targeted diagnostic and therapeutic agents with reduced species selectivity
US20220218852A1 (en) * 2019-04-18 2022-07-14 Provincial Health Services Authority Novel radiolabelled cxcr4-targeting compounds for diagnosis and therapy
WO2021150258A1 (en) * 2020-01-26 2021-07-29 Mainline Biosciences Llc Isotopically labelled selective cxcr4 binding peptide conjugate and methods for making and using the same
EP4232459A4 (en) * 2020-10-21 2024-12-04 Provincial Health Services Authority NEW COMPOUNDS TARGETING CXCR4
US20240124517A1 (en) * 2020-12-25 2024-04-18 Chugai Seiyaku Kabushiki Kaisha Method for producing peptide compound containing n-substituted-amino acid residue
CN116615411A (zh) * 2020-12-25 2023-08-18 中外制药株式会社 包含n-取代氨基酸残基的肽化合物的制造方法
EP4043041A1 (en) 2021-02-15 2022-08-17 Technische Universität München Cxcr4-ligands for diagnostic and therapeutic use and precursors thereof
JP2025513489A (ja) * 2022-04-20 2025-04-24 プロビンシャル・ヘルス・サービシーズ・オーソリティ Ｃｘｃｒ４標的化合物、およびその作製方法、およびその使用方法
CN115060901A (zh) * 2022-06-21 2022-09-16 中国医学科学院基础医学研究所 苹果酸酶2在制备矽肺病或肺纤维化相关疾病诊断试剂或治疗药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4391123B2 (ja) * 2002-10-24 2009-12-24 株式会社オーファンリンク 新規ｃｘｃｒ４アンタゴニスト
US8628750B2 (en) * 2006-02-27 2014-01-14 Technische Universitat Munchen Cancer imaging and treatment

Also Published As

Publication number Publication date
PT2160221E (pt) 2011-09-12
KR101319740B1 (ko) 2013-10-17
JO2776B1 (en) 2014-03-15
HK1141474A1 (en) 2010-11-12
JP2010529957A (ja) 2010-09-02
CA2688574C (en) 2014-02-18
CY1111815T1 (el) 2015-10-07
NZ580849A (en) 2012-03-30
AU2008260326B2 (en) 2011-07-21
USRE42274E1 (en) 2011-04-05
KR101169846B1 (ko) 2012-08-01
KR20110134519A (ko) 2011-12-14
ZA200908345B (en) 2011-02-23
KR20100003737A (ko) 2010-01-11
TW200902556A (en) 2009-01-16
EP2377579A1 (en) 2011-10-19
GT200900304A (es) 2011-11-09
MX2009012952A (es) 2009-12-11
US20100130409A1 (en) 2010-05-27
AU2008260326A1 (en) 2008-12-11
IL201685A (en) 2015-04-30
JP5358564B2 (ja) 2013-12-04
CN101678213A (zh) 2010-03-24
CO6241137A2 (es) 2011-01-20
PE20090299A1 (es) 2009-03-19
ATE516853T1 (de) 2011-08-15
BRPI0812134A2 (pt) 2014-11-18
TWI423987B (zh) 2014-01-21
EA017716B1 (ru) 2013-02-28
MA31666B1 (fr) 2010-09-01
CA2688574A1 (en) 2008-12-11
EP2160221B1 (en) 2011-07-20
CR11105A (es) 2010-04-12
CL2008001467A1 (es) 2008-12-05
US7691813B2 (en) 2010-04-06
IL201685A0 (en) 2010-05-31
EP2160221A1 (en) 2010-03-10
AR066648A1 (es) 2009-09-02
MY149432A (en) 2013-08-30
DOP2009000270A (es) 2010-01-15
EA200971129A1 (ru) 2010-04-30
TN2009000496A1 (en) 2011-03-31
US20080300177A1 (en) 2008-12-04
DK2160221T3 (da) 2011-09-19
HRP20110551T1 (hr) 2011-09-30
CN101678213B (zh) 2013-11-06
WO2008150689A1 (en) 2008-12-11

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