JP5350231B2 - 置換された１，３−ジフェニルプロパン誘導体、その製造および使用 - Google Patents

置換された１，３−ジフェニルプロパン誘導体、その製造および使用 Download PDF

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JP5350231B2
JP5350231B2 JP2009515889A JP2009515889A JP5350231B2 JP 5350231 B2 JP5350231 B2 JP 5350231B2 JP 2009515889 A JP2009515889 A JP 2009515889A JP 2009515889 A JP2009515889 A JP 2009515889A JP 5350231 B2 JP5350231 B2 JP 5350231B2
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propyl
phenyl
compound
oxo
group
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JP2009541270A5 (enExample
JP2009541270A (ja
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デルオメル，ジャン−フランソワ
アンフ，レミィ
コモン−ベルトラン，カリーヌ
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Genfit SA
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JP2009515889A 2006-06-21 2007-06-21 置換された１，３−ジフェニルプロパン誘導体、その製造および使用 Expired - Fee Related JP5350231B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0605540A FR2902789A1 (fr) 2006-06-21 2006-06-21 Derives de 1,3-diphenylpropane substitues, preparations et utilisations
FR06/05540 2006-06-21
PCT/EP2007/056225 WO2007147880A1 (fr) 2006-06-21 2007-06-21 Derives de 1,3-diphenylpropane substitues, preparations et utilisations

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JP2009541270A JP2009541270A (ja) 2009-11-26
JP2009541270A5 JP2009541270A5 (enExample) 2010-07-15
JP5350231B2 true JP5350231B2 (ja) 2013-11-27

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JP2009515888A Active JP5350230B2 (ja) 2006-06-21 2007-06-21 置換された１，３−ジフェニルプロパン誘導体、その製造および使用

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US (2) US8188148B2 (enExample)
EP (2) EP2046715B1 (enExample)
JP (2) JP5350231B2 (enExample)
KR (2) KR101416262B1 (enExample)
CN (3) CN101506138B (enExample)
AU (2) AU2007262939B2 (enExample)
BR (1) BRPI0713600B1 (enExample)
CA (2) CA2655643C (enExample)
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DK (2) DK2046716T3 (enExample)
EA (1) EA018437B1 (enExample)
ES (2) ES2434071T3 (enExample)
FR (1) FR2902789A1 (enExample)
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Publication number Priority date Publication date Assignee Title
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
FR2917084B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl propanoique activateurs des recpteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
SI2504005T1 (sl) * 2009-11-26 2014-04-30 Genfit Uporaba 1,3-difenilprop-2-en-1-on derivatov za zdravljenje ledviäśnih bolezni
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
AU2011254670B2 (en) 2010-05-17 2014-09-25 Genfit Improved preparation of chalcone derivatives
JP5593445B2 (ja) * 2010-07-12 2014-09-24 エフ．ホフマン−ラ ロシュ アーゲー １−ヒドロキシイミノ−３−フェニル−プロパン類
RU2014122487A (ru) * 2011-11-14 2015-12-27 Ф. Хоффманн-Ля Рош Аг 1-пиридазинил-гидроксиимино-3-фенил-пропаны в качестве агонистов сопряженного с g-белком рецептора желчных кислот gpbar1
AU2012360796B2 (en) * 2011-12-28 2017-02-02 Genfit 1,3-diphenylpropane derivatives, preparations and uses thereof
EP3416629A4 (en) * 2016-02-16 2019-08-07 CoNCERT Pharmaceuticals, Inc. DEUTERATED GFT-505
US12053445B2 (en) 2016-03-31 2024-08-06 Genfit Methods of treatment of cholestatic diseases
IT201600098338A1 (it) 2016-09-30 2018-03-30 Univ Degli Studi Padova Composti 1-fenilpropanone e loro impiego
RU186145U1 (ru) * 2018-08-08 2019-01-11 Общество с ограниченной ответственностью "Научно-производственное объединение "Центротех" (ООО "НПО "Центротех") Каркас виброрамы вибросита
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
EP4103166A1 (en) 2020-02-10 2022-12-21 Genfit Treatment of primary biliary cholangitis with elafibranor
WO2021169769A1 (zh) * 2020-02-28 2021-09-02 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途
US20230165821A1 (en) * 2020-05-18 2023-06-01 Genfit Elafibranor for the treatment of primary sclerosing cholangitis
KR20230058104A (ko) 2020-08-26 2023-05-02 장피트 원발 담즙성 담관염의 치료를 위한 조성물 및 방법
WO2022238450A1 (en) 2021-05-11 2022-11-17 Genfit Ppar-agonists for use in the treatment of liver failure
EP4337185A1 (en) 2021-05-11 2024-03-20 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis
TW202527918A (zh) 2023-10-13 2025-07-16 法商Ｇｅｎｆｉｔ公司 原發性膽汁性膽管炎之治療方法
TW202523277A (zh) 2023-10-25 2025-06-16 法商Ｇｅｎｆｉｔ公司 原發性膽汁性膽管炎的治療
WO2025215081A1 (en) 2024-04-09 2025-10-16 Genfit Elafibranor for use for long-term treatment of primary biliary cholangitis
CN119490528A (zh) * 2025-01-17 2025-02-21 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) 一种HSP90α选择性抑制剂及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149070C3 (de) 1971-10-01 1978-03-23 Boehringer Mannheim Gmbh, 6800 Mannheim Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel
HU200591B (en) * 1986-07-11 1990-07-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds
DE4121849A1 (de) * 1991-07-02 1993-01-14 Rhone Poulenc Rorer Gmbh (4-((omega)-arylalkyl)-phenyl)alkansaeuren, ihre salze und/oder ihre derivate
DE4327365A1 (de) * 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung
CA2370250C (en) * 1999-04-28 2009-12-29 Aventis Pharma Deutschland Gmbh Di-aryl acid derivatives as ppar receptor ligands
DE19933421A1 (de) * 1999-07-16 2001-01-25 Gruenenthal Gmbh 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
CA2538630A1 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd. Novel compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
MY147518A (en) * 2004-09-15 2012-12-31 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations

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